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Conserved domains on  [gi|966979281|ref|XP_001094705|]
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integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1 [Macaca mulatta]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 10065450)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722|GO:0006470|GO:0046872
PubMed:  9192069|8819174
SCOP:  3000909

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
108-390 2.58e-92

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


:

Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 277.67  E-value: 2.58e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 108 KGYVAERKGEREEMQDAHVILNDITEEcrppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISvEKTV 187
Cdd:cd00143    2 SAGVSDKGGDRKTNEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 188 KRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEE 267
Cdd:cd00143   72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCR------NGEAVQLTKDHKPVNEEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 268 RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347
Cdd:cd00143  146 RERIEKAGGRVSNGRVPGVLAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAK 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966979281 348 EKIQtregksavdaryeAACNRLANKAVQRGSADNVTVMVVRI 390
Cdd:cd00143  225 EDLQ-------------EAAQELVDLALRRGSHDNITVVVVRL 254
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
108-390 2.58e-92

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 277.67  E-value: 2.58e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 108 KGYVAERKGEREEMQDAHVILNDITEEcrppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISvEKTV 187
Cdd:cd00143    2 SAGVSDKGGDRKTNEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 188 KRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEE 267
Cdd:cd00143   72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCR------NGEAVQLTKDHKPVNEEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 268 RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347
Cdd:cd00143  146 RERIEKAGGRVSNGRVPGVLAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAK 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966979281 348 EKIQtregksavdaryeAACNRLANKAVQRGSADNVTVMVVRI 390
Cdd:cd00143  225 EDLQ-------------EAAQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
97-388 5.57e-83

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 253.84  E-value: 5.57e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281    97 VCKASSVIFGLkgyvAERKGEREEMQDAHVILNDiteecrppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFP 176
Cdd:smart00332   3 SGKNLGLRYGL----SSMQGVRKPMEDAHVITPD----------LSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELI 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281   177 KGDviSVEKTVKRCLLDTFKHTDEEFLkqassQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSL 256
Cdd:smart00332  69 KEK--DELEDVEEALRKAFLSTDEEIL-----EELEALSGSTAVVALISGNKLYVANVGDSRAVLCRNGK------AVQL 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281   257 SKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEE 336
Cdd:smart00332 136 TEDHKPSNEDERARIEAAGGFVINGRVNGVLALSRAIGDFFLK-PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQE 214
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 966979281   337 AVNFILSCLEDEkiqtregksavdarYEAACNRLANKAVQRGSADNVTVMVV 388
Cdd:smart00332 215 VVDIVRKHLSKD--------------PKEAAKRLIDLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
113-383 1.28e-65

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 209.11  E-value: 1.28e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281  113 ERKGEREEMQDAHVILNDITEECRPPSslitrVSYFAVFDGHGGIRASKFAAQNLHQNLIRK--FPKGDVisvektVKRC 190
Cdd:pfam00481   7 RMQGWRKSMEDAHIDLPNLNSSSGKDS-----WSFFAVFDGHGGSEAAKYCGKHLHTILALRrsFLEGEK------LEDA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281  191 LLDTF-KHTDEEFlkqASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesQKHAALSLSKEHNPTQYEERM 269
Cdd:pfam00481  76 LRKSFlEDTDEVL---RSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCR-----NGNAIKRLTKDHKPSDEDERR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281  270 RIQKAGGNV-RDGRVLGVLEVSRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLE 346
Cdd:pfam00481 148 RIRAAGGFVsRNGRVNGVLAVSRAFGDFELKPgeQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDLVRSELS 227
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 966979281  347 DEKIQTRegksavdaryeaACNRLANKAVQRGSADNV 383
Cdd:pfam00481 228 DGGSPME------------AAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
116-390 3.84e-42

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 151.85  E-value: 3.84e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 116 GEREEMQDAHVILnditeecrppssLITRVSYFAVFDGHGGIRASKFAAQNLHQnLIRKFPKgdvisvektvkrclldtf 195
Cdd:PTZ00224  31 GYRESMEDAHLLY------------LTDDWGFFGVFDGHVNDECSQYLARAWPQ-ALEKEPE------------------ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 196 KHTDEEFLKQASSQKPAWKD-----GSTAT-CVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERM 269
Cdd:PTZ00224  80 PMTDERMEELCLEIDEEWMDsgregGSTGTfCVIMKDVHLQVGNVGDSRVLVCR------DGKLVFATEDHKPNNPGERQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 270 RIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDrFILLACDGLFK-VFTPEEAVNF 340
Cdd:PTZ00224 154 RIEACGGRVVSNRVDGDLAVSRAFGDRSFKVKGtgdyleqkVIAVPDVTHLTCQSND-FIILACDGVFEgNFSNEEVVAF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 966979281 341 IlscledekiqtREGKSAVDARYEAACnRLANKAVQRGSADNVTVMVVRI 390
Cdd:PTZ00224 233 V-----------KEQLETCDDLAVVAG-RVCDEAIRRGSKDNISCLIVQL 270
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
118-391 5.05e-23

