NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622832707|ref|XP_001098279|]
View 

Krueppel-like factor 17 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
KLF17_N cd21574
N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like ...
9-287 1.10e-148

N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like factor 17, is a protein that, in humans, is encoded by the KLF17 gene and acts as a tumor suppressor. It negatively regulates epithelial-mesenchymal transition and metastasis in breast cancer. KLF17 is thought to be the human ortholog of the mouse gene, zinc finger protein 393 (Zfp393), although it has diverged significantly. KLF17 can regulate gene transcription from CACCC-box elements. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF17.


:

Pssm-ID: 410567  Cd Length: 286  Bit Score: 421.79  E-value: 1.10e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707   9 MEQEAGELSRWQVAHQAA-QDNENSAPILNMSSSSGSSGVHTSWNQGLPSIQHFPHSTEMLRSPLVSVGAPRQNMDEGGP 87
Cdd:cd21574     1 MEQEAEELSQWQAAQQQAtQDTEKSMSILDMSPSPGSSGVHTSWNHGPPGIQHFPQCTELERTPLVSAEAPRQNAGEVGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  88 QFSMPLPERGVSYCPQATLTPSQMIYCQRVSPPQQEMMIFSGPQLMPIGEPNIPRVARPFSGNLRMPPSGLPVSASTGIP 167
Cdd:cd21574    81 QFSMSLPEHGVSYCPQATLTPSQMIYCQGVSPSQPGMMIFKGPQMMPLGEPNIPGVAMTFSGNLRMPPSGLPVSASSGIP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707 168 MMSHAGNPPMPYPGLSTVPSE------ETLLGPTMPSTEAQAVLPSMAQMLPPQDAHDLGMPPAEPQSLLALGSQDSLVT 241
Cdd:cd21574   161 MMSHIRAPTMPYSGPPTVPSNrdsltpKMLLAPTMPSTEAQAVLPSLAQMLPPRDPHNLGMPPAGSPSLLALESQDSLVS 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622832707 242 QPDSQEDPFLPEQPRPAPQTAEKNSRPQERTGRGGSSEARPYRCNY 287
Cdd:cd21574   241 QPASQEDPFLPEQPIPAPQRAEQNSRAQERAPRRRSPVSRPYCCQY 286
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-352 5.34e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 5.34e-05
                          10        20
                  ....*....|....*....|....
gi 1622832707 329 ELRRHTRVHTRYRPYKCDQCSREF 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
343-365 6.25e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 6.25e-05
                          10        20
                  ....*....|....*....|...
gi 1622832707 343 YKCDQCSREFMRSDHLKQHQKTH 365
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
283-307 2.51e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.51e-04
                          10        20
                  ....*....|....*....|....*
gi 1622832707 283 YRCNYenCGKAYTKRSHLVSHQRKH 307
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF17_N cd21574
N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like ...
9-287 1.10e-148

N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like factor 17, is a protein that, in humans, is encoded by the KLF17 gene and acts as a tumor suppressor. It negatively regulates epithelial-mesenchymal transition and metastasis in breast cancer. KLF17 is thought to be the human ortholog of the mouse gene, zinc finger protein 393 (Zfp393), although it has diverged significantly. KLF17 can regulate gene transcription from CACCC-box elements. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF17.


Pssm-ID: 410567  Cd Length: 286  Bit Score: 421.79  E-value: 1.10e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707   9 MEQEAGELSRWQVAHQAA-QDNENSAPILNMSSSSGSSGVHTSWNQGLPSIQHFPHSTEMLRSPLVSVGAPRQNMDEGGP 87
Cdd:cd21574     1 MEQEAEELSQWQAAQQQAtQDTEKSMSILDMSPSPGSSGVHTSWNHGPPGIQHFPQCTELERTPLVSAEAPRQNAGEVGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  88 QFSMPLPERGVSYCPQATLTPSQMIYCQRVSPPQQEMMIFSGPQLMPIGEPNIPRVARPFSGNLRMPPSGLPVSASTGIP 167
Cdd:cd21574    81 QFSMSLPEHGVSYCPQATLTPSQMIYCQGVSPSQPGMMIFKGPQMMPLGEPNIPGVAMTFSGNLRMPPSGLPVSASSGIP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707 168 MMSHAGNPPMPYPGLSTVPSE------ETLLGPTMPSTEAQAVLPSMAQMLPPQDAHDLGMPPAEPQSLLALGSQDSLVT 241
Cdd:cd21574   161 MMSHIRAPTMPYSGPPTVPSNrdsltpKMLLAPTMPSTEAQAVLPSLAQMLPPRDPHNLGMPPAGSPSLLALESQDSLVS 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622832707 242 QPDSQEDPFLPEQPRPAPQTAEKNSRPQERTGRGGSSEARPYRCNY 287
Cdd:cd21574   241 QPASQEDPFLPEQPIPAPQRAEQNSRAQERAPRRRSPVSRPYCCQY 286
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-352 5.34e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 5.34e-05
                          10        20
                  ....*....|....*....|....
gi 1622832707 329 ELRRHTRVHTRYRPYKCDQCSREF 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
343-365 6.25e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 6.25e-05
                          10        20
                  ....*....|....*....|...
gi 1622832707 343 YKCDQCSREFMRSDHLKQHQKTH 365
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
283-307 2.51e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.51e-04
                          10        20
                  ....*....|....*....|....*
gi 1622832707 283 YRCNYenCGKAYTKRSHLVSHQRKH 307
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
130-282 1.01e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  130 PQLMPIGEPNIPRVARPfSGNLRMPPSGLPVSastgiPMMSHAGNPPMPYPGLSTVPSEE------TLLGPTMPSTEAQA 203
Cdd:PHA03247  2808 PAAVLAPAAALPPAASP-AGPLPPPTSAQPTA-----PPPPPGPPPPSLPLGGSVAPGGDvrrrppSRSPAAKPAAPARP 2881
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  204 VLPSMAQMLPPQDAHDLGMPPAEPQSLlalgSQDSLVTQPDSQEDPFLPEQPRPAPQT-AEKNSRPQERTGRGGSSEARP 282
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQPERP----PQPQAPPPPQPQPQPPPPPQPQPPPPPpPRPQPPLAPTTDPAGAGEPSG 2957
ZnF_C2H2 smart00355
zinc finger;
343-365 1.98e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.52  E-value: 1.98e-03
                           10        20
                   ....*....|....*....|...
gi 1622832707  343 YKCDQCSREFMRSDHLKQHQKTH 365
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
281-363 7.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707 281 RPYRCNYENCGKAYTKRSHLVSHqRKHTgerpyscnweSCSWSFFRSDELRRHTRVHTRYRPYKCDQCSREFMRSDHLKQ 360
Cdd:COG5189   348 KPYKCPVEGCNKKYKNQNGLKYH-MLHG----------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  ...
gi 1622832707 361 HQK 363
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KLF17_N cd21574
N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like ...
9-287 1.10e-148

