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Conserved domains on  [gi|967504181|ref|XP_002802638|]
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protein CBFA2T3 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 265-354 1.98e-41

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


:

Pssm-ID: 462195  Cd Length: 90  Bit Score: 145.87  E-value: 1.98e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  265 QLSKLKRFLTALQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 344
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 967504181  345 LAKQTPAQYL 354
Cdd:pfam07531  81 FIQQCPPQYL 90
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 470-536 3.98e-33

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


:

Pssm-ID: 430219  Cd Length: 67  Bit Score: 121.57  E-value: 3.98e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967504181  470 QEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRCSDTEDTK 536
Cdd:pfam08788   1 REEYIDTRLTDREWADEWRHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEELK 67
zf-MYND pfam01753
MYND finger;
647-683 4.89e-13

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.59  E-value: 4.89e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 967504181  647 CWNCGRKASET--CSGCNAARYCGSFCQHRDWEKHHHVC 683
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
DivIVA super family cl34642
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 581-628 6.46e-05

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3599:

Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 42.92  E-value: 6.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967504181 581 AEEAVNEVKRQAMSELQKAVSDAERKAHELIS---TERAKMERALAEAKRQ 628
Cdd:COG3599   74 AQETAEEVKENAEKEAELIIKEAELEAEKIIEeaqEKARKIVREIEELKRQ 124
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 39-263 1.69e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181   39 PQARPASHEPHGSHPLPRAEDTRL----AARRAWAFQRQRPNSRTPQLAQPLLFPSRLQEVGKGIPGRGLSWAPGWPLTV 114
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPrddpAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  115 AllmPASRLRDRAAGSASGSTRGSMSQPHPVLESGFPASAACSA-PRGPRKGGPAPGDRKAKASAMPDSPAEVKTQPRST 193
Cdd:PHA03247 2709 E---PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  194 PPSMPPPPPATSQGATRTPSFTPHTLMNGSSHSPTAISGAPSTPNGFSNGPATSSTASLSTQHLPPACGA 263
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
SMN super family cl26992
Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor ...
 353-433 6.73e-03

Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.


The actual alignment was detected with superfamily member pfam06003:

Pssm-ID: 428716 [Multi-domain]  Cd Length: 264  Bit Score: 39.21  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  353 YLAQHEQLLLDASASSPIDSSELLLEVNENGkrrTPDRTKENglDRDPLHPEHLSKRPCTLNPAQRYSPSNGP-PQPTPP 431
Cdd:pfam06003 107 YGNEEEQNLADLLTPPPDMDEDALKTANVNE---TESSTDES--DRSSGSAKHKSKSNFPMGPPSPWNPSFPPgPPPPPP 181


                  ..
gi 967504181  432 HY 433
Cdd:pfam06003 182 GF 183
 
Name Accession Description Interval E-value
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 265-354 1.98e-41

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 145.87  E-value: 1.98e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  265 QLSKLKRFLTALQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 344
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 967504181  345 LAKQTPAQYL 354
Cdd:pfam07531  81 FIQQCPPQYL 90
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 265-355 4.56e-38

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 136.44  E-value: 4.56e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181   265 QLSKLKRFLTALQQFGSDIS-PEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCA 343
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISqPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 967504181   344 RLAKQTPAQYLA 355
Cdd:smart00549  81 RLIEQSPPQPLA 92
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 470-536 3.98e-33

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


Pssm-ID: 430219  Cd Length: 67  Bit Score: 121.57  E-value: 3.98e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967504181  470 QEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRCSDTEDTK 536
Cdd:pfam08788   1 REEYIDTRLTDREWADEWRHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEELK 67
zf-MYND pfam01753
MYND finger;
647-683 4.89e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.59  E-value: 4.89e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 967504181  647 CWNCGRKASET--CSGCNAARYCGSFCQHRDWEKHHHVC 683
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 581-628 6.46e-05

