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Conserved domains on  [gi|297289690|ref|XP_001103985|]
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ankyrin repeat and SOCS box protein 10 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-343 2.74e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 2.74e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  99 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 177
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 178 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARDAEGWTPLlaacdircqstadaeattar 257
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 258 clqlcslllsagadadaadrdkhrplHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHcalqgpaAALAQSPEHVVRA 337
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 297289690 338 LLNHGA 343
Cdd:COG0666  238 LLEAGA 243
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 406-452 2.14e-05

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03723:

Pssm-ID: 470605  Cd Length: 48  Bit Score: 41.66  E-value: 2.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 297289690 406 QPRSLQHLSRCALRSHLEGSLPHALLRLPLPPRLLRYLQLDFEGVLY 452
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-343 2.74e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 2.74e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  99 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 177
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 178 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARDAEGWTPLlaacdircqstadaeattar 257
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 258 clqlcslllsagadadaadrdkhrplHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHcalqgpaAALAQSPEHVVRA 337
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 297289690 338 LLNHGA 343
Cdd:COG0666  238 LLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-230 6.50e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 6.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFgarVDGRSEEEEETPLHVAARLGHVELA 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 297289690  217 DLLLRRGACPDARD 230
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-319 2.39e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 133 GRTALHeacAAGHTAC------VHVLLVAGADPNIADQDGKRPLHLC-RGPGTLECAELLLRFGARVDGRSeEEEETPLH 205
Cdd:PHA03095  47 GKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADVNAKD-KVGRTPLH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 206 VAARlG---HVELADLLLRRGACPDARDAEGWTPL-----------------------LAACDIRCQSTADAEATTARCL 259
Cdd:PHA03095 123 VYLS-GfniNPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrllidagadVYAVDDRFRSLLHHHLQSFKPR 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 297289690 260 QLCSLLLSAGADADAADRDKHR-PLHLA-----CRRGhaaVVELLLSCGVSANAMDYGGHTPLHCA 319
Cdd:PHA03095 202 ARIVRELIRAGCDPAATDMLGNtPLHSMatgssCKRS---LVLPLLIAGISINARNRYGQTPLHYA 264
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 406-452 2.14e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 41.66  E-value: 2.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 297289690 406 QPRSLQHLSRCALRSHLEGSLPHALLRLPLPPRLLRYLQLDFEGVLY 452
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-161 9.33e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 9.33e-05
                           10        20
                   ....*....|....*....|....*....
gi 297289690   133 GRTALHEACAAGHTACVHVLLVAGADPNI 161
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-237 1.68e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 103 TPLHVAASRGHTEVLRLLLrrrarpDSAPG------------GRTALHEACAAGHTACVHVLLVAGADPNIADQDGkrpL 170
Cdd:cd22192   53 TALHVAALYDNLEAAVVLM------EAAPElvnepmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRATG---T 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297289690 171 HLCRGPGTLecaellLRFGarvdgrseeeeETPLHVAARLGHVELADLLLRRGACPDARDAEGWTPL 237
Cdd:cd22192  124 FFRPGPKNL------IYYG-----------EHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 406-429 3.32e-03

