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Conserved domains on  [gi|292617832|ref|XP_002663472|]
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cilia- and flagella- associated protein 210 isoform X1 [Danio rerio]

Protein Classification

trichohyalin-plectin-homology domain domain-containing protein( domain architecture ID 12159040)

trichohyalin-plectin-homology domain (TPH) domain-containing protein similar to meiosis-specific nuclear structural protein 1, trichoplein keratin filament-binding protein, and cilia- and flagella-associated proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 136-465 1.17e-21

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


:

Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 96.14  E-value: 1.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  136 MYYQTDRVKGFHGALMLAEVLKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQ 215
Cdd:pfam13868   1 LRENSDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  216 QIVDHELEKEQERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQL 295
Cdd:pfam13868  81 QIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  296 ASHKEKMMKMRKEKQEEIFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERL-TREQQEKEKKHTDMLNAIAA 374
Cdd:pfam13868 161 LKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKErQKEREEAEKKARQRQELQQA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  375 HRESMRQEQERK---VEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLyIQEMAEKRAKHQRTKKDQQEF 451
Cdd:pfam13868 241 REEQIELKERRLaeeAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQ-IEEREEQRAAEREEELEEGER 319

                         330
                  ....*....|....*..
gi 292617832  452 VEKSNAF---IIEEEKQ 465
Cdd:pfam13868 320 LREEEAErreRIEEERQ 336
 
Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 136-465 1.17e-21

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 96.14  E-value: 1.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  136 MYYQTDRVKGFHGALMLAEVLKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQ 215
Cdd:pfam13868   1 LRENSDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  216 QIVDHELEKEQERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQL 295
Cdd:pfam13868  81 QIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  296 ASHKEKMMKMRKEKQEEIFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERL-TREQQEKEKKHTDMLNAIAA 374
Cdd:pfam13868 161 LKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKErQKEREEAEKKARQRQELQQA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  375 HRESMRQEQERK---VEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLyIQEMAEKRAKHQRTKKDQQEF 451
Cdd:pfam13868 241 REEQIELKERRLaeeAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQ-IEEREEQRAAEREEELEEGER 319

                         330
                  ....*....|....*..
gi 292617832  452 VEKSNAF---IIEEEKQ 465
Cdd:pfam13868 320 LREEEAErreRIEEERQ 336
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 155-482 7.31e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.51  E-value: 7.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 155 VLKEREAQIE-LKRMKQNATK-----DIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQER 228
Cdd:COG1196  194 ILGELERQLEpLERQAEKAERyrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 229 QEVKREAEEIERLRNlhlweqamKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKE 308
Cdd:COG1196  274 LELEELELELEEAQA--------EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 309 KQ--EEIFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTD-MLNAIAAHRESMRQEQER 385
Cdd:COG1196  346 LEeaEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEeAEEALLERLERLEEELEE 425

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 386 KVEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKDQQEFVEKSnafIIEEEKQ 465
Cdd:COG1196  426 LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL---LLEAEAD 502

                        330
                 ....*....|....*..
gi 292617832 466 FQTYAKQVIETAERAGR 482
Cdd:COG1196  503 YEGFLEGVKAALLLAGL 519
PTZ00121 PTZ00121
MAEBL; Provisional
 67-480 5.36e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.47  E-value: 5.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   67 AEQREALHKRSKDIVKNWSNTIAGQRQKKLEAKKIREAIEEEERKLIDIEEAKYQAQMRKEAIEKAKTQMYYQTDRVKGF 146
Cdd:PTZ00121 1314 AKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKA 1393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  147 HGALMLAEVLKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKA--LQKKQEHQAIVESLKQQIvdhelEK 224
Cdd:PTZ00121 1394 DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAdeAKKKAEEAKKAEEAKKKA-----EE 1468

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  225 EQERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMK 304
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKA 1548

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  305 MRKEKQEEIfRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNaiAAHRESMRQEQE 384
Cdd:PTZ00121 1549 DELKKAEEL-KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK--KAEEAKIKAEEL 1625

