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Conserved domains on  [gi|1622971781|ref|XP_001098244|]
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oral-facial-digital syndrome 1 protein isoform X3 [Macaca mulatta]

Protein Classification

kinesin family protein; PEPP family PH domain-containing protein( domain architecture ID 13870895)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has an ATPase-containing motor domain; similar to N-type kinesins that are (+) end-directed motors and have an N-terminal motor domain| PEPP (phosphoinositol 3-phosphate-binding protein) family PH (pleckstrin homology) domain-containing protein similar to PH domain region of vertebrate pleckstrin homology domain-containing family A member 4/5/6/7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 205-516 7.91e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 205 REIEEQLRaemcqKLKffKDTEIAK----IKMEAKKkYEKELAMFQNDFEKACQAKSEALVLREKSTLERIQKHQEIETK 280
Cdd:COG1196   196 GELERQLE-----PLE--RQAEKAEryreLKEELKE-LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 281 EIYAQRQLLL---KDMDLLRGREAELKQRVEAFE---LYQLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTAINSKKE 354
Cdd:COG1196   268 ELEELRLELEeleLELEEAQAEEYELLAELARLEqdiARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELE 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 355 ELNQsvnRVKELELELESVKAQSLAITKQnhmLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAR 434
Cdd:COG1196   348 EAEE---ELEEAEAELAEAEEALLEAEAE---LAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 435 PAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501


                  ..
gi 1622971781 515 NE 516
Cdd:COG1196   502 DY 503
LisH_2 pfam16045
LisH;
75-101 9.48e-11

LisH;


:

Pssm-ID: 464992  Cd Length: 28  Bit Score: 57.09  E-value: 9.48e-11
                          10        20
                  ....*....|....*....|....*..
gi 1622971781  75 NSLVADHLQRCGYEYSLSVFFPESGLA 101
Cdd:pfam16045   2 NSLIAEYLQSQGYNYTLSVFLPESGLA 28
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 205-516 7.91e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 205 REIEEQLRaemcqKLKffKDTEIAK----IKMEAKKkYEKELAMFQNDFEKACQAKSEALVLREKSTLERIQKHQEIETK 280
Cdd:COG1196   196 GELERQLE-----PLE--RQAEKAEryreLKEELKE-LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 281 EIYAQRQLLL---KDMDLLRGREAELKQRVEAFE---LYQLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTAINSKKE 354
Cdd:COG1196   268 ELEELRLELEeleLELEEAQAEEYELLAELARLEqdiARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELE 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 355 ELNQsvnRVKELELELESVKAQSLAITKQnhmLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAR 434
Cdd:COG1196   348 EAEE---ELEEAEAELAEAEEALLEAEAE---LAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 435 PAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501


                  ..
gi 1622971781 515 NE 516
Cdd:COG1196   502 DY 503
LisH_2 pfam16045
LisH;
75-101 9.48e-11

LisH;


Pssm-ID: 464992  Cd Length: 28  Bit Score: 57.09  E-value: 9.48e-11
                          10        20
                  ....*....|....*....|....*..
gi 1622971781  75 NSLVADHLQRCGYEYSLSVFFPESGLA 101
Cdd:pfam16045   2 NSLIAEYLQSQGYNYTLSVFLPESGLA 28
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 303-514 2.65e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 2.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  303 LKQRVEAFELYQlELKDD--------YIIRTNRLIEDERKNKEKAVRLQEELTAINSKKEELNQSVNrvkELELELESVK 374
Cdd:TIGR02168  205 LERQAEKAERYK-ELKAElrelelalLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLE---ELRLEVSELE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  375 AQSLAITKQNHMLNEKVKEM-SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLARPAPELAVFQKE---LRKAE 450
Cdd:TIGR02168  281 EEIEELQKELYALANEISRLeQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEElesLEAEL 360

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622971781  451 KAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:TIGR02168  361 EELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424
PTZ00121 PTZ00121
MAEBL; Provisional
 173-482 4.59e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 4.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  173 AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKA 252
Cdd:PTZ00121  1387 AEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKA 1466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  253 CQAK---------SEALVLRE--KSTLERIQKHQEIETKEIYAQRQLLLKDMDLLR----GREAELKQRVEAFELYQLEL 317
Cdd:PTZ00121  1467 EEAKkadeakkkaEEAKKADEakKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKkadeAKKAEEAKKADEAKKAEEKK 1546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  318 KDDYIIRTNRLIEDERKNK-EKAVRLQEELTAINSKKEELNQS----VNRVKELELELESVKAQSLAITKQNHMLNEKVK 392
Cdd:PTZ00121  1547 KADELKKAEELKKAEEKKKaEEAKKAEEDKNMALRKAEEAKKAeearIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK 1626