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 42.92  E-value: 6.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967504181 581 AEEAVNEVKRQAMSELQKAVSDAERKAHELIS---TERAKMERALAEAKRQ 628
Cdd:COG3599   74 AQETAEEVKENAEKEAELIIKEAELEAEKIIEeaqEKARKIVREIEELKRQ 124
PHA03247 PHA03247
large tegument protein UL36; Provisional
 39-263 1.69e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181   39 PQARPASHEPHGSHPLPRAEDTRL----AARRAWAFQRQRPNSRTPQLAQPLLFPSRLQEVGKGIPGRGLSWAPGWPLTV 114
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPrddpAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  115 AllmPASRLRDRAAGSASGSTRGSMSQPHPVLESGFPASAACSA-PRGPRKGGPAPGDRKAKASAMPDSPAEVKTQPRST 193
Cdd:PHA03247 2709 E---PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  194 PPSMPPPPPATSQGATRTPSFTPHTLMNGSSHSPTAISGAPSTPNGFSNGPATSSTASLSTQHLPPACGA 263
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
PRK02292 PRK02292
V-type ATP synthase subunit E; Provisional
 575-629 4.77e-04

V-type ATP synthase subunit E; Provisional


Pssm-ID: 235026 [Multi-domain]  Cd Length: 188  Bit Score: 41.91  E-value: 4.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 967504181 575 EDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELISTERAKMERALAEAKRQA 629
Cdd:PRK02292   8 EDIRDEARARASEIRAEADEEAEEIIAEAEADAEEILEDREAEAEREIEQLREQE 62
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 579-637 3.29e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 38.19  E-value: 3.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967504181 579 RKAEEAVNEVKRQAMSELQKAVSDAERKAHELIstERAKME------RALAEAKRQASEDALTVV 637
Cdd:cd06503   65 AEAQEIIEEARKEAEKIKEEILAEAKEEAERIL--EQAKAEieqekeKALAELRKEVADLAVEAA 127
SMN pfam06003
Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor ...
 353-433 6.73e-03

Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.


Pssm-ID: 428716 [Multi-domain]  Cd Length: 264  Bit Score: 39.21  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  353 YLAQHEQLLLDASASSPIDSSELLLEVNENGkrrTPDRTKENglDRDPLHPEHLSKRPCTLNPAQRYSPSNGP-PQPTPP 431
Cdd:pfam06003 107 YGNEEEQNLADLLTPPPDMDEDALKTANVNE---TESSTDES--DRSSGSAKHKSKSNFPMGPPSPWNPSFPPgPPPPPP 181


                  ..
gi 967504181  432 HY 433
Cdd:pfam06003 182 GF 183
 
Name Accession Description Interval E-value
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 265-354 1.98e-41

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 145.87  E-value: 1.98e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  265 QLSKLKRFLTALQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCAR 344
Cdd:pfam07531   1 NVKKCKNFLSTLIKLAGEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNSAR 80

                          90
                  ....*....|
gi 967504181  345 LAKQTPAQYL 354
Cdd:pfam07531  81 FIQQCPPQYL 90
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 265-355 4.56e-38

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 136.44  E-value: 4.56e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181   265 QLSKLKRFLTALQQFGSDIS-PEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCA 343
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISqPEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHCA 80

                           90
                   ....*....|..
gi 967504181   344 RLAKQTPAQYLA 355
Cdd:smart00549  81 RLIEQSPPQPLA 92
NHR2 pfam08788
NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it ...
 470-536 3.98e-33

NHR2 domain like; The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerization and protein-protein interactions. It forms an alpha-helical tetramer.


