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Conserved domains on  [gi|967505822|ref|XP_001097027|]
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ankyrin repeat and SOCS box protein 12 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-218 2.13e-23

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.33  E-value: 2.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822   5 LQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYkrfINSRSGWGvpGTPLRLAASYG 84
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  85 HLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAE 164
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967505822 165 ANVKAKLPVWasniascsgPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA 218
Cdd:COG0666  212 VNAKDNDGKT---------ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 276-315 7.30e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


:

Pssm-ID: 462192  Cd Length: 39  Bit Score: 45.23  E-value: 7.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967505822  276 TPRSLLSQARLVIRRALCQAGqPQAINQLDIPPMLISYLK 315
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-218 2.13e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.33  E-value: 2.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822   5 LQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYkrfINSRSGWGvpGTPLRLAASYG 84
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  85 HLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAE 164
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967505822 165 ANVKAKLPVWasniascsgPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA 218
Cdd:COG0666  212 VNAKDNDGKT---------ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-168 5.54e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 5.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822   77 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEagACPGGSIYNNCSPVLTAARDGAVAILQ 156
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 967505822  157 ELLGHGAEANVK 168
Cdd:pfam12796  79 LLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-229 1.42e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.36  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACP----GGSIynncspVLTAARDG 150
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISdphaAGDL------LCTAAKRN 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967505822 151 AVAILQELLGHGAEANVKAKLPVWAsniascsgpLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLlarvpRPRTLLEI 229
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGADVDKANTDDDF-----SPTELREL 698
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 276-315 7.30e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 45.23  E-value: 7.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967505822  276 TPRSLLSQARLVIRRALCQAGqPQAINQLDIPPMLISYLK 315
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 276-317 1.53e-05

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 41.30  E-value: 1.53e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 967505822 276 TPRSLLSQARLVIRRALCQAGqPQAINQLDIPPMLISYLKHQ 317
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRR-LDLIDKLPLPPRLKDYLLYK 41
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 278-317 3.53e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 37.39  E-value: 3.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 967505822   278 RSLLSQARLVIRRALCQagqpqaINQLDIPPMLISYLKHQ 317
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG------IDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 184-209 1.66e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|....*.
gi 967505822   184 PLYLAAVYGHLDCFRLLLLHGADPDY 209
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-218 2.13e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.33  E-value: 2.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822   5 LQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYkrfINSRSGWGvpGTPLRLAASYG 84
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  85 HLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAE 164
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967505822 165 ANVKAKLPVWasniascsgPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA 218
Cdd:COG0666  212 VNAKDNDGKT---------ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
75-275 2.72e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 2.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAI 154
Cdd:COG0666   56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 155 LQELLGHGAEANVKAKlpvwasniaSCSGPLYLAAVYGHLDCFRLLLLHGADPDynctdqgllARVPRPRTLLEICLHHN 234
Cdd:COG0666  136 VKLLLEAGADVNAQDN---------DGNTPLHLAAANGNLEIVKLLLEAGADVN---------ARDNDGETPLHLAAENG 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 967505822 235 CePEYIQLLIDFGANIYLpslsldltsQDDKGIALLLQARA 275
Cdd:COG0666  198 H-LEIVKLLLEAGADVNA---------KDNDGKTALDLAAE 228
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-168 5.54e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 5.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822   77 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEagACPGGSIYNNCSPVLTAARDGAVAILQ 156
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 967505822  157 ELLGHGAEANVK 168
Cdd:pfam12796  79 LLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-229 1.42e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.36  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACP----GGSIynncspVLTAARDG 150
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISdphaAGDL------LCTAAKRN 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967505822 151 AVAILQELLGHGAEANVKAKLPVWAsniascsgpLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLlarvpRPRTLLEI 229
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGADVDKANTDDDF-----SPTELREL 698
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
64-170 3.07e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 3.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  64 INSRSGWGvpGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPV 143
Cdd:COG0666  179 VNARDNDG--ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256

