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Conserved domains on  [gi|195567619|ref|XP_002107356|]
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protein Diedel [Drosophila simulans]

Protein Classification

Diedel domain-containing protein( domain architecture ID 10587025)

Diedel domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Diedel pfam13164
Diedel; Diedel (die) was identified as an insect immune response protein. It is up-regulated ...
 26-99 1.35e-29

Diedel; Diedel (die) was identified as an insect immune response protein. It is up-regulated after a septic injury and may act as a negative regulator of the JAK/STAT signalling pathway. Its homologs can be found in Drosophila and Acyrtosiphon pisum. Interestingly, the orthologues of the die gene are present in the genome of insect DNA viruses of the Baculoviridae and Ascoviridae families. The viral homologs suppress the immune deficiency (IMD) pathway in Drosophila.


:

Pssm-ID: 463795  Cd Length: 75  Bit Score: 101.64  E-value: 1.35e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195567619   26 CCWTKAKLLFTMGKGSCGMVNAKTTKYG-CEATVCADGRVLKGSYCGVGSCNIFGCFCRGGCLAGNYGESFVEIN 99
Cdd:pfam13164   1 CCRRATKIRFKVTNGTCGTVGGKSSYPGtCEITICADGRALVGTYCGRGSCNIFGCNCDGGCLSGDWEKSFLRRN 75
 
Name Accession Description Interval E-value
Diedel pfam13164
Diedel; Diedel (die) was identified as an insect immune response protein. It is up-regulated ...
 26-99 1.35e-29

Diedel; Diedel (die) was identified as an insect immune response protein. It is up-regulated after a septic injury and may act as a negative regulator of the JAK/STAT signalling pathway. Its homologs can be found in Drosophila and Acyrtosiphon pisum. Interestingly, the orthologues of the die gene are present in the genome of insect DNA viruses of the Baculoviridae and Ascoviridae families. The viral homologs suppress the immune deficiency (IMD) pathway in Drosophila.


Pssm-ID: 463795  Cd Length: 75  Bit Score: 101.64  E-value: 1.35e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195567619   26 CCWTKAKLLFTMGKGSCGMVNAKTTKYG-CEATVCADGRVLKGSYCGVGSCNIFGCFCRGGCLAGNYGESFVEIN 99
Cdd:pfam13164   1 CCRRATKIRFKVTNGTCGTVGGKSSYPGtCEITICADGRALVGTYCGRGSCNIFGCNCDGGCLSGDWEKSFLRRN 75
 
Name Accession Description Interval E-value
Diedel pfam13164
Diedel; Diedel (die) was identified as an insect immune response protein. It is up-regulated ...
 26-99 1.35e-29

Diedel; Diedel (die) was identified as an insect immune response protein. It is up-regulated after a septic injury and may act as a negative regulator of the JAK/STAT signalling pathway. Its homologs can be found in Drosophila and Acyrtosiphon pisum. Interestingly, the orthologues of the die gene are present in the genome of insect DNA viruses of the Baculoviridae and Ascoviridae families. The viral homologs suppress the immune deficiency (IMD) pathway in Drosophila.


Pssm-ID: 463795  Cd Length: 75  Bit Score: 101.64  E-value: 1.35e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195567619   26 CCWTKAKLLFTMGKGSCGMVNAKTTKYG-CEATVCADGRVLKGSYCGVGSCNIFGCFCRGGCLAGNYGESFVEIN 99
Cdd:pfam13164   1 CCRRATKIRFKVTNGTCGTVGGKSSYPGtCEITICADGRALVGTYCGRGSCNIFGCNCDGGCLSGDWEKSFLRRN 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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