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 96.82  E-value: 5.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 118 REEMQDAHVILNDiteecrPPSSLitrvsyFAVFDGHGGIR----ASKFAAQNLHQNLIRKFPKGdvisvEKTVKRCLLD 193
Cdd:COG0631   13 RENNEDAFLVALD------PGGGL------FVVADGMGGHAagevASRLAVETLAELFQEALAPD-----PEDLEEALRE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 194 TFKHTDEEfLKQASSQKPAWKD-GSTATCVLAVDNILYIANLGDSRAILCRYNEESQkhaalsLSKEHNPTQYEERM-RI 271
Cdd:COG0631   76 AIRAANRA-ILELAQEDPELAGmGTTLVAALIAGGRLYIAHVGDSRAYLLRDGELEQ------LTRDHSLVQELVDAgRI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 272 QKAGGNVRDGRvlGVLevSRSIGDGQykrcgvTSVPDIRRCQLTPNDRFiLLACDGLFKVFTPEEavnfILSCLedekiq 351
Cdd:COG0631  149 TPEEARTHPQR--NVL--TRALGTDD------DVEPDISPLELEPGDRL-LLCSDGLTDMVSDEE----IAEIL------ 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966979281 352 tREGKSAvdaryEAACNRLANKAVQRGSADNVTVMVVRIG 391
Cdd:COG0631  208 -ASAGDP-----QEAAEALIELALEAGGPDNITVVLVRVE 241
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
108-390 2.58e-92

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 277.67  E-value: 2.58e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 108 KGYVAERKGEREEMQDAHVILNDITEEcrppsslitRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISvEKTV 187
Cdd:cd00143    2 SAGVSDKGGDRKTNEDAVVIKPNLNNE---------DGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLS-EEDI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 188 KRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEE 267
Cdd:cd00143   72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCR------NGEAVQLTKDHKPVNEEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 268 RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347
Cdd:cd00143  146 RERIEKAGGRVSNGRVPGVLAVTRALGDFDLK-PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSELAK 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966979281 348 EKIQtregksavdaryeAACNRLANKAVQRGSADNVTVMVVRI 390
Cdd:cd00143  225 EDLQ-------------EAAQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
97-388 5.57e-83

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 253.84  E-value: 5.57e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281    97 VCKASSVIFGLkgyvAERKGEREEMQDAHVILNDiteecrppssLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFP 176
Cdd:smart00332   3 SGKNLGLRYGL----SSMQGVRKPMEDAHVITPD----------LSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELI 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281   177 KGDviSVEKTVKRCLLDTFKHTDEEFLkqassQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEesqkhaALSL 256
Cdd:smart00332  69 KEK--DELEDVEEALRKAFLSTDEEIL-----EELEALSGSTAVVALISGNKLYVANVGDSRAVLCRNGK------AVQL 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281   257 SKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEE 336
Cdd:smart00332 136 TEDHKPSNEDERARIEAAGGFVINGRVNGVLALSRAIGDFFLK-PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQE 214
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 966979281   337 AVNFILSCLEDEkiqtregksavdarYEAACNRLANKAVQRGSADNVTVMVV 388
Cdd:smart00332 215 VVDIVRKHLSKD--------------PKEAAKRLIDLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
113-383 1.28e-65

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 209.11  E-value: 1.28e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281  113 ERKGEREEMQDAHVILNDITEECRPPSslitrVSYFAVFDGHGGIRASKFAAQNLHQNLIRK--FPKGDVisvektVKRC 190
Cdd:pfam00481   7 RMQGWRKSMEDAHIDLPNLNSSSGKDS-----WSFFAVFDGHGGSEAAKYCGKHLHTILALRrsFLEGEK------LEDA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281  191 LLDTF-KHTDEEFlkqASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesQKHAALSLSKEHNPTQYEERM 269
Cdd:pfam00481  76 LRKSFlEDTDEVL---RSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCR-----NGNAIKRLTKDHKPSDEDERR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281  270 RIQKAGGNV-RDGRVLGVLEVSRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLE 346
Cdd:pfam00481 148 RIRAAGGFVsRNGRVNGVLAVSRAFGDFELKPgeQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDLVRSELS 227
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 966979281  347 DEKIQTRegksavdaryeaACNRLANKAVQRGSADNV 383
Cdd:pfam00481 228 DGGSPME------------AAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
116-390 3.84e-42

