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Conserved domains on  [gi|327285210|ref|XP_003227327|]
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GPI transamidase component PIG-S [Anolis carolinensis]

Protein Classification

PIG-S family GPI transamidase component( domain architecture ID 10564829)

PIG-S family GPI transamidase component is part of the GPI (glycosylphosphatidylinositol) transamidase complex that is involved in the transfer of GPI to proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PIG-S pfam10510
Phosphatidylinositol-glycan biosynthesis class S protein; PIG-S is one of several key, core, ...
25-551 0e+00

Phosphatidylinositol-glycan biosynthesis class S protein; PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear.


:

Pssm-ID: 463126  Cd Length: 502  Bit Score: 542.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210   25 SFAAIAVVLGLPLWWKTTETYRASLPYAEIAEL-DTLRFQLTVPVSVVFAKGSLPAKQERKLPSR-KMQDVEIPLNPKTS 102
Cdd:pfam10510   1 AFWLVVLLLGLPLWWKTTSIYRAPLPLDEIESLsDGKACRIHFPIPVVLDSPSLPESDAEDLLDLvQQQLDDLLVKKDFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  103 VTSHYEMFYRRATTQEEMILaqksleevdsslrttEETSMGSITVYVVPQNSLLlPQDVAVFVGKHRSAVLRSPLNAEda 182
Cdd:pfam10510  81 LSTNWSLRLLLAEEDEQDSL---------------EEDPDGALTVRLVPDDSKS-AVSLVLGKGSHATIVFYDDNSVD-- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  183 LTKVDAHVQRVAHAMSFT---PDSLAEALADRVLIGQPGAEWKRPVKSSLGYEITFSLLNPDPrsHDVHWDIEGAIRRFV 259
Cdd:pfam10510 143 SDKLSSFIAQVLVEHFFEeehEELSISILLSYLLSTSSSKRSRRSVKYSPNYHLSFSLLNPDP--EPSSWDIEAALEEYL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  260 KPMLEKLSPVAEFSVDSQILYYAALGVTPRFDpASSSYRLSVHSLPHVINPVEARLGSSAaSLYPVLNFLLYIPEDLHSP 339
Cdd:pfam10510 221 TPFLDALSPIANFTVDTQVLYYADLSLKPKFE-KLAAYVLSEDDLSHFINAAEWSLSSSI-SEGPVLNFVVYVPSAEHSP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  340 LYIQGKDGSAVPTNAFHSPRWGGIMIYNVGPDTANEtsfPKRVDVN-MVAVMEVFLAQLRLLFGVSQTplpegaLLANPG 418
Cdd:pfam10510 299 LYIRDSDGSISKTNSFLIPQWGGVIILNPPLKTCDS---PSHLSEEeLQPIMEVFSSQLRLLLGLPSD------LSSPPS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  419 NAGLCDWELDRLLWARTVENVATVSTTLTSLAQLLGKIGNIVIKDDVASEVFHAVESAQGALQELEAGQLEAAFLASKAA 498
Cdd:pfam10510 370 LPLLADWELDSLKRRRTLENLLSASSTLGSLARLTQSLPNIVIPDEVADDVTTALELLEEACDELNEGRLDEALALSREA 449
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 327285210  499 VTSSERAFFHPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSMAKILRESRAA 551
Cdd:pfam10510 450 VALAERAFFDPSMVSQLYFPDEHKYAVYLPLFGPISVPLLLSLLKELKEYKKR 502
 
Name Accession Description Interval E-value
PIG-S pfam10510
Phosphatidylinositol-glycan biosynthesis class S protein; PIG-S is one of several key, core, ...
25-551 0e+00

Phosphatidylinositol-glycan biosynthesis class S protein; PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear.


