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Conserved domains on  [gi|297812359|ref|XP_002874063|]
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dynein assembly factor 1, axonemal [Arabidopsis lyrata subsp. lyrata]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-377 6.76e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 6.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  37 LSKFKNLEKLDLRFNNLKDLQGLKSCVNLKWLSVVENKlqslkGIEALTKLTVLNAGKNQLKSM-NEISSLVNLRALILN 115
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 116 DNEISSICK-LDLLKDLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIKAIGSSLKSCSDLKELRLAHNEIKALPAEL 194
Cdd:COG4886  145 NNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 195 ALNKRLLNLDVGNNmitKLSGLEVLGTLSCLRNLNIRGNPISD--NEKSAKKVRTLLLPS--VNVFNAQPLEKSSRNAKH 270
Cdd:COG4886  225 ANLTNLETLDLSNN---QLTDLPELGNLTNLEELDLSNNQLTDlpPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSL 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 271 TRLDTDDENFDAHHNKLGEEEQSKEYRKSKKSSKRNKSEEEEEEANNDDHKTKKKKSKSNPSVDQVETEKKEEHKQKKIQ 350
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                        330       340
                 ....*....|....*....|....*..
gi 297812359 351 SNNDDDDAEKKQKRDTPKQELDAIDDA 377
Cdd:COG4886  382 LALLLLTLLLLLLTTTAGVLLLTLALL 408
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-377 6.76e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 6.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  37 LSKFKNLEKLDLRFNNLKDLQGLKSCVNLKWLSVVENKlqslkGIEALTKLTVLNAGKNQLKSM-NEISSLVNLRALILN 115
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 116 DNEISSICK-LDLLKDLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIKAIGSSLKSCSDLKELRLAHNEIKALPAEL 194
Cdd:COG4886  145 NNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 195 ALNKRLLNLDVGNNmitKLSGLEVLGTLSCLRNLNIRGNPISD--NEKSAKKVRTLLLPS--VNVFNAQPLEKSSRNAKH 270
Cdd:COG4886  225 ANLTNLETLDLSNN---QLTDLPELGNLTNLEELDLSNNQLTDlpPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSL 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 271 TRLDTDDENFDAHHNKLGEEEQSKEYRKSKKSSKRNKSEEEEEEANNDDHKTKKKKSKSNPSVDQVETEKKEEHKQKKIQ 350
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                        330       340
                 ....*....|....*....|....*..
gi 297812359 351 SNNDDDDAEKKQKRDTPKQELDAIDDA 377
Cdd:COG4886  382 LALLLLTLLLLLLTTTAGVLLLTLALL 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-236 4.12e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 85.61  E-value: 4.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  52 NLKDLQGLKSCVNLKWLSVVENKLQSLKGIEALTKLTVLNAGKNQLKSMNEISSLVNLRALILNDNEISSICKLDLLKDL 131
Cdd:cd21340   13 NITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 132 NSLVLSRNPISEiGDSLsklknlskisLSDCR-IKAIGSSLKScsdlkeLRLAHNEIKALpAELALNKRLLNLDVGNNMI 210
Cdd:cd21340   93 EELHIENQRLPP-GEKL----------TFDPRsLAALSNSLRV------LNISGNNIDSL-EPLAPLRNLEQLDASNNQI 154

