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Conserved domains on  [gi|109019837|ref|XP_001093900|]
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kynurenine 3-monooxygenase [Macaca mulatta]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11428987)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 7-364 8.61e-43

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 153.56  E-value: 8.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   7 QRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRvadfTRGRSInlALSHRGRQALKAVGLEDQIVSQGIPMRARM 86
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPR----PDGRGI--ALSPRSLELLRRLGLWDRLLARGAPIRGIR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  87 IH-SLSGKK-SAVPYG-TKSQYILSVSRENLNKDLLTAAEKnPGVKMHFNHKLLKCNPEEGMITVLGSDKvpKDVTCDLI 163
Cdd:COG0654   76 VRdGSDGRVlARFDAAeTGLPAGLVVPRADLERALLEAARA-LGVELRFGTEVTGLEQDADGVTVTLADG--RTLRADLV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 164 VGCDGAYSTVRSHLMKKPR-FDYSQQyiphgymeltippkngdyamepnylhiwprntfMMIAlpnmsksftctlfmpfd 242
Cdd:COG0654  153 VGADGARSAVRRLLGIGFTgRDYPQR---------------------------------ALWA----------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 243 efdklltsnDVIDFFQKYFPDAIPLIGEKLLVQDFFLLpaqPMISVKCSSFHfQSHCVLLGDAAHAIVPFFGQGMNAGFE 322
Cdd:COG0654  183 ---------GVRTELRARLAAAGPRLGELLELSPRSAF---PLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANLALR 249

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 109019837 323 DCLVFDELMDKFNNDLSLC--LPAFSRLRIPDSHAISDLSMYNY 364
Cdd:COG0654  250 DAAALAWKLAAALRGRDDEaaLARYERERRPRAARVQRAADALG 293
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 7-364 8.61e-43

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 153.56  E-value: 8.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   7 QRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRvadfTRGRSInlALSHRGRQALKAVGLEDQIVSQGIPMRARM 86
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPR----PDGRGI--ALSPRSLELLRRLGLWDRLLARGAPIRGIR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  87 IH-SLSGKK-SAVPYG-TKSQYILSVSRENLNKDLLTAAEKnPGVKMHFNHKLLKCNPEEGMITVLGSDKvpKDVTCDLI 163
Cdd:COG0654   76 VRdGSDGRVlARFDAAeTGLPAGLVVPRADLERALLEAARA-LGVELRFGTEVTGLEQDADGVTVTLADG--RTLRADLV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 164 VGCDGAYSTVRSHLMKKPR-FDYSQQyiphgymeltippkngdyamepnylhiwprntfMMIAlpnmsksftctlfmpfd 242
Cdd:COG0654  153 VGADGARSAVRRLLGIGFTgRDYPQR---------------------------------ALWA----------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 243 efdklltsnDVIDFFQKYFPDAIPLIGEKLLVQDFFLLpaqPMISVKCSSFHfQSHCVLLGDAAHAIVPFFGQGMNAGFE 322
Cdd:COG0654  183 ---------GVRTELRARLAAAGPRLGELLELSPRSAF---PLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANLALR 249

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 109019837 323 DCLVFDELMDKFNNDLSLC--LPAFSRLRIPDSHAISDLSMYNY 364
Cdd:COG0654  250 DAAALAWKLAAALRGRDDEaaLARYERERRPRAARVQRAADALG 293
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 11-356 6.85e-21

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 93.81  E-value: 6.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   11 VAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRVAD-FTRGRSInlALSHRGRQALKAVGLEDQIVsqgiPMRARMIHS 89
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEATPLPAPADpGFDNRVS--ALSAASIRLLEKLGVWDKIE----PARAQPIRD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   90 L----SGKKSAV-----PYGTKS-QYIlsVSRENLNKDLLTAAEKNPGVKMHFNHKL--LKCNPEEGMITvLGSDKVpkd 157
Cdd:TIGR01988  76 IhvsdGGSFGALrfdadEIGLEAlGYV--VENRVLQQALWERLQELPNVTLLCPARVveLPRHSDHVELT-LDDGQQ--- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  158 VTCDLIVGCDGAYSTVRSHL-MKKPRFDYSQqyipHGY---MELTIPPKNgdYAMEpnylHIWPRNTFMMIALP--NMSK 231
Cdd:TIGR01988 150 LRARLLVGADGANSKVRQLAgIPTTGWDYGQ----SAVvanVKHERPHQG--TAWE----RFTPTGPLALLPLPdnRSSL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  232 SFTCT-------LFMPFDEFDKLLTSNdvidfFQKYFPdAIPLIGEKLLVQDFFLLPAQpmisvkcssfHFQSHCVLLGD 304
Cdd:TIGR01988 220 VWTLPpeeaerlLALSDEEFLAELQRA-----FGSRLG-AITLVGERHAFPLSLTHAKR----------YVAPRLALIGD 283

