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Conserved domains on  [gi|1622834116|ref|XP_001108035|]
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exostosin-like 1 isoform X1 [Macaca mulatta]

Protein Classification

exostosin( domain architecture ID 10503393)

exostosin is a family 47 glycosyltransferase that is required for the biosynthesis of heparan-sulfate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
418-654 7.66e-121

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


:

Pssm-ID: 430488  Cd Length: 241  Bit Score: 359.69  E-value: 7.66e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 418 FSALIWV-GPPGQPPLKLIQAVAGSQHCAQILVLWSNERPLP--SSWPETAMPLTVIDGHRKV-SDRFFPYSTIRTDAIL 493
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNNPKPPPelSRWPGTGVPVTVIRQKRNSlNNRFLPYPEIETDAVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 494 SLDARSSLSTSEVDFAFVVWQSFPERMVGFLTSSHFWDEAHGGWGYTAERTNEFSMVLTTAAFYHRYYHTLFTHSLPKAL 573
Cdd:pfam09258  81 SLDDDILLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPKSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 574 RTLADEAPTCVDVLMNFLVAAVTKRPPIKVPYGKQRQEAAPLASGGPGPRPKPQAPAPNCVNQIAAAFGHMPLLSSRLRL 653
Cdd:pfam09258 161 RTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQIRL 240

                  .
gi 1622834116 654 D 654
Cdd:pfam09258 241 D 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
91-334 1.67e-37

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


:

Pssm-ID: 397245  Cd Length: 290  Bit Score: 141.41  E-value: 1.67e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116  91 RGDGLKVFVY--------------PASGPISETHHRILASIEGSR--FHTFSPA----------GACLLLLLSLDAQTGE 144
Cdd:pfam03016   1 SCKGLKVYVYdlpprfnedllqpcRSLTGWYSAEQFLLESILHSRieCRTSDPDeadcffvpfyASLDASRHLLNSALTD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 145 CSSMPLQ--------WNR--GRNHLVLRLHPAPCPKT----FQLGQAMVA--EASPTVDSFRPGFDVALPFLPEAHPlrg 208
Cdd:pfam03016  81 LFRELLDwlksqypyWNRsgGRDHFIVSGHPAWSFRRtapdVDWGRAMLLnlTVLFSEDQFRPGKDVALPYPTPFHP--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 209 gAPGQLQQHSPQPG-IALLALEEERGGWRTADTGSS---ACPWDARCEQDSG----PGQTQRGETLPNATFCLISGHRPE 280
Cdd:pfam03016 158 -DIGQWQDISPSNRrKTLLFFAGNRRRGYSGKIRPLlleECKGNPDADICGGlqctPGRDKYMELLRSSRFCLQPPGDTP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622834116 281 AASRFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIVADERLPLQVLAALQEM 334
Cdd:pfam03016 237 TSPRLFDALLAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
418-654 7.66e-121

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 359.69  E-value: 7.66e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 418 FSALIWV-GPPGQPPLKLIQAVAGSQHCAQILVLWSNERPLP--SSWPETAMPLTVIDGHRKV-SDRFFPYSTIRTDAIL 493
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNNPKPPPelSRWPGTGVPVTVIRQKRNSlNNRFLPYPEIETDAVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 494 SLDARSSLSTSEVDFAFVVWQSFPERMVGFLTSSHFWDEAHGGWGYTAERTNEFSMVLTTAAFYHRYYHTLFTHSLPKAL 573
Cdd:pfam09258  81 SLDDDILLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPKSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 574 RTLADEAPTCVDVLMNFLVAAVTKRPPIKVPYGKQRQEAAPLASGGPGPRPKPQAPAPNCVNQIAAAFGHMPLLSSRLRL 653
Cdd:pfam09258 161 RTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQIRL 240

                  .
gi 1622834116 654 D 654
Cdd:pfam09258 241 D 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
91-334 1.67e-37

