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Conserved domains on  [gi|109003585|ref|XP_001097790|]
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sodium- and chloride-dependent glycine transporter 1 isoform X2 [Macaca mulatta]

Protein Classification

SLC5/6 family protein; NCS1 family transporter( domain architecture ID 10183817)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter| NCS1 (nucleobase-cation-symport-1) family transporter is an essential component of salvage pathways for nucleobases and related metabolites such as allantoin, uracil, thiamine, and nicotinamide riboside

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
30-613 0e+00

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


:

Pssm-ID: 212067  Cd Length: 585  Bit Score: 1147.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  30 NGAVPNEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQF 109
Cdd:cd11498    1 NGAVPGEATKRDENLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 110 ASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSR 189
Cdd:cd11498   81 ASQGCLGVWRVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTRVLPWTYCNNPWNTPDCAGVLSTNRSNATFA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 190 PAT-LPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATF 268
Cdd:cd11498  161 NMSaVVSNLTELLNRTLKRTSPSEEYWRRYVLNISDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 269 PYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISIT 348
Cdd:cd11498  241 PYVVLTILFIRGITLEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISIT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 349 NCATSVYAGFVIFSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 428
Cdd:cd11498  321 NCATSVYAGFVIFSILGFMANHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 429 AIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM 508
Cdd:cd11498  401 AVVDEIGNDWIIRNKTYVTLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAIMYIYGHRNYFKDIEM 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 509 MLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQ 588
Cdd:cd11498  481 MLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNDYVYPGWAIVIGFLMALSSVICIPIYAIFKICMSEGDTFLE 560
                        570       580
                 ....*....|....*....|....*
gi 109003585 589 RLKNATKPSRDWGPALLEHRTGRYA 613
Cdd:cd11498  561 RLKNAVKPSKDWGPALQEHRTGRYA 585
 
Name Accession Description Interval E-value
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
30-613 0e+00

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 1147.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  30 NGAVPNEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQF 109
Cdd:cd11498    1 NGAVPGEATKRDENLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 110 ASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSR 189
Cdd:cd11498   81 ASQGCLGVWRVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTRVLPWTYCNNPWNTPDCAGVLSTNRSNATFA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 190 PAT-LPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATF 268
Cdd:cd11498  161 NMSaVVSNLTELLNRTLKRTSPSEEYWRRYVLNISDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 269 PYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISIT 348
Cdd:cd11498  241 PYVVLTILFIRGITLEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISIT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 349 NCATSVYAGFVIFSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 428
Cdd:cd11498  321 NCATSVYAGFVIFSILGFMANHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 429 AIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM 508
Cdd:cd11498  401 AVVDEIGNDWIIRNKTYVTLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAIMYIYGHRNYFKDIEM 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 509 MLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQ 588
Cdd:cd11498  481 MLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNDYVYPGWAIVIGFLMALSSVICIPIYAIFKICMSEGDTFLE 560
                        570       580
                 ....*....|....*....|....*
gi 109003585 589 RLKNATKPSRDWGPALLEHRTGRYA 613
Cdd:cd11498  561 RLKNAVKPSKDWGPALQEHRTGRYA 585
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
46-579 0e+00

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 779.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585   46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMF 124
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWrKICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNgsrpatlpsnlshllnhS 204
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTELPWASCNNSWNTPNCTEFFSANNTTN-----------------S 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:pfam00209 144 LNKTSPVEEFWERKVLKLSDGIEDLGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVVYFTATFPYVVLLVLLVRGVTLP 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:pfam00209 224 GAADGILFYLTPDWSKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVL 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  365 GFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWiLQKKT 444
Cdd:pfam00209 304 GFMAQEQGVPISEVAESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFPILL-RKRRE 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  445 YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRF 524
Cdd:pfam00209 383 LFTLIVCVASFLLGLILVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVYGIDRFYDDIKEMLGFRPGLFWRLCWKF 462
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 109003585  525 VSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLC 579
Cdd:pfam00209 463 VSPLILLFLFIFSIVQYQPLTYNNYVYPNWANALGWLMALSSMLCIPLYSIYKLL 517
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
45-538 9.35e-77

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 251.94  E-value: 9.35e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  45 KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRI---S 121
Cdd:COG0733    4 KREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKlapG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 122 PMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLpwaycnnpwntrdcagvldasnltNGSRPATLPSNLSHLL 201
Cdd:COG0733   84 KKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGAF------------------------GGLDAEDAGAFFGAFL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 202 nhslqrTSPSEeywrlyvlklsddignfgevrlpLLGCLGVSWVVVFLCLIRGVKSS-GKVVYFTATFPYVVLTILFVRG 280
Cdd:COG0733  140 ------SSPGE-----------------------VLIWHLLFLLLTALIVARGVQKGiEKASKILMPLLFVLLIILVIRA 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 281 VTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVI 360
Cdd:COG0733  191 LTLPGAAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAI 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 361 FSILgFMAshlGVDVSRvadhGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGnewiL 440
Cdd:COG0733  271 FPAV-FAF---GLEPAA----GPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSAISLLEVVVAALIDKFG----L 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 441 QKKTyVTLGVAVAGFLLGIP------LTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPP 514
Cdd:COG0733  339 SRKK-ATLIVGLLIFLLGIPsalsfnVSVTIGLTFFDLVDFLVSNILLPLGGLLIAIFVGWVLGKEKLREELNAGSDIKL 417
                        490       500
                 ....*....|....*....|....
gi 109003585 515 PLFFQICWRFVSPAIIFFILVFTV 538
Cdd:COG0733  418 GKWWRFLIRYVAPVALLIIFLNGL 441
 
Name Accession Description Interval E-value
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
30-613 0e+00

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 1147.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  30 NGAVPNEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQF 109
Cdd:cd11498    1 NGAVPGEATKRDENLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 110 ASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSR 189
Cdd:cd11498   81 ASQGCLGVWRVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTRVLPWTYCNNPWNTPDCAGVLSTNRSNATFA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 190 PAT-LPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATF 268
Cdd:cd11498  161 NMSaVVSNLTELLNRTLKRTSPSEEYWRRYVLNISDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 269 PYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISIT 348
Cdd:cd11498  241 PYVVLTILFIRGITLEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISIT 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 349 NCATSVYAGFVIFSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 428
Cdd:cd11498  321 NCATSVYAGFVIFSILGFMANHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 429 AIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM 508
Cdd:cd11498  401 AVVDEIGNDWIIRNKTYVTLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAIMYIYGHRNYFKDIEM 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 509 MLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQ 588
Cdd:cd11498  481 MLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNDYVYPGWAIVIGFLMALSSVICIPIYAIFKICMSEGDTFLE 560
                        570       580
                 ....*....|....*....|....*
gi 109003585 589 RLKNATKPSRDWGPALLEHRTGRYA 613
Cdd:cd11498  561 RLKNAVKPSKDWGPALQEHRTGRYA 585
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
46-579 0e+00

