BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLM 97
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLM 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622944486  98 IQGEEEANDVWKAAEFLQMLEAIKALEVRNKEN 130
Cdd:cd18221    81 VQGEEEANDVWKAAEYLQMQEAIKALEFRNKES 113

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486 264 HCEKCNRSFKLFYHFKEHMKSHS--------TESFKCEICNKRYLRESAWKQHLNCYHLEEGgvskkqrtGKKIHVC--Q 333
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSVNHSGE--------SLKPFSCpyS 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486 334 YCEKQFDHFGHFKEHLRKHTGEKPFECP--NCHERFARNSTLKCHLTACQTgVGAKKGRKklYECQVCNSVFNSWDQF-- 409
Cdd:COG5048   328 LCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQY-KDLKNDKK--SETLSNSCIRNFKRDSnl 404

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1622944486 410 KDHLVIHTGDKP--NHCTLCDLWFMQGNELRRHLSDAHN 446
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTN 443

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLM 97
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLM 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622944486  98 IQGEEEANDVWKAAEFLQMLEAIKALEVRNKEN 130
Cdd:cd18221    81 VQGEEEANDVWKAAEYLQMQEAIKALEFRNKES 113

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486   37 DITLIVDGHHFKAHKAVLAACSKFFYKFFQ---EFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQgEEEANDVWKAAEF 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsdfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP-EENVEELLELADY 79

                           90
                   ....*....|.
gi 1622944486  114 LQMLEAIKALE 124
Cdd:smart00225  80 LQIPGLVELCE 90

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486 264 HCEKCNRSFKLFYHFKEHMKSHS--------TESFKCEICNKRYLRESAWKQHLNCYHLEEGgvskkqrtGKKIHVC--Q 333
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSVNHSGE--------SLKPFSCpyS 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486 334 YCEKQFDHFGHFKEHLRKHTGEKPFECP--NCHERFARNSTLKCHLTACQTgVGAKKGRKklYECQVCNSVFNSWDQF-- 409
Cdd:COG5048   328 LCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQY-KDLKNDKK--SETLSNSCIRNFKRDSnl 404

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1622944486 410 KDHLVIHTGDKP--NHCTLCDLWFMQGNELRRHLSDAHN 446
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTN 443

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLM 97
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLM 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622944486  98 IQGEEEANDVWKAAEFLQMLEAIKALEVRNKEN 130
Cdd:cd18221    81 VQGEEEANDVWKAAEYLQMQEAIKALEFRNKES 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQ---EFTQEPLVEIEGVSKMAFRHLIEFTYTA 94
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSsdsDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622944486  95 KLMIQGeEEANDVWKAAEFLQMLEAIKALE 124
Cdd:cd18306    81 RLEVPA-DLVKSVYSAAKKLKMDRVKKACG 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  14 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEftQEPLVEIEGVSKMAFRHLIEFTYT 93
Cdd:cd18206     1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD--QKDVVHLDISNAAGLGQVLEFMYT 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622944486  94 AKLMIQgEEEANDVWKAAEFLQMLEAIKALE 124
Cdd:cd18206    79 AKLSLS-PENVDDVLAVATFLQMQDIVTACH 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE----FTQEPLVEIEGVSKMAFRHLIEFTYT 93
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEkgavSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622944486  94 AKLMIQGEEEAnDVWKAAEFLQMLEAIKALEVRNKE 129
Cdd:cd18202    82 SELTFDFCSMA-EVAMLARHLFMNEVLEICESVHKQ 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  14 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE-FTQEPLVEIEG--VSKMAFRHLIEF 90
Cdd:cd18194     2 EFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDrLDKRDLVRLNSdiVTAPAFGLLLDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622944486  91 TYTAKLMIQgEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENT 138
Cdd:cd18194    82 MYEGRLALR-DLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAEADST 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  14 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQ-EFTQEPLVEIEG--VSKMAFRHLIEF 90
Cdd:cd18324     2 EFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKdQLDKRDIVHLNSdiVTAPAFALLLEF 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622944486  91 TYTAKLMIQGeEEANDVWKAAEFLQMLEAIKALEVRNKENSapleenTTGKNEAKKRKIAETSNVITESLPSA 163
Cdd:cd18324    82 MYEGKLQFKD-LPIEDVLAAASYLHMYDIVKVCKKKLKEKA------TTEADSTKKEEDASSCSDKVESFSSG 147

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486   37 DITLIVDGHHFKAHKAVLAACSKFFYKFFQ---EFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQgEEEANDVWKAAEF 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSsdfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP-EENVEELLELADY 79

                           90
                   ....*....|.
gi 1622944486  114 LQMLEAIKALE 124
Cdd:smart00225  80 LQIPGLVELCE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  17 EHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFY-KFFQEFT---------QEPLVEIEGVSKMAFRH 86
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRsKLVGQASprlvlvspaGKCVLDLHHVTVTGFAP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622944486  87 LIEFTYTAKLMIQgEEEANDVWKAAEFLQM 116
Cdd:cd18228    81 LLEYAYTSTLSIN-TENIIDVLAAASYMQM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQE-PLVEIEGVSKMAFRHLIEFTYTAKL 96
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNiVFLDQSQVSADGFQKLLEFIYTGNL 80

                          90       100
                  ....*....|....*....|....*...
gi 1622944486  97 MIQGEEEAnDVWKAAEFLQMLEAIKALE 124
Cdd:cd18217    81 NLDSWNVA-EIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFY-KFFQEFTQEPLVEI-EGVSKMAFRHLIEFTYTAK 95
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHsRIVGQADAELNITLpEEVTVKGFEPLIQFAYTAK 89

