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Conserved domains on  [gi|219113961|ref|XP_002176163|]
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predicted protein [Phaeodactylum tricornutum CCAP 1055/1]

Protein Classification

SET domain-containing protein( domain architecture ID 1562517)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 327-491 7.85e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10540:

Pssm-ID: 394802  Cd Length: 112  Bit Score: 56.49  E-value: 7.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 327 HVEPRTSTIvpqAGRGAFAVRSLLRDQVITTTPLLhvadadffnlynvtsMFDENDNEHYQKhvdtvvgsQILLNYCF-G 405
Cdd:cd10540    1 RLEVKPSTL---KGRGVFATRPIKKGEVIEEAPVI---------------VLPKEEYQHLCK--------TVLDHYVFsW 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 406 HEETTVILCPYGSginYINHDATlANVkiRWAVDFdvvhddevvqswtvedlENDTkprlaLDYFATRDIEPGEELLLDY 485
Cdd:cd10540   55 GDGCLALALGYGS---MFNHSYT-PNA--EYEIDF-----------------ENQT-----IVFYALRDIEAGEELTINY 106


                 ....*.
gi 219113961 486 GAVWEE 491
Cdd:cd10540  107 GDDLWD 112
 
Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 327-491 7.85e-10

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 56.49  E-value: 7.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 327 HVEPRTSTIvpqAGRGAFAVRSLLRDQVITTTPLLhvadadffnlynvtsMFDENDNEHYQKhvdtvvgsQILLNYCF-G 405
Cdd:cd10540    1 RLEVKPSTL---KGRGVFATRPIKKGEVIEEAPVI---------------VLPKEEYQHLCK--------TVLDHYVFsW 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 406 HEETTVILCPYGSginYINHDATlANVkiRWAVDFdvvhddevvqswtvedlENDTkprlaLDYFATRDIEPGEELLLDY 485
Cdd:cd10540   55 GDGCLALALGYGS---MFNHSYT-PNA--EYEIDF-----------------ENQT-----IVFYALRDIEAGEELTINY 106


                 ....*.
gi 219113961 486 GAVWEE 491
Cdd:cd10540  107 GDDLWD 112
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 340-486 3.64e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.14  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961  340 GRGAFAVRSLLRDQVI---TTTPLLHVADADFfNLYNVTSMFDENDNEHYQKHVDTVVGsqillnYCFGHEETtvilcPY 416
Cdd:pfam00856   1 GRGLFATEDIPKGEFIgeyVEVLLITKEEADK-RELLYYDKLELRLWGPYLFTLDEDSE------YCIDARAL-----YY 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961  417 GSGINYINHDATlANVKIRWavdFDVVHDDEVVqswtvedlendtkprlaldYFATRDIEPGEELLLDYG 486
Cdd:pfam00856  69 GNWARFINHSCD-PNCEVRV---VYVNGGPRIV-------------------IFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
326-492 3.00e-06

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 46.88  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 326 DHVEPRTSTIvpqAGRGAFAVRSLLRDQVIT--TTPLLHVADADffnlynvtSMFDENDNEHyqkhvdtvvgsqillNYC 403
Cdd:COG2940    6 PRIEVRPSPI---HGRGVFATRDIPKGTLIGeyPGEVITWAEAE--------RREPHKEPLH---------------TYL 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 404 FGHEETTVILCPYGSGI-NYINHDATlANVKIRWavdfdvvhddevvqswtvedlENDTkprlaLDYFATRDIEPGEELL 482
Cdd:COG2940   60 FELDDDGVIDGALGGNPaRFINHSCD-PNCEADE---------------------EDGR-----IFIVALRDIAAGEELT 112

                        170
                 ....*....|
gi 219113961 483 LDYGAVWEEA 492
Cdd:COG2940  113 YDYGLDYDEE 122
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 422-492 1.91e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 41.55  E-value: 1.91e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219113961   422 YINHDATlANVKIRWAvdfdvvhddevvqswtvedlENDTKPRLALdyFATRDIEPGEELLLDYGAVWEEA 492
Cdd:smart00317  77 FINHSCE-PNCELLFV--------------------EVNGDDRIVI--FALRDIKPGEELTIDYGSDYANE 124
 
Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 327-491 7.85e-10

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 56.49  E-value: 7.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 327 HVEPRTSTIvpqAGRGAFAVRSLLRDQVITTTPLLhvadadffnlynvtsMFDENDNEHYQKhvdtvvgsQILLNYCF-G 405
Cdd:cd10540    1 RLEVKPSTL---KGRGVFATRPIKKGEVIEEAPVI---------------VLPKEEYQHLCK--------TVLDHYVFsW 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 406 HEETTVILCPYGSginYINHDATlANVkiRWAVDFdvvhddevvqswtvedlENDTkprlaLDYFATRDIEPGEELLLDY 485
Cdd:cd10540   55 GDGCLALALGYGS---MFNHSYT-PNA--EYEIDF-----------------ENQT-----IVFYALRDIEAGEELTINY 106


                 ....*.
gi 219113961 486 GAVWEE 491
Cdd:cd10540  107 GDDLWD 112
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 340-486 3.64e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.14  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961  340 GRGAFAVRSLLRDQVI---TTTPLLHVADADFfNLYNVTSMFDENDNEHYQKHVDTVVGsqillnYCFGHEETtvilcPY 416
Cdd:pfam00856   1 GRGLFATEDIPKGEFIgeyVEVLLITKEEADK-RELLYYDKLELRLWGPYLFTLDEDSE------YCIDARAL-----YY 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961  417 GSGINYINHDATlANVKIRWavdFDVVHDDEVVqswtvedlendtkprlaldYFATRDIEPGEELLLDYG 486
Cdd:pfam00856  69 GNWARFINHSCD-PNCEVRV---VYVNGGPRIV-------------------IFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
326-492 3.00e-06

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 46.88  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 326 DHVEPRTSTIvpqAGRGAFAVRSLLRDQVIT--TTPLLHVADADffnlynvtSMFDENDNEHyqkhvdtvvgsqillNYC 403
Cdd:COG2940    6 PRIEVRPSPI---HGRGVFATRDIPKGTLIGeyPGEVITWAEAE--------RREPHKEPLH---------------TYL 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 404 FGHEETTVILCPYGSGI-NYINHDATlANVKIRWavdfdvvhddevvqswtvedlENDTkprlaLDYFATRDIEPGEELL 482
Cdd:COG2940   60 FELDDDGVIDGALGGNPaRFINHSCD-PNCEADE---------------------EDGR-----IFIVALRDIAAGEELT 112

                        170
                 ....*....|
gi 219113961 483 LDYGAVWEEA 492
Cdd:COG2940  113 YDYGLDYDEE 122
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 422-486 7.99e-06

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 46.03  E-value: 7.99e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219113961 422 YINHDATLANVKIRwavdfdvVHDdevvqswtVEDlendtKPRLALdyFATRDIEPGEELLLDYG 486
Cdd:cd10528   97 LINHSKKKPNLKTK-------LLV--------IDG-----VPHLIL--VAKRDIKPGEELLYDYG 139
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 422-486 1.69e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 43.01  E-value: 1.69e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219113961 422 YINHDATlANVKirwavdFDVVHDDevvqswtvedlendTKPRLAldYFATRDIEPGEELLLDYG 486
Cdd:cd08161   31 FINHSCE-PNCE------FEEVYVG--------------GKPRVF--IVALRDIKAGEELTVDYG 72
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 422-486 3.53e-05

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 45.44  E-value: 3.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219113961 422 YINH--DATLANVKIRwavdfdVVHDDEVVqswtvedlendtkPRLALdyFATRDIEPGEELLLDYG 486
Cdd:cd10538  172 FINHscDPNLFPFNVV------IDHDDLRY-------------PRIAL--FATRDILPGEELTFDYG 217
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 415-491 1.14e-04