                        170       180
                 ....*....|....*....|....*..
gi 297812359 211 TKLSGL-EVLGTLSCLRNLNIRGNPIS 236
Cdd:cd21340  155 SDLEELlDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-222 1.23e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  37 LSKFKNLEKLDLRFNNL--KDLQGLKSCVNLKWLSVVENKLQSL--KGIEALTKLTVLNAGKNQLKSmnEISS------L 106
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLtgEIPEGLCSSGNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDNSFSG--ELPSeftklpL 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 107 VNLraLILNDNEISSicKLDLLK----DLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIK-AIGSSLKSCSDLKELR 181
Cdd:PLN00113 430 VYF--LDISNNNLQG--RINSRKwdmpSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 297812359 182 LAHNEIKA-LPAELALNKRLLNLDVGNNMIT-----KLSGLEVLGTL 222
Cdd:PLN00113 506 LSENKLSGeIPDELSSCKKLVSLDLSHNQLSgqipaSFSEMPVLSQL 552
LRR_8 pfam13855
Leucine rich repeat;
108-164 3.97e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  108 NLRALILNDNEISSICK--LDLLKDLNSLVLSRNPISEI-GDSLSKLKNLSKISLSDCRI 164
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-377 6.76e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 6.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  37 LSKFKNLEKLDLRFNNLKDLQGLKSCVNLKWLSVVENKlqslkGIEALTKLTVLNAGKNQLKSM-NEISSLVNLRALILN 115
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 116 DNEISSICK-LDLLKDLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIKAIGSSLKSCSDLKELRLAHNEIKALPAEL 194
Cdd:COG4886  145 NNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 195 ALNKRLLNLDVGNNmitKLSGLEVLGTLSCLRNLNIRGNPISD--NEKSAKKVRTLLLPS--VNVFNAQPLEKSSRNAKH 270
Cdd:COG4886  225 ANLTNLETLDLSNN---QLTDLPELGNLTNLEELDLSNNQLTDlpPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSL 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 271 TRLDTDDENFDAHHNKLGEEEQSKEYRKSKKSSKRNKSEEEEEEANNDDHKTKKKKSKSNPSVDQVETEKKEEHKQKKIQ 350
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                        330       340
                 ....*....|....*....|....*..
gi 297812359 351 SNNDDDDAEKKQKRDTPKQELDAIDDA 377
Cdd:COG4886  382 LALLLLTLLLLLLTTTAGVLLLTLALL 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-236 4.12e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 85.61  E-value: 4.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  52 NLKDLQGLKSCVNLKWLSVVENKLQSLKGIEALTKLTVLNAGKNQLKSMNEISSLVNLRALILNDNEISSICKLDLLKDL 131
Cdd:cd21340   13 NITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 132 NSLVLSRNPISEiGDSLsklknlskisLSDCR-IKAIGSSLKScsdlkeLRLAHNEIKALpAELALNKRLLNLDVGNNMI 210
Cdd:cd21340   93 EELHIENQRLPP-GEKL----------TFDPRsLAALSNSLRV------LNISGNNIDSL-EPLAPLRNLEQLDASNNQI 154

                        170       180
                 ....*....|....*....|....*..
gi 297812359 211 TKLSGL-EVLGTLSCLRNLNIRGNPIS 236
Cdd:cd21340  155 SDLEELlDLLSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-237 2.24e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 2.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  17 DPDFVKELNLGHKALTDVSCLSKFKNLEKLDLRFNNLKDLQGLKSCVNLKWLSVVENKLQSLKGIEALTKLTVLNAGKNQ 96
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  97 LKSMNEISSLVNLRALILNDNEissicKLDLLKDLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIKAIGSSLKSCSD 176
Cdd:COG4886   86 LLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297812359 177 LKELRLAHNEIKALPAELALNKRLLNLDVGNNMITKLSglEVLGTLSCLRNLNIRGNPISD 237
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP--EPLGNLTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-262 3.35e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 3.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  22 KELNLGHKALTDVSC-LSKFKNLEKLDLRFNNLKDL-QGLKSCVNLKWLSVVENKLQSL-KGIEALTKLTVLNAGKNQLK 98
Cdd:COG4886  162 KSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  99 SMNEISSLVNLRALILNDNEISSICKLDLLKDLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIKAIGSSLKSCSDLK 178
Cdd:COG4886  242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 179 ELRLAHNEIKALPAELALNKRLLNLDVGNNMITKLSGLEVLGTLSCLRNLNIRGNPISDNEKSAKKVRTLLLPSVNVFNA 258
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401


                 ....
gi 297812359 259 QPLE 262
Cdd:COG4886  402 LLTL 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 31-164 1.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  31 LTDVSCLSKFKNLEKLDLRFNNLKDLQGLKSCVNLKWLSVVENKLQSLKGIEALTKLTVLNAGKNQL----------KSM 100
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLppgekltfdpRSL 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297812359 101 NEISSlvNLRALILNDNEISSICKLDLLKDLNSLVLSRNPIS---EIGDSLSKLKNLSKISLSDCRI 164
Cdd:cd21340  116 AALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 21-237 1.84e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  21 VKELNLGHKALTDVSCLSKFKNLEK------LDLRFNNL-KDLQGLKSCvnlkwlsvvenkLQSLKGIEALTKLTVLNA- 92
Cdd:cd00116   25 LQVLRLEGNTLGEEAAKALASALRPqpslkeLCLSLNETgRIPRGLQSL------------LQGLTKGCGLQELDLSDNa 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  93 -GKNQLKSMNEISSLVNLRALILNDNEISS-----ICK--LDLLKDLNSLVLSRNpiseigdslsklknlskiSLSDCRI 164
Cdd:cd00116   93 lGPDGCGVLESLLRSSSLQELKLNNNGLGDrglrlLAKglKDLPPALEKLVLGRN------------------RLEGASC 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 165 KAIGSSLKSCSDLKELRLAHNE-----IKALPAELALNKRLLNLDVGNNMITKLSGL---EVLGTLSCLRNLNIRGNPIS 236
Cdd:cd00116  155 EALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTDEGASalaETLASLKSLEVLNLGDNNLT 234