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  393 EMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLARPAPELAVFQKELRKAE-----KAIVVEHEEFESRR-QA 466
Cdd:PTZ00121  1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEedekkAAEALKKEAEEAKKaEE 1706

                          330
                   ....*....|....*.
gi 1622971781  467 LHKQLQDEIEHSAQLK 482
Cdd:PTZ00121  1707 LKKKEAEEKKKAEELK 1722
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 191-510 1.90e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.27  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  191 IKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKACQAKSEALVLREkstLER 270
Cdd:pfam02463  158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDY---LKL 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  271 IQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFElyqLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTaIN 350
Cdd:pfam02463  235 NEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENK---EEEKEKKLQEEELKLLAKEEEELKSELLKLERR-KV 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  351 SKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKvkemsdysllkEEKLELLAQNKLLKQQLEESRNENLRLLN 430
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIK-----------REAEEEEEEELEKLQEKLEQLEEELLAKK 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  431 RLARPAPELAVFQKELRKAEKAIvveheefESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQ 510
Cdd:pfam02463  380 KLESERLSSAAKLKEEELELKSE-------EEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEE 452
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 205-516 7.91e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 205 REIEEQLRaemcqKLKffKDTEIAK----IKMEAKKkYEKELAMFQNDFEKACQAKSEALVLREKSTLERIQKHQEIETK 280
Cdd:COG1196   196 GELERQLE-----PLE--RQAEKAEryreLKEELKE-LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 281 EIYAQRQLLL---KDMDLLRGREAELKQRVEAFE---LYQLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTAINSKKE 354
Cdd:COG1196   268 ELEELRLELEeleLELEEAQAEEYELLAELARLEqdiARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELE 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 355 ELNQsvnRVKELELELESVKAQSLAITKQnhmLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAR 434
Cdd:COG1196   348 EAEE---ELEEAEAELAEAEEALLEAEAE---LAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 435 PAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501


                  ..
gi 1622971781 515 NE 516
Cdd:COG1196   502 DY 503
LisH_2 pfam16045
LisH;
75-101 9.48e-11

LisH;


Pssm-ID: 464992  Cd Length: 28  Bit Score: 57.09  E-value: 9.48e-11
                          10        20
                  ....*....|....*....|....*..
gi 1622971781  75 NSLVADHLQRCGYEYSLSVFFPESGLA 101
Cdd:pfam16045   2 NSLIAEYLQSQGYNYTLSVFLPESGLA 28
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 192-483 9.20e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 9.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 192 KFESLEIKLNEYKREIEE-QLRAEMCQKLKFFKDTEIAKIKMEAKKKyEKELAMFQNDfekacqaksEALVLREKSTLER 270
Cdd:COG1196   233 KLRELEAELEELEAELEElEAELEELEAELAELEAELEELRLELEEL-ELELEEAQAE---------EYELLAELARLEQ 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 271 IQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTAIN 350
Cdd:COG1196   303 DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 351 SKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEmsdyslLKEEKLELLAQNKLLKQQLEESRNENLRLLN 430
Cdd:COG1196   383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE------LEEALAELEEEEEEEEEALEEAAEEEAELEE 456

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622971781 431 RLARPAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKA 483
Cdd:COG1196   457 EEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 303-514 2.65e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 2.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  303 LKQRVEAFELYQlELKDD--------YIIRTNRLIEDERKNKEKAVRLQEELTAINSKKEELNQSVNrvkELELELESVK 374
Cdd:TIGR02168  205 LERQAEKAERYK-ELKAElrelelalLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLE---ELRLEVSELE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  375 AQSLAITKQNHMLNEKVKEM-SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLARPAPELAVFQKE---LRKAE 450
Cdd:TIGR02168  281 EEIEELQKELYALANEISRLeQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEElesLEAEL 360