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 109019837  305 AAHAIVPFFGQGMNAGFED------CLVFDELMDKFNNDLSLcLPAFSRLRIPDSHAI 356
Cdd:TIGR01988 284 AAHTIHPLAGQGLNLGLRDvaalaeVLEDARRRGEDIGSLRV-LQRYERRRRFDNAAM 340
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 10-323 5.16e-17

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 81.99  E-value: 5.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   10 KVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPrvADFTRGRSINlalsHRGRQALKAVGLEDQIVSQGIPmRARMIHS 89
Cdd:pfam01494   3 DVLIVGGGPAGLMLALLLARAGVRVVLVERHATT--SVLPRAHGLN----QRTMELLRQAGLEDRILAEGVP-HEGMGLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   90 LSGKKSAVPYG--TKSQYILSVSRENLNKDLLTAAEKNpGVKMHFNHKLLKCNPEEGMIT---VLGSDKVPKDVTCDLIV 164
Cdd:pfam01494  76 FYNTRRRADLDflTSPPRVTVYPQTELEPILVEHAEAR-GAQVRFGTEVLSLEQDGDGVTavvRDRRDGEEYTVRAKYLV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  165 GCDGAYSTVRSHLmkkpRFDY-SQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNT----FMMIALPNMSKS---FTCT 236
Cdd:pfam01494 155 GCDGGRSPVRKTL----GIEFeGFEGVPFGSLDVLFDAPDLSDPVERAFVHYLIYAPhsrgFMVGPWRSAGREryyVQVP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  237 LFMPFDEfdkllTSNDVIDffQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFQShcVLL-GDAAHAIVPFFGQ 315
Cdd:pfam01494 231 WDEEVEE-----RPEEFTD--EELKQRLRSIVGIDLALVEILWKSIWGVASRVATRYRKGR--VFLaGDAAHIHPPTGGQ 301


                  ....*...
gi 109019837  316 GMNAGFED 323
Cdd:pfam01494 302 GLNTAIQD 309
PRK07364 PRK07364
FAD-dependent hydroxylase;
11-323 6.72e-13

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 70.05  E-value: 6.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  11 VAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRVAdfTRGRSinLALSHRGRQALKAVGLEDQIVSQGIPMRaRMIHSL 90
Cdd:PRK07364  21 VAIVGGGIVGLTLAAALKDSGLRIALIEAQPAEAAA--AKGQA--YALSLLSARIFEGIGVWEKILPQIGKFR-QIRLSD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  91 SGKKSAVPYGT---KSQYILSVSREN-LNKDLLTAAEKNPGVKMHFNHKLLKCNPEEGMITV-LGSDKVPKDVTCDLIVG 165
Cdd:PRK07364  96 ADYPGVVKFQPtdlGTEALGYVGEHQvLLEALQEFLQSCPNITWLCPAEVVSVEYQQDAATVtLEIEGKQQTLQSKLVVA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 166 CDGAYSTVRSHLMKKPR-FDYSQQYIphgymELTIPPK--NGDYAMEpnylHIWPRNTFMMIALPNMSKSFTCTlfMPFD 242
Cdd:PRK07364 176 ADGARSPIRQAAGIKTKgWKYWQSCV-----TATVKHEapHNDIAYE----RFWPSGPFAILPLPGNRCQIVWT--APHA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 243 EFDKL--LTSNDVIDFFQKYFPDaipLIGEKLLVQDFFLLPAQPMISVKcssfHFQSHCVLLGDAAHAIVPFFGQGMNAG 320
Cdd:PRK07364 245 QAKALlaLPEAEFLAELQQRYGD---QLGKLELLGDRFLFPVQLMQSDR----YVQHRLALVGDAAHCCHPVGGQGLNLG 317


                 ...
gi 109019837 321 FED 323
Cdd:PRK07364 318 IRD 320
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 7-364 8.61e-43

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 153.56  E-value: 8.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   7 QRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRvadfTRGRSInlALSHRGRQALKAVGLEDQIVSQGIPMRARM 86
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPR----PDGRGI--ALSPRSLELLRRLGLWDRLLARGAPIRGIR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  87 IH-SLSGKK-SAVPYG-TKSQYILSVSRENLNKDLLTAAEKnPGVKMHFNHKLLKCNPEEGMITVLGSDKvpKDVTCDLI 163
Cdd:COG0654   76 VRdGSDGRVlARFDAAeTGLPAGLVVPRADLERALLEAARA-LGVELRFGTEVTGLEQDADGVTVTLADG--RTLRADLV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 164 VGCDGAYSTVRSHLMKKPR-FDYSQQyiphgymeltippkngdyamepnylhiwprntfMMIAlpnmsksftctlfmpfd 242
Cdd:COG0654  153 VGADGARSAVRRLLGIGFTgRDYPQR---------------------------------ALWA----------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 243 efdklltsnDVIDFFQKYFPDAIPLIGEKLLVQDFFLLpaqPMISVKCSSFHfQSHCVLLGDAAHAIVPFFGQGMNAGFE 322
Cdd:COG0654  183 ---------GVRTELRARLAAAGPRLGELLELSPRSAF---PLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANLALR 249

