BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  13 GSDRLVQLAARLRPA--LCDTLITVGSQQFPAHSLVLAGVSQQLGR------RGQWALGEGISPSTFAQLLHFVYGESVE 84
Cdd:cd18218    1 HSDRLLHLAARLRPAgaLCDTLITVGSQEFPAHSLVLAGASQQLGRqltnpnPGQWCLGEGISPSTFKQLLDFVYGESVE 80

                         90       100
                 ....*....|....*....|....*....
gi 109124388  85 LQPGELRPLEEAARALGVQSLEEACWRAR 113
Cdd:cd18218   81 VQPGELRPLLEAARALEVESLEEACWRAL 109

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 109124388 373 YACSVCGKRFSLKHQMETHYR--VHTGE--KPFSC--SLCPQRSRDFSAMTKHLRTH 423
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  13 GSDRLVQLAARLRPA--LCDTLITVGSQQFPAHSLVLAGVSQQLGR------RGQWALGEGISPSTFAQLLHFVYGESVE 84
Cdd:cd18218    1 HSDRLLHLAARLRPAgaLCDTLITVGSQEFPAHSLVLAGASQQLGRqltnpnPGQWCLGEGISPSTFKQLLDFVYGESVE 80

                         90       100
                 ....*....|....*....|....*....
gi 109124388  85 LQPGELRPLEEAARALGVQSLEEACWRAR 113
Cdd:cd18218   81 VQPGELRPLLEAARALEVESLEEACWRAL 109

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388    30 DTLITVGSQQFPAHSLVLAGVSQ-----QLGRRGQWALGE----GISPSTFAQLLHFVYGESVELQPGELRPLEEAARAL 100
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPyfkalFSSDFKESDKSEiyldDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 109124388   101 GVQSLEEACWRARADR 116
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 109124388   373 YACSVCGKRFSLKHQMETHYRVH 395
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 109124388   428 YRCPLCGAGCPSVASMQAHMRGH 450
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  13 GSDRLVQLAARLRPA--LCDTLITVGSQQFPAHSLVLAGVSQQLGR------RGQWALGEGISPSTFAQLLHFVYGESVE 84
Cdd:cd18218    1 HSDRLLHLAARLRPAgaLCDTLITVGSQEFPAHSLVLAGASQQLGRqltnpnPGQWCLGEGISPSTFKQLLDFVYGESVE 80

                         90       100
                 ....*....|....*....|....*....
gi 109124388  85 LQPGELRPLEEAARALGVQSLEEACWRAR 113
Cdd:cd18218   81 VQPGELRPLLEAARALEVESLEEACWRAL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVSQQL----GRRGQWALGEGISPSTFAQLLHFVYGESVELQPGELRPLEEAAR 98
Cdd:cd18205   13 RLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFeilfHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAE 92

                         90
                 ....*....|...
gi 109124388  99 ALGVQSLEEACWR 111
Cdd:cd18205   93 ILEIEYLEEQCLK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVS------------QQLGRRGQWALgEGISPSTFAQLLHFVYGESVELQPGEL 90
Cdd:cd18245    9 REEPHLCDATLVVGGEEIPVQKNVLAAASpyfraklnynppKDDGSTYKIEL-EGISVEVMEEILDYIYTGQIKLSEDNI 87

                         90
                 ....*....|....*....
gi 109124388  91 RPLEEAARALGVQSLEEAC 109
Cdd:cd18245   88 QDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  28 LCDTLITVGSQQFPAHSLVLAGVSQQLGRRGQW--------ALGEGISPSTFAQLLHFVYGESVELQPGELRPLEEAARA 99
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGqtdgdlviTLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                         90
                 ....*....|.
gi 109124388 100 LGVQSLEEACW 110
Cdd:cd18955   81 LGVHNIEKACF 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVS----QQLGRRGQWALGE-----GISPSTFAQLLHFVYGESVEL-QPGELRP 92
Cdd:cd18223   13 RIQGILCDVTIVVEDTKFKAHKNVLAASSlyfkNAFSSQEIWISSHvlelpDLKAEVFAEILNFIYSSKVVVkRQETVTD 92

                         90
                 ....*....|....
gi 109124388  93 LEEAARALGVQSLE 106
Cdd:cd18223   93 LVAAGKKLGITFLE 106

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  30 DTLITVGSQQFPAHSLVLAGVSQQLGR--RGQWALG-------EGISPSTFAQLLHFVYGESVELqPGELRPLEEAARA- 99
Cdd:cd18286   19 DITIKVDGKTFKAHRCILCARSSYFAAmlSGSWAESnsseitlTGVSHAAVSFVLLFIYGGVLDL-PDDVNLGELLSLAd 97

                         90
                 ....*....|
gi 109124388 100 -LGVQSLEEA 108
Cdd:cd18286   98 mYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  28 LCDTLITVGSQQFPAHSLVLAGVSQQLGRRGQWALGEG---------ISPSTFAQLLHFVYGESVELQPGELRPLEEAAR 98
Cdd:cd18238   15 LCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESkqdsitikdIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAAS 94

                         90
                 ....*....|.
gi 109124388  99 ALGVQSLEEAC 109
Cdd:cd18238   95 LLQVEEVAKAC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  28 LCDTLITVGSQQFPAHSLVLAGVSQQL--------GRRGQWALG-EGISPSTFAQLLHFVYGESVELQPGELRPLEEAAR 98
Cdd:cd18306   18 FCDVILQVGGHEIPAHRAVLACASPYLfelfssdsDGESILTVKlDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAK 97

                         90
                 ....*....|.
gi 109124388  99 ALGVQSLEEAC 109
Cdd:cd18306   98 KLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVSQQLgrRGQWALGE----GIS----PSTFAQLLHFVYGESVELQPGELRPLE 94
Cdd:cd18222   20 RMQGRLCDIVVNVQGQSFRAHKVVLAASSPYF--RDHMSLNEmstvSISviknPTVFEQLLSFCYTGRICLQLADIISYL 97

                         90
                 ....*....|....*
gi 109124388  95 EAARALGVQSLEEAC 109
Cdd:cd18222   98 TAASFLQMQHIIDKC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  28 LCDTLITVGSQQFPAHSLVLAGVSQQLG---------RRGQWALGEGISPSTFAQLLHFVYGESVELQPGELRPLEEAAR 98
Cdd:cd18336   19 LCDVLLIAGNLKIPAHRLVLSAVSDYFAamftndvreAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAAC 98

                         90
                 ....*....|.
gi 109124388  99 ALGVQSLEEAC 109
Cdd:cd18336   99 LLQLSQVIDVC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVSQQLGRR--GQW------ALGEGISPSTFAQLLHFVYGESVELQPGELRPLE 94
Cdd:cd18277   22 RKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRivGQAdaelniTLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVC 101

                         90
                 ....*....|....*..
gi 109124388  95 EAARALGVQSLEEACWR 111
Cdd:cd18277  102 KCVEFLSVHNIEESCFQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  19 QLAARLRPA-----LCDTLITVGSQQFPAHSLVLAGVS---------QQLGRRGQWAL-GEGISPSTFAQLLHFVYGESV 83
Cdd:cd18956    9 RLLGRLRQQrelgfLCDCTVLVGDARFPAHRAVLAACSvyfhlfyrdRPAGGRDTVRLnGDIVTAPAFGRLLDFMYEGRL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 109124388  84 ELQPGELRPLEEAARALGVQSLEEACwrarADRAKEPDPVLKK 126
Cdd:cd18956   89 DLRSLPVEDVLAAASYLHMYDIVKVC----KGRLREKDPALPR 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  28 LCDTLITVGSQQFPAHSLVLAGVSQQLG---------RRGQWALGEGISPSTFAQLLHFVYGESVELQPGELRPLEEAAR 98
Cdd:cd18335   19 LCDVILIAGNRKIPAHRLVLSAVSDYFAamftsdvceAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAAC 98

                         90
                 ....*....|.
gi 109124388  99 ALGVQSLEEAC 109
Cdd:cd18335   99 LLQLSQVVEVC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  12 YGSDRLVQL-AARLRPALCDTLITVGSQQFPAHSLVLAGVSQQLGRRGQWALGEGIS------PSTFAQLLHFVYGESVE 84
Cdd:cd18220    8 YSNTVLSQLnELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSisviknPNVFEQLLSFCYTGRMS 87

                         90       100
                 ....*....|....*....|....*
gi 109124388  85 LQPGELRPLEEAARALGVQSLEEAC 109
Cdd:cd18220   88 LQLKDVVSFLTAASFLQMQCVIDKC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388   6 IRLPSP-YGSDRLVQL-AARLRPALCDTLITVGSQQFPAHSLVLAGVSQ---QLGRRGQWALGEGI------SPSTFAQL 74
Cdd:cd18326    1 IGIPFPdHSSDILSSLnEQRTQGLLCDVVILVEGREFPTHRSVLAACSQyfkKLFTSGAVVDQQNVyeidfvSAEALTAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 109124388  75 LHFVYGESVELQPGELRPLEEAARALGVQSLEEAC 109
Cdd:cd18326   81 LDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  15 DRLVQlaARL-RPALCDTLITVGSQQ--FPAHSLVLAGVSQ----------QLgRRGQWALgEGISPSTFAQLLHFVYGE 81
Cdd:cd18231    2 DRLNE--QRLfQPDLCDVDIVLVRQRstFPAHKGVLAAYSQffhslftqnkQL-QRVELSL-EALTSQGLQQILNFIYTS 77