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 141.41  E-value: 1.67e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116  91 RGDGLKVFVY--------------PASGPISETHHRILASIEGSR--FHTFSPA----------GACLLLLLSLDAQTGE 144
Cdd:pfam03016   1 SCKGLKVYVYdlpprfnedllqpcRSLTGWYSAEQFLLESILHSRieCRTSDPDeadcffvpfyASLDASRHLLNSALTD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 145 CSSMPLQ--------WNR--GRNHLVLRLHPAPCPKT----FQLGQAMVA--EASPTVDSFRPGFDVALPFLPEAHPlrg 208
Cdd:pfam03016  81 LFRELLDwlksqypyWNRsgGRDHFIVSGHPAWSFRRtapdVDWGRAMLLnlTVLFSEDQFRPGKDVALPYPTPFHP--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 209 gAPGQLQQHSPQPG-IALLALEEERGGWRTADTGSS---ACPWDARCEQDSG----PGQTQRGETLPNATFCLISGHRPE 280
Cdd:pfam03016 158 -DIGQWQDISPSNRrKTLLFFAGNRRRGYSGKIRPLlleECKGNPDADICGGlqctPGRDKYMELLRSSRFCLQPPGDTP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622834116 281 AASRFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIVADERLPLQVLAALQEM 334
Cdd:pfam03016 237 TSPRLFDALLAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
267-342 7.82e-03

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 39.24  E-value: 7.82e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622834116 267 PNATFCLISGHRPEAASRFLQALQAGCIPVLLSPRWELPFSEVIdwtkaaiVADERLPLQVLAA-LQEMSPARVLAL 342
Cdd:PRK10773   36 PGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLV-------VKDTRLAFGQLAAwVRQQVPARVVAL 105
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
418-654 7.66e-121

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 359.69  E-value: 7.66e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 418 FSALIWV-GPPGQPPLKLIQAVAGSQHCAQILVLWSNERPLP--SSWPETAMPLTVIDGHRKV-SDRFFPYSTIRTDAIL 493
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNNPKPPPelSRWPGTGVPVTVIRQKRNSlNNRFLPYPEIETDAVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 494 SLDARSSLSTSEVDFAFVVWQSFPERMVGFLTSSHFWDEAHGGWGYTAERTNEFSMVLTTAAFYHRYYHTLFTHSLPKAL 573
Cdd:pfam09258  81 SLDDDILLSTDEIDFAFRVWRSFPDRIVGFPPRSHFWDLSSGRWGYTSEWTNEYSMVLTGAAFYHRYYLYLYTHSLPKSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 574 RTLADEAPTCVDVLMNFLVAAVTKRPPIKVPYGKQRQEAAPLASGGPGPRPKPQAPAPNCVNQIAAAFGHMPLLSSRLRL 653
Cdd:pfam09258 161 RTLVDETQNCEDILMNFLVANVTRKPPVKVTQRKQFKEGKNSGKVGLSSRPGHFLQRSKCINKFAAVFGYMPLVYSQIRL 240

                  .
gi 1622834116 654 D 654
Cdd:pfam09258 241 D 241
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
91-334 1.67e-37

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 141.41  E-value: 1.67e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116  91 RGDGLKVFVY--------------PASGPISETHHRILASIEGSR--FHTFSPA----------GACLLLLLSLDAQTGE 144
Cdd:pfam03016   1 SCKGLKVYVYdlpprfnedllqpcRSLTGWYSAEQFLLESILHSRieCRTSDPDeadcffvpfyASLDASRHLLNSALTD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 145 CSSMPLQ--------WNR--GRNHLVLRLHPAPCPKT----FQLGQAMVA--EASPTVDSFRPGFDVALPFLPEAHPlrg 208
Cdd:pfam03016  81 LFRELLDwlksqypyWNRsgGRDHFIVSGHPAWSFRRtapdVDWGRAMLLnlTVLFSEDQFRPGKDVALPYPTPFHP--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834116 209 gAPGQLQQHSPQPG-IALLALEEERGGWRTADTGSS---ACPWDARCEQDSG----PGQTQRGETLPNATFCLISGHRPE 280
Cdd:pfam03016 158 -DIGQWQDISPSNRrKTLLFFAGNRRRGYSGKIRPLlleECKGNPDADICGGlqctPGRDKYMELLRSSRFCLQPPGDTP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622834116 281 AASRFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIVADERLPLQVLAALQEM 334
Cdd:pfam03016 237 TSPRLFDALLAGCIPVIISDGWELPFADVIDWRKFSVFVPENDIPELKSILRSL 290
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
267-342 7.82e-03

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 39.24  E-value: 7.82e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622834116 267 PNATFCLISGHRPEAASRFLQALQAGCIPVLLSPRWELPFSEVIdwtkaaiVADERLPLQVLAA-LQEMSPARVLAL 342
Cdd:PRK10773   36 PGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLV-------VKDTRLAFGQLAAwVRQQVPARVVAL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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