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 779.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585   46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMF 124
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWrKICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNgsrpatlpsnlshllnhS 204
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTELPWASCNNSWNTPNCTEFFSANNTTN-----------------S 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:pfam00209 144 LNKTSPVEEFWERKVLKLSDGIEDLGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVVYFTATFPYVVLLVLLVRGVTLP 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:pfam00209 224 GAADGILFYLTPDWSKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVL 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  365 GFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWiLQKKT 444
Cdd:pfam00209 304 GFMAQEQGVPISEVAESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFPILL-RKRRE 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  445 YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRF 524
Cdd:pfam00209 383 LFTLIVCVASFLLGLILVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVYGIDRFYDDIKEMLGFRPGLFWRLCWKF 462
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 109003585  525 VSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLC 579
Cdd:pfam00209 463 VSPLILLFLFIFSIVQYQPLTYNNYVYPNWANALGWLMALSSMLCIPLYSIYKLL 517
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
46-602 0e+00

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 682.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11500    1 RGQWGGKLEFLLSCIGYCVGLGNVWRFPYLCYRNGGGAFLIPYFIMLAFCGIPLFFMELSLGQYGSLGPLTVWKCCPIFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCagvldasnltngsrpaTLPSNLSHLLNHSL 205
Cdd:cd11500   81 GIGYGMLLVSGLVCIYYNVIIAWTLFYLFASFTSVLPWEHCGNWWNTESC----------------LEHRGNGALTVNLT 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 206 QRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd11500  145 RTVSPSEEYWNRRVLGIqgSSGIGDPGEVRWELALCLLLAWVIVFFCLFKGVKSSGKVVYFTATFPYIILIVLLVRGVTL 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd11500  225 EGALKGIQFYLTPDFHRLASSQVWYDAASQIFYSLGIGFGGLLTMASYNKFNNNIYRDTLIITLGNCITSVFAGFAIFSV 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVgNEWILQKK 443
Cdd:cd11500  305 LGHMAHELGVPVKDVADAGPGLAFVAYPEALTLLPVSPFWSILFFFMLLTLGLDSQFAMLETIVTAVTDEF-PYLLRKYK 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 444 TYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWR 523
Cdd:cd11500  384 TWFLGLICVGMYLLGLLLVTDGGMYWLTLMDWYSASFGLMVLALFMCLAISWVYGIQRFCRDIKMMIGFEPNLYFKACWM 463
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109003585 524 FVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKPSRDWGP 602
Cdd:cd11500  464 FISPALLLFILVYSIVKYQPSEYGSYRYPPWAELLGILMGLLSCLMIPIGAIVAILREEG-SLWERLKQACRPAMDWGP 541
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
46-596 0e+00

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 666.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11496    1 RGKWSNKIDFLLSVAGYAIGLGNVWRFPYLCYKNGGGAFLIPYFIFLVLCGIPIFFLETSLGQYTSQGGITAWKICPLFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSRPATLPSNLshllnhsl 205
Cdd:cd11496   81 GIGYASAVIVFWLNIYYIVILAWALFYLFNSFTSPLPWTTCDNWWNTECCVEFYSNNNLSNSRENASNNTNA-------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 206 qrTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEG 285
Cdd:cd11496  153 --TSPVEEFWERRVLGISDGIDEIGSIRWELVLCLLLAWVIVYFCIWKGVKSTGKVVYFTATFPYVMLIILLIRGVTLPG 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 286 AFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG 365
Cdd:cd11496  231 ASDGIKFYLKPDLTKLLDPQVWIDAGTQIFFSYGIGLGSLTALGSYNKFNNNCYKDSIILCFLNSGTSFFAGFAIFSILG 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 366 FMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEvgNEWILQKKTY 445
Cdd:cd11496  311 FMAQEQGVPISEVAESGPGLAFIAYPRAVSLLPLPQLWAVLFFIMLLLLGLDSQFVGVEGFVTAIVDL--YPRVLRRRYR 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 446 ---VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQIC 521
Cdd:cd11496  389 reiFVAIVCLVSFLIGLPMVTEGGIYVFQLFDYYAASgICLLWLAFFECIAISWVYGADRFYDNIKDMIGYRPGPWWKYC 468
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109003585 522 WRFVSPAIIFFILVFTVIQYQPITYN-HYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKP 596
Cdd:cd11496  469 WLFGTPAICLGIFIFSLVKYTPLTYGnTYVYPWWAEAIGWFLALSSMLCIPLYAIYELLRTPG-TFKERLRKLTTP 543
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
46-618 0e+00

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 637.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11499    1 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLALAGLPIFLLEVSLGQFASQGPVSVWKAIPALQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAG----VLDASNLTN-------------GS 188
Cdd:cd11499   81 GCGIAMLIISVLIAIYYNIIMCYTLFYLFASLVEVLPWASCNNPWNTPECKDkdmlLLDSCIISDrpiiqiknstfcmTA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 189 RPATLPSNLSHLLNHSLqrTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATF 268
Cdd:cd11499  161 YPNVTMVNFTSVDNKTF--VSGSEEYFKYNVLKISAGIEYPGEIRWPLAACLFLAWLIVYASLAKGIKTSGKVVYFTATF 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 269 PYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISIT 348
Cdd:cd11499  239 PYVVLVILLIRGVTLPGAGSGIWYFITPKWEKLNDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCT 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 349 NCATSVYAGFVIFSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 428
Cdd:cd11499  319 NSATSIFAGFVIFSVIGFMAHELKVPIESVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVT 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 429 AIVDEVgNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM 508
Cdd:cd11499  399 SVSDEF-PKYLRTHKPQFTLVCCLSFFIMGFPMITQGGIYMLQLVDTYAASYSLVIIAIFELVGISYIYGLQRFCEDIEM 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 509 MLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQ 588
Cdd:cd11499  478 MIGFQPNKFWKVCWAFVTPTILTFILAFSFYQWEPMTYGSYTYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPG-SFIE 556
                        570       580       590
                 ....*....|....*....|....*....|
gi 109003585 589 RLKNATKPSRDWGPALLEHRTGRYAPTIIP 618
Cdd:cd11499  557 RLKLVCSPQPDWGPFLAKHRGERYKNMIDP 586
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
46-596 0e+00

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 595.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMF 124
Cdd:cd11497    1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGGAFLIPYLIMLIFGGLPLFYMELALGQFNRSGCITVWkKICPLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLT--NGSRPatlpsnlshlln 202
Cdd:cd11497   81 KGVGYAICIIAFYVAFYYNVIIAWALYYLFSSFTSELPWTSCNNPWNTPNCTDVSNRNNSSsiNGTGL------------ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 203 hslqrTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRG 280
Cdd:cd11497  149 -----TSPAEEYFERKVLELqkSEGIDDLGPIKWQLALCLFAVFIIVYFSLWKGVKSSGKVVWVTATMPYVVLSILLIRG 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 281 VTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVI 360
Cdd:cd11497  224 LTLPGASDGIKYYLTPDFSKLKDPEVWIDAATQIFFSLGPGFGVLLALSSYNKFHNNCYRDALVTSSINCATSFFSGFVI 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 361 FSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWil 440
Cdd:cd11497  304 FSVLGYMAHKQNVPIEDVATEGPGLVFIVYPEAIATLPGSTFWAIIFFLMLITLGLDSTFGGLEAVITGLCDEFPFLS-- 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 441 QKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQI 520
Cdd:cd11497  382 RRRELFVLGLVIICFLLALPTVTYGGIYVVTLLDRYAAGISILFIVFFEAVAVSWFYGVDRFSDDIEEMLGFRPGLYWRV 461
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109003585 521 CWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 596
Cdd:cd11497  462 CWKFISPIFLLFIVIFSLVSYEPLQYQDYVYPPWANVVGWVIACSSIVLIPIYAIYKLISTPGTFRQRIAYCITPE 537
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
46-577 0e+00