N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like factor 17, is a protein that, in humans, is encoded by the KLF17 gene and acts as a tumor suppressor. It negatively regulates epithelial-mesenchymal transition and metastasis in breast cancer. KLF17 is thought to be the human ortholog of the mouse gene, zinc finger protein 393 (Zfp393), although it has diverged significantly. KLF17 can regulate gene transcription from CACCC-box elements. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF17.


Pssm-ID: 410567  Cd Length: 286  Bit Score: 421.79  E-value: 1.10e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707   9 MEQEAGELSRWQVAHQAA-QDNENSAPILNMSSSSGSSGVHTSWNQGLPSIQHFPHSTEMLRSPLVSVGAPRQNMDEGGP 87
Cdd:cd21574     1 MEQEAEELSQWQAAQQQAtQDTEKSMSILDMSPSPGSSGVHTSWNHGPPGIQHFPQCTELERTPLVSAEAPRQNAGEVGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  88 QFSMPLPERGVSYCPQATLTPSQMIYCQRVSPPQQEMMIFSGPQLMPIGEPNIPRVARPFSGNLRMPPSGLPVSASTGIP 167
Cdd:cd21574    81 QFSMSLPEHGVSYCPQATLTPSQMIYCQGVSPSQPGMMIFKGPQMMPLGEPNIPGVAMTFSGNLRMPPSGLPVSASSGIP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707 168 MMSHAGNPPMPYPGLSTVPSE------ETLLGPTMPSTEAQAVLPSMAQMLPPQDAHDLGMPPAEPQSLLALGSQDSLVT 241
Cdd:cd21574   161 MMSHIRAPTMPYSGPPTVPSNrdsltpKMLLAPTMPSTEAQAVLPSLAQMLPPRDPHNLGMPPAGSPSLLALESQDSLVS 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622832707 242 QPDSQEDPFLPEQPRPAPQTAEKNSRPQERTGRGGSSEARPYRCNY 287
Cdd:cd21574   241 QPASQEDPFLPEQPIPAPQRAEQNSRAQERAPRRRSPVSRPYCCQY 286
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-352 5.34e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 5.34e-05
                          10        20
                  ....*....|....*....|....
gi 1622832707 329 ELRRHTRVHTRYRPYKCDQCSREF 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
343-365 6.25e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 6.25e-05
                          10        20
                  ....*....|....*....|...
gi 1622832707 343 YKCDQCSREFMRSDHLKQHQKTH 365
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
283-307 2.51e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.51e-04
                          10        20
                  ....*....|....*....|....*
gi 1622832707 283 YRCNYenCGKAYTKRSHLVSHQRKH 307
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
130-282 1.01e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  130 PQLMPIGEPNIPRVARPfSGNLRMPPSGLPVSastgiPMMSHAGNPPMPYPGLSTVPSEE------TLLGPTMPSTEAQA 203
Cdd:PHA03247  2808 PAAVLAPAAALPPAASP-AGPLPPPTSAQPTA-----PPPPPGPPPPSLPLGGSVAPGGDvrrrppSRSPAAKPAAPARP 2881
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707  204 VLPSMAQMLPPQDAHDLGMPPAEPQSLlalgSQDSLVTQPDSQEDPFLPEQPRPAPQT-AEKNSRPQERTGRGGSSEARP 282
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQPERP----PQPQAPPPPQPQPQPPPPPQPQPPPPPpPRPQPPLAPTTDPAGAGEPSG 2957
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
343-365 1.91e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|...
gi 1622832707 343 YKCDQCSREFMRSDHLKQHQKTH 365
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
ZnF_C2H2 smart00355
zinc finger;
343-365 1.98e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.52  E-value: 1.98e-03
                           10        20
                   ....*....|....*....|...
gi 1622832707  343 YKCDQCSREFMRSDHLKQHQKTH 365
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
281-363 7.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622832707 281 RPYRCNYENCGKAYTKRSHLVSHqRKHTgerpyscnweSCSWSFFRSDELRRHTRVHTRYRPYKCDQCSREFMRSDHLKQ 360
Cdd:COG5189   348 KPYKCPVEGCNKKYKNQNGLKYH-MLHG----------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  ...
gi 1622832707 361 HQK 363
Cdd:COG5189   417 HRK 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH