BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881  151 LSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY-GTIKQEDfw 229
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEE-- 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 356550881  230 kHRLALLGAADKYEIGDLKDACEESLLEDL 259
Cdd:pfam00651  79 -NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881  151 LSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY-GTIKQEDfw 229
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEE-- 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 356550881  230 kHRLALLGAADKYEIGDLKDACEESLLEDL 259
Cdd:pfam00651  79 -NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 160 HADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIKQEDFWKHRLALLGAA 239
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIY-TGELELSEENVEELLAAA 79

                 ...
gi 356550881 240 DKY 242
Cdd:cd18186   80 DKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881  151 LSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY-GTIKQEDfw 229
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYtGKLISEE-- 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 356550881  230 kHRLALLGAADKYEIGDLKDACEESLLEDL 259
Cdd:pfam00651  79 -NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 160 HADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIKQEDFWKHRLALLGAA 239
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIY-TGELELSEENVEELLAAA 79

                 ...
gi 356550881 240 DKY 242
Cdd:cd18186   80 DKL 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 149 RCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYGTIKQEDF 228
Cdd:cd18286    6 KDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPD 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 356550881 229 WKHRLALLGAADKYEIGDLKDACEESLLEDLN 260
Cdd:cd18286   86 DVNLGELLSLADMYGLDGLKDVVAYTLRRDYC 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 147 TLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIKQE 226
Cdd:cd18237    8 FMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY-TARIS 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 356550881 227 DFWKHRLALLGAADKYEIGDLKDACEESLLEDLNSGNVL 265
Cdd:cd18237   87 VNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 153 HMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYG---TIKQEDfw 229
Cdd:cd18300    2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTdqaPILEDG-- 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 356550881 230 kHRLALLGAADKYEIGDLKDACEESLLEDL 259
Cdd:cd18300   80 -DCVGLIVLANRLCLPRLVALCEQYIVKEL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 151 LSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIKQEDFWK 230
Cdd:cd18279    9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIY-TGKAPNLDK 87

                         90       100       110
                 ....*....|....*....|....*....|...
gi 356550881 231 HRLALLGAADKYEIGDLKDACEESLLEDLNSGN 263
Cdd:cd18279   88 MADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 162 DLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIKQEDFWKHRLALLGAADK 241
Cdd:cd18342   24 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIY-TGKAPNLDKMADDLLAAADK 102

                         90       100
                 ....*....|....*....|..
gi 356550881 242 YEIGDLKDACEESLLEDLNSGN 263
Cdd:cd18342  103 YALERLKVMCEDALCSNLSVEN 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 144 AQSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY--- 220
Cdd:cd18325    7 SRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYegk 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 356550881 221 ---GTIKQEDfwkhrlaLLGAADKYEIGDLKDACEESLLE-DLNSGN 263
Cdd:cd18325   87 lefSSLPVED-------VLAAASYLHMYDIVKVCKGKLKDkELCSEE 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 143 AAQSTLRC-LSHMLDEAIHADLTIITADGTLR----AHKAVLSASSTVLHSLYldNGDEKETS-TINMEDMSQESCMALL 216
Cdd:cd18281    4 ASKTTVKErFAFLFNNETLSDVHFIVGKGDNEqripAHKFVLSIGSAVFDAMF--NGGMATTSaEIELPDVEPAAFLALL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 356550881 217 SYLYG---TIKQEDFwkhrLALLGAADKYEIGDLKDACEESLLEDLNSGN 263
Cdd:cd18281   82 RFLYSdevQIGPETV----MTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 148 LRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYG---TIK 224
Cdd:cd18268   11 LRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTgeiLIT 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 356550881 225 QEDFwkhrLALLGAADKYEIGDLKDACEESLLEDLNSGNVL 265
Cdd:cd18268   91 RDNV----LPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 145 QSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIK 224
Cdd:cd18306    3 ESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAY-TSR 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 356550881 225 QEDFWKHRLALLGAADKYEIGDLKDACEESLLEDLNSGNVLD 266
Cdd:cd18306   82 LEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIG 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 160 HADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEkETSTINMEDMSQESCMALLSYLY-GTIKQEDFwkhrlallga 238
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPD-EHPVIILPDVPYSELKALLDFIYtGEVNVSQE---------- 69

                         90
                 ....*....|....*
gi 356550881 239 adkyEIGDLKDACEE 253
Cdd:cd18315   70 ----QLESLLKLAEL 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 175 HKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYG---TIKQEDFwkhrLALLGAADKYEIGDLKDAC 251
Cdd:cd18265   38 HRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGgglRIQEDNV----ESVLEASDLLQVSKLREAC 113

                         90
                 ....*....|....
gi 356550881 252 EESLLEDLNSGNVL 265
Cdd:cd18265  114 VRFLEGQLHPCNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 145 QSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTIK 224
Cdd:cd18338    6 KKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVY-TAE 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 356550881 225 QEDFWKHRLALLGAADKYEIGDLKDACEESLLEDLN 260
Cdd:cd18338   85 IQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLH 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 144 AQSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgTI 223
Cdd:cd18253    2 SESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVY-TG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 356550881 224 KQEDFWKHRLALLGAADKYEIGDLKDACEESLLEDLNSGN 263
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 144 AQSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY-GT 222
Cdd:cd18256    4 ASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYtGV 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 356550881 223 IK------QEdfwkhrlaLLGAADKYEIGDLKDACEESLLEDLNSGNVL 265
Cdd:cd18256   84 VEvtvsnvQE--------LLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 149 RCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY-GTIK--Q 225
Cdd:cd18298    1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYtDQVDlpP 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 356550881 226 EDfwkhRLALLGAADKYEIGDLKDACEESL 255
Cdd:cd18298   81 ED----AIGLLDLANSYCEERLKKLCEDII 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 161 ADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYgtIKQEDFWKHRLA-LLGAA 239
Cdd:cd18314    7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMY--TGQVTLSEENVLdLLMLA 84

                         90
                 ....*....|..
gi 356550881 240 DKYEIGDLKDAC 251
Cdd:cd18314   85 SKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 150 CLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY-GTIKQEDF 228
Cdd:cd18287   12 DIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRLTLTDL 91

                         90       100
                 ....*....|....*....|...
gi 356550881 229 WKHR-LALLGAADKYEIGDLKDA 250
Cdd:cd18287   92 KEDVlLDVLGLAHQYGFEELEAA 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 151 LSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYldNGDEKETST--INMEDMSQESCMALLSYLYGTIKQ--E 226
Cdd:cd18235   12 MNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMF--TGDLSESRAnrVTLQDVDGKALLLLIDYVYTAEIQvtE 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 356550881 227 DfwkHRLALLGAADKYEIGDLKDACEESLLEDL 259
Cdd:cd18235   90 E---NVQVLLPAANLLQLTDVRDACCDFLQSQL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 151 LSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLY------GTIK 224
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYtdsccpASIL 80

                         90       100
                 ....*....|....*....|....*...
gi 356550881 225 QEdfwkhrLALLGAADKYEIGDLKDACE 252
Cdd:cd18360   81 QA------MALLICAEMYQVSRLQHICE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 356550881 162 DLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKEtSTINMEDMSQESCMALLSYLY 220
Cdd:cd18212   25 DITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQ-SIYMLEGMVAETFGALLEFIY 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 144 AQSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHSLYLDNGDEKETSTINMEDMSQESCMALLSYLYG-- 221
Cdd:cd18250    5 ALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTgr 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 356550881 222 -TIKQEDFwkhrLALLGAADKYEIGDLKDACEESLLEDLNSGNV 264
Cdd:cd18250   85 vTVTQDNV----EALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 149 RCLSHMLDEAIH--ADLTIITADG-TLRAHKAVLSASSTVLHSLYLDNGDEKETST--INMEDM------SQESCMALLS 217
Cdd:cd18310    5 SDLENLLDSPDLfySDAEIIVEGGrPVPVHRCILAARSPFFRDIFASAKAEGANTKpkLELRELipggivGYDAFMLVLS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 356550881 218 YLYGTikqedfwKHRLALLGAADKYEIGDLKDACEESLleDLnsgnVLDRLNDAWLYQLQALK 280
Cdd:cd18310   85 YLYSG-------RLRLVPKEGSACVDSDCWHVACRPAV--DF----ALEVLYAASVFQIPELV 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 144 AQSTLRCLSHMLDEAIHADLTIITADGTLRAHKAVLSASSTVLHS-LYLDNGDEKETSTINMEDmsQESCMAL----LSY 218
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVmLSNDWWSESKQSEIELVE--DPECAAVfekfLRY 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 356550881 219 LY-GTI---KQEDFWKHRLAllgaaDKYEIGDLKDACEE 253
Cdd:cd18292   79 LYtGQIsvnLETALPLLMLA-----DKYNVTDLKQLCVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 356550881 154 MLDEAIHADLTIIT----ADGTLRAHKAVLSASSTVLHSLYLdnGDEKET-STINMEDMSQESCMALLSYLYG-TIKQED 227
Cdd:cd18349    2 MFNNELMADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMFY--GDLAEVkSEIHIPDVEPAAFLILLKYMYSdEIDLEA 79

                         90       100
                 ....*....|....*....|....
gi 356550881 228 fwKHRLALLGAADKYEIGDLKDAC 251
Cdd:cd18349   80 --DTVLATLYAAKKYIVPALAKAC 101