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 551.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd10332    1 RPAWDNKLQFLLATIGYAVGLGNVWRFPYLCQKNGGGAFLIPYFIMLILEGIPLFFLELAIGQRLRKGSIGVWNtISPYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnPwntrdcagvldasnlTNGSRPATLPSnlshllnhs 204
Cdd:cd10332   81 GGVGIASVVVSFLVALYYNVIIAWCFFYLFNSFQYPLPWSSC--P---------------TNGNGTGYVEE--------- 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:cd10332  135 CAKSSPTQYFWYRTTLDISPSIDESGGLNWWMTLCLLLAWIIVYLCMMKGIKSSGKVVYFTATFPYIVLIIFFIRGLTLK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:cd10332  215 GAGDGLKHMFTPKFEKLLDPQVWLDAATQIFFSLGLGFGSLIAFSSYNPPKNNCQRDAVLVSLINCFTSIFASIVVFSVL 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 365 GFMAShlGVDVSRVADH----------------GPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT 428
Cdd:cd10332  295 GFKIN--NVTLTENQTLgltncsledeldeavqGTGLAFIVFTEAITKMPGAPFWSVLFFLMLLTLGLGSMFGTLEGVVT 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 429 AIVDEVGNEWIlqKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM 508
Cdd:cd10332  373 PLFDSKILPKV--PKEYLTGLVCLVCFLIGLIFTQRSGNYWVQMFDSYAGTLPLLIIALFEMIAVSYVYGLDRFEEDIEY 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 509 MLGFPPPLFFQICWRFVSPAIIFFILVFTVIQY--QPITYN----------HYQYPGWAVAIGFLMALSSVLCIPLYAMF 576
Cdd:cd10332  451 MTGKRPGWYWKITWRYVSPLLMLVILVASIIQLitKPPTYSawnaelakteSLPYPNWGLAVIILLILLSILPIPGVALL 530

                 .
gi 109003585 577 R 577
Cdd:cd10332  531 R 531
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
47-538 0e+00

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 534.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  47 GNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLG-VWRISPMFK 125
Cdd:cd10324    1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGAFLIPYLIMLFLVGIPLFYLELALGQYTSRGPVGaFWRIAPLFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMthvlpwaycnnpwntrdcagvldasnltngsrpatlpsnlshllnhsl 205
Cdd:cd10324   81 GVGYAQVLVSFLVAIYYNVIIAWTLYYLFASF------------------------------------------------ 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 206 qrtspseeywrlyvlklsddignfgeVRLPLLGCLGVSWVVVFLCliRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEG 285
Cdd:cd10324  113 --------------------------INWELFLCLLLAWILVYLC--KGVKSIGKGVKFTGPFPYVLLLFLLIRGVTLPG 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 286 AFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG 365
Cdd:cd10324  165 AGDGILFYLTPDWSKLLDPKVWIAAATQIFFSLGIGFGGLITYASYNKFKNNIYRDALIVAILNTLTSLLAGFVIFSILG 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 366 FMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGneWILQKKTY 445
Cdd:cd10324  245 FLAHEPGTPVEDVVASGPGLAFIVYPEAIAQMPGPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALADEFP--KLRKRRWL 322
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 446 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFV 525
Cdd:cd10324  323 VTLGVCVVGFLLGLPYTTPGGIYVLDLFDYYAAGFSLLVIALLELIAIAWIYGVDRFLEDIEFMLGIRPSIYWRICWKFI 402
                        490
                 ....*....|...
gi 109003585 526 SPAIIFFILVFTV 538
Cdd:cd10324  403 TPVVLLIILVFSL 415
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
46-626 0e+00

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 532.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11501    1 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYKNGGGAFLIPYTIMLALAGLPLFFMECSLGQFASLGPISVWRILPLFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNpWNTRDCAGVLDASNLTNGSRPATLPSNLSHLLNHSL 205
Cdd:cd11501   81 GVGITMVLISTFVAIYYNVIIAYSLYYLFASFQSELPWSDCFS-WADENCSKTPIVTHCNVSTANNGIHENKSWVDINNL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 206 ----------QRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTI 275
Cdd:cd11501  160 tcingsiiyqPGQLPSEQYWNKVALQRSSGMDETGVIVWYLALCLLLSWIIVGAALFKGIKSSGKVVYFTALFPYVVLLI 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 276 LFVRGVTLEGAFTGIMYYLTPQWD--KILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATS 353
Cdd:cd11501  240 LLVRGATLEGASDGIEYYIGAQSNitKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIVVCVTNCLTS 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 354 VYAGFVIFSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDe 433
Cdd:cd11501  320 VFAGFAIFSVLGHMAHVSGRPVSEVVDSGFDLAFIAYPEALSKLPISPLWSILFFFMLLTLGLDSQFASIETITTTIQD- 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 434 VGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFP 513
Cdd:cd11501  399 AYPKVMKKMRIPITLGVCVILFLLGLVCVTQAGIYWVNLIDHFCAGWGILFAAVLELVGIIWIYGGNRFIEDIEMMIGAK 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 514 PPLF---FQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDtLLQRL 590
Cdd:cd11501  479 SWIFwlwWRACWFFITPVLLIAILIWSLVTFHSPTYGSVPYPDWGTALGWCMIIFCLIWIPIVAVIKIIKAKGN-LFQRI 557
                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 109003585 591 KNATKPSRDWGPALLEHRTGRYAPTIIPSPDDGFEV 626
Cdd:cd11501  558 KSCCRPTSNWGPYLECHRGERYKHMVDPKKEKDHEI 593
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
6-599 0e+00

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 529.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585   6 TRAAIARPGMAVAHGPVAPSSPEQngAVPNEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFM 85
Cdd:cd11506    5 TKVADGQISTEVSEAPIANDKPKT--LVVKVQKKKTDLPDRDTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  86 FPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAY 165
Cdd:cd11506   83 IPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIAWAIYYLYNSFTTTLPWKS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 166 CNNPWNTRDCAGVLDASNLTNgsrpatlpsnlshllnhslqRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWV 245
Cdd:cd11506  163 CDNPWNTDRCFSNYSMANTTN--------------------MTSAVVEFWERNMHQMTDGLEKPGQIRWPLAITLAIAWV 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 246 VVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGL 325
Cdd:cd11506  223 LVYFCIWKGVGWTGKVVYFSATYPYIMLFILFFRGVTLPGAKEGILFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSL 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 326 ITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSL 405
Cdd:cd11506  303 IALGSYNPFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRPIADVAASGPGLAFLAYPEAVTQLPISPLWAV 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 406 LFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLgVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVV 484
Cdd:cd11506  383 LFFSMLLMLGIDSQFCTVEGFITALVDEFPRLLRNRREIFIAV-VCIVSYLIGLSNITQGGIYVFKLFDYYSASgMSLLF 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 485 ISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMAL 564
Cdd:cd11506  462 LVFFECVSISWFYGVNRFYDNIEEMVGYRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGNYVFPKWGQGVGWFMAL 541
                        570       580       590
                 ....*....|....*....|....*....|....*
gi 109003585 565 SSVLCIPLYAMFRLCRTDGdTLLQRLKNATKPSRD 599
Cdd:cd11506  542 SSMVLIPGYMAYMFLTLKG-SLKQRLQVMIQPTED 575
SLC6sbd_BGT1 cd11511
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding ...
45-596 0e+00

Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain; BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212080  Cd Length: 541  Bit Score: 529.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  45 KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPM 123
Cdd:cd11511    1 ERGQWRNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYLIFLFTCGIPLFFLETALGQYTSQGGVTAWRkICPI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 124 FKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNgsrpATLPSNLshllnh 203
Cdd:cd11511   81 FEGIGYASQVIESYLNVYYIIILSWALFYLFSSFTSVLPWATCNNPWNSDLCVDFLNHSGADN----RTPPENA------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 204 slqrTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd11511  151 ----TSPVMEFWEKRVLGLTDGIHKLGTVRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVILLVRGVTL 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd11511  227 PGAAEGIIFYLKPDLSRLADPQVWMDAGTQILFSYAICQGCLTALGSYNKYTNNCYRDCIMLCFLNSATSFVAGFAIFSV 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQ-K 442
Cdd:cd11511  307 LGFMAREQGVPISEVAESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQFVCVESMVTASIDMFPGVFRKKgR 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 443 KTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQIC 521
Cdd:cd11511  387 RELLILAIAVICYLLGLLLVTEGGMYIFQLFDYYAASgTCLLFLAIFEVICIGWVYGANRFYDNIEDMIGYRPWPLIKIC 466
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109003585 522 WRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKP 596
Cdd:cd11511  467 WLVFTPGLCLAVFLFSLIKYTPLKYNNsYVYPPWGYVLGWLMALSSMVCIPLYAIFILLKTKG-SLKQRLMQLISP 541
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
46-596 1.58e-178

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 518.56  E-value: 1.58e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMF 124
Cdd:cd11556    1 RETWSKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGGIPLFYMELALGQYNRKGAITSWgRLCPLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSRPATLPSNLSHLLNHS 204
Cdd:cd11556   81 KGIGYAVVLIAFYVDFFYNVIIAWSLYYFFASFTFNLPWTSCNNSWNTPNCREFHWSEDGTVPCRSANQSFSAENQSAQS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 LQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVT 282
Cdd:cd11556  161 ENFTSAASEYFERGVLELnrSEGVHDLGNIRWDIALCLFAVYLICYFSLWKGIHTSGKVVWFTALFPYVVLFILLIRGVT 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 283 LEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFS 362
Cdd:cd11556  241 LPGSFNGIQYYLTPNFEALKKAEVWVDAATQVFFSLGPGFGVLLAYASYNKFHNNVYKDALLTSFINCATSFLSGFVIFS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 363 ILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVgnEWILQK 442
Cdd:cd11556  321 VLGYMAHRSGVPIEDVATEGPGLVFVVYPEALSTMPGSTFWSLIFFMMLMTLGLDSSFGGSEAIITALSDEF--PIIKRH 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 443 KTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICW 522
Cdd:cd11556  399 RELFVGCLFSFYFVIGLASCTQGGFYFFHLLDRYAAGYSILIAVLFEAIAVSWIYGTDRFCQDIKEMLGFPPGIYWKVCW 478
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109003585 523 RFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKP 596
Cdd:cd11556  479 KFIAPIFLLFIITYGLIGYQPLTYDDYVYPTWANALGWCIAGSSISMIPIVAIYKLLSTPG-TLRQRFKILTTP 551
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
46-609 8.25e-172

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 502.84  E-value: 8.25e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11509    1 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLIAFVGGIPIFFLEIALGQFMKAGGINAWNIAPLFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSRPATLPSNLShlLNHSL 205
Cdd:cd11509   81 GLGYASMVIVFFCNTYYIMVLAWGFYYLVKSFTNTLPWATCGNPWNTPNCTEIFRHADCNNGASSAGSLANLT--CDELA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 206 QRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEG 285
Cdd:cd11509  159 NRRSPVIEFWERKVLRLSGGLEEPGALNWELTLCLLATWVLVYFCVWKGVKSTGKVVYFTATFPYVVLVVLLVRGVTLPG 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 286 AFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG 365
Cdd:cd11509  239 ALDGIIYYLKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYKDAFILALINSGTSFFAGFVVFSILG 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 366 FMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTY 445
Cdd:cd11509  319 FMASEQGVDISKVAESGPGLAFIAYPKAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGILDLLPAKYYFRYQRE 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 446 VTLGVAVA-GFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWR 523
Cdd:cd11509  399 VVVALCCLlCFLIDLSMVTEGGMYVFQLFDYYSASgTTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPLPWMKWCWS 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 524 FVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKPSrdWGP 602
Cdd:cd11509  479 VITPLVCMGIFLFHVVNYKPLTYNKtYVYPWWGEAIGWCLALSSMLCIPLTVLYKLLRAKG-SLKERWQKLTTPV--WGL 555

                 ....*..
gi 109003585 603 ALLEHRT 609
Cdd:cd11509  556 HHLEYRA 562
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
46-599 5.38e-170

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 496.42  E-value: 5.38e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11507    1 RGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSQGGVTAWRkICPLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTNGSrpatlpsnlshllnhS 204
Cdd:cd11507   81 EGIGYASQVIVMLLNCYYIIVLAWALFYLFSSFTIDLPWGSCGHEWNTENCMEFQKANSTLNVT---------------S 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:cd11507  146 ENATSPVIEFWERRVLKISDGIQHLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVSLP 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:cd11507  226 GALQGIQFYLYPDLSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSIL 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 365 GFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNewILQKKT 444
Cdd:cd11507  306 GFMAEEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQFVCVESLVTALVDMYPT--IFRKKN 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 445 ---YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQI 520
Cdd:cd11507  384 rreLLILAVSIVSFLVGLIMLTEGGMYVFQLFDYYAASgMCLLFVAIFETLCVAWVYGADRFYDNIEDMIGYRPWAIIKY 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 521 CWRFVSPAIIFFILVFTVIQYQPITYN-HYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKPSRD 599
Cdd:cd11507  464 CWLFITPAVCMATFLFSLIKYTPLTYNkKYVYPWWGDALGWLLALSSMVCIPLWVGYKLSTIKG-SLRERFRQLTCPDED 542
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
45-596 2.60e-161

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 474.09  E-value: 2.60e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  45 KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPM 123
Cdd:cd11508    1 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRkVCPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 124 FKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGV--LDASNLTNGSRPatlpsnlshll 201
Cdd:cd11508   81 FEGIGYATQVIEAHLNVYYIIILAWAIFYLFNCFTTELPWATCGHEWNTENCVEFqkLNSSNCSHVSLQ----------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 202 nhslQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGV 281
Cdd:cd11508  150 ----NATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGV 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 282 TLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIF 361
Cdd:cd11508  226 TLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIF 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 362 SILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWIL- 440
Cdd:cd11508  306 SVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRg 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 441 QKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQ 519
Cdd:cd11508  386 YRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASgMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPLSLIK 465
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109003585 520 ICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKP 596
Cdd:cd11508  466 WCWMVITPGICAGIFIFFLVKYKPLKYNNvYTYPDWGYGIGWLMALSSMICIPLWICIKMWKTEG-TFPEKLQKLTTP 542
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
46-596 2.96e-161