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  385 RKVEEEKQKALEMLNA----KKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAeKRAKHQRTKKDQQEFVEKSNAFII 460
Cdd:PTZ00121 1626 KKAEEEKKKVEQLKKKeaeeKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA-KKAEEDEKKAAEALKKEAEEAKKA 1704

                         410       420
                  ....*....|....*....|
gi 292617832  461 EEEKQFQTYAKQVIETAERA 480
Cdd:PTZ00121 1705 EELKKKEAEEKKKAEELKKA 1724
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 156-427 1.46e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   156 LKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREA 235
Cdd:TIGR02168  222 LRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   236 EEIERLRNLHlwEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFR 315
Cdd:TIGR02168  302 QQKQILRERL--ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   316 ELQRHRETIIQKLavQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAiAAHRESMRQEQERKVEEEKQKAL 395
Cdd:TIGR02168  380 QLETLRSKVAQLE--LQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA-ELKELQAELEELEEELEELQEEL 456

                          250       260       270
                   ....*....|....*....|....*....|..
gi 292617832   396 EMLNAKKEADQIFMEKQQRRAQKAREEGKTLQ 427
Cdd:TIGR02168  457 ERLEEALEELREELEEAEQALDAAERELAQLQ 488
 
Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 136-465 1.17e-21

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 96.14  E-value: 1.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  136 MYYQTDRVKGFHGALMLAEVLKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQ 215
Cdd:pfam13868   1 LRENSDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  216 QIVDHELEKEQERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQL 295
Cdd:pfam13868  81 QIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  296 ASHKEKMMKMRKEKQEEIFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERL-TREQQEKEKKHTDMLNAIAA 374
Cdd:pfam13868 161 LKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKErQKEREEAEKKARQRQELQQA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  375 HRESMRQEQERK---VEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLyIQEMAEKRAKHQRTKKDQQEF 451
Cdd:pfam13868 241 REEQIELKERRLaeeAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQ-IEEREEQRAAEREEELEEGER 319

                         330
                  ....*....|....*..
gi 292617832  452 VEKSNAF---IIEEEKQ 465
Cdd:pfam13868 320 LREEEAErreRIEEERQ 336
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 155-482 7.31e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.51  E-value: 7.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 155 VLKEREAQIE-LKRMKQNATK-----DIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQER 228
Cdd:COG1196  194 ILGELERQLEpLERQAEKAERyrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 229 QEVKREAEEIERLRNlhlweqamKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKE 308
Cdd:COG1196  274 LELEELELELEEAQA--------EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 309 KQ--EEIFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTD-MLNAIAAHRESMRQEQER 385
Cdd:COG1196  346 LEeaEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEeAEEALLERLERLEEELEE 425

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 386 KVEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKDQQEFVEKSnafIIEEEKQ 465
Cdd:COG1196  426 LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL---LLEAEAD 502

                        330
                 ....*....|....*..
gi 292617832 466 FQTYAKQVIETAERAGR 482
Cdd:COG1196  503 YEGFLEGVKAALLLAGL 519
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 205-465 2.67e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.22  E-value: 2.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  205 EHQAIVESLKQQIVDHELEKEQERQEVKREAEEIERLRNLhlwEQAMKERKKQGEKRSILKAHRDLLTnreMMKATEAQK 284
Cdd:pfam17380 279 QHQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKL---EEAEKARQAEMDRQAAIYAEQERMA---MERERELER 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  285 LQEEEEKckqlashkekmMKMRKEKQEEIFRELQRHREtiIQKLAVQKQQliSNEEEIIAKAVSEREERLTREQQEKEKK 364
Cdd:pfam17380 353 IRQEERK-----------RELERIRQEEIAMEISRMRE--LERLQMERQQ--KNERVRQELEAARKVKILEEERQRKIQQ 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  365 HTDMLNAIAAHRESMRQEQERKVEEEKQKALEMLNAKKEADQIFMEkqqRRAQKAREEGKTLQDLYIQEMAEKRAKHQRT 444
Cdd:pfam17380 418 QKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVE---RLRQQEEERKRKKLELEKEKRDRKRAEEQRR 494

