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Conserved domains on  [gi|297263513|ref|XP_001106734|]
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anaphase-promoting complex subunit 7 isoform X1 [Macaca mulatta]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 19960403)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 339-551 6.27e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.09  E-value: 6.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 339 AEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYL 418
Cdd:COG2956    8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 419 ASNSIREAMVMANNVYKTLGANAQTLTLLATVCLE--DPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGI 496
Cdd:COG2956   88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQegDW---EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAI 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 297263513 497 ALLRNALANQSDCV-LHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQK 551
Cdd:COG2956  165 EALEKALKLDPDCArALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAE 220
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 133-426 1.04e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  133 PSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQR-TPKINMMLANLYKKAGQERPSVTSYKEVLRQCP---LALdAILG 208
Cdd:TIGR02917 564 PQEIEPALALAQYYLGKGQLKKALAILNEAADAAPdSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPdsaLAL-LLLA 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  209 LLSLSVKG-AEVASMTMNVIQTVPNLdWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLgsLADLYFRAGDN 287
Cdd:TIGR02917 643 DAYAVMKNyAKAITSLKRALELKPDN-TEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL--EGDLYLRQKDY 719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  288 KNSVLKFEQAQMLDPYLIKGMDVYGYLLAR------EGRLEDV-----------------------ENLGCRLFNISDQH 338
Cdd:TIGR02917 720 PAAIQAYRKALKRAPSSQNAIKLHRALLASgntaeaVKTLEAWlkthpndavlrtalaelylaqkdYDKAIKHYQTVVKK 799

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  339 AE--PWVVSGCHSFYSKRY-SRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIE 415
Cdd:TIGR02917 800 APdnAVVLNNLAWLYLELKdPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLAL 879

                         330
                  ....*....|.
gi 297263513  416 CYLASNSIREA 426
Cdd:TIGR02917 880 ALLATGRKAEA 890
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 339-551 6.27e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.09  E-value: 6.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 339 AEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYL 418
Cdd:COG2956    8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 419 ASNSIREAMVMANNVYKTLGANAQTLTLLATVCLE--DPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGI 496
Cdd:COG2956   88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQegDW---EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAI 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 297263513 497 ALLRNALANQSDCV-LHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQK 551
Cdd:COG2956  165 EALEKALKLDPDCArALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAE 220
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 179-569 6.37e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.94  E-value: 6.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  179 YKKAGQERPSVTSYKEVLRQCPLALDA--ILGLLSL---SVKGAE-----VASMTMNVIQTVPNLdwlsvwikAYAFVHT 248
Cdd:TIGR02917  32 YLQKNKYKAAIIQLKNALQKDPNDAEArfLLGKIYLalgDYAAAEkelrkALSLGYPKNQVLPLL--------ARAYLLQ 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  249 GDNSRAINTicsLEKKSLLRDN--VDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVEN 326
Cdd:TIGR02917 104 GKFQQVLDE---LPGKTLLDDEgaAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  327 LGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCR 406
Cdd:TIGR02917 181 LIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  407 LDC--YEGLIEcyLASNSIREAMvmaNNVYKTLGANAQTLT--LLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKK 482
Cdd:TIGR02917 261 PLAhyLKALVD--FQKKNYEDAR---ETLQDALKSAPEYLPalLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLL 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  483 AELLSREQKYEDGIALLRNALA-NQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND-----QKSLEGMQKMEKEE 556
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGlDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENaaartQLGISKLSQGDPSE 415

                         410
                  ....*....|...
gi 297263513  557 SPTDATQEEDVDD 569
Cdd:TIGR02917 416 AIADLETAAQLDP 428
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 133-426 1.04e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  133 PSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQR-TPKINMMLANLYKKAGQERPSVTSYKEVLRQCP---LALdAILG 208
Cdd:TIGR02917 564 PQEIEPALALAQYYLGKGQLKKALAILNEAADAAPdSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPdsaLAL-LLLA 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  209 LLSLSVKG-AEVASMTMNVIQTVPNLdWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLgsLADLYFRAGDN 287
Cdd:TIGR02917 643 DAYAVMKNyAKAITSLKRALELKPDN-TEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL--EGDLYLRQKDY 719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  288 KNSVLKFEQAQMLDPYLIKGMDVYGYLLAR------EGRLEDV-----------------------ENLGCRLFNISDQH 338
Cdd:TIGR02917 720 PAAIQAYRKALKRAPSSQNAIKLHRALLASgntaeaVKTLEAWlkthpndavlrtalaelylaqkdYDKAIKHYQTVVKK 799