Pssm-ID: 430219  Cd Length: 67  Bit Score: 121.57  E-value: 3.98e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967504181  470 QEEVIDHKLTEREWAEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRCSDTEDTK 536
Cdd:pfam08788   1 REEYIDTRLTDREWADEWRHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEELK 67
zf-MYND pfam01753
MYND finger;
647-683 4.89e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.59  E-value: 4.89e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 967504181  647 CWNCGRKASET--CSGCNAARYCGSFCQHRDWEKHHHVC 683
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 581-628 6.46e-05

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 42.92  E-value: 6.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967504181 581 AEEAVNEVKRQAMSELQKAVSDAERKAHELIS---TERAKMERALAEAKRQ 628
Cdd:COG3599   74 AQETAEEVKENAEKEAELIIKEAELEAEKIIEeaqEKARKIVREIEELKRQ 124
PHA03247 PHA03247
large tegument protein UL36; Provisional
 39-263 1.69e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181   39 PQARPASHEPHGSHPLPRAEDTRL----AARRAWAFQRQRPNSRTPQLAQPLLFPSRLQEVGKGIPGRGLSWAPGWPLTV 114
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPrddpAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  115 AllmPASRLRDRAAGSASGSTRGSMSQPHPVLESGFPASAACSA-PRGPRKGGPAPGDRKAKASAMPDSPAEVKTQPRST 193
Cdd:PHA03247 2709 E---PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  194 PPSMPPPPPATSQGATRTPSFTPHTLMNGSSHSPTAISGAPSTPNGFSNGPATSSTASLSTQHLPPACGA 263
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
NtpE COG1390
Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal ...
 575-629 2.48e-04

Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 441000 [Multi-domain]  Cd Length: 196  Bit Score: 42.62  E-value: 2.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 967504181 575 EDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELISTERAKMERALAEAKRQA 629
Cdd:COG1390    9 EEILEEAEAEAEEILEEAEEEAEKILEEAEEEAEEIKEEILEKAEREAEREKRRI 63
PRK02292 PRK02292
V-type ATP synthase subunit E; Provisional
 575-629 4.77e-04

V-type ATP synthase subunit E; Provisional


Pssm-ID: 235026 [Multi-domain]  Cd Length: 188  Bit Score: 41.91  E-value: 4.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 967504181 575 EDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELISTERAKMERALAEAKRQA 629
Cdd:PRK02292   8 EDIRDEARARASEIRAEADEEAEEIIAEAEADAEEILEDREAEAEREIEQLREQE 62
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 579-637 3.29e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 38.19  E-value: 3.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967504181 579 RKAEEAVNEVKRQAMSELQKAVSDAERKAHELIstERAKME------RALAEAKRQASEDALTVV 637
Cdd:cd06503   65 AEAQEIIEEARKEAEKIKEEILAEAKEEAERIL--EQAKAEieqekeKALAELRKEVADLAVEAA 127
NtpH COG2811
Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Archaeal ...
 579-641 6.17e-03

Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit H is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 442060 [Multi-domain]  Cd Length: 108  Bit Score: 37.20  E-value: 6.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967504181 579 RKAEEAVNEVKRQAMSELQKAVSDAERKAHELISTERAKME----RALAEAKRQASEDALTVVNQQE 641
Cdd:COG2811   11 KEAEEEADEIIEEAKEEREERIAEAREEAEEIIEQAEEEAEeeaqERLEEAREEAEAEAEEIIEEGE 77
SMN pfam06003
Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor ...
 353-433 6.73e-03

Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.


Pssm-ID: 428716 [Multi-domain]  Cd Length: 264  Bit Score: 39.21  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967504181  353 YLAQHEQLLLDASASSPIDSSELLLEVNENGkrrTPDRTKENglDRDPLHPEHLSKRPCTLNPAQRYSPSNGP-PQPTPP 431
Cdd:pfam06003 107 YGNEEEQNLADLLTPPPDMDEDALKTANVNE---TESSTDES--DRSSGSAKHKSKSNFPMGPPSPWNPSFPPgPPPPPP 181


                  ..
gi 967504181  432 HY 433
Cdd:pfam06003 182 GF 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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