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 109019837 323 DCLVFDELMDKFNNDLSLC--LPAFSRLRIPDSHAISDLSMYNY 364
Cdd:COG0654  250 DAAALAWKLAAALRGRDDEaaLARYERERRPRAARVQRAADALG 293
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 11-356 6.85e-21

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 93.81  E-value: 6.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   11 VAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRVAD-FTRGRSInlALSHRGRQALKAVGLEDQIVsqgiPMRARMIHS 89
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEATPLPAPADpGFDNRVS--ALSAASIRLLEKLGVWDKIE----PARAQPIRD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   90 L----SGKKSAV-----PYGTKS-QYIlsVSRENLNKDLLTAAEKNPGVKMHFNHKL--LKCNPEEGMITvLGSDKVpkd 157
Cdd:TIGR01988  76 IhvsdGGSFGALrfdadEIGLEAlGYV--VENRVLQQALWERLQELPNVTLLCPARVveLPRHSDHVELT-LDDGQQ--- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  158 VTCDLIVGCDGAYSTVRSHL-MKKPRFDYSQqyipHGY---MELTIPPKNgdYAMEpnylHIWPRNTFMMIALP--NMSK 231
Cdd:TIGR01988 150 LRARLLVGADGANSKVRQLAgIPTTGWDYGQ----SAVvanVKHERPHQG--TAWE----RFTPTGPLALLPLPdnRSSL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  232 SFTCT-------LFMPFDEFDKLLTSNdvidfFQKYFPdAIPLIGEKLLVQDFFLLPAQpmisvkcssfHFQSHCVLLGD 304
Cdd:TIGR01988 220 VWTLPpeeaerlLALSDEEFLAELQRA-----FGSRLG-AITLVGERHAFPLSLTHAKR----------YVAPRLALIGD 283

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 109019837  305 AAHAIVPFFGQGMNAGFED------CLVFDELMDKFNNDLSLcLPAFSRLRIPDSHAI 356
Cdd:TIGR01988 284 AAHTIHPLAGQGLNLGLRDvaalaeVLEDARRRGEDIGSLRV-LQRYERRRRFDNAAM 340
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
16-216 9.94e-19

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 86.17  E-value: 9.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  16 GGLVGSLQACFLAKRNFQIDVYEAREDPR---VADftrgrsinlALSHRGRQALKAVGLEDQIVSqgiPMRARMIHSLSG 92
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGSFPGdkiCGG---------GLLPRALEELEPLGLDEPLER---PVRGARFYSPGG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  93 KKSAVPYGTKSQYIlsVSRENLNKDLLTAAEKNpGVKMHFNHKLLKCNPEEGMITVLGSDkvPKDVTCDLIVGCDGAYST 172
Cdd:COG0644   69 KSVELPPGRGGGYV--VDRARFDRWLAEQAEEA-GAEVRTGTRVTDVLRDDGRVVVRTGD--GEEIRADYVVDADGARSL 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 109019837 173 VRSHLMKKPRFDYSQQYIpHGYMELTIPPKNGDYamEPNYLHIW 216
Cdd:COG0644  144 LARKLGLKRRSDEPQDYA-LAIKEHWELPPLEGV--DPGAVEFF 184
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 10-323 5.16e-17

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 81.99  E-value: 5.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   10 KVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPrvADFTRGRSINlalsHRGRQALKAVGLEDQIVSQGIPmRARMIHS 89
Cdd:pfam01494   3 DVLIVGGGPAGLMLALLLARAGVRVVLVERHATT--SVLPRAHGLN----QRTMELLRQAGLEDRILAEGVP-HEGMGLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   90 LSGKKSAVPYG--TKSQYILSVSRENLNKDLLTAAEKNpGVKMHFNHKLLKCNPEEGMIT---VLGSDKVPKDVTCDLIV 164
Cdd:pfam01494  76 FYNTRRRADLDflTSPPRVTVYPQTELEPILVEHAEAR-GAQVRFGTEVLSLEQDGDGVTavvRDRRDGEEYTVRAKYLV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  165 GCDGAYSTVRSHLmkkpRFDY-SQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNT----FMMIALPNMSKS---FTCT 236
Cdd:pfam01494 155 GCDGGRSPVRKTL----GIEFeGFEGVPFGSLDVLFDAPDLSDPVERAFVHYLIYAPhsrgFMVGPWRSAGREryyVQVP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  237 LFMPFDEfdkllTSNDVIDffQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFQShcVLL-GDAAHAIVPFFGQ 315
Cdd:pfam01494 231 WDEEVEE-----RPEEFTD--EELKQRLRSIVGIDLALVEILWKSIWGVASRVATRYRKGR--VFLaGDAAHIHPPTGGQ 301