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622971781  451 KAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:TIGR02168  361 EELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 196-514 4.44e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 54.30  E-value: 4.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  196 LEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKACQAKsealvlrEKSTLERIQKHQ 275
Cdd:TIGR02169  193 IDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEEL-------EKLTEEISELEK 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  276 EIETKEIyAQRQLLLKDMDLLRGREAELKQRVEAFELYqlelkddyIIRTNRLIED-ERKNKEKAVRLQEELTAINSKKE 354
Cdd:TIGR02169  266 RLEEIEQ-LLEELNKKIKDLGEEEQLRVKEKIGELEAE--------IASLERSIAEkERELEDAEERLAKLEAEIDKLLA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  355 ELNQSVNRVKELELELESVKAqslAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAR 434
Cdd:TIGR02169  337 EIEELEREIEEERKRRDKLTE---EYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQE 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  435 PAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:TIGR02169  414 ELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELA 493
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 263-514 6.89e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 6.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  263 REKSTLERIQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAF--ELYQLELKDDYIIRTNRLIEDERKN-KEKA 339
Cdd:TIGR02168  239 EELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELqkELYALANEISRLEQQKQILRERLANlERQL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  340 VRLQEELTAINSKKEELNQSVNRVKElelELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQN-KLLKQQL 418
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEE---KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKvAQLELQI 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  419 EESRNENLRLLNRLARPAPELAVFQKELRKAEKAIVVE-----HEEFESRRQALHKQLQDEIEHSAQLKAQilgyKASVK 493
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAelkelQAELEELEEELEELQEELERLEEALEEL----REELE 471

                          250       260
                   ....*....|....*....|.
gi 1622971781  494 RLTTQVADLKLQLKQTQTALE 514
Cdd:TIGR02168  472 EAEQALDAAERELAQLQARLD 492
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 162-514 9.19e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.67  E-value: 9.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  162 QTSSTLSRDSLAEKL-QLIDDQFADAYPQRIKFESLEIKLNEYKREIEeQLRAEMCQKLKFFKDTEIAKIKMEAK-KKYE 239
Cdd:TIGR02168  668 TNSSILERRREIEELeEKIEELEEKIAELEKALAELRKELEELEEELE-QLRKELEELSRQISALRKDLARLEAEvEQLE 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  240 KELAMFQNDFEKACQAKSEALVLREKSTLERIQKHQEIETKEiyAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKD 319
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE--AQIEQLKEELKALREALDELRAELTLLNEEAANLRE 824

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  320 DYIIRTNRLIEDERKN---KEKAVRLQEELTAINSKKEELNQSVNrvkELELELESVKAQSLAITKQNHMLNekvkemSD 396
Cdd:TIGR02168  825 RLESLERRIAATERRLedlEEQIEELSEDIESLAAEIEELEELIE---ELESELEALLNERASLEEALALLR------SE 895

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  397 YSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLARPAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIe 476
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRL- 974

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622971781  477 hsAQLKAQI--LG---------YKASVKR---LTTQVADLKLQLKQTQTALE 514
Cdd:TIGR02168  975 --KRLENKIkeLGpvnlaaieeYEELKERydfLTAQKEDLTEAKETLEEAIE 1024
PTZ00121 PTZ00121
MAEBL; Provisional
 173-482 4.59e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 4.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  173 AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKA 252
Cdd:PTZ00121  1387 AEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKA 1466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  253 CQAK---------SEALVLRE--KSTLERIQKHQEIETKEIYAQRQLLLKDMDLLR----GREAELKQRVEAFELYQLEL 317
Cdd:PTZ00121  1467 EEAKkadeakkkaEEAKKADEakKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKkadeAKKAEEAKKADEAKKAEEKK 1546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  318 KDDYIIRTNRLIEDERKNK-EKAVRLQEELTAINSKKEELNQS----VNRVKELELELESVKAQSLAITKQNHMLNEKVK 392
Cdd:PTZ00121  1547 KADELKKAEELKKAEEKKKaEEAKKAEEDKNMALRKAEEAKKAeearIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK 1626

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  393 EMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLARPAPELAVFQKELRKAE-----KAIVVEHEEFESRR-QA 466
Cdd:PTZ00121  1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEedekkAAEALKKEAEEAKKaEE 1706