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 35.22  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|....
gi 297289690  406 QPRSLQHLSRCALRSHLEGSLPHA 429
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA 24
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-343 2.74e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 2.74e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  99 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 177
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 178 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARDAEGWTPLlaacdircqstadaeattar 257
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 258 clqlcslllsagadadaadrdkhrplHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHcalqgpaAALAQSPEHVVRA 337
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 297289690 338 LLNHGA 343
Cdd:COG0666  238 LLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
105-343 6.11e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 117.75  E-value: 6.11e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 105 LHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAEL 184
Cdd:COG0666   26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 185 LLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARDAEGWTPLlaacdircqstadaeattarclqlcsl 264
Cdd:COG0666  106 LLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL--------------------------- 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297289690 265 llsagadadaadrdkhrplHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHcalqgpAAALAQSPEhVVRALLNHGA 343
Cdd:COG0666  158 -------------------HLAAANGNLEIVKLLLEAGADVNARDNDGETPLH------LAAENGHLE-IVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
103-241 2.15e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 2.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 181
Cdd:COG0666  122 TPLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 182 AELLLRFGARVDGRSeEEEETPLHVAARLGHVELADLLLRRGACPDARDAEGWTPLLAAC 241
Cdd:COG0666  202 VKLLLEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-230 6.50e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 6.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFgarVDGRSEEEEETPLHVAARLGHVELA 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 297289690  217 DLLLRRGACPDARD 230
Cdd:pfam12796  78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
102-237 2.61e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 102 TTPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 180
Cdd:COG0666  154 NTPLHLAAANGNLEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 297289690 181 CAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDARDAEGWTPL 237
Cdd:COG0666  234 IVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-319 2.39e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 133 GRTALHeacAAGHTAC------VHVLLVAGADPNIADQDGKRPLHLC-RGPGTLECAELLLRFGARVDGRSeEEEETPLH 205
Cdd:PHA03095  47 GKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADVNAKD-KVGRTPLH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 206 VAARlG---HVELADLLLRRGACPDARDAEGWTPL-----------------------LAACDIRCQSTADAEATTARCL 259
Cdd:PHA03095 123 VYLS-GfniNPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrllidagadVYAVDDRFRSLLHHHLQSFKPR 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 297289690 260 QLCSLLLSAGADADAADRDKHR-PLHLA-----CRRGhaaVVELLLSCGVSANAMDYGGHTPLHCA 319
Cdd:PHA03095 202 ARIVRELIRAGCDPAATDMLGNtPLHSMatgssCKRS---LVLPLLIAGISINARNRYGQTPLHYA 264
Ank_2 pfam12796
Ankyrin repeats (3 copies);
204-343 2.93e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 2.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  204 LHVAARLGHVELADLLLRRGACPDARDAEGWTpllaacdircqstadaeattarclqlcslllsagadadaadrdkhrPL 283
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRT----------------------------------------------AL 34

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  284 HLACRRGHAAVVELLLSCgVSANAMDYgGHTPLHCalqgpaAALAQSPEhVVRALLNHGA 343
Cdd:pfam12796  35 HLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHY------AARSGHLE-IVKLLLEKGA 85
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 137-233 8.97e-11

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 64.15  E-value: 8.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELA 216
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT-LLDKDGKTPLELAEENGFREVV 164

                         90
                 ....*....|....*..
gi 297289690 217 DLLLRRGACPDARDAEG 233
Cdd:PTZ00322 165 QLLSRHSQCHFELGANA 181
PHA03095 PHA03095
ankyrin-like protein; Provisional
 152-343 1.06e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 152 LLVAGADPNIADQDGKRPLHLCRGPGTLECAE---LLLRFGARVDGRsEEEEETPLHVAARLGHVE-LADLLLRRGACPD 227
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAP-ERCGFTPLHLYLYNATTLdVIKLLIKAGADVN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 228 ARDAEGWTPLlaacdircqstadaeattarclqlcslllsagadadaadrdkHrpLHLACRRGHAAVVELLLSCGVSANA 307
Cdd:PHA03095 112 AKDKVGRTPL------------------------------------------H--VYLSGFNINPKVIRLLLRKGADVNA 147

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 297289690 308 MDYGGHTPLHCALQGPAAALAqspehVVRALLNHGA 343
Cdd:PHA03095 148 LDLYGMTPLAVLLKSRNANVE-----LLRLLIDAGA 178
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 39-208 2.87e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.22  E-value: 2.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  39 RPSPLLCQDMALQNAlytgDLARLQElfppHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPL-HVAASrGHTEVL 117
Cdd:PTZ00322  28 RAKPISFERMAAIQE----EIARIDT----HLEALEATENKDATPDHNLTTEEVIDPVVAHMLTVELcQLAAS-GDAVGA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 118 RLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR-------FG 189
Cdd:PTZ00322  99 RILLTGGADPNCRDyDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhsqchfeLG 178

                        170       180
                 ....*....|....*....|....
gi 297289690 190 AR-----VDGRSEEEEETPLHVAA 208
Cdd:PTZ00322 179 ANakpdsFTGKPPSLEDSPISSHH 202
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-163 2.08e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 2.08e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297289690  103 TPLHVAASRGHTEVLRLLLRRrARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 163
Cdd:pfam12796  32 TALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
283-346 2.65e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 2.65e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297289690  283 LHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHcalqgpAAALAQSPEhVVRALLNHGAVRV 346
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALH------LAAKNGHLE-IVKLLLEHADVNL 57
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 149-343 1.75e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.04  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 149 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 229 RDAEGWTPLLAACDIRCQSTADAEATTARCLQLCSLLLSAgadadaadrdkhrPLHLACRRGHaAVVELLLScGVSANAM 308
Cdd:PHA02874 186 KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFT-------------PLHNAIIHNR-SAIELLIN-NASINDQ 250

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 297289690 309 DYGGHTPLHCALQGPAAalaqspEHVVRALLNHGA 343
Cdd:PHA02874 251 DIDGSTPLHHAINPPCD------IDIIDILLYHKA 279
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-249 2.93e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 2.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 133 GRTALHEACAAGHT--ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTleCAELLLRF----GARVDGRSEEEEeTPLHV 206
Cdd:PHA03095 187 FRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMATGSS--CKRSLVLPlliaGISINARNRYGQ-TPLHY 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 297289690 207 AARLGHVELADLLLRRGACPDARDAEGWTPLLAA---CDIRCQSTA 249
Cdd:PHA03095 264 AAVFNNPRACRRLIALGADINAVSSDGNTPLSLMvrnNNGRAVRAA 309
Ank_5 pfam13857
Ankyrin repeats (many copies);
185-237 5.13e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 5.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 297289690  185 LLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARDAEGWTPL 237
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 149-343 5.61e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.53  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 149 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:PHA02875  51 IKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 229 RDAEGWTPLLAAC---DIR-CQSTADAEATTarclqlcslllsagadaDAADRDKHRPLHLACRRGHAAVVELLLSCGVS 304
Cdd:PHA02875 131 PNTDKFSPLHLAVmmgDIKgIELLIDHKACL-----------------DIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 297289690 305 ANAMDYGGHTPLHCalqgpaAALAQSPEHVVRALLNHGA 343
Cdd:PHA02875 194 IDYFGKNGCVAALC------YAIENNKIDIVRLFIKRGA 226
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 133-320 1.09e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.65  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEeTPLHVA-ARLG 211
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISvGYCK 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 212 HVELADLLLRRGACPDARDAegwtpllaacdIRCQStadaeattarclqlcslllsagadadaadrdkhrPLHLACRrgH 291
Cdd:PHA02878 247 DYDILKLLLEHGVDVNAKSY-----------ILGLT----------------------------------ALHSSIK--S 279

                        170       180
                 ....*....|....*....|....*....
gi 297289690 292 AAVVELLLSCGVSANAMDYGGHTPLHCAL 320
Cdd:PHA02878 280 ERKLKLLLEYGADINSLNSYKLTPLSSAV 308
Ank_4 pfam13637
Ankyrin repeats (many copies);
202-241 4.45e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 4.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 297289690  202 TPLHVAARLGHVELADLLLRRGACPDARDAEGWTPLLAAC 241
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAA 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-186 1.04e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 1.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 297289690  133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLL 186
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 103-228 1.63e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 103 TPLHVAASRGHTE---VLRLLLRRRARPDSapGGRTALHEACAAGHTACVHVL--LVAGADPNIADQdgkrplHLCRGP- 176
Cdd:PLN03192 560 TPLHIAASKGYEDcvlVLLKHACNVHIRDA--NGNTALWNAISAKHHKIFRILyhFASISDPHAAGD------LLCTAAk 631

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 297289690 177 -GTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:PLN03192 632 rNDLTAMKELLKQGLNVDSE-DHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 406-452 2.14e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 41.66  E-value: 2.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 297289690 406 QPRSLQHLSRCALRSHLEGSLPHALLRLPLPPRLLRYLQLDFEGVLY 452
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 180-343 2.35e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 180 ECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARDaegwtpllaacdiRCQSTadaeattarcl 259
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPD-------------KTNNS----------- 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 260 qlcslllsagadadaadrdkhrPLHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHCALqgpAAALAQSpehVVRALL 339
Cdd:PHA02878 204 ----------------------PLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV---GYCKDYD---ILKLLL 255


                 ....
gi 297289690 340 NHGA 343
Cdd:PHA02878 256 EHGV 259
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-163 2.55e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.55e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 297289690  133 GRTALHEACA-AGHTACVHVLLVAGADPNIAD 163
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 201-230 3.08e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 3.08e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 297289690  201 ETPLHVAA-RLGHVELADLLLRRGACPDARD 230
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 149-309 3.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 149 VHVLLVAGADPNIADQDGKRPLHLC--RGPGTLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVEL----------- 215
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGE-NLLHLYLESNKIDLkilkllidkgv 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 216 -------ADLLLRRGACPDARDAEGWTPLLAACD----------IRCQstADAEATTARClqlcslllsagadadaadrd 278
Cdd:PHA03100 168 dinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYnnnpefvkylLDLG--ANPNLVNKYG-------------------- 225

