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Conserved domains on  [gi|290975041|ref|XP_002670252|]
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uncharacterized protein NAEGRDRAFT_59730 [Naegleria gruberi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 1246-1340 1.72e-28

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


:

Pssm-ID: 433574  Cd Length: 89  Bit Score: 110.44  E-value: 1.72e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041  1246 LEAGLRDCLIVYDFHCNIDKKKQESILNrlatfgDILASQDMSTIYGSSIAFILRMCYGSQNTLNLRNISMHGYFSKDNF 1325
Cdd:pfam13910    1 LERLLRDLLQLAGGKSNNKSRDTPRLLR------DLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEF 74

                           90
                   ....*....|....*
gi 290975041  1326 HSQHLWFLLLVFSNL 1340
Cdd:pfam13910   75 NPSYASFLLLLLASL 89
CNH super family cl02434
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 196-361 9.07e-11

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


The actual alignment was detected with superfamily member pfam00780:

Pssm-ID: 470577  Cd Length: 261  Bit Score: 64.57  E-value: 9.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041   196 NNRLLVC-VKKKINILHYTEQdclSVG----LDEYVLPESVQderCLALFDRTLIVGFKKEYSLISIGGADAKSaIPSTI 270
Cdd:pfam00780   95 NGRFLVVaVKRTIKLLEWYEP---LLDkfrkFKEFYLPSPPV---SIELLKSKLCVGCAKGFEIVSLDSKATES-LLTSL 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041   271 LQLSDKSGDRALCVSM--DDEVLLRTEAICVFVNMTnkstseqrGMPSIRPPITWSSPPQHISFSFPYIVGVLDQGrkIE 348
Cdd:pfam00780  168 LFANRQENLKPLAVVRldRSEFLLCYNEFGVYVNLQ--------GRRSRPWEIEWEGAPEAVAYLYPYLLAFHDNF--IE 237

                          170
                   ....*....|...
gi 290975041   349 IYSIYDARLVKTL 361
Cdd:pfam00780  238 IRDVETGELVQEI 250
Vps39_2 super family cl11034
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 1008-1083 3.85e-10

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


The actual alignment was detected with superfamily member pfam10367:

Pssm-ID: 402126  Cd Length: 109  Bit Score: 58.81  E-value: 3.85e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 290975041  1008 ILNKYAKHIDPISAIKLLPNNLSTKKILPFLTCTLRQTATNNRTTSIMKNMSKIDFFNAQAELVKYQSRKKFVTRK 1083
Cdd:pfam10367    3 LLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEE 78
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 1246-1340 1.72e-28

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 110.44  E-value: 1.72e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041  1246 LEAGLRDCLIVYDFHCNIDKKKQESILNrlatfgDILASQDMSTIYGSSIAFILRMCYGSQNTLNLRNISMHGYFSKDNF 1325
Cdd:pfam13910    1 LERLLRDLLQLAGGKSNNKSRDTPRLLR------DLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEF 74

                           90
                   ....*....|....*
gi 290975041  1326 HSQHLWFLLLVFSNL 1340
Cdd:pfam13910   75 NPSYASFLLLLLASL 89
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 196-361 9.07e-11

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 64.57  E-value: 9.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041   196 NNRLLVC-VKKKINILHYTEQdclSVG----LDEYVLPESVQderCLALFDRTLIVGFKKEYSLISIGGADAKSaIPSTI 270
Cdd:pfam00780   95 NGRFLVVaVKRTIKLLEWYEP---LLDkfrkFKEFYLPSPPV---SIELLKSKLCVGCAKGFEIVSLDSKATES-LLTSL 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041   271 LQLSDKSGDRALCVSM--DDEVLLRTEAICVFVNMTnkstseqrGMPSIRPPITWSSPPQHISFSFPYIVGVLDQGrkIE 348
Cdd:pfam00780  168 LFANRQENLKPLAVVRldRSEFLLCYNEFGVYVNLQ--------GRRSRPWEIEWEGAPEAVAYLYPYLLAFHDNF--IE 237

                          170
                   ....*....|...
gi 290975041   349 IYSIYDARLVKTL 361
Cdd:pfam00780  238 IRDVETGELVQEI 250
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 1008-1083 3.85e-10

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 58.81  E-value: 3.85e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 290975041  1008 ILNKYAKHIDPISAIKLLPNNLSTKKILPFLTCTLRQTATNNRTTSIMKNMSKIDFFNAQAELVKYQSRKKFVTRK 1083
Cdd:pfam10367    3 LLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEE 78
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 1246-1340 1.72e-28

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 110.44  E-value: 1.72e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041  1246 LEAGLRDCLIVYDFHCNIDKKKQESILNrlatfgDILASQDMSTIYGSSIAFILRMCYGSQNTLNLRNISMHGYFSKDNF 1325
Cdd:pfam13910    1 LERLLRDLLQLAGGKSNNKSRDTPRLLR------DLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEF 74

                           90
                   ....*....|....*
gi 290975041  1326 HSQHLWFLLLVFSNL 1340
Cdd:pfam13910   75 NPSYASFLLLLLASL 89
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 196-361 9.07e-11

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 64.57  E-value: 9.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041   196 NNRLLVC-VKKKINILHYTEQdclSVG----LDEYVLPESVQderCLALFDRTLIVGFKKEYSLISIGGADAKSaIPSTI 270
Cdd:pfam00780   95 NGRFLVVaVKRTIKLLEWYEP---LLDkfrkFKEFYLPSPPV---SIELLKSKLCVGCAKGFEIVSLDSKATES-LLTSL 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290975041   271 LQLSDKSGDRALCVSM--DDEVLLRTEAICVFVNMTnkstseqrGMPSIRPPITWSSPPQHISFSFPYIVGVLDQGrkIE 348
Cdd:pfam00780  168 LFANRQENLKPLAVVRldRSEFLLCYNEFGVYVNLQ--------GRRSRPWEIEWEGAPEAVAYLYPYLLAFHDNF--IE 237

                          170
                   ....*....|...
gi 290975041   349 IYSIYDARLVKTL 361
Cdd:pfam00780  238 IRDVETGELVQEI 250
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 1008-1083 3.85e-10

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 58.81  E-value: 3.85e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 290975041  1008 ILNKYAKHIDPISAIKLLPNNLSTKKILPFLTCTLRQTATNNRTTSIMKNMSKIDFFNAQAELVKYQSRKKFVTRK 1083
Cdd:pfam10367    3 LLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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