                  ....*...
gi 109019837  316 GMNAGFED 323
Cdd:pfam01494 302 GLNTAIQD 309
PRK07364 PRK07364
FAD-dependent hydroxylase;
11-323 6.72e-13

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 70.05  E-value: 6.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  11 VAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRVAdfTRGRSinLALSHRGRQALKAVGLEDQIVSQGIPMRaRMIHSL 90
Cdd:PRK07364  21 VAIVGGGIVGLTLAAALKDSGLRIALIEAQPAEAAA--AKGQA--YALSLLSARIFEGIGVWEKILPQIGKFR-QIRLSD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  91 SGKKSAVPYGT---KSQYILSVSREN-LNKDLLTAAEKNPGVKMHFNHKLLKCNPEEGMITV-LGSDKVPKDVTCDLIVG 165
Cdd:PRK07364  96 ADYPGVVKFQPtdlGTEALGYVGEHQvLLEALQEFLQSCPNITWLCPAEVVSVEYQQDAATVtLEIEGKQQTLQSKLVVA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 166 CDGAYSTVRSHLMKKPR-FDYSQQYIphgymELTIPPK--NGDYAMEpnylHIWPRNTFMMIALPNMSKSFTCTlfMPFD 242
Cdd:PRK07364 176 ADGARSPIRQAAGIKTKgWKYWQSCV-----TATVKHEapHNDIAYE----RFWPSGPFAILPLPGNRCQIVWT--APHA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 243 EFDKL--LTSNDVIDFFQKYFPDaipLIGEKLLVQDFFLLPAQPMISVKcssfHFQSHCVLLGDAAHAIVPFFGQGMNAG 320
Cdd:PRK07364 245 QAKALlaLPEAEFLAELQQRYGD---QLGKLELLGDRFLFPVQLMQSDR----YVQHRLALVGDAAHCCHPVGGQGLNLG 317


                 ...
gi 109019837 321 FED 323
Cdd:PRK07364 318 IRD 320
PRK06847 PRK06847
hypothetical protein; Provisional
 9-360 8.98e-13

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 69.52  E-value: 8.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   9 KKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRVadftRGRSINL---ALshrgrQALKAVGLEDQIVSQGIPMRAR 85
Cdd:PRK06847   5 KKVLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWRV----YGAGITLqgnAL-----RALRELGVLDECLEAGFGFDGV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  86 MIHSLSGKKSA-----------VPYGtksqyiLSVSRENLNKDLLTAAEKNpGVKMHFNHKLLKCNPEEGMITVLGSDKv 154
Cdd:PRK06847  76 DLFDPDGTLLAelptprlagddLPGG------GGIMRPALARILADAARAA-GADVRLGTTVTAIEQDDDGVTVTFSDG- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 155 pKDVTCDLIVGCDGAYSTVRSHLM---KKPRF----------------DYSQQYIP-------------HGYMELTIPPK 202
Cdd:PRK06847 148 -TTGRYDLVVGADGLYSKVRSLVFpdePEPEYtgqgvwravlprpaevDRSLMYLGpttkagvvplsedLMYLFVTEPRP 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 203 nGDYAMEPnylHIWPRntfmmiALPNMSKSFTCTLfmpFDEFDKLLTSNDVIDFfqkyfpdaIPLigEKLLVQdffllpa 282
Cdd:PRK06847 227 -DNPRIEP---DTLAA------LLRELLAPFGGPV---LQELREQITDDAQVVY--------RPL--ETLLVP------- 276

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109019837 283 QPMisvkcssfhFQSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKfNNDLSLCLPAFSRLRIPDSHAISDLS 360
Cdd:PRK06847 277 APW---------HRGRVVLIGDAAHATTPHLAQGAGMAIEDAIVLAEELAR-HDSLEAALQAYYARRWERCRMVVEAS 344
PRK06753 PRK06753
hypothetical protein; Provisional
 10-360 2.30e-12