                          330
                   ....*....|....*.
gi 1622971781  467 LHKQLQDEIEHSAQLK 482
Cdd:PTZ00121  1707 LKKKEAEEKKKAEELK 1722
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
192-516 7.15e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.98  E-value: 7.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 192 KFESLEIKLNEYKREIEEQL--------RAEMCQKLKFFKDTEIAKIKMEAKK------KYEKELAMFQNDFEKACQAKS 257
Cdd:PRK03918  159 DYENAYKNLGEVIKEIKRRIerlekfikRTENIEELIKEKEKELEEVLREINEisselpELREELEKLEKEVKELEELKE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 258 EALVL-REKSTLERIQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQL--ELKDDYIIRTNRLIEDERK 334
Cdd:PRK03918  239 EIEELeKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKlsEFYEEYLDELREIEKRLSR 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 335 NKEKAVRLQEELTAINSKKEELNQSVNRVKELELELESVKAQSLAItkqnHMLNEKVKEMSDYSLLKEEKLELLAQNKLL 414
Cdd:PRK03918  319 LEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGLTPEKLEKELE 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 415 -----KQQLEESRNENLRLLNRLARPAPELAVFQKELRKAE-KAIVVEHEEFESRRQALHKQLQDEIEHSaqlkaqilgy 488
Cdd:PRK03918  395 elekaKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKgKCPVCGRELTEEHRKELLEEYTAELKRI---------- 464

                         330       340
                  ....*....|....*....|....*...
gi 1622971781 489 KASVKRLTTQVADLKLQLKQTQTALENE 516
Cdd:PRK03918  465 EKELKEIEEKERKLRKELRELEKVLKKE 492
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
260-476 2.13e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  260 LVLREKSTLERIQK-----------HQEIETKEiyAQRQLLL------KDMDLLRGREAELKQRVEAFELYQLELKDDyi 322
Cdd:COG4913    216 YMLEEPDTFEAADAlvehfddleraHEALEDAR--EQIELLEpirelaERYAAARERLAELEYLRAALRLWFAQRRLE-- 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  323 irtnRLIEDERKNKEKAVRLQEELTAINSKKEELNQsvnRVKELELELESVKAQSLA-ITKQNHMLNEKVKEMSDysllk 401
Cdd:COG4913    292 ----LLEAELEELRAELARLEAELERLEARLDALRE---ELDELEAQIRGNGGDRLEqLEREIERLERELEERER----- 359

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622971781  402 eeklELLAQNKLLKQqLEESRNENLRLLNRLARPAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIE 476
Cdd:COG4913    360 ----RRARLEALLAA-LGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIA 429
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 134-513 4.35e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.19  E-value: 4.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  134 ENQKGFLMHFLKELAEYHQAKEScnMETQTSSTLSRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRA 213
Cdd:TIGR00618  362 EVATSIREISCQQHTLTQHIHTL--QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRY 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  214 EMCQKLKFFKDTEIAKIK----MEAKKKYeKELAMFQNDFEKACQAKSEALVLREKSTLEriQKHQEIETKEIYAQRQLL 289
Cdd:TIGR00618  440 AELCAAAITCTAQCEKLEkihlQESAQSL-KEREQQLQTKEQIHLQETRKKAVVLARLLE--LQEEPCPLCGSCIHPNPA 516

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  290 LKDMDLLRGREAELKQRVEAFELYQLELKDDYIIRTNrLIEDERKNKEKAVRLQEELTA----INSKKEELNQSVNRVKE 365
Cdd:TIGR00618  517 RQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTS-ERKQRASLKEQMQEIQQSFSIltqcDNRSKEDIPNLQNITVR 595

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  366 LELELESVKAQSLAITKQNHMLNEKVKEmsdysllkeeklellAQNKLLKQQLEESRNENLRLLnRLARPAPELAVFQKE 445
Cdd:TIGR00618  596 LQDLTEKLSEAEDMLACEQHALLRKLQP---------------EQDLQDVRLHLQQCSQELALK-LTALHALQLTLTQER 659

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622971781  446 LRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTAL 513
Cdd:TIGR00618  660 VREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENAS 727
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
307-517 4.46e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 307 VEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVR-LQEELTAINSKK------EELNQSVNRVKELELELESVKAQSLA 379
Cdd:COG3206   158 AEAYLEQNLELRREEARKALEFLEEQLPELRKELEeAEAALEEFRQKNglvdlsEEAKLLLQQLSELESQLAEARAELAE 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 380 ITKQNHMLNEKVKEMSDYSLLKEEKLELLAqnklLKQQLEESRNENLRLLNRLARPAPELAVFQKELRKAEKAIvvehee 459
Cdd:COG3206   238 AEARLAALRAQLGSGPDALPELLQSPVIQQ----LRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQL------ 307

