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Conserved domains on  [gi|156846844|ref|XP_001646308|]
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uncharacterized protein Kpol_1032p44 [Vanderwaltozyma polyspora DSM 70294]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stn1 pfam10451
Telomere regulation protein Stn1; The budding yeast protein Stn1 is a DNA-binding protein ...
 5-254 8.60e-102

Telomere regulation protein Stn1; The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA. Structural profiling has predicted an OB-fold. This domain is the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution.


:

Pssm-ID: 371062  Cd Length: 252  Bit Score: 303.35  E-value: 8.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844    5 EKVSFYDRRYWKYCESYDTCYvPLLISDINCRIDSSKRVCNDI--YGGLIGDVLFWGNRPLVKICVIGCVIGWRWKWIRN 82
Cdd:pfam10451   6 NQVSFYFPTLLRWSEYYDNAT-PMFISDIHKRLDLSRRVGHLIsfYPHLQRDILFWLNRPIRRIKIVGCVIGWKWKWIAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844   83 EEYLIIKIDDSSDKhgFLDCKCSKSVLLSSGIVISNGIGMTLKLFGKVGLRYCEFNITFMEYTDGLVSEVNHWRSSIQQR 162
Cdd:pfam10451  85 EDYAVLHIDDCSDM--VLRCKCSKSQLLSLGIRAIAMIGNTVCVFGKINRSEVELIVTFIEYVRGLNSEIKHWRKRMLYR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  163 VLLQNPWEFDGLKYQEEEEKEGEVEereenVTTSHPRITNNqIIVSSSPIEQ----KNFNDPLEIASPYREIEESMYDNG 238
Cdd:pfam10451 163 KNLTKPWELDPEILNELYSGRREAA-----VEARTPKKSYF-CGNPADHIEQlqkcIRQEDKLEVASPYTIREESIYVKA 236

                         250
                  ....*....|....*.
gi 156846844  239 EISVIMLDSTDPVEVE 254
Cdd:pfam10451 237 KELHLTLLHIDTVEQE 252
Stn1_C pfam12659
Telomere capping C-terminal wHTH; This domain consists of tandem winged helix-turn-helix ...
 268-429 4.34e-52

Telomere capping C-terminal wHTH; This domain consists of tandem winged helix-turn-helix motifs. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localize at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution.


:

Pssm-ID: 463659  Cd Length: 164  Bit Score: 172.49  E-value: 4.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  268 AVLKILLNEPKDRISTVQLYQLPKFMSIINQISINRIRKENISH-KGLEDIKIEVFYKLLKTFSKNGLIKYI-DETEIDL 345
Cdd:pfam12659   1 ALLKILLELSEESISTVDLYQLPGLSSILEQIAINRFQNQNLSIlKSLEQLKSELFYDYLAQLAKMGLISLEsDGNQIDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  346 SLLHKIYKNFQRQVSVLILLRCTTGNIDLTKLKQLPDINSSSNIEFADILQESIEKIAKSSPNLLKIWRIKKIDKNNYKL 425
Cdd:pfam12659  81 KPLKNLYRYIQKRINTLIKLQCLTGTIDYKQIRQKLGLPQISKKLIIDIFKESLRTTASQSPNLLKSWWIDLKSEERSKV 160


                  ....
gi 156846844  426 NFVY 429
Cdd:pfam12659 161 HFEY 164
 
Name Accession Description Interval E-value
Stn1 pfam10451
Telomere regulation protein Stn1; The budding yeast protein Stn1 is a DNA-binding protein ...
 5-254 8.60e-102

Telomere regulation protein Stn1; The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA. Structural profiling has predicted an OB-fold. This domain is the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution.


Pssm-ID: 371062  Cd Length: 252  Bit Score: 303.35  E-value: 8.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844    5 EKVSFYDRRYWKYCESYDTCYvPLLISDINCRIDSSKRVCNDI--YGGLIGDVLFWGNRPLVKICVIGCVIGWRWKWIRN 82
Cdd:pfam10451   6 NQVSFYFPTLLRWSEYYDNAT-PMFISDIHKRLDLSRRVGHLIsfYPHLQRDILFWLNRPIRRIKIVGCVIGWKWKWIAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844   83 EEYLIIKIDDSSDKhgFLDCKCSKSVLLSSGIVISNGIGMTLKLFGKVGLRYCEFNITFMEYTDGLVSEVNHWRSSIQQR 162
Cdd:pfam10451  85 EDYAVLHIDDCSDM--VLRCKCSKSQLLSLGIRAIAMIGNTVCVFGKINRSEVELIVTFIEYVRGLNSEIKHWRKRMLYR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  163 VLLQNPWEFDGLKYQEEEEKEGEVEereenVTTSHPRITNNqIIVSSSPIEQ----KNFNDPLEIASPYREIEESMYDNG 238
Cdd:pfam10451 163 KNLTKPWELDPEILNELYSGRREAA-----VEARTPKKSYF-CGNPADHIEQlqkcIRQEDKLEVASPYTIREESIYVKA 236

                         250
                  ....*....|....*.
gi 156846844  239 EISVIMLDSTDPVEVE 254
Cdd:pfam10451 237 KELHLTLLHIDTVEQE 252
Stn1_C pfam12659
Telomere capping C-terminal wHTH; This domain consists of tandem winged helix-turn-helix ...
 268-429 4.34e-52

Telomere capping C-terminal wHTH; This domain consists of tandem winged helix-turn-helix motifs. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localize at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution.