                        170       180       190
                 ....*....|....*....|....*....|.
gi 297289690 279 kHRPLHLACRRGHAAVVELLLSCGVSANAMD 309
Cdd:PHA03100 226 -DTPLHIAILNNNKEIFKLLLNNGPSIKTII 255
PHA02946 PHA02946
ankyin-like protein; Provisional
 149-317 4.68e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.43  E-value: 4.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 149 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGrSEEEEETPLHVAARLGH--VELADLLLRRGA-C 225
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNA-CDKQHKTPLYYLSGTDDevIERINLLVQYGAkI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 226 PDARDAEGWTPLLAACDircqstadaeatTARCLQLCSLLLSAGADADAADRDKHRPLHLACRRGHAAVVELLLSCGVSA 305
Cdd:PHA02946 134 NNSVDEEGCGPLLACTD------------PSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTISWMMKLGISP 201

                        170
                 ....*....|..
gi 297289690 306 NAMDYGGHTPLH 317
Cdd:PHA02946 202 SKPDHDGNTPLH 213
Ank_4 pfam13637
Ankyrin repeats (many copies);
102-153 5.14e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 5.14e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 297289690  102 TTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLL 153
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGnGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 183-343 5.43e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 5.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 183 ELLLRFGARVDGrSEEEEETPLHVAARLGHV-----ELADLLLRRGACPDARDAEGWTPLL-AACDIRCQST-------- 248
Cdd:PHA03100  52 KILLDNGADINS-STKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLyAISKKSNSYSiveylldn 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 249 -ADAEATTARClqlcslllsagadadaadrdkHRPLHLACRRGHA--AVVELLLSCGVSANAMD-------YG------- 311
Cdd:PHA03100 131 gANVNIKNSDG---------------------ENLLHLYLESNKIdlKILKLLIDKGVDINAKNrvnyllsYGvpinikd 189

                        170       180       190
                 ....*....|....*....|....*....|....
gi 297289690 312 --GHTPLHcalqgpAAALAQSPEhVVRALLNHGA 343
Cdd:PHA03100 190 vyGFTPLH------YAVYNNNPE-FVKYLLDLGA 216
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 134-343 7.68e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 7.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHV 213
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPD-VKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 214 ELADLLLRRGA-CPDARDAEGWTPLLAacdircqstadaeATTARCLQLCSLLLSAGADADAADRDKHRPLHLACRRGHA 292
Cdd:PHA02875  82 KAVEELLDLGKfADDVFYKDGMTPLHL-------------ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297289690 293 AVVELLLSCGVSANAMDYGGHTPLhcalqgpAAALAQSPEHVVRALLNHGA 343
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPL-------IIAMAKGDIAICKMLLDSGA 192
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-161 9.33e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 9.33e-05
                           10        20
                   ....*....|....*....|....*....
gi 297289690   133 GRTALHEACAAGHTACVHVLLVAGADPNI 161
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 133-204 1.12e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 44.27  E-value: 1.12e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297289690 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG--TLECAELLLRFGARVDGRSEEEEETPL 204
Cdd:PHA02946  72 GNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDdeVIERINLLVQYGAKINNSVDEEGCGPL 145
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 133-343 1.43e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 133 GRTALHEACAAGH-TACVHVLLVAGADPNIADQDGKRPLH----LCRGPGTLECaelLLRFGARVDGRsEEEEETPLHVA 207
Cdd:PHA02876 307 GETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqastLDRNKDIVIT---LLELGANVNAR-DYCDKTPIHYA 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 208 ARLGHVELADLLLRRGACPDARDAEGWTPL-LAACD----IRCQSTADAEATTARCLQLCSLllsagadadaadrdkhrP 282
Cdd:PHA02876 383 AVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGtnpyMSVKTLIDRGANVNSKNKDLST-----------------P 445

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 297289690 283 LHLACRRG-HAAVVELLLSCGVSANAMDYGGHTPLHCALQgpaaalaqsPEHVVRALLNHGA 343
Cdd:PHA02876 446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALE---------YHGIVNILLHYGA 498
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-237 1.68e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 103 TPLHVAASRGHTEVLRLLLrrrarpDSAPG------------GRTALHEACAAGHTACVHVLLVAGADPNIADQDGkrpL 170
Cdd:cd22192   53 TALHVAALYDNLEAAVVLM------EAAPElvnepmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRATG---T 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297289690 171 HLCRGPGTLecaellLRFGarvdgrseeeeETPLHVAARLGHVELADLLLRRGACPDARDAEGWTPL 237
Cdd:cd22192  124 FFRPGPKNL------IYYG-----------EHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 103-224 2.31e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 181
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSpLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297289690 182 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGA 224
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGA 226
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-220 4.47e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 4.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 297289690  168 RPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELADLLL 220
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
281-322 4.89e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 4.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 297289690  281 RPLHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHCALQG 322
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 282-319 6.15e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 6.15e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 297289690 282 PLHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHCA 319
Cdd:PTZ00322 118 PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 140-343 8.82e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.78  E-value: 8.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 140 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLL 219
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIR-DANGNTALWNAISAKHHKIFRIL 610