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622971781 460 fESRRQALHKQLQDEIEhsaQLKAQILGYKASVKRLTTQVADLKlQLKQTQTALENEV 517
Cdd:COG3206   308 -QQEAQRILASLEAELE---ALQAREASLQAQLAQLEARLAELP-ELEAELRRLEREV 360
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
204-494 5.13e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 204 KREIEEQLRAEMCQKLKffkdTEIAKIKMEAKK--KYEKELAMFQNDFEKACQAKSEALVLRE-----KSTLERIQKHQE 276
Cdd:PRK03918  442 GRELTEEHRKELLEEYT----AELKRIEKELKEieEKERKLRKELRELEKVLKKESELIKLKElaeqlKELEEKLKKYNL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 277 IETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDdyIIRTNRLIEDERKNKEKAVR---------LQEELT 347
Cdd:PRK03918  518 EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE--LEKKLDELEEELAELLKELEelgfesveeLEERLK 595

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 348 AINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMsdyslLKEEKLELLAQNKLLKQQLEESRNENLR 427
Cdd:PRK03918  596 ELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRL-----EELRKELEELEKKYSEEEYEELREEYLE 670

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622971781 428 LLNRLARPAPELAVFQKELRKAEKAIVVEHEEFESRRQALH--KQLQDEIEHSAQLKAQILGYKASVKR 494
Cdd:PRK03918  671 LSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKelEKLEKALERVEELREKVKKYKALLKE 739
PTZ00121 PTZ00121
MAEBL; Provisional
 173-516 5.41e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 5.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  173 AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKlkffkdTEIAKIKMEAKKKYEKELAmfqnDFEKA 252
Cdd:PTZ00121  1472 ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKK------AEEAKKADEAKKAEEAKKA----DEAKK 1541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  253 CQAKSEALVLREKSTLERIQKHQEIETKEIYAQRqlllKDMDLLRG---REAELKQRVEAFELYQLELKDDyiIRTNRLI 329
Cdd:PTZ00121  1542 AEEKKKADELKKAEELKKAEEKKKAEEAKKAEED----KNMALRKAeeaKKAEEARIEEVMKLYEEEKKMK--AEEAKKA 1615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  330 EDERKNKEKAVRLQEELTAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMsdyslLKEEKLELLA 409
Cdd:PTZ00121  1616 EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA-----KKAEEDEKKA 1690

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  410 QNKLLKQQLEESRNENLRLLNRLARPAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYK 489
Cdd:PTZ00121  1691 AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKA 1770

                          330       340
                   ....*....|....*....|....*..
gi 1622971781  490 ASVKRLTTQVADLKLQLKQTQTALENE 516
Cdd:PTZ00121  1771 EEIRKEKEAVIEEELDEEDEKRRMEVD 1797
PTZ00121 PTZ00121
MAEBL; Provisional
 202-480 6.24e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 6.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  202 EYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEK-----ELAMFQNDFEKACQAKSEALVLREKSTLERIQKHQE 276
Cdd:PTZ00121  1209 EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEernneEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  277 IETKEIYAQRQLLLKDMDLLRGREA-----ELKQRVEAFELYQLELKDDyiirtnrliEDERKNKEKAVRLQEEltainS 351
Cdd:PTZ00121  1289 KKKADEAKKAEEKKKADEAKKKAEEakkadEAKKKAEEAKKKADAAKKK---------AEEAKKAAEAAKAEAE-----A 1354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  352 KKEELNQSVNRVKELELELESVKAQSLAITKQNH------MLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRN-E 424
Cdd:PTZ00121  1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEekkkadEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKaD 1434

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622971781  425 NLRLLNRLARPAPELAVFQKELRKAEKAIVVEHEEF---ESRRQALHKQLQDEIEHSAQ 480
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKkadEAKKKAEEAKKADEAKKKAE 1493
PTZ00121 PTZ00121
MAEBL; Provisional
 197-481 1.37e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  197 EIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKACQAKSE-ALVLREKSTLERIQKHQ 275
Cdd:PTZ00121  1514 EAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDkNMALRKAEEAKKAEEAR 1593