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  339 AE--PWVVSGCHSFYSKRY-SRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIE 415
Cdd:TIGR02917 800 APdnAVVLNNLAWLYLELKdPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLAL 879

                         330
                  ....*....|.
gi 297263513  416 CYLASNSIREA 426
Cdd:TIGR02917 880 ALLATGRKAEA 890
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
280-404 1.16e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 280 LYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLgcrlfnisdqhaepwvvsgchsfyskrysral 359
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-------------------------------- 48

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 297263513 360 ylgAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:COG3063   49 ---EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 373-404 1.14e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 1.14e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 297263513   373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 373-404 1.60e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 1.60e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 297263513  373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDP 32
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 339-551 6.27e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.09  E-value: 6.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 339 AEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYL 418
Cdd:COG2956    8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 419 ASNSIREAMVMANNVYKTLGANAQTLTLLATVCLE--DPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGI 496
Cdd:COG2956   88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQegDW---EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAI 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 297263513 497 ALLRNALANQSDCV-LHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQK 551
Cdd:COG2956  165 EALEKALKLDPDCArALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAE 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 353-563 9.22e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 86.71  E-value: 9.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 353 KRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANN 432
Cdd:COG2956   56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 433 VYKTLGANAQTLTLLATVCLE--DPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALA-NQSDC 509
Cdd:COG2956  136 LLKLGPENAHAYCELAELYLEqgDY---DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEqDPDYL 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 297263513 510 VLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQ 563
Cdd:COG2956  213 PALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALA 266
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
366-542 2.60e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 78.90  E-value: 2.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 366 IQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLT 445
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 446 LLATVC--LEDPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCV-LHRILGDFLVAV 522
Cdd:COG0457   81 NLGLALqaLGRY---EEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDAdALYNLGIALEKL 157

                        170       180
                 ....*....|....*....|
gi 297263513 523 NEYQEAMDQYSIALSLDPND 542
Cdd:COG0457  158 GRYEEALELLEKLEAAALAA 177
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 277-539 6.72e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 6.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 277 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYS 356
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 357 RALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKT 436
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 437 LGANAQTLTLLATVCLE--DPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRI 514
Cdd:COG2956  174 DPDCARALLLLAELYLEqgDY---EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLA 250

                        250       260
                 ....*....|....*....|....*
gi 297263513 515 LGDFLVAVNEYQEAMDQYSIALSLD 539
Cdd:COG2956  251 LADLLERKEGLEAALALLERQLRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 354-544 1.38e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 80.04  E-value: 1.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 354 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMvmannv 433
Cdd:COG3914   59 LLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEAL------ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 434 yktlganaqtltllatvcledpvtqekakTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCV-LH 512
Cdd:COG3914  133 -----------------------------AALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAeAL 183

                        170       180       190
                 ....*....|....*....|....*....|..
gi 297263513 513 RILGDFLVAVNEYQEAMDQYSIALSLDPNDQK 544
Cdd:COG3914  184 NNLGNALQDLGRLEEAIAAYRRALELDPDNAD 215
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 242-472 4.92e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.84  E-value: 4.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 242 AYAFVHTGDNSRAINTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRL 321
Cdd:COG2956   49 GNLYRRRGEYDRAIRIHQKLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 322 EDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIR 401
Cdd:COG2956  127 EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297263513 402 LAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLAtvCLEDPVTQEKAKTLLDKALTQR 472
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALAD--LLERKEGLEAALALLERQLRRH 275
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
269-504 1.47e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 1.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 269 DNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCH 348
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 349 SFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMV 428
Cdd:COG0457   86 LQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 429 M----ANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALA 504
Cdd:COG0457  166 LleklEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 267-426 1.56e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.33  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 267 LRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSG 346
Cdd:COG3914   74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLG 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 347 CHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREA 426
Cdd:COG3914  154 EALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVY 233
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
300-541 3.13e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.87  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 300 LDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLK 379
Cdd:COG0457    3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 380 GAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLAtVCLEDPVTQE 459
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLG-IALEKLGRYE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 460 KAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLD 539
Cdd:COG0457  162 EALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALY 241