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 473.93  E-value: 2.96e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11513    1 RETWGKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRkICPIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLTngsrpatlpsnlshLLNHS 204
Cdd:cd11513   81 KGIGYAICIIALYVASYYNTIIAWALYYLYSSFTDELPWTSCNNSWNTGNCTNYFAKDNIT--------------WTLHS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 lqrTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVT 282
Cdd:cd11513  147 ---TSPAEEFYTRHVLQVhrSKGLGDLGGISWQLTLCLFLIFTIVYFSIWKGVKTSGKVVWVTATFPYIVLFILLVRGAT 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 283 LEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFS 362
Cdd:cd11513  224 LPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLALASYNKFNNNCYQDALVTSVVNCLTSFVSGFVIFT 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 363 ILGFMASHLGVDVSRVA-DHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQ 441
Cdd:cd11513  304 VLGYMAEMRNEDVSEVAkDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWSKR 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 442 KKTYVtLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQIC 521
Cdd:cd11513  384 REKFV-LGLVIVCFLGSLATLTFGGAYVVKLLEEYATGPAVLTVVLLEAVAVSWFYGITQFCNDVKEMLGFSPGWFWRVC 462
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 109003585 522 WRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKP 596
Cdd:cd11513  463 WVAISPLFLLFIICSFLMNPPQLRLFDYNYPYWSIVVGYCIGTSSIICIPIYMAYRLIITPG-TLKERIIKSITP 536
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
46-599 3.60e-161

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 474.45  E-value: 3.60e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11512    1 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPCFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAG--VLDASNLTNGSRpatlpsnlshllnH 203
Cdd:cd11512   81 GVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTSELPWTTCGNVWNSPNCTDpkLLNASVLGNGTK-------------Y 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 204 SLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGV 281
Cdd:cd11512  148 SKYKLTPAAEFYERGVLHLheSAGIHDLGLPRWQLTLCLFVVVIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIHGV 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 282 TLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIF 361
Cdd:cd11512  228 TLPGAFNGINAYLHIDFKRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIF 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 362 SILGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVgnEWILQ 441
Cdd:cd11512  308 SILGYMAHEHKVKIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDF--SILKK 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 442 KKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQIC 521
Cdd:cd11512  386 HRKLFTFGVAFITFLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSDDIQQMMGFRPGLYWRLC 465
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109003585 522 WRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKPSRD 599
Cdd:cd11512  466 WKFVSPAFLLFVVIVSIINFKPLTYDDYNFPPWANRTGWGIALSSMLLVPIYVIYKFFTVPG-TFEERLAYCITPENE 542
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
46-599 7.59e-161

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 473.26  E-value: 7.59e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFK 125
Cdd:cd11514    1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVIAGMPLFYMELALGQFNREGAAGVWKICPIFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 126 GVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCagvldasnltngSRPATLPSNLSHLLNHSL 205
Cdd:cd11514   81 GVGFTVILISLYVGFFYNVIIAWALFYLFSSFTGELPWIHCNNSWNSPNC------------SDAHPGDSSGDSSGLNDT 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 206 QRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd11514  149 YKTTPAAEYFERGVLHLheSHGIHDLGPPRWQLTSCLVVVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTL 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd11514  229 PGAIDGIKAYLSVDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFFSGFVVFSF 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVgnEWILQKK 443
Cdd:cd11514  309 LGYMAQKHNVPIGDVAKDGPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEF--KFLHRHR 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 444 TYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWR 523
Cdd:cd11514  387 ELFTLFIVLSTFLISLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGQRPGLYWRLCWK 466
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109003585 524 FVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKPSRD 599
Cdd:cd11514  467 FVSPCFLLFVVVVSIVTFRPPKYGSYIFPDWANMVGWCLAISSMAMVPLYAIYKFCSLPG-SFREKLAYAITPEKE 541
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
46-596 1.26e-157

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 464.71  E-value: 1.26e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMF 124
Cdd:cd11510    1 REKWASKIDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQYTSEGGITCWeKLCPIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTRDCAGVLDASNLT-NGSRPATlpsnlshllnh 203
Cdd:cd11510   81 TGIGYASIVIVSLLNIYYIVILAWALYYLFQSFQSELPWAHCNQKWNTPCCVEDTLRKNKTlWASINAT----------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 204 slQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd11510  150 --NFTSPVTEFWERNVLSLSAGIEHVGTIKWDLALCLLLVWVVCFFCIWKGVKSTGKVVYFTATFPFLMLIVLLIRGVTL 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd11510  228 PGAAEGIKFYLYPDITRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGCLNSGTSFVSGFAIFSV 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMASHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNewILQKK 443
Cdd:cd11510  308 LGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPS--FLRKG 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 444 TYVTLGVAVA---GFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQ 519
Cdd:cd11510  386 YRREIFIAIVcfiSYLLGLTMVTEGGMYVFQLFDYYAASgVCLLWVAFFECIAVAWVYGGDNMYDAIEDMIGYRPGPWMK 465
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109003585 520 ICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGdTLLQRLKNATKP 596
Cdd:cd11510  466 YSWIVITPVLCVGCFIFSLVKYEPLTYNKvYVYPEWAIGLGWVLALSSMICIPMVAVIRIIQTDG-PLIERIKALTTP 542
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
46-577 1.30e-128

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 389.69  E-value: 1.30e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11515    1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLIVIGIPLFFLELSVGQRIRRGSIGVWNyISPRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnpwntrdcagvldasnltngsrpaTLPSNLSH-LLNH 203
Cdd:cd11515   81 GGIGFASCVVCLFVALYYNVIIGWSLFYFSQSFQQPLPWDQC-------------------------PLVKNASHtFVEP 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 204 SLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd11515  136 ECEKSSATTYYWYREALNISDSISESGGLNWKMTICLLAAWVIVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLL 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd11515  216 NGSVDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAV 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMA--------SHLGVDVSRVAD------HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTA 429
Cdd:cd11515  296 LGFKIqkvkeeefPALHLNPCLIEDelnkavQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGITTP 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 430 IVDEVGnewilQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMM 509
Cdd:cd11515  376 IVDTFK-----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVAFVYGIDKFMEDLKDM 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 510 LGFPPPLFFQICWRFVSPAIIFFILVFTVIQY--QPITYNHY----------QYPGWAVAIGFLMALSSVLCIPLYAMFR 577
Cdd:cd11515  451 LGFRPYRYYYYMWKYISPLMLLSLLIASIVNMglSPPGYNAWiedkaserflSYPTWGMVLCISLIVVAILPIPVVFILR 530
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
46-578 4.92e-126

