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Conserved domains on  [gi|297298670|ref|XP_002805269|]
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BAG family molecular chaperone regulator 5 isoform X2 [Macaca mulatta]

Protein Classification

BAG family molecular chaperone regulator( domain architecture ID 10644980)

BAG (Bcl-2 associated athanogene) family molecular chaperone regulator which may function as a co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses; similar to Homo sapiens BAG family molecular chaperone regulators

CATH:  1.20.58.120
Gene Ontology:  GO:0051087|GO:0006457
PubMed:  12406544
SCOP:  4002965

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 365-442 7.54e-17

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 75.04  E-value: 7.54e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   365 SHKAVWNVLGNL-SEIQGEVLSFDGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLKS 442
Cdd:smart00264   1 SIKKINEVLDEVqKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 9-86 1.12e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 74.65  E-value: 1.12e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670     9 SISRLQEIQKEVKS-VEQQVVGFSGLSDDKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNA 86
Cdd:smart00264   1 SIKKINEVLDEVQKkIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 182-260 2.78e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 73.50  E-value: 2.78e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   182 SVAKINFVMCEVNKARGVLIALLMGVNNSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEE 260
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 275-350 8.62e-12

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 60.79  E-value: 8.62e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   275 SILKIEKVLTRMR-EIKNELLQA--QNPPELYLSSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLKE 350
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVAdgKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 365-442 7.54e-17

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 75.04  E-value: 7.54e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   365 SHKAVWNVLGNL-SEIQGEVLSFDGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLKS 442
Cdd:smart00264   1 SIKKINEVLDEVqKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 9-86 1.12e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 74.65  E-value: 1.12e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670     9 SISRLQEIQKEVKS-VEQQVVGFSGLSDDKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNA 86
Cdd:smart00264   1 SIKKINEVLDEVQKkIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 182-260 2.78e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 73.50  E-value: 2.78e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   182 SVAKINFVMCEVNKARGVLIALLMGVNNSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEE 260
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 369-441 8.26e-14

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 66.48  E-value: 8.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297298670  369 VWNVLGNLSEIQGEVLSFDGN----RTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLK 441
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSppskKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 13-84 1.22e-13

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 65.71  E-value: 1.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 297298670   13 LQEIQKEVKSVEQQVVGFSGLSD----DKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQ 84
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSPPskkrDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 275-350 8.62e-12

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 60.79  E-value: 8.62e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   275 SILKIEKVLTRMR-EIKNELLQA--QNPPELYLSSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLKE 350
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVAdgKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 279-349 1.72e-06

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 45.68  E-value: 1.72e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297298670  279 IEKVLTRMREIKNELLQAQNPPELYLSSKT------ELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLK 349
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSPPSKKRDKEykrlseMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 186-258 2.65e-06

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 44.91  E-value: 2.65e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 297298670  186 INFVMCEVNKARG---VLIALLMGVNNSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDL 258
Cdd:pfam02179   1 IDAILKEVDKLEPqveAFEGSPPSKKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 365-442 7.54e-17

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 75.04  E-value: 7.54e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   365 SHKAVWNVLGNL-SEIQGEVLSFDGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLKS 442
Cdd:smart00264   1 SIKKINEVLDEVqKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 9-86 1.12e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 74.65  E-value: 1.12e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670     9 SISRLQEIQKEVKS-VEQQVVGFSGLSDDKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNA 86
Cdd:smart00264   1 SIKKINEVLDEVQKkIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 182-260 2.78e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 73.50  E-value: 2.78e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   182 SVAKINFVMCEVNKARGVLIALLMGVNNSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEE 260
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 369-441 8.26e-14

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 66.48  E-value: 8.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297298670  369 VWNVLGNLSEIQGEVLSFDGN----RTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDLK 441
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSppskKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 13-84 1.22e-13

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 65.71  E-value: 1.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 297298670   13 LQEIQKEVKSVEQQVVGFSGLSD----DKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQ 84
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSPPskkrDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 275-350 8.62e-12

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 60.79  E-value: 8.62e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297298670   275 SILKIEKVLTRMR-EIKNELLQA--QNPPELYLSSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLKE 350
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVAdgKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 279-349 1.72e-06

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 45.68  E-value: 1.72e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297298670  279 IEKVLTRMREIKNELLQAQNPPELYLSSKT------ELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLK 349
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSPPSKKRDKEykrlseMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 186-258 2.65e-06

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 44.91  E-value: 2.65e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 297298670  186 INFVMCEVNKARG---VLIALLMGVNNSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDL 258
Cdd:pfam02179   1 IDAILKEVDKLEPqveAFEGSPPSKKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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