                         90       100
                 ....*....|....*....|....*..
gi 967505822 144 LTAARDGAVAILQELLGHGAEANVKAK 170
Cdd:COG0666  257 LLAAAAGAALIVKLLLLALLLLAAALL 283
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-258 5.97e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.62  E-value: 5.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  39 LNQAVYDNDSYTLDQLLRQERYKRFINSRSGwgvpGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 118
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDG----MTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGD 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 119 LDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAEANVKAKLPvwasniasCSGPLYLAAVYGHLDCFR 198
Cdd:PHA02875 148 IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG--------CVAALCYAIENNKIDIVR 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967505822 199 LLLLHGADPDYNCTDQGllarvpRPRTLLEICLHH--NCEPEYIQLLI-DFGANIYLPSLSLD 258
Cdd:PHA02875 220 LFIKRGADCNIMFMIEG------EECTILDMICNMctNLESEAIDALIaDIAIRIHKKTIRRD 276
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 89-211 1.66e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.44  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  89 LQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAEANVK 168
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 967505822 169 AklpvwaSNIAScsgPLYLAAVYGHLDCFRLLLLHGADPDYNC 211
Cdd:PHA02874 187 D------NNGES---PLHNAAEYGDYACIKLLIDHGNHIMNKC 220
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 79-223 3.52e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.60  E-value: 3.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  79 LAASyGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQEL 158
Cdd:PTZ00322  89 LAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967505822 159 LGHGAEanvkaklpvwASNIASCSGPLYLAAVYGHLDCFRLLLLHgadPDYnctdqgllARVPRP 223
Cdd:PTZ00322 168 SRHSQC----------HFELGANAKPDSFTGKPPSLEDSPISSHH---PDF--------SAVPQP 211
Ank_4 pfam13637
Ankyrin repeats (many copies);
75-126 4.81e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 4.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 967505822   75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL 126
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 75-250 2.91e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.07  E-value: 2.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGH-LSCLQVLLAHGADVDSLDVKAQTPLFTAVS-HGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAV 152
Cdd:PHA02876 309 TPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 153 AILQELLGHGAEANVKAKLPVWASNIASCSGPLYLAAvyghldcfRLLLLHGAdpDYNCTDQGLlarvprpRTLLEICLH 232
Cdd:PHA02876 389 VIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSV--------KTLIDRGA--NVNSKNKDL-------STPLHYACK 451

                        170
                 ....*....|....*...
gi 967505822 233 HNCEPEYIQLLIDFGANI 250
Cdd:PHA02876 452 KNCKLDVIEMLLDNGADV 469
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 107-250 5.44e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 5.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 107 QTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAEANVKA----------------- 169
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpdieselhdaveegdvk 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 170 ------KLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGL---LARVPRPRTLLEICLHHN---- 234
Cdd:PHA02875  83 aveellDLGKFADDVFYKDGmtPLHLATILKKLDIMKLLIARGADPDIPNTDKFSplhLAVMMGDIKGIELLIDHKacld 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 967505822 235 ------CEP----------EYIQLLIDFGANI 250
Cdd:PHA02875 163 iedccgCTPliiamakgdiAICKMLLDSGANI 194
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 89-251 7.24e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 7.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  89 LQVLLAHGADVDSLDVKAQTPLFTAVSH--GHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAV--AILQELLGHGAE 164
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVD 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 165 ANVKAKL--------PVWASNIASCSgPLYLAAVYGHLDCFRLLLLHGADPDYnCTDQGLlarvprprTLLEICLhHNCE 236
Cdd:PHA03100 169 INAKNRVnyllsygvPINIKDVYGFT-PLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGD--------TPLHIAI-LNNN 237

                        170
                 ....*....|....*
gi 967505822 237 PEYIQLLIDFGANIY 251
Cdd:PHA03100 238 KEIFKLLLNNGPSIK 252
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 75-170 3.65e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 3.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAI 154
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90
                 ....*....|....*.
gi 967505822 155 LQELLGHGAEANVKAK 170
Cdd:PHA02874 206 IKLLIDHGNHIMNKCK 221
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-240 4.09e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGG-SIYNNCSPVLTAARDGAVA 153
Cdd:PHA02878 170 TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHISVGYCKDYD 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 154 ILQELLGHGAEANVKaklpvwaSNIASCSgPLYLAavYGHLDCFRLLLLHGADPD-YNCTDQGLLARVPRPRTLLEIC-- 230
Cdd:PHA02878 250 ILKLLLEHGVDVNAK-------SYILGLT-ALHSS--IKSERKLKLLLEYGADINsLNSYKLTPLSSAVKQYLCINIGri 319

                        170
                 ....*....|.
gi 967505822 231 -LHHNCEPEYI 240
Cdd:PHA02878 320 lISNICLLKRI 330
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 276-315 7.30e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 45.23  E-value: 7.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967505822  276 TPRSLLSQARLVIRRALCQAGqPQAINQLDIPPMLISYLK 315
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 75-249 1.26e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGA--DVDSLDVKaqTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNN-CSPVLTAARDGA 151
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIE--SELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 152 VAILQELLGHGAEANVKAK-------LPVWA---------------SNIASCSG--PLYLAAVYGHLDCFRLLLLHGADP 207
Cdd:PHA02875 115 LDIMKLLIARGADPDIPNTdkfsplhLAVMMgdikgiellidhkacLDIEDCCGctPLIIAMAKGDIAICKMLLDSGANI 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 967505822 208 DYnctdqglLARvpRPRTLLEICLHHNCEPEYIQLLIDFGAN 249
Cdd:PHA02875 195 DY-------FGK--NGCVAALCYAIENNKIDIVRLFIKRGAD 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 89-250 6.98e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.18  E-value: 6.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  89 LQVLLAHGADVDSLDV-KAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAEANV 167
Cdd:PHA02878 150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 168 KAKlpvwasniasC-SGPLYLAAVY-GHLDCFRLLLLHGADPDYNCTDQGLlarvprprTLLEICLHhncEPEYIQLLID 245
Cdd:PHA02878 230 RDK----------CgNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGL--------TALHSSIK---SERKLKLLLE 288