                         250       260
                  ....*....|....*....|.
gi 292617832  445 KKDQQEFVEKSNAFIIEEEKQ 465
Cdd:pfam17380 495 KILEKELEERKQAMIEEERKR 515
PTZ00121 PTZ00121
MAEBL; Provisional
 67-480 5.36e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.47  E-value: 5.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   67 AEQREALHKRSKDIVKNWSNTIAGQRQKKLEAKKIREAIEEEERKLIDIEEAKYQAQMRKEAIEKAKTQMYYQTDRVKGF 146
Cdd:PTZ00121 1314 AKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKA 1393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  147 HGALMLAEVLKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKA--LQKKQEHQAIVESLKQQIvdhelEK 224
Cdd:PTZ00121 1394 DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAdeAKKKAEEAKKAEEAKKKA-----EE 1468

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  225 EQERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMK 304
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKA 1548

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  305 MRKEKQEEIfRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNaiAAHRESMRQEQE 384
Cdd:PTZ00121 1549 DELKKAEEL-KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK--KAEEAKIKAEEL 1625

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  385 RKVEEEKQKALEMLNA----KKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAeKRAKHQRTKKDQQEFVEKSNAFII 460
Cdd:PTZ00121 1626 KKAEEEKKKVEQLKKKeaeeKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA-KKAEEDEKKAAEALKKEAEEAKKA 1704

                         410       420
                  ....*....|....*....|
gi 292617832  461 EEEKQFQTYAKQVIETAERA 480
Cdd:PTZ00121 1705 EELKKKEAEEKKKAEELKKA 1724
PTZ00121 PTZ00121
MAEBL; Provisional
 7-465 4.65e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.38  E-value: 4.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832    7 ITGVVKYGRRKGSSKQAVNSEMEKTGANLRQVVVLSKSEWQRLQDSVNGINHHNRSVMAAAEQREALHKRSKDIVKNWSN 86
Cdd:PTZ00121 1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKAD 1305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   87 TIAGQRQKKLEAKKIREAIEEEERKlidIEEAKYQAQMRKEAIEKAKTQMYYQTDRVKGFHGALMLAEvLKEREAQIELK 166
Cdd:PTZ00121 1306 EAKKKAEEAKKADEAKKKAEEAKKK---ADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE-KKKEEAKKKAD 1381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  167 RMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQ---EVKREAEEIERLRN 243
Cdd:PTZ00121 1382 AAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKkadEAKKKAEEAKKAEE 1461

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  244 LHLWEQAMKE----RKKQGEKRSILKAHRDLLTNREmmKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFR-ELQ 318
Cdd:PTZ00121 1462 AKKKAEEAKKadeaKKKAEEAKKADEAKKKAEEAKK--KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKaDEA 1539

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  319 RHRETIIQKLAVQKQQLISNEEEIIAKAVSEREE-------RLTREQQEKEKKHTDMLNAIAAHRESMRQEQERKVEEEK 391
Cdd:PTZ00121 1540 KKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEedknmalRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 292617832  392 QKALEMLNAKKEAdqifmEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKDQQEFVEKSNAFIIEEEKQ 465
Cdd:PTZ00121 1620 IKAEELKKAEEEK-----KKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEK 1688
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 156-469 9.76e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 58.21  E-value: 9.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  156 LKEREAQIELKRMKQNATKDIDRDMLAEMASREEqalLEEQKKALQKKQEHQAIVESlKQQIVDHELEKEQERQEVKREA 235
Cdd:pfam17380 284 VSERQQQEKFEKMEQERLRQEKEEKAREVERRRK---LEEAEKARQAEMDRQAAIYA-EQERMAMERERELERIRQEERK 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  236 EEIERLRNlhlWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKcKQLASHKEKMMKMRKEKQEEIFR 315
Cdd:pfam17380 360 RELERIRQ---EEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQ-RKIQQQKVEMEQIRAEQEEARQR 435