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 68.18  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  10 KVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRVAdftrGRSINLAlsHRGRQALKAVGLEDQIVSQGIPMRARMIHS 89
Cdd:PRK06753   2 KIAIIGAGIGGLTAAALLQEQGHEVKVFEKNESVKEV----GAGIGIG--DNVIKKLGNHDLAKGIKNAGQILSTMNLLD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  90 LSGK---KSAVPYGTKSqyiLSVSRENLNKDLLTAAEKNpgvKMHFNHKLLKCNPEEGMITVLGSDKVPKDVtcDLIVGC 166
Cdd:PRK06753  76 DKGTllnKVKLKSNTLN---VTLHRQTLIDIIKSYVKED---AIFTGKEVTKIENETDKVTIHFADGESEAF--DLCIGA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 167 DGAYSTVRSHLMKKPRFDYsQQYIPHGYMELTIPPKNGDYAMEpnylhIW-PRNTFMMIALPNMSKS-FTCTLFMPFDEF 244
Cdd:PRK06753 148 DGIHSKVRQSVNADSKVRY-QGYTCFRGLIDDIDLKLPDCAKE-----YWgTKGRFGIVPLLNNQAYwFITINAKERDPK 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 245 DKLLTSNDVIDFFqKYFPDAIPLI-----GEKLLVQDFFLLpaQPMisvkcSSFHFQsHCVLLGDAAHAIVPFFGQGMNA 319
Cdd:PRK06753 222 YSSFGKPHLQAYF-NHYPNEVREIldkqsETGILHHDIYDL--KPL-----KSFVYG-RIVLLGDAAHATTPNMGQGAGQ 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 109019837 320 GFEDCLVfdeLMDKFNN-DLSLCLPAFSRLRIPDSHAISDLS 360
Cdd:PRK06753 293 AMEDAIV---LANCLNAyDFEKALQRYDKIRVKHTAKVIKRS 331
PRK07045 PRK07045
putative monooxygenase; Reviewed
 11-356 7.77e-10

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 60.31  E-value: 7.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  11 VAVIGGGLVGSLQACFLAKRNFQIDVYEaredpRVAdftRGRSINLA--LSHRGRQALKAVGLEDQIVSQGIPMRARM-I 87
Cdd:PRK07045   8 VLINGSGIAGVALAHLLGARGHSVTVVE-----RAA---RNRAQNGAdlLKPSGIGVVRAMGLLDDVFAAGGLRRDAMrL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  88 HSLSGKKSAVPYGTKSQ--YILSVSRENLNKDLLTAAEKNPGVKMHFNHKLLKCNPEE-GMITVL----GSDKVPKdvtc 160
Cdd:PRK07045  80 YHDKELIASLDYRSASAlgYFILIPCEQLRRLLLAKLDGLPNVRLRFETSIERIERDAdGTVTSVtlsdGERVAPT---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 161 dLIVGCDGAYSTVRSHLMKKP--RFDYSQQyIPHGYMELTippkngDYAMEPNYLHIwPRNTFMMIALPNMSKSFTCTLF 238
Cdd:PRK07045 156 -VLVGADGARSMIRDDVLRMPaeRVPYATP-MAFGTIALT------DSVRECNRLYV-DSNQGLAYFYPIGDQATRLVVS 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 239 MPFDEFDKLL---TSNDVIDFFQKYF----PDAIPLIGEKllvQDFFLLPAQPMisvKCSSFHfQSHCVLLGDAAHAIVP 311
Cdd:PRK07045 227 FPADEMQGYLadtTRTKLLARLNEFVgdesADAMAAIGAG---TAFPLIPLGRM---NLDRYH-KRNVVLLGDAAHSIHP 299

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 109019837 312 FFGQGMNAGFEDCLVFDELMDKFNND---LSLCLPAFSRLRIPDSHAI 356
Cdd:PRK07045 300 ITGQGMNLAIEDAGELGACLDLHLSGqiaLADALERFERIRRPVNEAV 347
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 11-323 2.18e-09