                         90       100
                 ....*....|....*....|....*...
gi 109124388  82 SVELQPGELRPLEEAARALGVQSLEEAC 109
Cdd:cd18231   78 KLLVNSCNVQDVLNAAAVLQMNDIAASC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  14 SDRLVQLAA-RLRPALCDTLITVGSQQFPAHSLVLAGVSQ--------QLGRR-GQWALGEGISPSTFAQLLHFVYGESV 83
Cdd:cd18215    4 SDVLLNLNRlRSRDILTDVVLVVGREQFRAHKTVLMACSGlfysiftdQLKNNvSVINLDPEIEPEGFRILLDFMYTSRL 83

                         90       100
                 ....*....|....*....|....*...
gi 109124388  84 ELQPGELRPLEEAARALGVQSLEEACWR 111
Cdd:cd18215   84 NLREGNIMAVMATAMYLQMEHVVDTCRK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388   6 IRLPSPYGSDRLVQL--AARLRPALCDTLITVGSQQFPAHSLVLAGVSQQL--------GRRGQWALGEG--------IS 67
Cdd:cd18327    1 IGIPFPEHSSELLSClnEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFrklftgggGGSGDLGAGGGqdvceldfVG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 109124388  68 PSTFAQLLHFVYGESVELQPGELRPLEEAARALGVQSLEEAC 109
Cdd:cd18327   81 PEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADAC 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  28 LCDTLITVGSQQFPAHSLVLAGVSQ--------QLGRRGQWALG-EGISPSTFAQLLHFVYGESVELQPGELRPLEEAAR 98
Cdd:cd18265   23 FTDVVLLVDGKDFPCHRATLSANSAyframfggHLKESRQAVVEiQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASD 102

                         90
                 ....*....|.
gi 109124388  99 ALGVQSLEEAC 109
Cdd:cd18265  103 LLQVSKLREAC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVSQQL--GRRGQW------ALGEGISPSTFAQLLHFVYGESVELQPGELRPLE 94
Cdd:cd18278   26 RKQDILCDVTLIVEGKEFRAHRAVLAACSEYFlqALVGQTendlvvSLPEEVTARGFGPLLQFAYTAKLLLSRENIQEVI 105

                         90
                 ....*....|....*..
gi 109124388  95 EAARALGVQSLEEACWR 111
Cdd:cd18278  106 RCAEFLRMHNLEDSCFR 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388   6 IRLPSP-YGSDRLVQLAARLRPAL-CDTLITVGSQQFPAHSLVLAGVSQ---QLGRRGQWALGEGI------SPSTFAQL 74
Cdd:cd18328    1 IGIPFPnHSSEVLCSLNEQRHDGLlCDVVLIVQDQEYRTHRSVLAACSKyfkKLFTAGTLADQPYVyeidfvTPEALSAI 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 109124388  75 LHFVYGESVELQPGELRPLEEAARALGVQSLEEAC 109
Cdd:cd18328   81 LEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  30 DTLITVGSQQFPAHSLVLAGVSQQLGRRGQWALGE---------GISPSTFAQLLHFVYGESVELQPGELRPLEEAARAL 100
Cdd:cd18250   23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELREsradrvvlhGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102

                 ....*....
gi 109124388 101 GVQSLEEAC 109
Cdd:cd18250  103 QFPSVKEAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  11 PYGSDRLVQ--LAARLRPALCDTLITVGSQQFPAHSLVLAGVS--------QQLGRRGQWAL-GEGISPSTFAQLLHFVY 79
Cdd:cd18323    4 PDHSRHLLQslREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSpffhmfykEQLDKRDLVCInNEIVTAPAFSLLLEFMY 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 109124388  80 GESVELQPGELRPLEEAARALGVQSLEEACWRARADRA 117
Cdd:cd18323   84 EGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQARA 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVS---------QQLGRRGQWALGEGISPSTFAQLLHFVYGESVELQPGELRPL 93
Cdd:cd18246   34 RQRGLLCDIVLHVGTKEIKAHKVVLASCSpyfhamftnEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTL 113

                         90
                 ....*....|....*.
gi 109124388  94 EEAARALGVQSLEEAC 109
Cdd:cd18246  114 LPAASLLQLNGVRDAC 129

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 109124388  373 YACSVCGKRFSLKHQMETHYRVH 395
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 109124388  29 CDTLITVGSQQFPAHSLVLAGVS-----QQLGRRGQWALGE----GISPSTFAQLLHFVYGES 82
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSpvfrsMLFGPMREENEGEivieDVEPPVFKALLHFIYKDE 77

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 109124388   373 YACSVCGKRFSLKHQMETHYRVH 395
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109124388  23 RLRPALCDTLITVGSQQFPAHSLVLAGVSQQLGRRGQWALGE---------GISPSTFAQLLHFVYGESVELQPGELRPL 93
Cdd:cd18235   16 RKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSEsranrvtlqDVDGKALLLLIDYVYTAEIQVTEENVQVL 95

                         90
                 ....*....|....*.
gi 109124388  94 EEAARALGVQSLEEAC 109
Cdd:cd18235   96 LPAANLLQLTDVRDAC 111