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Conserved domains on  [gi|1622933459|ref|XP_001100961|]
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runt-related transcription factor 2 isoform X2 [Macaca mulatta]

Protein Classification

Runt and RunxI domain-containing protein( domain architecture ID 10467269)

Runt and RunxI domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
170-298 2.69e-97

Runt domain;


:

Pssm-ID: 459963  Cd Length: 129  Bit Score: 292.37  E-value: 2.69e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 170 MVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVAR 249
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622933459 250 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRH 298
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRSK 129
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
498-589 7.24e-42

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


:

Pssm-ID: 430037  Cd Length: 98  Bit Score: 145.86  E-value: 7.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 498 SQSQSGPFQTSSTPY-LYYGTSSGSYQFPMV-----PGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSS 571
Cdd:pfam08504   1 PQNQSGPFQTNSPPYhLYYGTSSGSYQFSMVggsstSGGDRSPSRMLASCTNASTGSNLLNPNLGNQSDSVDADGSHSNS 80
                          90
                  ....*....|....*...
gi 1622933459 572 PTVLNSSGRMDESVWRPY 589
Cdd:pfam08504  81 PTAMGTSGRMDEAVWRPY 98
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
334-544 7.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 334 PRPSLNSaPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSylsqMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTA 413
Cdd:pfam05109 551 PTPNATS-PTPAVTTPTPNATIPTLGKTSPTSAVTTPTPN----ATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNA 625
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 414 TSDFCLWPSTLSKKSQAGASeLGPfsdprqfPSIS-SLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATT---HYHTY 489
Cdd:pfam05109 626 TSAVTTGQHNITSSSTSSMS-LRP-------SSISeTLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTsthHVSTS 697
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 490 LPPPYPGSSQSQSGPFQTSSTPY-----LYYGTSSGSYQFPMVPGGDRSPsrmLPPCTTT 544
Cdd:pfam05109 698 SPAPRPGTTSQASGPGNSSTSTKpgevnVTKGTPPKNATSPQAPSGQKTA---VPTVTST 754
 
Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
170-298 2.69e-97

Runt domain;


Pssm-ID: 459963  Cd Length: 129  Bit Score: 292.37  E-value: 2.69e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 170 MVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVAR 249
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622933459 250 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRH 298
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRSK 129
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
498-589 7.24e-42

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


Pssm-ID: 430037  Cd Length: 98  Bit Score: 145.86  E-value: 7.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 498 SQSQSGPFQTSSTPY-LYYGTSSGSYQFPMV-----PGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSS 571
Cdd:pfam08504   1 PQNQSGPFQTNSPPYhLYYGTSSGSYQFSMVggsstSGGDRSPSRMLASCTNASTGSNLLNPNLGNQSDSVDADGSHSNS 80
                          90
                  ....*....|....*...
gi 1622933459 572 PTVLNSSGRMDESVWRPY 589
Cdd:pfam08504  81 PTAMGTSGRMDEAVWRPY 98
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
334-544 7.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 334 PRPSLNSaPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSylsqMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTA 413
Cdd:pfam05109 551 PTPNATS-PTPAVTTPTPNATIPTLGKTSPTSAVTTPTPN----ATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNA 625
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 414 TSDFCLWPSTLSKKSQAGASeLGPfsdprqfPSIS-SLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATT---HYHTY 489
Cdd:pfam05109 626 TSAVTTGQHNITSSSTSSMS-LRP-------SSISeTLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTsthHVSTS 697
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 490 LPPPYPGSSQSQSGPFQTSSTPY-----LYYGTSSGSYQFPMVPGGDRSPsrmLPPCTTT 544
Cdd:pfam05109 698 SPAPRPGTTSQASGPGNSSTSTKpgevnVTKGTPPKNATSPQAPSGQKTA---VPTVTST 754
 
Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
170-298 2.69e-97

Runt domain;


Pssm-ID: 459963  Cd Length: 129  Bit Score: 292.37  E-value: 2.69e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 170 MVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVAR 249
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622933459 250 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRH 298
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRSK 129
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
498-589 7.24e-42

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


Pssm-ID: 430037  Cd Length: 98  Bit Score: 145.86  E-value: 7.24e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 498 SQSQSGPFQTSSTPY-LYYGTSSGSYQFPMV-----PGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSS 571
Cdd:pfam08504   1 PQNQSGPFQTNSPPYhLYYGTSSGSYQFSMVggsstSGGDRSPSRMLASCTNASTGSNLLNPNLGNQSDSVDADGSHSNS 80
                          90
                  ....*....|....*...
gi 1622933459 572 PTVLNSSGRMDESVWRPY 589
Cdd:pfam08504  81 PTAMGTSGRMDEAVWRPY 98
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
334-544 7.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 334 PRPSLNSaPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSylsqMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTA 413
Cdd:pfam05109 551 PTPNATS-PTPAVTTPTPNATIPTLGKTSPTSAVTTPTPN----ATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNA 625
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 414 TSDFCLWPSTLSKKSQAGASeLGPfsdprqfPSIS-SLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATT---HYHTY 489
Cdd:pfam05109 626 TSAVTTGQHNITSSSTSSMS-LRP-------SSISeTLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTsthHVSTS 697
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933459 490 LPPPYPGSSQSQSGPFQTSSTPY-----LYYGTSSGSYQFPMVPGGDRSPsrmLPPCTTT 544
Cdd:pfam05109 698 SPAPRPGTTSQASGPGNSSTSTKpgevnVTKGTPPKNATSPQAPSGQKTA---VPTVTST 754
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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