                          90
                  ....*....|....*....
gi 1622944486  96 LMIQgEEEANDVWKAAEFL 114
Cdd:cd18277    90 LILS-KDNVDEVCKCVEFL 107

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  35 FTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEI--EGVSKMAFRHLIEFTYTAKlMIQGEEEANDVWKAAE 112
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIilPDVPYSELKALLDFIYTGE-VNVSQEQLESLLKLAE 79

                  ...
gi 1622944486 113 FLQ 115
Cdd:cd18315    80 LLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE--------FTQEPLVEIEGvskmaFRHLIE 89
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDqlknnvsvINLDPEIEPEG-----FRILLD 76

                          90       100
                  ....*....|....*....|....*..
gi 1622944486  90 FTYTAKLMIQGeEEANDVWKAAEFLQM 116
Cdd:cd18215    77 FMYTSRLNLRE-GNIMAVMATAMYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKmAFRHLIEFTYTAKLM 97
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAE-VFGLLLDFFYTGELA 79

                          90       100
                  ....*....|....*....|...
gi 1622944486  98 IQgEEEANDVWKAAEFLQMLEAI 120
Cdd:cd18232    80 LT-RENRDRVLLAAKELRVPEAV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  11 CLQeFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQE--------FTQEPLVEIEGvskm 82
Cdd:cd18331     1 CIQ-FTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDqlkcnlsvINLDPEINPEG---- 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622944486  83 aFRHLIEFTYTAKLMIQgEEEANDVWKAAEFLQM 116
Cdd:cd18331    76 -FNILLDFMYTSRLNLR-EGNIMAVMATAMYLQM 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQ--EPLVEIEGVSKMAFRHLIEFTYTAK 95
Cdd:cd18212     6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEvgQSIYMLEGMVAETFGALLEFIYTGC 85

                          90       100
                  ....*....|....*....|....*....
gi 1622944486  96 LMIqGEEEANDVWKAAEFLQMLEAIKALE 124
Cdd:cd18212    86 LQV-GEKSLEQILATAQFLKVNDLVKAYS 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQ---EFTQEPLVEIEGVSKMAFRHLIEFTYTA 94
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDIFHILLDFIYTG 82

                          90       100
                  ....*....|....*....|....*...
gi 1622944486  95 KLMIqGEEEANDVWKAAEFLQMLEAIKA 122
Cdd:cd18256    83 VVEV-TVSNVQELLVAADMLQLTEVVEI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  15 FPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP----------LVEIEGVSKMAF 84
Cdd:cd18327     5 FPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSgdlgagggqdVCELDFVGPEAL 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622944486  85 RHLIEFTYTAKLMIQgEEEANDVWKAAEFLQM 116
Cdd:cd18327    85 GALLEFAYTATLTIS-SSNMREVLRAARLLEI 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFF----YKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYT 93
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFrmllSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100
                  ....*....|....*....|....*..
gi 1622944486  94 AKLMIQGeEEANDVWKAAEFLQMLEAI 120
Cdd:cd18199    81 GKLSLTS-QNVIEVMSAASYLQMTDVI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  16 PEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFT----QEPLVEIEGVSKMAFRHLIEFT 91
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQktsdQATVTHLDIVTAQGFKAIIDFM 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622944486  92 YTAKLMIQgEEEANDVWKAAEFLQMLEAIKA 122
Cdd:cd18230    82 YSAHLALT-SKNVIEVMSAASYLQMTDIVQA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  16 PEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP---LVEIEGVSKMAFRHLIEFTY 92
Cdd:cd18235     2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESranRVTLQDVDGKALLLLIDYVY 81

                          90       100
                  ....*....|....*....|....*.
gi 1622944486  93 TAKLMIQgEEEANDVWKAAEFLQMLE 118
Cdd:cd18235    82 TAEIQVT-EENVQVLLPAANLLQLTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  18 HHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEP---LVEIEGVSKMAFRHLIEFTYTA 94
Cdd:cd18264    11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESkarVIHLPVVSAAGLQRVLDFIYTS 90

                          90       100
                  ....*....|....*....|....*..
gi 1622944486  95 KLMIQgEEEANDVWKAAEFLQMLEAIK 121
Cdd:cd18264    91 WLSLS-LDTLEDTLEAASYLQVTEAIG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  14 EFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYT 93
Cdd:cd18289     8 EIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQILSFCYT 87

                          90       100
                  ....*....|....*....|...
gi 1622944486  94 AKLMIQGEEEANDVWKAAeFLQM 116
Cdd:cd18289    88 GKLTMAASEQLVVMYTAG-FLQI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  15 FPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEI-----EGVSKMAFRHLIE 89
Cdd:cd18196     1 FPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMiqldsEVVTAEAFAALID 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622944486  90 FTYTAKLMIqGEEEANDVWKAAEFLQMLEAIKA 122
Cdd:cd18196    81 MMYTSTLML-GESNVMDVLLAASHLHLNSVVKA 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622944486  15 FPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFfqeFTQEPLVEIEG--VSKMAFRHLIEFTY 92
Cdd:cd18334     1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL---VLHDNLINLDTdmVNPTVFRQILDFIY 77

                          90       100
                  ....*....|....*....|....*..
gi 1622944486  93 TAKLMIQ---GEEEANDVWKAAEFLQM 116
Cdd:cd18334    78 TGKLLTSdqpGEQNFNALLTAASYLQL 104