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  316 ELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKhtdmlnaiaahRESMRQEQERKV-----EEE 390
Cdd:pfam17380 436 EVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKR-----------DRKRAEEQRRKIlekelEER 504

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  391 KQKALEMLNAKKEADQ--------IFMEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKDQQEFVEKSNAFIIEE 462
Cdd:pfam17380 505 KQAMIEEERKRKLLEKemeerqkaIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVES 584


                  ....*..
gi 292617832  463 EKQFQTY 469
Cdd:pfam17380 585 EKARAEY 591
PTZ00121 PTZ00121
MAEBL; Provisional
 66-489 1.14e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.23  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   66 AAEQREALHKRSKDIVKNWSNTIAGQRQKKLEAKKIREAIEEEERKLIDIEEAKYQAQMRKEAIEKAKTQMYYQTDrvkg 145
Cdd:PTZ00121 1344 AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKK---- 1419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  146 fhgALMLAEVLKEREAQIELKRMKQNATKDIDRDMLAEMASREEQAL--LEEQKKA--LQKKQEHQAIVESLKQQIVDHE 221
Cdd:PTZ00121 1420 ---ADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKkkAEEAKKAdeAKKKAEEAKKADEAKKKAEEAK 1496

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  222 LEKEQERQ--EVKREAEEIERLRNLHLWEQAMK--ERKKQGEKRSI--LKAHRDLLTNREMMKATEAQKLQE---EEEKC 292
Cdd:PTZ00121 1497 KKADEAKKaaEAKKKADEAKKAEEAKKADEAKKaeEAKKADEAKKAeeKKKADELKKAEELKKAEEKKKAEEakkAEEDK 1576

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  293 KQLASHKEKMMKMRKEKQEEIFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDM---- 368
Cdd:PTZ00121 1577 NMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELkkae 1656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  369 -LNAIAAHRESMRQEQE-RKVEEEKQKALEmlnAKKEADQIFMEKQQRRA----QKAREEGKTLQDLYIQEMAEKRAKHQ 442
Cdd:PTZ00121 1657 eENKIKAAEEAKKAEEDkKKAEEAKKAEED---EKKAAEALKKEAEEAKKaeelKKKEAEEKKKAEELKKAEEENKIKAE 1733

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 292617832  443 RTKKDQQEFVEKSNAFIIEEE--KQFQTYAKQVIETAERAGRNTYPLIK 489
Cdd:PTZ00121 1734 EAKKEAEEDKKKAEEAKKDEEekKKIAHLKKEEEKKAEEIRKEKEAVIE 1782
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 207-493 7.18e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 7.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 207 QAIVESLKQQIvdHELEKEQER----QEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTnremmkatea 282
Cdd:COG1196  192 EDILGELERQL--EPLERQAEKaeryRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELE---------- 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 283 QKLQEEEEKCKQLASHKEKMMKMRKEKQEEiFRELQRHRETIIQKLAVQKQQLISNEEEIIAKAVSERE--ERLTREQQE 360
Cdd:COG1196  260 AELAELEAELEELRLELEELELELEEAQAE-EYELLAELARLEQDIARLEERRRELEERLEELEEELAEleEELEELEEE 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 361 KEKKHTD--MLNAIAAHRESMRQEQERKVEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLyiQEMAEKR 438
Cdd:COG1196  339 LEELEEEleEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--EALLERL 416

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 292617832 439 AKHQRTKKDQQEFVEKSNAFIIEEEKQFQTYAKQVIETAERAGRNTYPLIKAARE 493
Cdd:COG1196  417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 91-424 1.18e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.94  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  91 QRQKKLEAKK--IREAIEEEERKLIDIEEAKYQAQMRKEAIEKAKTQmyyqtdrvkgfhgALMLAEVLKEREAQIELKRM 168
Cdd:COG1196  208 QAEKAERYRElkEELKELEAELLLLKLRELEAELEELEAELEELEAE-------------LEELEAELAELEAELEELRL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 169 KQNATKDidrdmLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREAEEIERLRnlhlwe 248
Cdd:COG1196  275 ELEELEL-----ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELE------ 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 249 qamKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLAshkekmmkMRKEKQEEIFRELQRHRETIIQKL 328
Cdd:COG1196  344 ---EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEEL--------LEALRAAAELAAQLEELEEAEEAL 412