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 384.55  E-value: 4.92e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11517    2 RPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGGAFLIPYFIALVFEGIPLFHLELAIGQRLRKGSIGVWTtISPYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnPWNtrdcagvldaSNLTNgsrpatlpsnlshlLNHS 204
Cdd:cd11517   82 GGVGLGCVTVSFLVSLYYNTILAWVLWYFLNSFQHPLPWSSC--PLD----------LNRTG--------------FVEE 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:cd11517  136 CQGSTAVSYFWYRQTLNITPDINDSGSIQWWLLLCLAACWAIVYLCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLP 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:cd11517  216 GATEGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNDCEKDAVTIALVNSMTSLYASIPVFSVL 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 365 GFMAS-----------------------------------HL-GVDVSRVAD----------------HGPGLAFVAYPE 392
Cdd:cd11517  296 GFKATndyehcldrnilslinefdfpeqsisrdnypsvlmHLnATWPERVAQlplkaclledfldksaSGPGLAFIVFTE 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 393 ALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD-EVGNEWIlqKKTYVTLGVAVAGFLLGIPLTSQAGIYWLL 471
Cdd:cd11517  376 AVLHMPGAQVWAVLFFGMLFTLGLSSMFGNVEGVITPLLDvGVLPRWV--PKEALTGLVCLVCFLSALCFTLQSGNYWLE 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 472 LMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILV-FTVIQYQ-PITYNHY 549
Cdd:cd11517  454 IFDSFAASLNLLVIAFFEVVGVVYVYGIKRFCDDIEWMTGRRPSLYWRLTWRVVSPLLLLTIFVaYIILLFQkPPSYKAW 533
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 109003585 550 Q-------------YPGWAVAIGFLMALSSVLCIPLYAMFRL 578
Cdd:cd11517  534 NpkyelfpsreeklYPGWVQAICVLLSLLPVLWVPVVALAQL 575
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
46-575 2.50e-119

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 367.36  E-value: 2.50e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11518    4 RPLWDNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGGFLIPYLIMLILEGMPLLYLELAVGQLMRQGSIGAWKsISPYL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnPWNtrdcagvldaSNLTNgsrpatlpsnlshlLNHS 204
Cdd:cd11518   84 GGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSNC--PLN----------SNHTA--------------YNEE 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:cd11518  138 CEKASPTQYFWYRKTLNISPSILENGGIQWELAVCLILAWLVVYLCILRGTESTGKVVYVTALIPYLVLLIYLIRGLTLH 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:cd11518  218 GAANGLAYMFTPKLEQLANPKTWINAATQIFFSLGLGFGSLIAFASYNEPSNNCERHAIIVSLINSGTSIFASIVTFSIY 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 365 GF-----------------------------------MASHLGVDVSR-------------------VADHGPGLAFVAY 390
Cdd:cd11518  298 GFkatfnyencmkkvillltntfdleegsvttenlgdMKNYLASAFPQeyssivpqikncslekeldTAVQGTGLAFIVY 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 391 PEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTyVTLGVAVAGFLLGIPLTSQAGIYWL 470
Cdd:cd11518  378 TEAIKNMEVSQLWSVLYFLMLLMLGIGSMLGNTAAILTPLTDSKFISSHLPKEA-ISGLLCFTNCIIGLVFTMEAGNYWF 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 471 LLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQ 550
Cdd:cd11518  457 DIFNDYAATLSLLLIVLVETIAVCYVYGLRRFENDLEAMTGHKLSWYWKIMWAFVSPLLIVSLFIFYLTDYIMTGTLQYQ 536
                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 109003585 551 -------------YPGWAVAIGFLMALSSVLCIPLYAM 575
Cdd:cd11518  537 awdatlgqlvtkdYPPYALAVIGLLVAASTCCIPLVAI 574
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
46-580 2.33e-118

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 364.98  E-value: 2.33e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11516    1 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWStIHPTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnPWNTRDCAGVLDASnltngsrpatlpsnlshllnhs 204
Cdd:cd11516   81 KGVGIASMCVSFLVSLYYNTIIAWVMWYFFNSFQEPLPWSQC--PLNENRTGYIPECA---------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 lqRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:cd11516  137 --KSSPVDYFWYRETLNTSTSIDDSGGIQWWMVLCLACAWGVLYVCTIRGIETTGKAVYVTSTLPYLVLTIFLIRGLTLK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:cd11516  215 GSVNGIKFLFTPDINELANPVTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEKDAVIISVINGFTSIYAATVIYSII 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 365 GFMASHL---------------------------GVDVSRVADH-------------------------GPGLAFVAYPE 392
Cdd:cd11516  295 GFRATERfddcfdgniltlinafdlpegnitqdnYQDMQQSLNStdpdiisslslqtcdlnnflsegveGTGLAFIVFTE 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 393 ALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD--EVGNEWilqKKTYVTLGVAVAGFLLGIPLTSQAGIYWL 470
Cdd:cd11516  375 AITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVLVPLQDlkVIPKSW---PKEIITGLICLVSFLIGLIFVLGSGNYWL 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 471 LLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAI--IFFILVFTVIQYQPITYNH 548
Cdd:cd11516  452 ALFDSFAGSIPLLIIAFCEMFSVVYVYGIDRFNKDIEFMIGHKPNIFWQATWRVISPLImlVIFLFYFVVKVSQELFYSA 531
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 109003585 549 YQ-------------YPGWAVAIGFLMALSSVLCIPLYAMFRLCR 580
Cdd:cd11516  532 WDpeyeefpksqkisYPTWIYVIIVILAGVPSLAIPGYAIYKAIR 576
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
46-577 2.78e-117

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 362.38  E-value: 2.78e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11521    1 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWNyICPRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnpwntrdcagvldaSNLTNGSrpatlpsnlSHLLNHS 204
Cdd:cd11521   81 GGIGYASCLVCFFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC---------------PVVRNGS---------VAVVEAE 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 LQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 284
Cdd:cd11521  137 CEKSSATTYFWYREALDISNSISESGGLNWKMTLCLLVAWSLVGMAMIKGIQSSGKVMYFSSLFPYVVLVCFLVRGLLLR 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 285 GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSIL 364
Cdd:cd11521  217 GAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 365 GFMA-----------------------------------SH-----------------------LGVDVSRVAD------ 380
Cdd:cd11521  297 GFKAnimnekcvvenaekilgylntnvlshdlipphvnfSHlttkdynemyrvimtvkedhfkeLGLDACLLEDeldksv 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 381 HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGnewilQKKTYVTLGVAVAGFLLGIP 460
Cdd:cd11521  377 QGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMSGITTPIIDTFK-----VRKEVFTVGCCIFAFLVGLI 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 461 LTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ 540
Cdd:cd11521  452 FVQRSGNYFVTMFDDYSATLPLTVVVILENIAVAWIYGTKKFMQELTEMLGFRPYQFYFYTWKYVSPICMAVLMTASIIQ 531
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*....
gi 109003585 541 Y--QPITYNHY----------QYPGWAVAIGFLMALSSVLCIPLYAMFR 577
Cdd:cd11521  532 LgvSPPGYSAWireeaaekflFYPTWAMALLITLIILASLPLPVVFILR 580
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
46-577 3.46e-116

