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Conserved domains on  [gi|302760449|ref|XP_002963647|]
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cleavage stimulation factor subunit 50 [Selaginella moellendorffii]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
119-431 3.18e-49

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 3.18e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQQmmlpdvgsirpaIRTFFDHIHPINDLDFHPQAHILVSGA 198
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL------------LRTLTGHSGAVTSVAFSPDGKLLASGS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 199 KDRTIKFFDFAKTSARRAVKAiqDTHNVRSVCFHPCGDFLLAGTDHPIPHLYDSNTLQCyvSASLqeKHVGSAINQVRFS 278
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTL--TGHSGSVRSVAFS 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 279 ESGGLYVTASKDGGVRFWDGKTARCVRAIQGAhvSAEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVKRYIGsqHSQ 358
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGH--SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--HTG 331
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302760449 359 TRCQAVFTHNEEFVLSSDEpKGEVVVWDALTGDLMSRLnSNHAGALRCIEHSPSEACFVTCGSDRTVRFWQTA 431
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSD-DGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
119-431 3.18e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 3.18e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQQmmlpdvgsirpaIRTFFDHIHPINDLDFHPQAHILVSGA 198
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL------------LRTLTGHSGAVTSVAFSPDGKLLASGS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 199 KDRTIKFFDFAKTSARRAVKAiqDTHNVRSVCFHPCGDFLLAGTDHPIPHLYDSNTLQCyvSASLqeKHVGSAINQVRFS 278
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTL--TGHSGSVRSVAFS 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 279 ESGGLYVTASKDGGVRFWDGKTARCVRAIQGAhvSAEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVKRYIGsqHSQ 358
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGH--SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--HTG 331
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302760449 359 TRCQAVFTHNEEFVLSSDEpKGEVVVWDALTGDLMSRLnSNHAGALRCIEHSPSEACFVTCGSDRTVRFWQTA 431
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSD-DGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
118-429 1.73e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 1.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 118 SQQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQQmmlpdvgsirpaIRTFFDHIHPINDLDFHPQAHILVSG 197
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL------------LRTLKGHTGPVRDVAASADGTYLASG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 198 AKDRTIKFFDFAKTSARRAVKaiQDTHNVRSVCFHPCGDFLLAGTDHPIPHLYDSNTLQCyvSASLQEkHVGSaINQVRF 277
Cdd:cd00200   70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRG-HTDW-VNSVAF 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 278 SESGGLYVTASKDGGVRFWDGKTARCVRAIQGaHVSaEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVKRYIGsqHS 357
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTG-HTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HE 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302760449 358 QTRCQAVFTHNEEFVLSSDEpKGEVVVWDALTGDLMSRLnSNHAGALRCIEHSPSEACFVTCGSDRTVRFWQ 429
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGSE-DGTIRVWDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
172-207 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 302760449   172 IRTFFDHIHPINDLDFHPQAHILVSGAKDRTIKFFD 207
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
119-293 1.08e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 47.37  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449  119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQqmmlPDVGSIRPAIRTFFDHIHPINDLDFH---------- 188
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR----SSEKRSRNTQTEFPRKDHVIAETPFHilcghddiit 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449  189 -----PQAHILVSGAKDRTIKFfdfaktsarravKAIQDTHNVRSVCfHPCGDFL--LAGTDHPIPHLYDSNTLQCYVSa 261
Cdd:pfam20426 194 clyvsVELDIVISGSKDGTCIF------------HTLREGRYVRSIR-HPSGCPLskLVASRHGRIVLYADDDLSLHLY- 259
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 302760449  262 SLQEKHVGSA-----INQVRFSESGGLYVTASKDGGV 293
Cdd:pfam20426 260 SINGKHIASSesngrLNCIELSSCGEFLVCAGDQGQI 296
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
119-431 3.18e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 3.18e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQQmmlpdvgsirpaIRTFFDHIHPINDLDFHPQAHILVSGA 198
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL------------LRTLTGHSGAVTSVAFSPDGKLLASGS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 199 KDRTIKFFDFAKTSARRAVKAiqDTHNVRSVCFHPCGDFLLAGTDHPIPHLYDSNTLQCyvSASLqeKHVGSAINQVRFS 278
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTL--TGHSGSVRSVAFS 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 279 ESGGLYVTASKDGGVRFWDGKTARCVRAIQGAhvSAEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVKRYIGsqHSQ 358
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRTLTGH--SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--HTG 331
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302760449 359 TRCQAVFTHNEEFVLSSDEpKGEVVVWDALTGDLMSRLnSNHAGALRCIEHSPSEACFVTCGSDRTVRFWQTA 431
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSD-DGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
118-429 1.73e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 1.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 118 SQQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQQmmlpdvgsirpaIRTFFDHIHPINDLDFHPQAHILVSG 197
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL------------LRTLKGHTGPVRDVAASADGTYLASG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 198 AKDRTIKFFDFAKTSARRAVKaiQDTHNVRSVCFHPCGDFLLAGTDHPIPHLYDSNTLQCyvSASLQEkHVGSaINQVRF 277