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 59.39  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   11 VAVIGGGLVGSLQACFLAK----RNFQIDVYEAREDPRVAD---FTRGRSIN---LALSHRGRQALKAVGLEDQIVSQGI 80
Cdd:TIGR01989   3 VVIVGGGPVGLALAAALGNnpltKDLKVLLLDAVDNPKLKSrnyEKPDGPYSnrvSSITPASISFFKKIGAWDHIQSDRI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   81 PMRARMIHSLSGKKSAVPY--GTKSQYILSVSRENLNKDLLT---AAEKNPGVKMHFNHKLLKC-------NPEEGMITV 148
Cdd:TIGR01989  83 QPFGRMQVWDGCSLALIRFdrDNGKEDMACIIENDNIQNSLYnrlQEYNGDNVKILNPARLISVtipskypNDNSNWVHI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  149 LGSDKvpKDVTCDLIVGCDGAYSTVRSHL-MKKPRFDYSQQYIPhGYMELTIPPKN----------GDYAMEP---NYLH 214
Cdd:TIGR01989 163 TLSDG--QVLYTKLLIGADGSNSNVRKAAnIDTTGWNYNQHAVV-ATLKLEEATENdvawqrflptGPIALLPlpdNNST 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  215 I-W---PRNTFMMIALPnmSKSFTCTLFMPFDEFDKLLTSNDVIDFFQKYFPDAIPLIGEKlLVQDFFLLPAqpMISVKC 290
Cdd:TIGR01989 240 LvWstsPEEALRLLSLP--PEDFVDALNAAFDLGYSDHPYSYLLDYAMEKLNEDIGFRTEG-SKSCFQVPPR--VIGVVD 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 109019837  291 SS---F-----HFQSHC----VLLGDAAHAIVPFFGQGMNAGFED 323
Cdd:TIGR01989 315 KSraaFplglgHADEYVtkrvALVGDAAHRVHPLAGQGVNLGFGD 359
PRK07538 PRK07538
hypothetical protein; Provisional
 10-177 2.81e-09

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 58.75  E-value: 2.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  10 KVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRvadfTRGRSINLaLSHRGRQaLKAVGLEDQIVSQGIPMRARMIHS 89
Cdd:PRK07538   2 KVLIAGGGIGGLTLALTLHQRGIEVVVFEAAPELR----PLGVGINL-LPHAVRE-LAELGLLDALDAIGIRTRELAYFN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  90 LSGKKS-AVPYGTKSQYI---LSVSRENLNKDLLTAAEKNPGV-KMHFNHKLLKCNPEEGMITVL---GSDKVPKDVTCD 161
Cdd:PRK07538  76 RHGQRIwSEPRGLAAGYDwpqYSIHRGELQMLLLDAVRERLGPdAVRTGHRVVGFEQDADVTVVFlgdRAGGDLVSVRGD 155

                        170
                 ....*....|....*.
gi 109019837 162 LIVGCDGAYSTVRSHL 177
Cdd:PRK07538 156 VLIGADGIHSAVRAQL 171
PRK06126 PRK06126
hypothetical protein; Provisional
 8-323 3.79e-09

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 58.85  E-value: 3.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   8 RKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDPRV---ADFTRGRSinlaLSHRGRqalkaVGLEDQIVSQGIPM-- 82
Cdd:PRK06126   7 ETPVLIVGGGPVGLALALDLGRRGVDSILVERKDGTAFnpkANTTSARS----MEHFRR-----LGIADEVRSAGLPVdy 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  83 -------------------------RARMIHSLSGKKSAvpygtkSQYILSVSRENLNKDLLTAAEKNPGVKMHFNHKLL 137
Cdd:PRK06126  78 ptdiayftrltgyelarfrlpsareAITPVGGPDGSWPS------PELPHRIPQKYLEPILLEHAAAQPGVTLRYGHRLT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 138 KCNPEEGMITV----LGSDKvPKDVTCDLIVGCDGAYSTVRSHL-----------------MKKPRFdysQQYIPH--GY 194
Cdd:PRK06126 152 DFEQDADGVTAtvedLDGGE-SLTIRADYLVGCDGARSAVRRSLgisyegtsglqrdlsiyIRAPGL---AALVGHdpAW 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 195 MELTIppkNGDYAMepNYLHIWPRNTFMMIALpnmsksftctlfmPFDEFDKLLTSNDVIDFFQKyfpdaipLIGEKLlv 274
Cdd:PRK06126 228 MYWLF---NPDRRG--VLVAIDGRDEWLFHQL-------------RGGEDEFTIDDVDARAFVRR-------GVGEDI-- 280

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 109019837 275 qDFFLLPAQPMISVKCSSFHFQS-HCVLLGDAAHAIVPFFGQGMNAGFED 323
Cdd:PRK06126 281 -DYEVLSVVPWTGRRLVADSYRRgRVFLAGDAAHLFTPTGGYGMNTGIGD 329
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
11-323 4.13e-09