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 329 AVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTdmLNAIAAHRESMRQEQERKVEEEKQKALEMLNAKKEADQIF 408
Cdd:COG1196  413 LERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE--EAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAA 490

                        330
                 ....*....|....*.
gi 292617832 409 MEKQQRRAQKAREEGK 424
Cdd:COG1196  491 ARLLLLLEAEADYEGF 506
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 91-396 1.42e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  91 QRQKKLEAKKIREAIEEEERKLIDIEEAK-------YQAQMRKEAIEKAKTQMYYQTDRVKGFHGALML--AEVLKEREA 161
Cdd:COG1196  224 ELEAELLLLKLRELEAELEELEAELEELEaeleeleAELAELEAELEELRLELEELELELEEAQAEEYEllAELARLEQD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 162 QIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEH-QAIVESLKQQIVDHELEKEQERQEVKREAEEIER 240
Cdd:COG1196  304 IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEaEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 241 LRN--LHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFRELQ 318
Cdd:COG1196  384 LAEelLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 292617832 319 RHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAIAAHRESMRQEQERKVEEEKQKALE 396
Cdd:COG1196  464 LLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALE 541
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 156-427 1.46e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   156 LKEREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREA 235
Cdd:TIGR02168  222 LRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   236 EEIERLRNLHlwEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFR 315
Cdd:TIGR02168  302 QQKQILRERL--ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEE 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   316 ELQRHRETIIQKLavQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAiAAHRESMRQEQERKVEEEKQKAL 395
Cdd:TIGR02168  380 QLETLRSKVAQLE--LQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA-ELKELQAELEELEEELEELQEEL 456

                          250       260       270
                   ....*....|....*....|....*....|..
gi 292617832   396 EMLNAKKEADQIFMEKQQRRAQKAREEGKTLQ 427
Cdd:TIGR02168  457 ERLEEALEELREELEEAEQALDAAERELAQLQ 488
PTZ00121 PTZ00121
MAEBL; Provisional
 158-480 8.37e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 8.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  158 EREAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREAEE 237
Cdd:PTZ00121 1203 EAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  238 IERLRNLHLWEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFREL 317
Cdd:PTZ00121 1283 LKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAA 1362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  318 QRHRETIIQKLAVQKQQlisnEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAIAAHRESM-----RQEQERKVEEEKQ 392
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKK----ADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKAdeakkKAEEKKKADEAKK 1438

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  393 KALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLyiQEMAEKRAKHQRTKKDQQEFVEKSNAFIIEEEKQFQTYAKQ 472
Cdd:PTZ00121 1439 KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA--KKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK 1516


                  ....*...
gi 292617832  473 VIETAERA 480
Cdd:PTZ00121 1517 KAEEAKKA 1524
PTZ00121 PTZ00121
MAEBL; Provisional
 21-475 1.81e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.30  E-value: 1.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   21 KQAVNSEMEKTGANLRQVVVLSKSEWQRLQDSVNGINHHNRS--VMAAAEQREALHKRSKDIVKNWSNTIAGQRQKKLEA 98
Cdd:PTZ00121 1143 EEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAeeVRKAEELRKAEDARKAEAARKAEEERKAEEARKAED 1222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   99 KKIREAIEEEERKLIDIEEAKYQAQMRkeaiekaktqmyyQTDRVKGFHGALMLAEVLKEREAQIELKRMKQNATKDIDR 178
Cdd:PTZ00121 1223 AKKAEAVKKAEEAKKDAEEAKKAEEER-------------NNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK 1289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  179 DMLAEMASREEQALLEE-QKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREAEEIERLRNLHLWEQAMKERKKQ 257
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEaKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  258 GEKRSILKAHRDLLTNR--EMMKATEAQKLQEEEEK----CKQLASHKEKMMKMRKEKQE-EIFRELQRHRETIIQKLAV 330
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKaeEKKKADEAKKKAEEDKKkadeLKKAAAAKKKADEAKKKAEEkKKADEAKKKAEEAKKADEA 1449