Cdd:cd00200   70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRG-HTDW-VNSVAF 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 278 SESGGLYVTASKDGGVRFWDGKTARCVRAIQGaHVSaEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVKRYIGsqHS 357
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTG-HTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HE 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302760449 358 QTRCQAVFTHNEEFVLSSDEpKGEVVVWDALTGDLMSRLnSNHAGALRCIEHSPSEACFVTCGSDRTVRFWQ 429
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGSE-DGTIRVWDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
70-431 5.16e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 5.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449  70 APARGSASIDAGTSSIGYGPLPVLPSRLTDFNSLQTGKRASKFFPKLVSQQISEHKNAARCARFSPDGRLVATGGADASI 149
Cdd:COG2319   23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 150 KLFEVEKiqqmmlpdvgsiRPAIRTFFDHIHPINDLDFHPQAHILVSGAKDRTIKFFDFAKTSARRAVKAIQDThnVRSV 229
Cdd:COG2319  103 RLWDLAT------------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA--VTSV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 230 CFHPCGDFLL-AGTDHPIpHLYDSNTLQCYvsASLQEkHvGSAINQVRFSESGGLYVTASKDGGVRFWDGKTARCVRAIQ 308
Cdd:COG2319  169 AFSPDGKLLAsGSDDGTV-RLWDLATGKLL--RTLTG-H-TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 309 GAhvSAEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVKRYIGsqHSQTRCQAVFTHNEEFVLSSDEpKGEVVVWDAL 388
Cdd:COG2319  244 GH--SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSD-DGTVRLWDLA 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 302760449 389 TGDLMSRLnSNHAGALRCIEHSPSEACFVTCGSDRTVRFWQTA 431
Cdd:COG2319  319 TGKLLRTL-TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
119-344 1.70e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKiqqmmlpdvgsiRPAIRTFFDHIHPINDLDFHPQAHILVSGA 198
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT------------GKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 199 KDRTIKFFDFAKTSARRAVKAiqDTHNVRSVCFHPCGDFLLAGTDHPIPHLYDSNTLQCYVSASLQEKHVGSainqVRFS 278
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS----VAFS 339
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302760449 279 ESGGLYVTASKDGGVRFWDGKTARCVRAIQGaHvSAEATSAVFTRDQRYVLSCGKDLAVVLWDVGS 344
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGELLRTLTG-H-TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
270-431 1.95e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 270 SAINQVRFSESGGLYVTASKDGGVRFWDGKTARCVRAIQGaHvSAEATSAVFTRDQRYVLSCGKDLAVVLWDVGSGRQVK 349
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449 350 RYIGsqhsqtrcqavfthneefvlssdepkgevvvwdaltgdlmsrlnsnHAGALRCIEHSPSEACFVTCGSDRTVRFWQ 429
Cdd:cd00200   88 TLTG----------------------------------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                 ..
gi 302760449 430 TA 431
Cdd:cd00200  122 VE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
172-207 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 302760449   172 IRTFFDHIHPINDLDFHPQAHILVSGAKDRTIKFFD 207
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
119-293 1.08e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 47.37  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449  119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFEVEKIQqmmlPDVGSIRPAIRTFFDHIHPINDLDFH---------- 188
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR----SSEKRSRNTQTEFPRKDHVIAETPFHilcghddiit 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302760449  189 -----PQAHILVSGAKDRTIKFfdfaktsarravKAIQDTHNVRSVCfHPCGDFL--LAGTDHPIPHLYDSNTLQCYVSa 261
Cdd:pfam20426 194 clyvsVELDIVISGSKDGTCIF------------HTLREGRYVRSIR-HPSGCPLskLVASRHGRIVLYADDDLSLHLY- 259
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 302760449  262 SLQEKHVGSA-----INQVRFSESGGLYVTASKDGGV 293
Cdd:pfam20426 260 SINGKHIASSesngrLNCIELSSCGEFLVCAGDQGQI 296
WD40 pfam00400
WD domain, G-beta repeat;
172-207 1.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 302760449  172 IRTFFDHIHPINDLDFHPQAHILVSGAKDRTIKFFD 207
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
119-153 5.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 302760449   119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFE 153
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-153 2.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 302760449  119 QQISEHKNAARCARFSPDGRLVATGGADASIKLFE 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
117-153 6.22e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 6.22e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 302760449 117 VSQQISEHKNAARCARFSPDGRLVATGGADASIKLFE 153
Cdd:cd00200  253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
400-428 1.89e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*....
gi 302760449  400 HAGALRCIEHSPSEACFVTCGSDRTVRFW 428
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
270-297 2.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.01e-03
                           10        20
                   ....*....|....*....|....*...
gi 302760449   270 SAINQVRFSESGGLYVTASKDGGVRFWD 297
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
398-428 2.98e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.98e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302760449   398 SNHAGALRCIEHSPSEACFVTCGSDRTVRFW 428
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
123-156 7.21e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 7.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 302760449  123 EHKNAARCARFSPDGRLVATGGADASIKLFEVEK 156
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAEN 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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