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 58.38  E-value: 4.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  11 VAVIGGGLVGSLQACFLAKRNFQIDVYEarEDPRVADFTRGRSINlalsHRGRQALKAVGLEDQIVSQGIPMRARMIHSL 90
Cdd:PRK06183  13 VVIVGAGPVGLTLANLLGQYGVRVLVLE--RWPTLYDLPRAVGID----DEALRVLQAIGLADEVLPHTTPNHGMRFLDA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  91 SGK---KSAVPYGTKSQYilsvSREN------LNKDLLTAAEKNPGVKMHFNHKLLKCNPEEGMITVL--GSDKVPKDVT 159
Cdd:PRK06183  87 KGRclaEIARPSTGEFGW----PRRNafhqplLEAVLRAGLARFPHVRVRFGHEVTALTQDDDGVTVTltDADGQRETVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 160 CDLIVGCDGAYSTVRSHlMKKPRFDYSQqyiPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMSKSFtctlfm 239
Cdd:PRK06183 163 ARYVVGCDGANSFVRRT-LGVPFEDLTF---PERWLVVDVLIANDPLGGPHTYQYCDPARPYTSVRLPHGRRRW------ 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 240 pfdEFdKLLTSNDVIDFFQkyfPDAI-PLIGEkllvqdfFLLPAQPMISVKCSSFHFQS---------HCVLLGDAAHAI 309
Cdd:PRK06183 233 ---EF-MLLPGETEEQLAS---PENVwRLLAP-------WGPTPDDAELIRHAVYTFHArvadrwrsgRVLLAGDAAHLM 298

                        330
                 ....*....|....
gi 109019837 310 VPFFGQGMNAGFED 323
Cdd:PRK06183 299 PPFAGQGMNSGIRD 312
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 294-352 1.80e-07

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 53.24  E-value: 1.80e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109019837 294 HFQSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDK--FNNDLSlcLPAFSRLRIPD 352
Cdd:PRK08849 276 YVKNNCVLLGDAAHTINPLAGQGVNLGFKDVDVLLAETEKqgVLNDAS--FARYERRRRPD 334
PRK06475 PRK06475
FAD-binding protein;
13-351 2.95e-06

FAD-binding protein;


Pssm-ID: 180582 [Multi-domain]  Cd Length: 400  Bit Score: 49.44  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  13 VIGGGLVGSLQACFLAKRNFQIDVYEAREDPRvadfTRGRSINL---ALSHRGR----QALKAVGLEDQIVS--QGIPMR 83
Cdd:PRK06475   7 IAGAGVAGLSAALELAARGWAVTIIEKAQELS----EVGAGLQLapnAMRHLERlgvaDRLSGTGVTPKALYlmDGRKAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  84 ARM---IHSLSGKKSAVPYgtksqyiLSVSRENLNKDLLTAAEKNPGVKMHFNHKLLKCNPEEGMITV-LGSDKVPKDVT 159
Cdd:PRK06475  83 PLLamqLGDLARKRWHHPY-------IVCHRADLQSALLDACRNNPGIEIKLGAEMTSQRQTGNSITAtIIRTNSVETVS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 160 CDLIVGCDGAYSTVRShlmKKP--RFDYSQQYIPHGYMELTIPPKNGDYAM-EPNYLHIW--PRNTFmmIALP-NMSKSF 233
Cdd:PRK06475 156 AAYLIACDGVWSMLRA---KAGfsKARFSGHIAWRTTLAADALPASFLSAMpEHKAVSAWlgNKAHF--IAYPvKGGKFF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837 234 TCTLFMPFDEFDKLLTSNDVIDFFQKYFPDAIPLIGEKLLVQDFFllPAQPMISVKCSSFHFQSHCVLLGDAAHAIVPFF 313
Cdd:PRK06475 231 NFVAITGGENPGEVWSKTGDKAHLKSIYADWNKPVLQILAAIDEW--TYWPLFEMADAQFVGPDRTIFLGDASHAVTPFA 308

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 109019837 314 GQGMNAGFEDCLVFDELMDkfNNDLSLCLPAFSRLRIP 351
Cdd:PRK06475 309 AQGAAMAIEDAAALAEALD--SDDQSAGLKRFDSVRKE 344
PRK05732 PRK05732
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 11-187 4.91e-06

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 235584 [Multi-domain]  Cd Length: 395  Bit Score: 48.70  E-value: 4.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  11 VAVIGGGLVGS-----LQAcfLAKRNFQIDVYEARE----DPRVADftrGRSInlALSHRGRQALKAVGLEDQIVSQGIP 81
Cdd:PRK05732   6 VIIVGGGMAGAtlalaLSR--LSHGGLPVALIEAFApesdAHPGFD---ARAI--ALAAGTCQQLARLGVWQALADCATP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837  82 MRArmIH-SLSGKKSAVPYgTKSQYILS-----VSRENLNKDLLTAAEKNPGVKMHFNHKLLKCNPEEGMITV-LGSDKV 154
Cdd:PRK05732  79 ITH--IHvSDRGHAGFVRL-DAEDYGVPalgyvVELHDVGQRLFALLDKAPGVTLHCPARVANVERTQGSVRVtLDDGET 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 109019837 155 pkdVTCDLIVGCDGAYSTVRSHL-MKKPRFDYSQ 187
Cdd:PRK05732 156 ---LTGRLLVAADGSHSALREALgIDWQQHPYEQ 186
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
13-43 1.36e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.90  E-value: 1.36e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 109019837   13 VIGGGLVGSLQACFLAKRNFQIDVYEAREDP 43
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRL 31
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
296-323 6.26e-05