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 359.23  E-value: 3.46e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd11522    1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNyISPKL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnpwntrdcagvldasnltngsrpaTLPSNLSH-LLNH 203
Cdd:cd11522   81 GGIGFASCIVCFFVALYYNVIIGWSLFYFSQSFQQPLPWDQC-------------------------PLVKNASHtFVEP 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 204 SLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd11522  136 ECEKSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLL 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd11522  216 NGSVDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAV 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMAS----------------------------------------------------------HLGVDVSRVAD----- 380
Cdd:cd11522  296 LGFKANvinekciiqnsekiikllkmgnlsqdiiphhinfssitaedynlvydiiqkvkeeefpALGLKSCQIEDelnka 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 381 -HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGnewilQKKTYVTLGVAVAGFLLGI 459
Cdd:cd11522  376 vQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIITPIVDTFK-----VRKEILTVICCLLAFCIGL 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 460 PLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVI 539
Cdd:cd11522  451 IFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFMEDLKDMLGFTPNRYYYYMWKYISPLVLLSLLVASVV 530
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 109003585 540 QY--QPITYNHY----------QYPGWAVAIGFLMALSSVLCIPLYAMFR 577
Cdd:cd11522  531 QMglSPPGYNAWiedkateeflSYPTWGLVVCISLVVLAILPVPVVFIIR 580
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
46-568 1.38e-100

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 315.59  E-value: 1.38e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMF 124
Cdd:cd10334    1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGGAFLIPYLIALLTAGIPLLILEYGLGHKYRGSAPLAFRrLNKKF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 125 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHvlpwAYCNNPWntrdcagvldasnltngsrpatlpsnlSHLLNHs 204
Cdd:cd10334   81 EWIGWWQVLVAFVIATYYAVIIAWALSYLFFSFTL----AWGDDPE---------------------------AFFFGD- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 205 lqrtspseeywrlyVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSS-GKVVYFTATFPYVVLTILFVRGVTL 283
Cdd:cd10334  129 --------------FLQLSDSPFDLGGIVWPILIALVLVWLIIWFILYRGVKKGiEKASKIFMPLLFVLFLILVIRALTL 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 284 EGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSI 363
Cdd:cd10334  195 PGAADGLNALFTPDWSALLDPKVWIAAYGQIFFSLSLGFGIMITYASYLPKKSDLTNNALITAFANSGFEILAGIGVFSI 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 364 LGFMASHLGVDVSRVADHGPGLAFVAYPEALTLL-PISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGnewiLQK 442
Cdd:cd10334  275 LGFMAQAQGVPVSEVVSSGIGLAFVAFPKAINLMpPLGALFGVLFFLSLVFAGLTSLISLVEVVISAVQDKFG----LSR 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 443 KTyVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG------HRNYFQDIQmmLGFpppl 516
Cdd:cd10334  351 KK-AVTIVCLVGFLVSLLFATGAGLYLLDIVDHFINNYGIVLVGLVEVIVVGWVFGaeklreHLNAVSDFK--VGK---- 423
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 109003585 517 FFQICWRFVSPAIIFFILVFTVIQYqpITYNHYQYPGWAVAIGFLMALSSVL 568
Cdd:cd10334  424 WWDFLIKVVTPLVLGYMLILGLIGL--LTEPYGGYPVWALLLFGWGIVALIL 473
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
49-571 2.17e-88

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 285.48  E-value: 2.17e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  49 WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGV 127
Cdd:cd11502    4 WSKKTEYILAQVGFSVGLSSIWRFPYLWHHNGGGSFLLIYILMLFLVGIPLLFLEMAVGQRLRQGSIGVWKiLSPWLGGV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 128 GYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCnnpwntrdcagvldasnltngsrpaTLPSNLShLLNHSLQR 207
Cdd:cd11502   84 GYSSFLVCFIVGLYNNVLNSWSLFYLSQSFQFPLPWEKC-------------------------PLVKNSS-DFDPECAR 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 208 TSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAF 287
Cdd:cd11502  138 TTPSQYFWYRQTLKASDRIEDGGVLVLSLTLSLFLAWCLLCVFMINGLKSTGKMLYVLVLLPYIILLCFLIRTLFLEGAK 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 288 TGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFM 367
Cdd:cd11502  218 FGLKHLLVAKVSALYSLSVWRQAGGQVLYSLGLGFGTIISFSSYMPRSNNCLKDAFLVALVNLVTSLLTTPFIFAVLGFW 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 368 A----------SHLGVDV-SRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFC 421
Cdd:cd11502  298 AtpasiylswlNNLPQHIkSQVlskvpecsiqkqkekIMEGPGFAFLAFSEAISLFPGSSFWSILFFLMLLILGLSTMLG 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 422 LLETLVTAIVDEVGnewILQKKT-YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHR 500
Cdd:cd11502  378 IMQGIITPLQDTFS---FFRKHPkLLTVGVCLLMFLCSLIFTRPSGSYYVSLLDDYWVPMPIIFIVICENLAVAWAYGAK 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 501 NYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQY--QPITYNHY----------QYPGWavAIGFLMALSSVL 568
Cdd:cd11502  455 RFLADLMILLGHPISPIFTWLWCYLTPVVLLVLFTITLIQLyvKPITYLAWdsstshevtrPYPSW--ALGLVIFLSVIV 532

                 ...
gi 109003585 569 CIP 571
Cdd:cd11502  533 LLP 535
SLC6sbd_u2 cd11554
uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins ...
48-520 8.31e-83

uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, and are the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 212092 [Multi-domain]  Cd Length: 406  Bit Score: 266.88  E-value: 8.31e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  48 NWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMFKG 126
Cdd:cd11554    2 QWGSRTAFVLAAMGGAVGLGNLLRFPSVVYNNGGLQFFIPYLLALVLLAIPILILELALGQAYRGGCVKAFnLINRRAKG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 127 VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMThvlpwaycnnpwntrdcagvldasnltngsrpatlpsnlshllnhslq 206
Cdd:cd11554   82 VGAAVVFGGFVVCTYYVPILAWIMVYFRHSFT------------------------------------------------ 113
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 207 rtspseeywrlyvlklsddignfgevrlplLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 286
Cdd:cd11554  114 ------------------------------VGWLAFTWFVVWLCVFRGVGSTGRVVYITMGLPIVLIIILLGRGASLPNA 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 287 FTGIMYYLTPQW-DKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG 365
Cdd:cd11554  164 GDGIRLYFATWRgDKLASGEIWQAAAGQVFFSTGVGFGYMTAYASYNSKFSNAVQDALIIAGSNSLFEIIAGFAVFGIVG 243
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 366 FMASHLGVDVSRVAdhGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD-EVGNEWilqKKT 444
Cdd:cd11554  244 YLGMTPGVEGEALG--GFVLGFVTYPEAIAQMPGSNFFAVLFFLTLFLLGISSAFALLEAVVTLICDsGWGRKV---KRW 318
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109003585 445 YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGhrnyFQDIQMMLGFPPPLFFQI 520
Cdd:cd11554  319 WIATVVCFVSFLLSLPYCTRFGYYLLDAVDAWISNVALVFVVWAECVAATTVYR----FEDVVDQVGLPAFAYYNV 390
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
45-538 9.35e-77