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  276 EIETKEIYAQRqlllKDMDLLRGREAElKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKaVRLQEELTAINSKKEE 355
Cdd:PTZ00121  1594 IEEVMKLYEEE----KKMKAEEAKKAE-EAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE-LKKAEEENKIKAAEEA 1667

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  356 LNQSVNRVKELEL----ELESVKAQSLAITKQNHMLNEKVK-----EMSDYSLLKEEKLELLAQNKLLKQQLEESRN--E 424
Cdd:PTZ00121  1668 KKAEEDKKKAEEAkkaeEDEKKAAEALKKEAEEAKKAEELKkkeaeEKKKAEELKKAEEENKIKAEEAKKEAEEDKKkaE 1747

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622971781  425 NLRL----LNRLARPAPELAVFQKELRKAEKAIVVE--HEEFESRRQALHKQLQDEIEHSAQL 481
Cdd:PTZ00121  1748 EAKKdeeeKKKIAHLKKEEEKKAEEIRKEKEAVIEEelDEEDEKRRMEVDKKIKDIFDNFANI 1810
PRK12704 PRK12704
phosphodiesterase; Provisional
 256-431 1.47e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 256 KSEALVLREKSTLERIQKHQEIETKEIYaqrqlllkdmdllrgREAELKQRVEAFELyQLELKDDYIIRTNRLIEDERKN 335
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAKKEAEAIK---------------KEALLEAKEEIHKL-RNEFEKELRERRNELQKLEKRL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 336 KEKAVRLQEELTAINSKKEELNQSVNRVKELELELESVKAqslaitKQNHMLNEKVKEMSDYSllkeEKLELLAQNKLLK 415
Cdd:PRK12704   92 LQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEE------ELEELIEEQLQELERIS----GLTAEEAKEILLE 161

                         170
                  ....*....|....*.
gi 1622971781 416 QQLEESRNENLRLLNR 431
Cdd:PRK12704  162 KVEEEARHEAAVLIKE 177
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 191-510 1.90e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.27  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  191 IKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKACQAKSEALVLREkstLER 270
Cdd:pfam02463  158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDY---LKL 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  271 IQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFElyqLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTaIN 350
Cdd:pfam02463  235 NEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENK---EEEKEKKLQEEELKLLAKEEEELKSELLKLERR-KV 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  351 SKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKvkemsdysllkEEKLELLAQNKLLKQQLEESRNENLRLLN 430
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIK-----------REAEEEEEEELEKLQEKLEQLEEELLAKK 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  431 RLARPAPELAVFQKELRKAEKAIvveheefESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQ 510
Cdd:pfam02463  380 KLESERLSSAAKLKEEELELKSE-------EEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEE 452
PTZ00121 PTZ00121
MAEBL; Provisional
 190-516 1.99e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  190 RIKFESLEIKLNEYKREIEEQLRAEMCQKL--KFFKDTEIAKIKMEAKKKYEkELAMFQNDFEKACQAKSEALVLRE--- 264
Cdd:PTZ00121  1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKaeEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEAKKade 1448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  265 -KSTLERIQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDDyiirtnrliEDERKNKEKAVRLQ 343
Cdd:PTZ00121  1449 aKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA---------AEAKKKADEAKKAE 1519

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  344 EELTAINSKKEELNQSVNRVKELElelESVKAQSLAITKQNHMLNEKVKemSDYSLLKEEKLELLAQNKLLKQQLEESRN 423
Cdd:PTZ00121  1520 EAKKADEAKKAEEAKKADEAKKAE---EKKKADELKKAEELKKAEEKKK--AEEAKKAEEDKNMALRKAEEAKKAEEARI 1594

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  424 ENLRLLNRLARP--APELAVFQKELRKAEKaiVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVAD 501
Cdd:PTZ00121  1595 EEVMKLYEEEKKmkAEEAKKAEEAKIKAEE--LKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEE 1672

                          330
                   ....*....|....*
gi 1622971781  502 LKLQLKQTQTALENE 516
Cdd:PTZ00121  1673 DKKKAEEAKKAEEDE 1687
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 160-380 2.25e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  160 ETQTSSTLSRDSLAEKLQliddQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFfkdteiakikMEAKKKYE 239
Cdd:TIGR02169  298 ELEAEIASLERSIAEKER----ELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKL----------TEEYAELK 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  240 KELAMFQNDFEkACQAKSEALVLREKSTLERIQKHQEiETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKD 319
Cdd:TIGR02169  364 EELEDLRAELE-EVDKEFAETRDELKDYREKLEKLKR-EINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEE 441