                 ..
gi 297263513 540 PN 541
Cdd:COG0457  242 QY 243
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 312-447 7.93e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.01  E-value: 7.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 312 GYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQE 391
Cdd:COG3914   85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 297263513 392 AIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLL 447
Cdd:COG3914  165 AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 277-478 8.07e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.01  E-value: 8.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 277 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYS---- 352
Cdd:COG3914    7 LALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLElaal 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 353 -----KRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAM 427
Cdd:COG3914   87 llqalGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297263513 428 VMANNVYKTLGANAQTLTLLATVcLEDPVTQEKAKTLLDKALTQRPDYIKA 478
Cdd:COG3914  167 AALRRALELDPDNAEALNNLGNA-LQDLGRLEEAIAAYRRALELDPDNADA 216
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 370-542 6.70e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 6.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 370 SNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVmannvyktlganaqtltllat 449
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIV--------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 450 vcledpvtqekaktLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCV-LHRILGDFLVAVNEYQEA 528
Cdd:COG4783   60 --------------LLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPeAYLRLARAYRALGRPDEA 125

                        170
                 ....*....|....
gi 297263513 529 MDQYSIALSLDPND 542
Cdd:COG4783  126 IAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 336-508 1.24e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.74  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 336 DQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPcrldcYEGLIE 415
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP-----DEPEAR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 416 CYLAsnsirEAMVMANNVyktlganaqtltllatvcledpvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDG 495
Cdd:COG4783   76 LNLG-----LALLKAGDY-------------------------DEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                        170
                 ....*....|...
gi 297263513 496 IALLRNALANQSD 508
Cdd:COG4783  126 IAALEKALELDPD 138
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 364-485 2.56e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 2.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 364 KAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQT 443
Cdd:COG4235    8 QALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 297263513 444 LTLLATVCLE--DPvtqEKAKTLLDKALTQRPDYIKAVVKKAEL 485
Cdd:COG4235   88 LYLLGLAAFQqgDY---AEAIAAWQKLLALLPADAPARLLEASI 128
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 179-569 6.37e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.94  E-value: 6.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  179 YKKAGQERPSVTSYKEVLRQCPLALDA--ILGLLSL---SVKGAE-----VASMTMNVIQTVPNLdwlsvwikAYAFVHT 248
Cdd:TIGR02917  32 YLQKNKYKAAIIQLKNALQKDPNDAEArfLLGKIYLalgDYAAAEkelrkALSLGYPKNQVLPLL--------ARAYLLQ 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  249 GDNSRAINTicsLEKKSLLRDN--VDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVEN 326
Cdd:TIGR02917 104 GKFQQVLDE---LPGKTLLDDEgaAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  327 LGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCR 406
Cdd:TIGR02917 181 LIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  407 LDC--YEGLIEcyLASNSIREAMvmaNNVYKTLGANAQTLT--LLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKK 482
Cdd:TIGR02917 261 PLAhyLKALVD--FQKKNYEDAR---ETLQDALKSAPEYLPalLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLL 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  483 AELLSREQKYEDGIALLRNALA-NQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND-----QKSLEGMQKMEKEE 556
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGlDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENaaartQLGISKLSQGDPSE 415

                         410
                  ....*....|...
gi 297263513  557 SPTDATQEEDVDD 569
Cdd:TIGR02917 416 AIADLETAAQLDP 428
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 311-426 6.98e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 6.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 311 YGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQ 390
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 297263513 391 EAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREA 426
Cdd:COG4783   90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 241-543 5.05e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 5.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  241 KAYAFVHTGDNSRAINticSLEKK-SLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREG 319
Cdd:TIGR02917 471 LGAIYLGKGDLAKARE---AFEKAlSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  320 RLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREA 399
Cdd:TIGR02917 548 NEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKL 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  400 IRLAPcrldcYEGLIECYLAsnsirEAMVMANNVyktlganaqtltllatvcledpvtqEKAKTLLDKALTQRPDYIKAV 479
Cdd:TIGR02917 628 LALQP-----DSALALLLLA-----DAYAVMKNY-------------------------AKAITSLKRALELKPDNTEAQ 672