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 151.85  E-value: 3.84e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 116 GEREEMQDAHVILnditeecrppssLITRVSYFAVFDGHGGIRASKFAAQNLHQnLIRKFPKgdvisvektvkrclldtf 195
Cdd:PTZ00224  31 GYRESMEDAHLLY------------LTDDWGFFGVFDGHVNDECSQYLARAWPQ-ALEKEPE------------------ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 196 KHTDEEFLKQASSQKPAWKD-----GSTAT-CVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERM 269
Cdd:PTZ00224  80 PMTDERMEELCLEIDEEWMDsgregGSTGTfCVIMKDVHLQVGNVGDSRVLVCR------DGKLVFATEDHKPNNPGERQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 270 RIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDrFILLACDGLFK-VFTPEEAVNF 340
Cdd:PTZ00224 154 RIEACGGRVVSNRVDGDLAVSRAFGDRSFKVKGtgdyleqkVIAVPDVTHLTCQSND-FIILACDGVFEgNFSNEEVVAF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 966979281 341 IlscledekiqtREGKSAVDARYEAACnRLANKAVQRGSADNVTVMVVRI 390
Cdd:PTZ00224 233 V-----------KEQLETCDDLAVVAG-RVCDEAIRRGSKDNISCLIVQL 270
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
116-388 7.25e-38

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 140.05  E-value: 7.25e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 116 GEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLI--RKFPKgdvisvekTVKRCLLD 193
Cdd:PLN03145  74 GSRSSMEDVYICVDNFMSDFGLKNSEDGPSAFYGVFDGHGGKHAADFACYHLPRFIVedEDFPR--------EIEKVVSS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 194 TFKHTDEEFLKqASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRyneesqKHAALSLSKEHNPTQYEERMRIQK 273
Cdd:PLN03145 146 AFLQTDTAFAE-ACSLDASLASGTTALAALVVGRSLVVANAGDCRAVLCR------RGKAIEMSRDHKPMCSKERKRIEA 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 274 AGGNVRDGRVLGVLEVSRSIGDGQY-----KRCG-VTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347
Cdd:PLN03145 219 SGGYVYDGYLNGQLNVARALGDWHMegmkgSDGGpLSAEPELMTTQLTEEDEFLIIGCDGIWDVFRSQNAVDFARRRLQE 298
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966979281 348 EKIQTregksavdaryeAACNRLANKAVQRGSADNVTVMVV 388
Cdd:PLN03145 299 HNDPV------------MCSKELVDEALKRKSGDNLAVVVV 327
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
118-391 5.05e-23

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 96.82  E-value: 5.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 118 REEMQDAHVILNDiteecrPPSSLitrvsyFAVFDGHGGIR----ASKFAAQNLHQNLIRKFPKGdvisvEKTVKRCLLD 193
Cdd:COG0631   13 RENNEDAFLVALD------PGGGL------FVVADGMGGHAagevASRLAVETLAELFQEALAPD-----PEDLEEALRE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 194 TFKHTDEEfLKQASSQKPAWKD-GSTATCVLAVDNILYIANLGDSRAILCRYNEESQkhaalsLSKEHNPTQYEERM-RI 271
Cdd:COG0631   76 AIRAANRA-ILELAQEDPELAGmGTTLVAALIAGGRLYIAHVGDSRAYLLRDGELEQ------LTRDHSLVQELVDAgRI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979281 272 QKAGGNVRDGRvlGVLevSRSIGDGQykrcgvTSVPDIRRCQLTPNDRFiLLACDGLFKVFTPEEavnfILSCLedekiq 351
Cdd:COG0631  149 TPEEARTHPQR--NVL--TRALGTDD------DVEPDISPLELEPGDRL-LLCSDGLTDMVSDEE----IAEIL------ 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966979281 352 tREGKSAvdaryEAACNRLANKAVQRGSADNVTVMVVRIG 391
Cdd:COG0631  208 -ASAGDP-----QEAAEALIELALEAGGPDNITVVLVRVE 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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