                 .
gi 297812359 237 D 237
Cdd:cd00116  235 D 235
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 25-242 4.97e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 4.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  25 NLGHKALTDVSCLSKFKNLEKLDLRFNNLkDLQGLKSC---------VNLKWLSVVENKLQSLKGI-EAL---TKLTVLN 91
Cdd:COG5238  164 RLGLLAAISMAKALQNNSVETVYLGCNQI-GDEGIEELaealtqnttVTTLWLKRNPIGDEGAEILaEALkgnKSLTTLD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  92 AGKNQLKS---MNEISSLVN---LRALILNDNEIS-----SICK-LDLLKDLNSLVLSRNPISE-----IGDSLSKLKNL 154
Cdd:COG5238  243 LSNNQIGDegvIALAEALKNnttVETLYLSGNQIGaegaiALAKaLQGNTTLTSLDLSVNRIGDegaiaLAEGLQGNKTL 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 155 SKISLSDCRI-----KAIGSSLKSCSDLKELRLAHNEI-----KALPAELALNKRLLNLDVGNNMITKLSGLEVLGTL-- 222
Cdd:COG5238  323 HTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALqt 402

                        250       260
                 ....*....|....*....|
gi 297812359 223 SCLRNLNIRGNPISDNEKSA 242
Cdd:COG5238  403 NRLHTLILDGNLIGAEAQQR 422
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-222 1.23e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  37 LSKFKNLEKLDLRFNNL--KDLQGLKSCVNLKWLSVVENKLQSL--KGIEALTKLTVLNAGKNQLKSmnEISS------L 106
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLtgEIPEGLCSSGNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDNSFSG--ELPSeftklpL 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 107 VNLraLILNDNEISSicKLDLLK----DLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIK-AIGSSLKSCSDLKELR 181
Cdd:PLN00113 430 VYF--LDISNNNLQG--RINSRKwdmpSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 297812359 182 LAHNEIKA-LPAELALNKRLLNLDVGNNMIT-----KLSGLEVLGTL 222
Cdd:PLN00113 506 LSENKLSGeIPDELSSCKKLVSLDLSHNQLSgqipaSFSEMPVLSQL 552
PLN03150 PLN03150
hypothetical protein; Provisional
 144-257 1.74e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 144 IGDSLSKLKNLSKISLSDCRIK-AIGSSLKSCSDLKELRLAHNEikalpaelalnkrllnldvgnnmitkLSGL--EVLG 220
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNS--------------------------FNGSipESLG 487

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 297812359 221 TLSCLRNLNIRGNPISDNEKSAKKVRTLLLPSVNVFN 257
Cdd:PLN03150 488 QLTSLRILNLNGNSLSGRVPAALGGRLLHRASFNFTD 524
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-239 6.02e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 6.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  37 LSKFKNLEKLDLRFNNLKD-----LQGLKSCVNLKWLSVVENKLQSLKG---IEALT----KLTVLNAGKNQLKS----- 99
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDRGLrllAKGLKdlppALEKLVLGRNRLEGascea 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 100 -MNEISSLVNLRALILNDNEIS------------SICKLDLLkDLNSLVLSRNPISEIGDSLSKLKNLSKISLSDCRIKA 166
Cdd:cd00116  157 lAKALRANRDLKELNLANNGIGdagiralaeglkANCNLEVL-DLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTD 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359 167 IG-----SSLKSCSD-LKELRLAHNEIKALPAE-----LALNKRLLNLDVGNNMITKLSGLEVLGTLSCLRNLNIRGNPI 235
Cdd:cd00116  236 AGaaalaSALLSPNIsLLTLSLSCNDITDDGAKdlaevLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVK 315


                 ....
gi 297812359 236 SDNE 239
Cdd:cd00116  316 DDSF 319
LRR_8 pfam13855
Leucine rich repeat;
108-164 3.97e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 297812359  108 NLRALILNDNEISSICK--LDLLKDLNSLVLSRNPISEI-GDSLSKLKNLSKISLSDCRI 164
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 21-61 7.06e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 297812359   21 VKELNLGHKALTDVSCLSKFKNLEKLDLRFNN-LKDLQGLKS 61
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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