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  331 QKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAiAAHRESMRQEQERKVEEEKQKALEMLNA--KKEADQIF 408
Cdd:PTZ00121 1450 KKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK-KAEEAKKKADEAKKAAEAKKKADEAKKAeeAKKADEAK 1528

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 292617832  409 MEKQQRRAQKAR--------EEGKTLQDLYIQEMAEKRAKHQRTKKDQQEFVEKSNAFIIEEEKQFQTYAKQVIE 475
Cdd:PTZ00121 1529 KAEEAKKADEAKkaeekkkaDELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEE 1603
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 160-438 2.87e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.12  E-value: 2.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  160 EAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQeVKREAEEIE 239
Cdd:pfam17380 345 ERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRK-IQQQKVEME 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  240 RLRNLHlwEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEE--IFREL 317
Cdd:pfam17380 424 QIRAEQ--EEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRkiLEKEL 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  318 QRHRETIIQKlaVQKQQLISNEEEIIAKAVSEREERltREQQEKEKKHTDMlnaiaaHRESMRQEQERKVEEEKQKALEM 397
Cdd:pfam17380 502 EERKQAMIEE--ERKRKLLEKEMEERQKAIYEEERR--REAEEERRKQQEM------EERRRIQEQMRKATEERSRLEAM 571

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 292617832  398 LNAKKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAEKR 438
Cdd:pfam17380 572 EREREMMRQIVESEKARAEYEATTPITTIKPIYRPRISEYQ 612
PTZ00121 PTZ00121
MAEBL; Provisional
 160-448 1.09e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  160 EAQIELKRMKQNATKDIDRDMLAEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREAEEIE 239
Cdd:PTZ00121 1061 EAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDAR 1140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  240 RLRNLHLWEQAmkerKKQGEKRSILKAHRDLLTNR-EMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFR-EL 317
Cdd:PTZ00121 1141 KAEEARKAEDA----KRVEIARKAEDARKAEEARKaEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKaEE 1216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  318 QRHRETIIQKLAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAiAAHRESMRQEQERKVEEEKQKALEM 397
Cdd:PTZ00121 1217 ARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQA-AIKAEEARKADELKKAEEKKKADEA 1295

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 292617832  398 LNAKKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKDQ 448
Cdd:PTZ00121 1296 KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAE 1346
PTZ00121 PTZ00121
MAEBL; Provisional
 63-343 6.24e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   63 VMAAAEQREALHKRSKDIVKNWSNTIAGQRQKKLEAKKIREAIEEEERKLIDIEEAKYQAQMRKEAIEKAKTQMYYQTDR 142
Cdd:PTZ00121 1551 LKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEE 1630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  143 VKGFHGALMLAEVLKEREAQIELKRMKQNATKDidrdmlAEMASREEqallEEQKKALQKKQEHQAIVESlKQQIVDHEL 222
Cdd:PTZ00121 1631 EKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA------AEEAKKAE----EDKKKAEEAKKAEEDEKKA-AEALKKEAE 1699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  223 EKEQERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSilkahrdlltNREMMKATEAQKLQEEEEKCKQLASHKEKM 302
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEA----------EEDKKKAEEAKKDEEEKKKIAHLKKEEEKK 1769

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 292617832  303 M-KMRKEKQEEIFRELQRHRETIIQKLAVQKQQLISNEEEII 343
Cdd:PTZ00121 1770 AeEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII 1811
PRK12704 PRK12704
phosphodiesterase; Provisional
 157-332 9.87e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 9.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 157 KEREAQIELKRMKQNATKdidrdmlaEMASREEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREAE 236
Cdd:PRK12704  32 KIKEAEEEAKRILEEAKK--------EAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 237 EIERLRN-LHLWEQAMKERKKQGEKRsilKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEK----MMKMRKEKQE 311
Cdd:PRK12704 104 LLEKREEeLEKKEKELEQKQQELEKK---EEELEELIEEQLQELERISGLTAEEAKEILLEKVEEEarheAAVLIKEIEE 180

