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Conserved domains on  [gi|109114292|ref|XP_001095325|]
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homeobox protein DLX-3 [Macaca mulatta]

Protein Classification

homeobox domain-containing protein( domain architecture ID 13781299)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
130-186 2.02e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.65  E-value: 2.02e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 109114292  130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKK 186
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 27-107 2.38e-20

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


:

Pssm-ID: 463567  Cd Length: 83  Bit Score: 82.87  E-value: 2.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109114292   27 KDSPTLPESSVTDLGYYSAPQHDYY---SGQPYGQTVNPYTYhhqFNLNGLAGTGAYSPKS-EYTYGASYRQYGAY-REQ 101
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYgscAGQPYGQPLNSYQY---FNLNGMNGTGAYSTKAyEYGYNTSYRQYGAYgRSQ 77


                  ....*.
gi 109114292  102 PLPAQD 107
Cdd:pfam12413  78 SPPPQD 83
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
109-232 2.50e-12

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.61  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109114292 109 VSVKEEPEAEVRMVNGKPKKVRKprtiySSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLY 188
Cdd:COG5576   36 DSEMKLERKQDGSSPPKSKRRRT-----TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 109114292 189 KnGEVPLEHSPNNSDSMACNSPPSPAL--WDTSSHSTPAPARSQLP 232
Cdd:COG5576  111 S-GKVEQRPGEEEADLAKIGSLSTGQIsiIETLEFSRTSYEEGGLQ 155
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
130-186 2.02e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.65  E-value: 2.02e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 109114292  130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKK 186
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 130-185 7.41e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.54  E-value: 7.41e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 109114292   130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFK 185
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 130-186 6.72e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 88.84  E-value: 6.72e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 109114292 130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKK 186
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 27-107 2.38e-20

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


Pssm-ID: 463567  Cd Length: 83  Bit Score: 82.87  E-value: 2.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109114292   27 KDSPTLPESSVTDLGYYSAPQHDYY---SGQPYGQTVNPYTYhhqFNLNGLAGTGAYSPKS-EYTYGASYRQYGAY-REQ 101
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYgscAGQPYGQPLNSYQY---FNLNGMNGTGAYSTKAyEYGYNTSYRQYGAYgRSQ 77


                  ....*.
gi 109114292  102 PLPAQD 107
Cdd:pfam12413  78 SPPPQD 83
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
109-232 2.50e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.61  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109114292 109 VSVKEEPEAEVRMVNGKPKKVRKprtiySSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLY 188
Cdd:COG5576   36 DSEMKLERKQDGSSPPKSKRRRT-----TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 109114292 189 KnGEVPLEHSPNNSDSMACNSPPSPAL--WDTSSHSTPAPARSQLP 232
Cdd:COG5576  111 S-GKVEQRPGEEEADLAKIGSLSTGQIsiIETLEFSRTSYEEGGLQ 155
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
130-186 2.02e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.65  E-value: 2.02e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 109114292  130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKK 186
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 130-185 7.41e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.54  E-value: 7.41e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 109114292   130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFK 185
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 130-186 6.72e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 88.84  E-value: 6.72e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 109114292 130 RKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKK 186
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 27-107 2.38e-20

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


Pssm-ID: 463567  Cd Length: 83  Bit Score: 82.87  E-value: 2.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109114292   27 KDSPTLPESSVTDLGYYSAPQHDYY---SGQPYGQTVNPYTYhhqFNLNGLAGTGAYSPKS-EYTYGASYRQYGAY-REQ 101
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYgscAGQPYGQPLNSYQY---FNLNGMNGTGAYSTKAyEYGYNTSYRQYGAYgRSQ 77


                  ....*.
gi 109114292  102 PLPAQD 107
Cdd:pfam12413  78 SPPPQD 83
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
109-232 2.50e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.61  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109114292 109 VSVKEEPEAEVRMVNGKPKKVRKprtiySSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLY 188
Cdd:COG5576   36 DSEMKLERKQDGSSPPKSKRRRT-----TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 109114292 189 KnGEVPLEHSPNNSDSMACNSPPSPAL--WDTSSHSTPAPARSQLP 232
Cdd:COG5576  111 S-GKVEQRPGEEEADLAKIGSLSTGQIsiIETLEFSRTSYEEGGLQ 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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