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Conserved domains on  [gi|1622862436|ref|XP_001114733|]
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autophagy-related protein 2 homolog A isoform X5 [Macaca mulatta]

Protein Classification

bridge-like lipid transfer protein; VPS13 family protein( domain architecture ID 10330881)

bridge-like lipid transfer protein similar to Homo sapiens bridge-like lipid transfer protein family member 3A/3B, which acts as tube-forming lipid transport protein that mediates the transfer of lipids between membranes at organelle contact sites| VPS13 family protein similar to intermembrane lipid transfer protein VPS13B that mediates the transfer of lipids between membranes at organelle contact sites

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1839-1932 1.62e-37

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


:

Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 136.48  E-value: 1.62e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436 1839 RRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQ 1918
Cdd:pfam09333    3 LYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQ 82

                           90
                   ....*....|....
gi 1622862436 1919 IVPDAHKDHALKWR 1932
Cdd:pfam09333   83 LDPENRRESEDKYK 96
Chorein_N super family cl14987
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 14-108 8.62e-10

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


The actual alignment was detected with superfamily member pfam12624:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 57.96  E-value: 8.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436   14 ERVCRYLLHHYLGHFFQEhLSLDQLSLDLYKGSVALRDIHLeiwsVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDH 93
Cdd:pfam12624    2 ESLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKL----KKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90
                   ....*....|....*
gi 1622862436   94 CTVRVSGLQLTLQPR 108
Cdd:pfam12624   77 VVIEIEDVYLLAVPK 91
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
43-240 9.40e-03

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 41.02  E-value: 9.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436   43 YKGSVALRDIHLEiwsvNEVLESMESPLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQSWA 122
Cdd:COG5043     31 WGGDVSLHNLRIK----PSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYIEDIYLLISPQAKNSLTREELPQSQ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436  123 SCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEHSPGDgergvaveVRVQRLE--- 199
Cdd:COG5043    107 QALKQRQLDSWEILRETLEESSSSPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDNLSA--------DLEGPYSfgl 178

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622862436  200 --YCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELP 240
Cdd:COG5043    179 tlYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEIS 221
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1839-1932 1.62e-37

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 136.48  E-value: 1.62e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436 1839 RRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQ 1918
Cdd:pfam09333    3 LYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQ 82

                           90
                   ....*....|....
gi 1622862436 1919 IVPDAHKDHALKWR 1932
Cdd:pfam09333   83 LDPENRRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 14-108 8.62e-10

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 57.96  E-value: 8.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436   14 ERVCRYLLHHYLGHFFQEhLSLDQLSLDLYKGSVALRDIHLeiwsVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDH 93
Cdd:pfam12624    2 ESLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKL----KKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90
                   ....*....|....*
gi 1622862436   94 CTVRVSGLQLTLQPR 108
Cdd:pfam12624   77 VVIEIEDVYLLAVPK 91
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
43-240 9.40e-03

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 41.02  E-value: 9.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436   43 YKGSVALRDIHLEiwsvNEVLESMESPLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQSWA 122
Cdd:COG5043     31 WGGDVSLHNLRIK----PSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYIEDIYLLISPQAKNSLTREELPQSQ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436  123 SCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEHSPGDgergvaveVRVQRLE--- 199
Cdd:COG5043    107 QALKQRQLDSWEILRETLEESSSSPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDNLSA--------DLEGPYSfgl 178

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622862436  200 --YCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELP 240
Cdd:COG5043    179 tlYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEIS 221
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1839-1932 1.62e-37

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 136.48  E-value: 1.62e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436 1839 RRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQ 1918
Cdd:pfam09333    3 LYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQ 82

                           90
                   ....*....|....
gi 1622862436 1919 IVPDAHKDHALKWR 1932
Cdd:pfam09333   83 LDPENRRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 14-108 8.62e-10

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 57.96  E-value: 8.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436   14 ERVCRYLLHHYLGHFFQEhLSLDQLSLDLYKGSVALRDIHLeiwsVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDH 93
Cdd:pfam12624    2 ESLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKL----KKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90
                   ....*....|....*
gi 1622862436   94 CTVRVSGLQLTLQPR 108
Cdd:pfam12624   77 VVIEIEDVYLLAVPK 91
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
43-240 9.40e-03

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 41.02  E-value: 9.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436   43 YKGSVALRDIHLEiwsvNEVLESMESPLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQSWA 122
Cdd:COG5043     31 WGGDVSLHNLRIK----PSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYIEDIYLLISPQAKNSLTREELPQSQ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862436  123 SCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEHSPGDgergvaveVRVQRLE--- 199
Cdd:COG5043    107 QALKQRQLDSWEILRETLEESSSSPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDNLSA--------DLEGPYSfgl 178

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622862436  200 --YCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELP 240
Cdd:COG5043    179 tlYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEIS 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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