                        170       180
                 ....*....|....*....|..
gi 292617832 312 EIFRELQRH-RETIIQklAVQK 332
Cdd:PRK12704 181 EAKEEADKKaKEILAQ--AIQR 200
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 187-455 1.86e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   187 REEQALLEEQKKALQKKQEHQAIVESLKQQIVDHELEKEQ--ERQEVKREAEEIERLRNLHLWEQAMKERKKQGEKRSIL 264
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKaeRYQALLKEKREYEGYELLKEKEALERQKEAIERQLASL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   265 KAHRDLLTnremmkaTEAQKLQEE-EEKCKQLASHKEKMMKMRKEKQEEI---FRELQRHRETIIQKLAVQKQQLISNEE 340
Cdd:TIGR02169  250 EEELEKLT-------EEISELEKRlEEIEQLLEELNKKIKDLGEEEQLRVkekIGELEAEIASLERSIAEKERELEDAEE 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   341 EiIAKAVSERE------ERLTREQQEKEKKHTDMLNAIAAHRESMRQEQERKVEEEK------------QKALEMLNAKK 402
Cdd:TIGR02169  323 R-LAKLEAEIDkllaeiEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKefaetrdelkdyREKLEKLKREI 401

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 292617832   403 EADQIFMEKQQRRAQKAREEGKTLQDlYIQEMAEKRAKHQRTKKDQQEFVEKS 455
Cdd:TIGR02169  402 NELKRELDRLQEELQRLSEELADLNA-AIAGIEAKINELEEEKEDKALEIKKQ 453
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 322-450 3.18e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.20  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 322 ETIIQKLAVQKQQLisneEEIIAKAVSERE--ERLTREQQEKEKKhtdmlnaIAAHRESMRQEQERKVeeekQKALEmlN 399
Cdd:PRK00409 519 NELIASLEELEREL----EQKAEEAEALLKeaEKLKEELEEKKEK-------LQEEEDKLLEEAEKEA----QQAIK--E 581

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 292617832 400 AKKEADQI-----FMEKQQRRAQKAREEGKTLQDLyiQEMAEKRAKHQRTKKDQQE 450
Cdd:PRK00409 582 AKKEADEIikelrQLQKGGYASVKAHELIEARKRL--NKANEKKEKKKKKQKEKQE 635
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 185-364 3.71e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.20  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 185 ASREEQALLEEQK--KALQKKQEHQAIVESLKQQIVDHELEKEQERQEVKREAEEIerlrnlhlWEQAMKErkkqgekrs 262
Cdd:PRK00409 523 ASLEELERELEQKaeEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQA--------IKEAKKE--------- 585

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832 263 ILKAHRDLLTNREMMKAteAQKLQEEEEKCKQLASHKEKmMKMRKEKQEEIFRELQRHRETIIQKLAvQKQQLIS--NEE 340
Cdd:PRK00409 586 ADEIIKELRQLQKGGYA--SVKAHELIEARKRLNKANEK-KEKKKKKQKEKQEELKVGDEVKYLSLG-QKGEVLSipDDK 661

                        170       180       190
                 ....*....|....*....|....*....|
gi 292617832 341 EIIAKA------VSEREERLTREQQEKEKK 364
Cdd:PRK00409 662 EAIVQAgimkmkVPLSDLEKIQKPKKKKKK 691
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 190-327 4.01e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 39.41  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  190 QALLEEQKKALQKKQEH-QAIVESLKQQIVDHELEKEQERQEVKREAEEIERLRNLHlwEQAMKERKKQGEKRSILKA-H 267
Cdd:pfam15905 179 QEGMEGKLQVTQKNLEHsKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVS--EQVEKYKLDIAQLEELLKEkN 256