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 42.33  E-value: 1.14e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219113961 415 PYGSGINYINHDATlanvkirWAVDFDVVHDDEVvqsWTVEdlendtkprlaldYFATRDIEPGEELLLDYGAVWEE 491
Cdd:cd10522   69 KKGNLTRFINHSDQ-------PNLELIVRTLKGE---QHIG-------------FVAIRDIKPGEELFISYGPKYWK 122
SET_SETD9 cd10537
SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins; SETD9 is an ...
 414-485 1.25e-04

SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins; SETD9 is an uncharacterized protein that belongs to the class V-like SAM-binding methyltransferase superfamily.


Pssm-ID: 380935  Cd Length: 150  Bit Score: 42.56  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 414 CPYGSGiNYINHDA--TLANVKIrwaVDFDVVHD----------DEVVQSWTVEDLENDTKPRLALDYFATRDIEPGEEL 481
Cdd:cd10537   69 NPLALG-HYVNHPPkgTPPNVAY---QEYDFPEDfpeelrryipNVYYSPDQVFNMTRGKRPLRGVVLVATRDIKDGEEL 144


                 ....
gi 219113961 482 LLDY 485
Cdd:cd10537  145 FSNY 148
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 422-492 1.91e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 41.55  E-value: 1.91e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219113961   422 YINHDATlANVKIRWAvdfdvvhddevvqswtvedlENDTKPRLALdyFATRDIEPGEELLLDYGAVWEEA 492
Cdd:smart00317  77 FINHSCE-PNCELLFV--------------------EVNGDDRIVI--FALRDIKPGEELTIDYGSDYANE 124
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 448-490 4.39e-04

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 40.70  E-value: 4.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 219113961 448 VVQSWTVedlenDTKPRLALdyFATRDIEPGEELLLDYGAVWE 490
Cdd:cd10531   86 ETQKWIV-----NGEYRIGI--FALRDIPAGEELTFDYNFVNY 121
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 459-492 8.58e-04

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 41.51  E-value: 8.58e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 219113961 459 NDTKPRLALdyFATRDIEPGEELLLDYGAVWEEA 492
Cdd:cd10542  187 DPRLPRIAF--FAKRDIKAGEELTFDYLMTGTGG 218
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 463-486 2.09e-03

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 40.36  E-value: 2.09e-03
                         10        20
                 ....*....|....*....|....
gi 219113961 463 PRLALdyFATRDIEPGEELLLDYG 486
Cdd:cd10544  193 PKLAL--FAARDIVAGEELSFDYS 214
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 463-494 2.80e-03

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 39.63  E-value: 2.80e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 219113961 463 PRLAldYFATRDIEPGEELLLDYGavwEEAWR 494
Cdd:cd10543  187 PRIA--FFASRDIKAGEELGFDYG---EKFWR 213
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 448-485 3.25e-03

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 38.33  E-value: 3.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 219113961 448 VVQSWTVEDlendtkpRLALDYFATRDIEPGEELLLDY 485
Cdd:cd19172   88 ETQKWTVNG-------ELRVGFFAKRDIPAGEELTFDY 118
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 407-487 4.16e-03

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 39.35  E-value: 4.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219113961 407 EETTVILCPYgsgINYINHDATLANVKIRWAVDFDVVHddevvqswtvedlendtkprlaldYFATRDIEPGEELLLDYG 486
Cdd:cd10527  170 GGGGLALVPL---ADMLNHSPDAPNVRYEYDEDEGSFV------------------------LVATRDIAAGEEVFISYG 222


                 .
gi 219113961 487 A 487
Cdd:cd10527  223 P 223
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 470-486 9.01e-03

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 36.45  E-value: 9.01e-03
                         10
                 ....*....|....*..
gi 219113961 470 FATRDIEPGEELLLDYG 486
Cdd:cd10519  100 FAKRDIEAGEELFFDYG 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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