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 297263513  480 VKKAELLSREQKYEDGIALLRN-ALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQ 543
Cdd:TIGR02917 673 IGLAQLLLAAKRTESAKKIAKSlQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQ 737
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 277-404 5.71e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 5.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 277 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYS 356
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297263513 357 RALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:COG4783   90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
440-549 1.09e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 440 NAQTLTLLATVC--LEDPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRI-LG 516
Cdd:COG0457    7 DAEAYNNLGLAYrrLGRY---EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNnLG 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 297263513 517 DFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGM 549
Cdd:COG0457   84 LALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 355-543 2.74e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.93  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  355 YSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVY 434
Cdd:TIGR02917 379 FEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLE 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  435 KTLGANAQTLTLLATVCL--EDPvtqEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALA-NQSDCVL 511
Cdd:TIGR02917 459 KKQPDNASLHNLLGAIYLgkGDL---AKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTiDPKNLRA 535

                         170       180       190
                  ....*....|....*....|....*....|..
gi 297263513  512 HRILGDFLVAVNEYQEAMDQYSIALSLDPNDQ 543
Cdd:TIGR02917 536 ILALAGLYLRTGNEEEAVAWLEKAAELNPQEI 567
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 270-542 1.43e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  270 NVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHS 349
Cdd:TIGR02917 532 NLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQ 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  350 FYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVM 429
Cdd:TIGR02917 612 LAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKI 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  430 ANNVYKTLGANAQTLTLLATVCLEDPVTQEkAKTLLDKALTQRPDYiKAVVKKAELLSREQKYEDGIALLRNALANQ-SD 508
Cdd:TIGR02917 692 AKSLQKQHPKAALGFELEGDLYLRQKDYPA-AIQAYRKALKRAPSS-QNAIKLHRALLASGNTAEAVKTLEAWLKTHpND 769

                         250       260       270
                  ....*....|....*....|....*....|....
gi 297263513  509 CVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND 542
Cdd:TIGR02917 770 AVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDN 803
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
459-541 1.89e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 459 EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSL 538
Cdd:COG3063    9 EEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                 ...
gi 297263513 539 DPN 541
Cdd:COG3063   89 DPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 291-404 2.34e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 291 VLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNS 370
Cdd:COG4235    3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 297263513 371 NSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:COG4235   83 DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 460-546 2.52e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 460 KAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALA-NQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSL 538
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRlDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                 ....*...
gi 297263513 539 DPNDQKSL 546
Cdd:COG4235   81 DPDNPEAL 88
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 459-542 4.91e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 459 EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCV-LHRILGDFLVAVNEYQEAMDQYSIALS 537
Cdd:COG4235   34 DEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPeALYLLGLAAFQQGDYAEAIAAWQKLLA 113


                 ....*
gi 297263513 538 LDPND 542
Cdd:COG4235  114 LLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 133-426 1.04e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  133 PSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQR-TPKINMMLANLYKKAGQERPSVTSYKEVLRQCP---LALdAILG 208
Cdd:TIGR02917 564 PQEIEPALALAQYYLGKGQLKKALAILNEAADAAPdSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPdsaLAL-LLLA 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  209 LLSLSVKG-AEVASMTMNVIQTVPNLdWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLgsLADLYFRAGDN 287
Cdd:TIGR02917 643 DAYAVMKNyAKAITSLKRALELKPDN-TEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL--EGDLYLRQKDY 719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  288 KNSVLKFEQAQMLDPYLIKGMDVYGYLLAR------EGRLEDV-----------------------ENLGCRLFNISDQH 338
Cdd:TIGR02917 720 PAAIQAYRKALKRAPSSQNAIKLHRALLASgntaeaVKTLEAWlkthpndavlrtalaelylaqkdYDKAIKHYQTVVKK 799

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  339 AE--PWVVSGCHSFYSKRY-SRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIE 415
Cdd:TIGR02917 800 APdnAVVLNNLAWLYLELKdPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLAL 879