Pssm-ID: 463126  Cd Length: 502  Bit Score: 542.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210   25 SFAAIAVVLGLPLWWKTTETYRASLPYAEIAEL-DTLRFQLTVPVSVVFAKGSLPAKQERKLPSR-KMQDVEIPLNPKTS 102
Cdd:pfam10510   1 AFWLVVLLLGLPLWWKTTSIYRAPLPLDEIESLsDGKACRIHFPIPVVLDSPSLPESDAEDLLDLvQQQLDDLLVKKDFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  103 VTSHYEMFYRRATTQEEMILaqksleevdsslrttEETSMGSITVYVVPQNSLLlPQDVAVFVGKHRSAVLRSPLNAEda 182
Cdd:pfam10510  81 LSTNWSLRLLLAEEDEQDSL---------------EEDPDGALTVRLVPDDSKS-AVSLVLGKGSHATIVFYDDNSVD-- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  183 LTKVDAHVQRVAHAMSFT---PDSLAEALADRVLIGQPGAEWKRPVKSSLGYEITFSLLNPDPrsHDVHWDIEGAIRRFV 259
Cdd:pfam10510 143 SDKLSSFIAQVLVEHFFEeehEELSISILLSYLLSTSSSKRSRRSVKYSPNYHLSFSLLNPDP--EPSSWDIEAALEEYL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  260 KPMLEKLSPVAEFSVDSQILYYAALGVTPRFDpASSSYRLSVHSLPHVINPVEARLGSSAaSLYPVLNFLLYIPEDLHSP 339
Cdd:pfam10510 221 TPFLDALSPIANFTVDTQVLYYADLSLKPKFE-KLAAYVLSEDDLSHFINAAEWSLSSSI-SEGPVLNFVVYVPSAEHSP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  340 LYIQGKDGSAVPTNAFHSPRWGGIMIYNVGPDTANEtsfPKRVDVN-MVAVMEVFLAQLRLLFGVSQTplpegaLLANPG 418
Cdd:pfam10510 299 LYIRDSDGSISKTNSFLIPQWGGVIILNPPLKTCDS---PSHLSEEeLQPIMEVFSSQLRLLLGLPSD------LSSPPS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  419 NAGLCDWELDRLLWARTVENVATVSTTLTSLAQLLGKIGNIVIKDDVASEVFHAVESAQGALQELEAGQLEAAFLASKAA 498
Cdd:pfam10510 370 LPLLADWELDSLKRRRTLENLLSASSTLGSLARLTQSLPNIVIPDEVADDVTTALELLEEACDELNEGRLDEALALSREA 449
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 327285210  499 VTSSERAFFHPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSMAKILRESRAA 551
Cdd:pfam10510 450 VALAERAFFDPSMVSQLYFPDEHKYAVYLPLFGPISVPLLLSLLKELKEYKKR 502
 
Name Accession Description Interval E-value
PIG-S pfam10510
Phosphatidylinositol-glycan biosynthesis class S protein; PIG-S is one of several key, core, ...
25-551 0e+00

Phosphatidylinositol-glycan biosynthesis class S protein; PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear.


Pssm-ID: 463126  Cd Length: 502  Bit Score: 542.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210   25 SFAAIAVVLGLPLWWKTTETYRASLPYAEIAEL-DTLRFQLTVPVSVVFAKGSLPAKQERKLPSR-KMQDVEIPLNPKTS 102
Cdd:pfam10510   1 AFWLVVLLLGLPLWWKTTSIYRAPLPLDEIESLsDGKACRIHFPIPVVLDSPSLPESDAEDLLDLvQQQLDDLLVKKDFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  103 VTSHYEMFYRRATTQEEMILaqksleevdsslrttEETSMGSITVYVVPQNSLLlPQDVAVFVGKHRSAVLRSPLNAEda 182
Cdd:pfam10510  81 LSTNWSLRLLLAEEDEQDSL---------------EEDPDGALTVRLVPDDSKS-AVSLVLGKGSHATIVFYDDNSVD-- 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  183 LTKVDAHVQRVAHAMSFT---PDSLAEALADRVLIGQPGAEWKRPVKSSLGYEITFSLLNPDPrsHDVHWDIEGAIRRFV 259
Cdd:pfam10510 143 SDKLSSFIAQVLVEHFFEeehEELSISILLSYLLSTSSSKRSRRSVKYSPNYHLSFSLLNPDP--EPSSWDIEAALEEYL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  260 KPMLEKLSPVAEFSVDSQILYYAALGVTPRFDpASSSYRLSVHSLPHVINPVEARLGSSAaSLYPVLNFLLYIPEDLHSP 339
Cdd:pfam10510 221 TPFLDALSPIANFTVDTQVLYYADLSLKPKFE-KLAAYVLSEDDLSHFINAAEWSLSSSI-SEGPVLNFVVYVPSAEHSP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  340 LYIQGKDGSAVPTNAFHSPRWGGIMIYNVGPDTANEtsfPKRVDVN-MVAVMEVFLAQLRLLFGVSQTplpegaLLANPG 418
Cdd:pfam10510 299 LYIRDSDGSISKTNSFLIPQWGGVIILNPPLKTCDS---PSHLSEEeLQPIMEVFSSQLRLLLGLPSD------LSSPPS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327285210  419 NAGLCDWELDRLLWARTVENVATVSTTLTSLAQLLGKIGNIVIKDDVASEVFHAVESAQGALQELEAGQLEAAFLASKAA 498
Cdd:pfam10510 370 LPLLADWELDSLKRRRTLENLLSASSTLGSLARLTQSLPNIVIPDEVADDVTTALELLEEACDELNEGRLDEALALSREA 449
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 327285210  499 VTSSERAFFHPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSMAKILRESRAA 551
Cdd:pfam10510 450 VALAERAFFDPSMVSQLYFPDEHKYAVYLPLFGPISVPLLLSLLKELKEYKKR 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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