                 ....*
gi 967505822 246 FGANI 250
Cdd:PHA02878 289 YGADI 293
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 75-160 9.97e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 9.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL-------EAGAC------PGGSIYNNCS 141
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGANakpdsfTGKPPSLEDS 196

                         90
                 ....*....|....*....
gi 967505822 142 PVLTAARDGAvAILQELLG 160
Cdd:PTZ00322 197 PISSHHPDFS-AVPQPMMG 214
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 276-317 1.53e-05

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 41.30  E-value: 1.53e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 967505822 276 TPRSLLSQARLVIRRALCQAGqPQAINQLDIPPMLISYLKHQ 317
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRR-LDLIDKLPLPPRLKDYLLYK 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-167 2.37e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 2.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 967505822  92 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELLGHGAEANV 167
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-266 2.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  92 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVA-----ILQELLGHGAEAN 166
Cdd:PHA03100  21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 167 VKaklpvwasNIASCSgPLYLAAVY--GHLDCFRLLLLHGADpdynctdqgLLARVPRPRTLLEICLHHNC-EPEYIQLL 243
Cdd:PHA03100 101 AP--------DNNGIT-PLLYAISKksNSYSIVEYLLDNGAN---------VNIKNSDGENLLHLYLESNKiDLKILKLL 162

                        170       180       190
                 ....*....|....*....|....*....|
gi 967505822 244 IDFGANI-------YLPSLSLDLTSQDDKG 266
Cdd:PHA03100 163 IDKGVDInaknrvnYLLSYGVPINIKDVYG 192
Ank_4 pfam13637
Ankyrin repeats (many copies);
108-159 2.80e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 2.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 967505822  108 TPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAARDGAVAILQELL 159
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 275-317 7.05e-05

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 39.40  E-value: 7.05e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 967505822 275 ATPRSLLSQARLVIRRALCQAgQPQAINQLDIPPMLISYLKHQ 317
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRR-RLELIKKLPLPPRLKDYLLYE 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 92-251 1.69e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822  92 LLAHGADVDSLDVKAQTPLFTAVSHGHLDC---VRVLLEAGACPGGSIYNNCSPVLTAARDGAVA-ILQELLGHGAEANV 167
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGADVNA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967505822 168 KAKLpvwASNIAScsgpLYLAAVYGHLDCFRLLLLHGADP----DYNCTDQGLLARvprprtlleiclHHNCEPEYIQLL 243
Cdd:PHA03095 113 KDKV---GRTPLH----VYLSGFNINPKVIRLLLRKGADVnaldLYGMTPLAVLLK------------SRNANVELLRLL 173


                 ....*...
gi 967505822 244 IDFGANIY 251
Cdd:PHA03095 174 IDAGADVY 181
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 278-317 3.53e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 37.39  E-value: 3.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 967505822   278 RSLLSQARLVIRRALCQagqpqaINQLDIPPMLISYLKHQ 317
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG------IDKLPLPPRLKDYLLYY 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-103 1.01e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.79  E-value: 1.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 967505822   38 ALNQAVYDNDSYTLDQLLRQERYKRFINSRsgwgvpgTPLRLAASYGHLSCLQVLLAHGADVDSLD 103
Cdd:pfam12796  33 ALHLAAKNGHLEIVKLLLEHADVNLKDNGR-------TALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 75-148 1.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 1.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967505822  75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGACPGGSIYNNCSPVLTAAR 148
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 184-209 1.66e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|....*.
gi 967505822   184 PLYLAAVYGHLDCFRLLLLHGADPDY 209
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 75-103 2.90e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 967505822   75 TPLRLAA-SYGHLSCLQVLLAHGADVDSLD 103
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-130 2.96e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 2.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967505822   92 LLAHG-ADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA 130
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV 40
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 108-130 3.75e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.75e-03
                           10        20
                   ....*....|....*....|...
gi 967505822   108 TPLFTAVSHGHLDCVRVLLEAGA 130
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGA 26
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 75-100 3.90e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.90e-03
                           10        20
                   ....*....|....*....|....*.
gi 967505822    75 TPLRLAASYGHLSCLQVLLAHGADVD 100
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
64-110 7.12e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.24  E-value: 7.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 967505822   64 INSRSGWGVpgTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPL 110
Cdd:pfam13857   9 LNRLDGEGY--TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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