                         330
                  ....*....|.
gi 297263513  416 CYLASNSIREA 426
Cdd:TIGR02917 880 ALLATGRKAEA 890
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 296-426 1.94e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.95  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 296 QAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQA 375
Cdd:COG5010   11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297263513 376 LLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREA 426
Cdd:COG5010   91 YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEA 141
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 459-540 5.51e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.80  E-value: 5.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 459 EKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALA-NQSDCVLHRILGDFLVAVNEYQEAMDQYSIALS 537
Cdd:COG5010   71 EESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALAlSPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150


                 ...
gi 297263513 538 LDP 540
Cdd:COG5010  151 TSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
280-404 1.16e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 280 LYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLgcrlfnisdqhaepwvvsgchsfyskrysral 359
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-------------------------------- 48

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 297263513 360 ylgAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:COG3063   49 ---EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 295-404 1.41e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 295 EQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQ 374
Cdd:COG5010   44 AAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPN 123

                         90       100       110
                 ....*....|....*....|....*....|
gi 297263513 375 ALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:COG5010  124 AYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
346-419 5.17e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.82  E-value: 5.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297263513 346 GCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCrlDCYEGLIEcYLA 419
Cdd:COG4785  114 GLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPN--DPERALWL-YLA 184
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 354-473 7.99e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 7.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 354 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNV 433
Cdd:COG5010   35 NNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 297263513 434 YKTLGANAQTLTLLATVcLEDPVTQEKAKTLLDKALTQRP 473
Cdd:COG5010  115 LALSPDNPNAYSNLAAL-LLSLGQDDEAKAALQRALGTSP 153
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 373-404 1.14e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 1.14e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 297263513   373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 373-404 1.60e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 1.60e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 297263513  373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR_1 pfam00515
Tetratricopeptide repeat;
373-404 2.03e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 2.03e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 297263513  373 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNP 32
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
382-474 3.89e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 382 ALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMaNNVYKTLGANAQTLTLLATVCLEDPvTQEKA 461
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELG-DYDEA 78

                         90
                 ....*....|...
gi 297263513 462 KTLLDKALTQRPD 474
Cdd:COG3063   79 LAYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 249-579 5.13e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  249 GDNSRAINTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDP-----YLIKGMdvyGYLL---AREG- 319
Cdd:TIGR02917 343 GRVDEAIATLSPALGLD--PDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPenaaaRTQLGI---SKLSqgdPSEAi 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  320 -RLEDVENLGCRLfnisdQHAEPWVVSgcHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFRE 398
Cdd:TIGR02917 418 aDLETAAQLDPEL-----GRADLLLIL--SYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEK 490

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  399 AIRLAP---------CRLDCYEGLIEcylASNSIREAMVMAN-----------NVYKTLGANAQTLTLLATVCLEDPVTQ 458
Cdd:TIGR02917 491 ALSIEPdffpaaanlARIDIQEGNPD---DAIQRFEKVLTIDpknlrailalaGLYLRTGNEEEAVAWLEKAAELNPQEI 567

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513  459 EKAKTL---------LDKALTQRPDYIKAVVKKAE---LLSREQ----KYEDGIALLRNALANQSDCVL-HRILGDFLVA 521
Cdd:TIGR02917 568 EPALALaqyylgkgqLKKALAILNEAADAAPDSPEawlMLGRAQlaagDLNKAVSSFKKLLALQPDSALaLLLLADAYAV 647

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 297263513  522 VNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDAT-------QEEDVDDMEGSGEEGDL 579
Cdd:TIGR02917 648 MKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAkkiakslQKQHPKAALGFELEGDL 712
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 133-327 6.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 6.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 133 PSEIEVKYKMAECYTMLKQDKDAIAILD-GIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLls 211
Cdd:COG2956  107 PDDAEALRLLAEIYEQEGDWEKAIEVLErLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL-- 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297263513 212 lsvkgaevasmtmnviqtvpnldwlsvwikAYAFVHTGDNSRAINTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSV 291
Cdd:COG2956  185 ------------------------------AELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAL 232

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 297263513 292 LKFEQAQMLDPYLIKgMDVYGYLLAREGRLEDVENL 327
Cdd:COG2956  233 ELLRKALELDPSDDL-LLALADLLERKEGLEAALAL 267
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
353-404 7.49e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.36  E-value: 7.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297263513 353 KRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 404
Cdd:COG4785   87 GDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDP 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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