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622971781  320 DYIIRTNRLIEDERKNKEKAVRLQEELTAINSKKEELNQSVNRVKELELELESVKAQSLAI 380
Cdd:TIGR02169  442 EKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARAS 502
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 275-516 3.21e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 275 QEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELyQLELKDDYIIRTNRLIedeRKNKEKAVRLQEELTAINSKKE 354
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK-QLAALERRIAALARRI---RALEQELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 355 ELNQSVNRVKELELELESVKAQSLAITKQNHMLNEkvkemSDYSLLKEEKLELLAQNKLLKQQLEEsrnenlrllnrLAR 434
Cdd:COG4942    94 ELRAELEAQKEELAELLRALYRLGRQPPLALLLSP-----EDFLDAVRRLQYLKYLAPARREQAEE-----------LRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 435 PAPELAVFQKELRKAEKAIVVEHEEFESRRQALHKQLQDEIEHSAQLKAQILGYKASVKRLTTQVADLKLQLKQTQTALE 514
Cdd:COG4942   158 DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237


                  ..
gi 1622971781 515 NE 516
Cdd:COG4942   238 AA 239
PTZ00121 PTZ00121
MAEBL; Provisional
 197-494 3.93e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 3.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  197 EIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELAMFQNDFEKACQAKS-----EALVLREKSTLERI 271
Cdd:PTZ00121  1150 DAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEerkaeEARKAEDAKKAEAV 1229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  272 QKHQEIETKEIYAQRQLLLKDMDLLRGREaelKQRVEAFELYQLELKDDYIIRTNRLIEDERKNKEKAVRLQEELTAINS 351
Cdd:PTZ00121  1230 KKAEEAKKDAEEAKKAEEERNNEEIRKFE---EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADE 1306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  352 KKEELNQSvNRVKELELELESVKAQSLAITK---QNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRL 428
Cdd:PTZ00121  1307 AKKKAEEA-KKADEAKKKAEEAKKKADAAKKkaeEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK 1385

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622971781  429 LNRLARPAPELAVFQKELRKA----EKAIVVEHEEFESRRQALHKQLQDEIEHSAQ--LKAQILGYKASVKR 494
Cdd:PTZ00121  1386 KAEEKKKADEAKKKAEEDKKKadelKKAAAAKKKADEAKKKAEEKKKADEAKKKAEeaKKADEAKKKAEEAK 1457
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
284-484 6.84e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 6.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  284 AQRQLLLKDMDLLRGREAELKQRVEAFELYQLELKDdyIIRTNRLIEDERKNKEKAVRLQEELTAINSKKEELNQSVNRV 363
Cdd:COG4913    610 AKLAALEAELAELEEELAEAEERLEALEAELDALQE--RREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDL 687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781  364 KELELELESVKAQSLAITKQNHMLNEKVKEmsdysllkeeklellAQNKLlkQQLEESRNENLRLLNRLARPAPELAVFQ 443
Cdd:COG4913    688 AALEEQLEELEAELEELEEELDELKGEIGR---------------LEKEL--EQAEEELDELQDRLEAAEDLARLELRAL 750

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1622971781  444 KELRKAEkaivvehEEFESRRQALHKQLQDEIEHSAQLKAQ 484
Cdd:COG4913    751 LEERFAA-------ALGDAVERELRENLEERIDALRARLNR 784
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 198-394 7.88e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 198 IKLNEYKREIEEQLRAEMCQKLKffKDTEIAKIKMEAKKKYEK-----ELAMFQNDFEKACQAK-SEALVLREK------ 265
Cdd:pfam17380 353 IRQEERKRELERIRQEEIAMEIS--RMRELERLQMERQQKNERvrqelEAARKVKILEEERQRKiQQQKVEMEQiraeqe 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622971781 266 ----STLERIQKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQ-----------RVEAFELYQLELKDDYIIRTNRLIE 330
Cdd:pfam17380 431 earqREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRkklelekekrdRKRAEEQRRKILEKELEERKQAMIE 510

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622971781 331 DERKNKEKAVRLQEELTAINSKKEELNQSVNRVKELEL-ELESVKAQSLAITKQNHMLN--EKVKEM 394
Cdd:pfam17380 511 EERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMeERRRIQEQMRKATEERSRLEamEREREM 577
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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