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 251.94  E-value: 9.35e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  45 KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRI---S 121
Cdd:COG0733    4 KREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKlapG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 122 PMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLpwaycnnpwntrdcagvldasnltNGSRPATLPSNLSHLL 201
Cdd:COG0733   84 KKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGAF------------------------GGLDAEDAGAFFGAFL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 202 nhslqrTSPSEeywrlyvlklsddignfgevrlpLLGCLGVSWVVVFLCLIRGVKSS-GKVVYFTATFPYVVLTILFVRG 280
Cdd:COG0733  140 ------SSPGE-----------------------VLIWHLLFLLLTALIVARGVQKGiEKASKILMPLLFVLLIILVIRA 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 281 VTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVI 360
Cdd:COG0733  191 LTLPGAAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAI 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 361 FSILgFMAshlGVDVSRvadhGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGnewiL 440
Cdd:COG0733  271 FPAV-FAF---GLEPAA----GPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSAISLLEVVVAALIDKFG----L 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 441 QKKTyVTLGVAVAGFLLGIP------LTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPP 514
Cdd:COG0733  339 SRKK-ATLIVGLLIFLLGIPsalsfnVSVTIGLTFFDLVDFLVSNILLPLGGLLIAIFVGWVLGKEKLREELNAGSDIKL 417
                        490       500
                 ....*....|....*....|....
gi 109003585 515 PLFFQICWRFVSPAIIFFILVFTV 538
Cdd:COG0733  418 GKWWRFLIRYVAPVALLIIFLNGL 441
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
47-535 5.03e-49

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 177.25  E-value: 5.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  47 GNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW----RISP 122
Cdd:cd10336    1 EQWSSRLGFILAAAGSAVGLGNIWRFPYLAGENGGGAFLLVYLLFVLLIGLPLLIAEFAIGRRTRKNPVGAFaklaGGGK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 123 MFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMThvlpwaycnnpwntrdcagvldasNLTNGSRPATLPSNLSHLLN 202
Cdd:cd10336   81 KWKLIGWLGVLGGFLILSFYSVVGGWVLKYLFKSLT------------------------GLFAGADAAEVGAAFFGFIA 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 203 HSLQrtspseeywrlyvlklsddignfgevrlpLLGCLGVSWVVVFLCLIRGVKSS-GKVVYFTATFPYVVLTILFVRGV 281
Cdd:cd10336  137 SPLS-----------------------------PLLWHLLFLLLTALIVARGVKKGiERANKILMPLLFILLIILAIRSL 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 282 TLEGAFTGIMYYLTPQWDKILeAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIF 361
Cdd:cd10336  188 TLPGAGEGLKFLLKPDFSKLT-PEVVLAALGQAFFSLSLGMGVMITYGSYLSKDENLPKSALIVAVLDTLVALLAGLVIF 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 362 SILgFMAshlGVDVSRvadhGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGnewILQ 441
Cdd:cd10336  267 PAV-FAF---GLDPAA----GPGLLFITLPAVFAQMPGGRLFGILFFLLLLFAALTSAISLLEVVVAYLIDEFG---WSR 335
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 442 KKTYVTLGVAVagFLLGIPL---------TSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQM-MLG 511
Cdd:cd10336  336 KKATLIVGIII--FLLGIPSalsfgvlsdVTIFGKTFFDLLDFLVSNILLPLGGLLIAIFVGWVLGKEALLEELNKgGLG 413
                        490       500
                 ....*....|....*....|....
gi 109003585 512 FPPPLFFQICWRFVSPAIIFFILV 535
Cdd:cd10336  414 KKLFKIWLFLLRYVAPVAILIIFL 437
SLC5-6-like_sbd cd06857
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
53-537 8.08e-42

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


Pssm-ID: 271356 [Multi-domain]  Cd Length: 407  Bit Score: 156.36  E-value: 8.08e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  53 IEFVLTSVGYAVGLGNVWRFPYLCYRNGGGaFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMM 132
Cdd:cd06857    1 FDLILACIGLALGLANFIRFPQMTYSYGGA-FILPYIVLSIIVGIPLLVLELSMGQFSGIGFISMWRCSPFFKGLGVVSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 133 VVSTYIGIYYNVVICIAFYYFFSSMthvlpwaycnnpwntrdcagvldasnltngsrpatlpsnlshllnhslqrtspse 212
Cdd:cd06857   80 FLSFLLLIYYTYLAALALVYIINLY------------------------------------------------------- 104
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 213 eYWRLyvlklsddignfgevrlplLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE--GAFTGI 290
Cdd:cd06857  105 -YWIL-------------------ALGLFLIWVTIYGIFFRGLKSIGKLIVIAVIVLLVLLLVLTVRALFLEgaGASEGL 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 291 MYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMASH 370
Cdd:cd06857  165 NKGGTPDFMELNNSGIWTAATIQVFFSLGAGWGSVITIASFCLFKKNAQRDALIAAFLNLIASIIFVGLIGIAAGVLSFD 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 371 LGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEvgNEWILQKKTYVTLGV 450
Cdd:cd06857  245 PQNMVVLGLLNSLYLTFIASPQAISSLAGSNLWAFLYYAALLLAGLSSMATITNTVAQSLFDE--FRRKLKTGVIDTALI 322
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 451 AVAGFLLGIPLTsqAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQIcWRFVSPAII 530
Cdd:cd06857  323 VVLLVAAVIFLV--LGLRILFLTDKQLVGTSVVPLLLILLLVVFWIYGRERIQRDIEFMLGPVGSIVWFW-LWVIAPAIL 399

                 ....*..
gi 109003585 531 FFILVFT 537
Cdd:cd06857  400 VIILVWA 406
LeuT-like_sbd cd10333
Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino ...
46-568 2.75e-39

Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.


Pssm-ID: 271365 [Multi-domain]  Cd Length: 496  Bit Score: 151.31  E-value: 2.75e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585  46 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQ-------GCLGVW 118
Cdd:cd10333    1 REHWGSRIGLILAMAGNAVGLGNFLRFPVQAAQNGGGAFMIPYFIAFLLLGIPLMWIEWAMGRYGGKyghgttpMIFLLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 119 RISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPwaycnnpwntrdcagvldasnltngsrpatlpsnls 198
Cdd:cd10333   81 WENRFAKILGAIGLAIPLLVNSYYVYIESWTLGYAFKSLTGAYP------------------------------------ 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 199 hllnHSLQRTSPSEEYWRLYVLKlsddigNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVyftATFPYVVLTILFV 278
Cdd:cd10333  125 ----EPPSILRPTAEFFYSYIGK------PSGLAYIFFLITMALNFFILYRGVSKGIEAFAKIA---MPLLYVFAIILLI 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 279 RGVTLE-------GAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNncyrDSVIISITNCA 351
Cdd:cd10333  192 RVLTLGspvnpnwTALKGLNFLWNPDFSKLKNPKVWLAAAGQIFFTLSLGMGIIQNYASYLKKDD----DVVLSGLTAAS 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 352 TSVYAGFVIFSILGFMAS--HLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTA 429
Cdd:cd10333  268 LNEFAEVILGGSIAIPAAfaFLGVAVAIAKAGGFGLGFIALPNVFSQMPGGQFFGFLWFLLLFFAGITSSIAMYQPLIAF 347
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109003585 430 IVDEVGneWILQKKTYVTLGVAvagFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMM 509
Cdd:cd10333  348 LEEELG--ISRKHAAWVVFAIV---FFLGLPVVLEFDLKALDELDFWVGTILLVILGLIEIIVFGWIFGAKKGWEEINRG 422
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 109003585 510 LGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVA----IGFLMALSSVL 568
Cdd:cd10333  423 ALIKVPRFYKYVMKYITPAFLAVVLVFWTISYIPKGYFKMNLIPTVWIarfvIIGLFLFLAFL 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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