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Conserved domains on  [gi|109042277|ref|XP_001091623|]
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alpha-2-HS-glycoprotein [Macaca mulatta]

Protein Classification

CY domain-containing protein( domain architecture ID 11249404)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 7.17e-18

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 77.76  E-value: 7.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277  149 CPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTISGTDCVaKEATEAANCNLLAKKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 109042277  228 GFCKATLNEK 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 3.78e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 59.36  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277    31 NCDDPETEEAALVAVDYINQNLpwGYKHTLNQIDEVKVWPQQPFGEMFEIEIDTLETTCHVLDPTPvAGCRVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 109042277   111 EGDCDFQLLKV--NGKFSVEYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKpwENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 7.17e-18

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 77.76  E-value: 7.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277  149 CPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTISGTDCVaKEATEAANCNLLAKKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 109042277  228 GFCKATLNEK 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 146-248 1.42e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 71.69  E-value: 1.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277   146 CRDCPLLAPLNDTRVVHAAEAAVTAFNAQNNgSNFQLEEISRA---QLVPLPPSTYVEFTISGTDCVaKEATEAANCNLL 222
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 109042277   223 AKKQyGFCKATLNEKLG---GEEVAVTCT 248
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWenkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-247 4.15e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 64.80  E-value: 4.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277 148 DCPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRA--QLVplpPSTYVEFTISGTDCVAKEA---TEAANCNLL 222
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVV---AGTNYYITVEAGDTNCKKSsvpLDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 109042277 223 AKKQYGFCKATLNEKL---GGEEVAVTC 247
Cdd:cd00042   78 EEGKKKFCTAKVWEKPwenFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 3.78e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 59.36  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277    31 NCDDPETEEAALVAVDYINQNLpwGYKHTLNQIDEVKVWPQQPFGEMFEIEIDTLETTCHVLDPTPvAGCRVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 109042277   111 EGDCDFQLLKV--NGKFSVEYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKpwENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-121 4.67e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 47.85  E-value: 4.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277  28 RQPNCDDPETEEAALVAVDYINQNLpwgyKHTLNQIDEVK-----VWPqqpfGEMFEIEIDTLETTCHVLDPTPVagCRV 102
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVLsaksqVVA----GTNYYITVEAGDTNCKKSSVPLD--CPD 73

                         90
                 ....*....|....*....
gi 109042277 103 RQLKEHAVEGDCDFQLLKV 121
Cdd:cd00042   74 CKLLEEGKKKFCTAKVWEK 92
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 7.17e-18

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 77.76  E-value: 7.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277  149 CPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTISGTDCVaKEATEAANCNLLAKKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 109042277  228 GFCKATLNEK 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 146-248 1.42e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 71.69  E-value: 1.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277   146 CRDCPLLAPLNDTRVVHAAEAAVTAFNAQNNgSNFQLEEISRA---QLVPLPPSTYVEFTISGTDCVaKEATEAANCNLL 222
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 109042277   223 AKKQyGFCKATLNEKLG---GEEVAVTCT 248
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWenkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-247 4.15e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 64.80  E-value: 4.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277 148 DCPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRA--QLVplpPSTYVEFTISGTDCVAKEA---TEAANCNLL 222
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVV---AGTNYYITVEAGDTNCKKSsvpLDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 109042277 223 AKKQYGFCKATLNEKL---GGEEVAVTC 247
Cdd:cd00042   78 EEGKKKFCTAKVWEKPwenFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 3.78e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 59.36  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277    31 NCDDPETEEAALVAVDYINQNLpwGYKHTLNQIDEVKVWPQQPFGEMFEIEIDTLETTCHVLDPTPvAGCRVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 109042277   111 EGDCDFQLLKV--NGKFSVEYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKpwENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-121 4.67e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 47.85  E-value: 4.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109042277  28 RQPNCDDPETEEAALVAVDYINQNLpwgyKHTLNQIDEVK-----VWPqqpfGEMFEIEIDTLETTCHVLDPTPVagCRV 102
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVLsaksqVVA----GTNYYITVEAGDTNCKKSSVPLD--CPD 73

                         90
                 ....*....|....*....
gi 109042277 103 RQLKEHAVEGDCDFQLLKV 121
Cdd:cd00042   74 CKLLEEGKKKFCTAKVWEK 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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