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 292617832  268 RDLLTNREMMKATE---AQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFRELQRHRETIIQK 327
Cdd:pfam15905 257 DEIESLKQSLEEKEqelSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLE 319
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 142-406 8.55e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 39.05  E-value: 8.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   142 RVKGFHGALMLAEVLKEREAQIELKRMKQ-NATKDIDRDMLAEMASREEQALlEEQKKALQKKQEHQAIVESLKQQIVDH 220
Cdd:pfam12128  259 RLSHLHFGYKSDETLIASRQEERQETSAElNQLLRTLDDQWKEKRDELNGEL-SAADAAVAKDRSELEALEDQHGAFLDA 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   221 ELEKEQERQE----VKREAEEIERLRNLHLWEQAMKERKKQGekrsiLKAHRDLLTNREMMKATEAQKLQEEEeKCKQLA 296
Cdd:pfam12128  338 DIETAAADQEqlpsWQSELENLEERLKALTGKHQDVTAKYNR-----RRSKIKEQNNRDIAGIKDKLAKIREA-RDRQLA 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   297 ---SHKEKMMKMRKEKQEEIFRELQRHRETIIQKLAVQKQQL---ISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLN 370
Cdd:pfam12128  412 vaeDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLnqaTATPELLLQLENFDERIERAREEQEAANAEVERLQ 491

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 292617832   371 AIAAHRESMRQEQERKVEEEKQKALEMLNAKKEADQ 406
Cdd:pfam12128  492 SELRQARKRRDQASEALRQASRRLEERQSALDELEL 527
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 92-462 8.76e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 39.18  E-value: 8.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832    92 RQKKLEAKKIREAIEEEERKLIDIEEAKyqAQMRKEAIEKAKTQMYYQT-DRVKGFHGALMLAEVLKEREAQIELKRMKQ 170
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELK--LQELKLKEQAKKALEYYQLkEKLELEEEYLLYLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   171 NATKDIDRDMLAEMASREEQALLEEQKKALQKKQehQAIVESLKQQIVDHELEKEQERQEVKREAEEIERLRNLHLWEQA 250
Cdd:pfam02463  247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKE--KKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   251 MKERKKQGEKRSIL---KAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKEKMMKMRKEKQEEIFRELQRHRETIIQK 327
Cdd:pfam02463  325 KAEKELKKEKEEIEeleKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832   328 LAVQKQQLISNEEEIIAKAVSEREERLTREQQEKEKKHTDMLNAIAAHRESMRQEQERKVEEEKQKALEMLNAKKEADQI 407
Cdd:pfam02463  405 KEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQE 484

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 292617832   408 FMEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKDQQEFVEKSNAFIIEE 462
Cdd:pfam02463  485 QLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVE 539
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
223-479 9.85e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.74  E-value: 9.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  223 EKEQERQEVKREAEEIERLRnlhlwEQAMKERKKQGEKRSILKAHRDLLTNREMMKATEAQKLQEEEEKCKQLASHKE-K 301
Cdd:COG4913   614 ALEAELAELEEELAEAEERL-----EALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDlA 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  302 MMKMRKEKQEEIFRELQRHRETIIQKLAVQKQQLISNEEEIiaKAVSEREERLTREQQEKEKkhtdmLNAIAAHRESMRQ 381
Cdd:COG4913   689 ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEEL--DELQDRLEAAEDLARLELR-----ALLEERFAAALGD 761

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292617832  382 EQERKVEEEKQKALEMLNAKKEADQIFMEKQQRRAQKAREEGKTLQDLYIQEMAEKRAKHQRTKKD-----QQEFVEKSN 456
Cdd:COG4913   762 AVERELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLEEDglpeyEERFKELLN 841

                         250       260
                  ....*....|....*....|...
gi 292617832  457 AFIIEEEKQFQTYAKQVIETAER 479
Cdd:COG4913   842 ENSIEFVADLLSKLRRAIREIKE 864
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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