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 44.94  E-value: 6.26e-05
                         10        20
                 ....*....|....*....|....*...
gi 109019837 296 QSHCVLLGDAAHAIVPFFGQGMNAGFED 323
Cdd:PRK07608 279 APRVALVGDAAHLIHPLAGQGMNLGLRD 306
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 3-43 1.92e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 43.68  E-value: 1.92e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 109019837   3 SSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDP 43
Cdd:PRK01747 255 PGSPKARDAAIIGGGIAGAALALALARRGWQVTLYEADEAP 295
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 10-43 6.00e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 42.00  E-value: 6.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 109019837   10 KVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDP 43
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDP 34
PRK08013 PRK08013
oxidoreductase; Provisional
 295-323 6.40e-04

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 41.95  E-value: 6.40e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 109019837 295 FQSH-CVLLGDAAHAIVPFFGQGMNAGFED 323
Cdd:PRK08013 279 FAAHrLALVGDAAHTIHPLAGQGVNLGFMD 308
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 8-40 7.17e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 41.76  E-value: 7.17e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 109019837   8 RKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAR 40
Cdd:COG3349    3 PPRVVVVGGGLAGLAAAVELAEAGFRVTLLEAR 35
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 300-332 7.65e-04

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 41.51  E-value: 7.65e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 109019837 300 VLLGDAAHAIVPFFGQGMNAGFEDClvfDELMD 332
Cdd:PRK08020 284 ALVGDAAHTINPLAGQGVNLGYRDV---DALLD 313
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 301-356 1.11e-03

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 41.35  E-value: 1.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 109019837 301 LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNN------DLSLcLPAFSRLRIPDSHAI 356
Cdd:PRK05714 289 LIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHAAErgerlaDVRV-LSRFERRRMPHNLAL 349
PRK13984 PRK13984
putative oxidoreductase; Provisional
 9-43 2.36e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 40.52  E-value: 2.36e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 109019837   9 KKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDP 43
Cdd:PRK13984 284 KKVAIVGSGPAGLSAAYFLATMGYEVTVYESLSKP 318
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 8-76 2.40e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 40.20  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109019837   8 RKKVAVIGGGLVGsLQACF-LAKRNFQIDVYEAREDP-------RVADFT--RG-RSInLALSHRGRQALKAVGLEDQIV 76
Cdd:COG1232    1 MKRVAVIGGGIAG-LTAAYrLAKAGHEVTVLEASDRVgglirtvEVDGFRidRGpHSF-LTRDPEVLELLRELGLGDELV 78
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
301-323 2.46e-03

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 39.96  E-value: 2.46e-03
                         10        20
                 ....*....|....*....|...
gi 109019837 301 LLGDAAHAIVPFFGQGMNAGFED 323
Cdd:PRK07333 284 LVGDAAHGIHPIAGQGLNLGLKD 306
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
7-41 3.03e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 39.50  E-value: 3.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 109019837   7 QRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEARE 41
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGLDVTVLERGR 35
PRK07233 PRK07233
hypothetical protein; Provisional
 10-43 4.80e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 39.10  E-value: 4.80e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 109019837  10 KVAVIGGGLVGsLQACF-LAKRNFQIDVYEAREDP 43
Cdd:PRK07233   1 KIAIVGGGIAG-LAAAYrLAKRGHEVTVFEADDQL 34
PRK05335 PRK05335
tRNA (uracil-5-)-methyltransferase Gid; Reviewed
 9-40 6.19e-03

tRNA (uracil-5-)-methyltransferase Gid; Reviewed


Pssm-ID: 235416  Cd Length: 436  Bit Score: 38.97  E-value: 6.19e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 109019837   9 KKVAVIGGGLVGSLQACFLAKRNFQIDVYEAR 40
Cdd:PRK05335   3 KPVNVIGAGLAGSEAAWQLAKRGVPVELYEMR 34
TrmFO COG1206
Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and ...
 8-40 7.36e-03

Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and biogenesis]; Folate-dependent tRNA-U54 methylase TrmFO/GidA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440819  Cd Length: 436  Bit Score: 38.50  E-value: 7.36e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 109019837   8 RKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAR 40
Cdd:COG1206    1 MKPVTVIGGGLAGSEAAWQLAERGVPVRLYEMR 33
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 9-43 9.63e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 38.24  E-value: 9.63e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 109019837   9 KKVAVIGGGLVGsLQACF-LAKRNFQIDVYEAREDP 43
Cdd:PRK11749 141 KKVAVIGAGPAG-LTAAHrLARKGYDVTIFEARDKA 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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