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 220 LRRGACPDARdaegwtpllAACDIRCqstadaeattarclqlcslllsagadadaadrdkhrplhLACRRGHAAVVELLL 299
Cdd:PLN03192 611 YHFASISDPH---------AAGDLLC---------------------------------------TAAKRNDLTAMKELL 642

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 297289690 300 SCGVSANAMDYGGHTplhcALQgpaAALAQSPEHVVRALLNHGA 343
Cdd:PLN03192 643 KQGLNVDSEDHQGAT----ALQ---VAMAEDHVDMVRLLIMNGA 679
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 282-307 9.66e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 9.66e-04
                           10        20
                   ....*....|....*....|....*.
gi 297289690   282 PLHLACRRGHAAVVELLLSCGVSANA 307
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 282-309 1.17e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*....
gi 297289690  282 PLHLAC-RRGHAAVVELLLSCGVSANAMD 309
Cdd:pfam00023   5 PLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
282-319 1.26e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 297289690  282 PLHLACRRGHAAVVELLLSCGVSANAMDYGGHTPLHCA 319
Cdd:pfam13857  19 PLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 134-343 1.31e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDG---------------------------KRPLHLCRGPGT--LECAEL 184
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDlsvlecavdsknidtikaiidnrsninKNDLSLLKAIRNedLETSLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 185 LLRFGARVDGrSEEEEETPLHVAARLGHV-ELADLLLRRGACPDARDAEGWTPLLAAC-------DIRCQSTADAEATTA 256
Cdd:PHA02876 259 LYDAGFSVNS-IDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAkngydteNIRTLIMLGADVNAA 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 257 RCLQLCslllsagadadaadrdkhrPLHLACRRG-HAAVVELLLSCGVSANAMDYGGHTPLHcalqgpaAALAQSPEHVV 335
Cdd:PHA02876 338 DRLYIT-------------------PLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIH-------YAAVRNNVVII 391


                 ....*...
gi 297289690 336 RALLNHGA 343
Cdd:PHA02876 392 NTLLDYGA 399
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 202-228 1.58e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.58e-03
                           10        20
                   ....*....|....*....|....*..
gi 297289690   202 TPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 96-245 2.17e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.33  E-value: 2.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690  96 TYEEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 174
Cdd:PHA02874 119 IKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297289690 175 GPGTLECAELLLRFGARVDGRSeEEEETPLHVAarLGHVELADLLLRRGACPDARDAEGWTPLLAACDIRC 245
Cdd:PHA02874 199 EYGDYACIKLLIDHGNHIMNKC-KNGFTPLHNA--IIHNRSAIELLINNASINDQDIDGSTPLHHAINPPC 266
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 201-224 2.69e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....
gi 297289690  201 ETPLHVAARLGHVELADLLLRRGA 224
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGA 26
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 282-307 2.69e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 297289690  282 PLHLACRRGHAAVVELLLSCGVSANA 307
Cdd:pfam13606   5 PLHLAARNGRLEIVKLLLENGADINA 30
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 406-429 3.32e-03

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 35.22  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|....
gi 297289690  406 QPRSLQHLSRCALRSHLEGSLPHA 429
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA 24
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-161 3.76e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 3.76e-03
                          10        20
                  ....*....|....*....|....*....
gi 297289690  133 GRTALHEACAAGHTACVHVLLVAGADPNI 161
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 163-242 5.58e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 37.55  E-value: 5.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297289690 163 DQDGKRPLHLCRGPGTLECAE---LLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR-GACPDARDAEGWTPLL 238
Cdd:PHA02736  52 NRHGKQCVHIVSNPDKADPQEklkLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYY 131


                 ....
gi 297289690 239 AACD 242
Cdd:PHA02736 132 VACE 135
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 406-429 6.42e-03

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 34.37  E-value: 6.42e-03
                         10        20
                 ....*....|....*....|....
gi 297289690 406 QPRSLQHLSRCALRSHLEGSLPHA 429
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRRLDL 24
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-173 7.41e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 297289690  132 GGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLC 173
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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