Pssm-ID: 463659  Cd Length: 164  Bit Score: 172.49  E-value: 4.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  268 AVLKILLNEPKDRISTVQLYQLPKFMSIINQISINRIRKENISH-KGLEDIKIEVFYKLLKTFSKNGLIKYI-DETEIDL 345
Cdd:pfam12659   1 ALLKILLELSEESISTVDLYQLPGLSSILEQIAINRFQNQNLSIlKSLEQLKSELFYDYLAQLAKMGLISLEsDGNQIDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  346 SLLHKIYKNFQRQVSVLILLRCTTGNIDLTKLKQLPDINSSSNIEFADILQESIEKIAKSSPNLLKIWRIKKIDKNNYKL 425
Cdd:pfam12659  81 KPLKNLYRYIQKRINTLIKLQCLTGTIDYKQIRQKLGLPQISKKLIIDIFKESLRTTASQSPNLLKSWWIDLKSEERSKV 160


                  ....
gi 156846844  426 NFVY 429
Cdd:pfam12659 161 HFEY 164
 
Name Accession Description Interval E-value
Stn1 pfam10451
Telomere regulation protein Stn1; The budding yeast protein Stn1 is a DNA-binding protein ...
 5-254 8.60e-102

Telomere regulation protein Stn1; The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA. Structural profiling has predicted an OB-fold. This domain is the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution.


Pssm-ID: 371062  Cd Length: 252  Bit Score: 303.35  E-value: 8.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844    5 EKVSFYDRRYWKYCESYDTCYvPLLISDINCRIDSSKRVCNDI--YGGLIGDVLFWGNRPLVKICVIGCVIGWRWKWIRN 82
Cdd:pfam10451   6 NQVSFYFPTLLRWSEYYDNAT-PMFISDIHKRLDLSRRVGHLIsfYPHLQRDILFWLNRPIRRIKIVGCVIGWKWKWIAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844   83 EEYLIIKIDDSSDKhgFLDCKCSKSVLLSSGIVISNGIGMTLKLFGKVGLRYCEFNITFMEYTDGLVSEVNHWRSSIQQR 162
Cdd:pfam10451  85 EDYAVLHIDDCSDM--VLRCKCSKSQLLSLGIRAIAMIGNTVCVFGKINRSEVELIVTFIEYVRGLNSEIKHWRKRMLYR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  163 VLLQNPWEFDGLKYQEEEEKEGEVEereenVTTSHPRITNNqIIVSSSPIEQ----KNFNDPLEIASPYREIEESMYDNG 238
Cdd:pfam10451 163 KNLTKPWELDPEILNELYSGRREAA-----VEARTPKKSYF-CGNPADHIEQlqkcIRQEDKLEVASPYTIREESIYVKA 236

                         250
                  ....*....|....*.
gi 156846844  239 EISVIMLDSTDPVEVE 254
Cdd:pfam10451 237 KELHLTLLHIDTVEQE 252
Stn1_C pfam12659
Telomere capping C-terminal wHTH; This domain consists of tandem winged helix-turn-helix ...
 268-429 4.34e-52

Telomere capping C-terminal wHTH; This domain consists of tandem winged helix-turn-helix motifs. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localize at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution.


Pssm-ID: 463659  Cd Length: 164  Bit Score: 172.49  E-value: 4.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  268 AVLKILLNEPKDRISTVQLYQLPKFMSIINQISINRIRKENISH-KGLEDIKIEVFYKLLKTFSKNGLIKYI-DETEIDL 345
Cdd:pfam12659   1 ALLKILLELSEESISTVDLYQLPGLSSILEQIAINRFQNQNLSIlKSLEQLKSELFYDYLAQLAKMGLISLEsDGNQIDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156846844  346 SLLHKIYKNFQRQVSVLILLRCTTGNIDLTKLKQLPDINSSSNIEFADILQESIEKIAKSSPNLLKIWRIKKIDKNNYKL 425
Cdd:pfam12659  81 KPLKNLYRYIQKRINTLIKLQCLTGTIDYKQIRQKLGLPQISKKLIIDIFKESLRTTASQSPNLLKSWWIDLKSEERSKV 160


                  ....
gi 156846844  426 NFVY 429
Cdd:pfam12659 161 HFEY 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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