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Conserved domains on  [gi|109018062|ref|XP_001091471|]
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Golgi resident protein GCP60 [Macaca mulatta]

Protein Classification

acyl-CoA-binding domain-containing protein( domain architecture ID 10468367)

acyl-CoA-binding domain-containing protein binds acyl-CoA esters and may play a role in housekeeping and/or trafficking

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 397-527 6.05e-80

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


:

Pssm-ID: 464028  Cd Length: 133  Bit Score: 245.85  E-value: 6.05e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109018062  397 VGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVS--ESSDDDEEEEENISSEEKAKKNANKP 474
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSesSDEEDEEEEEENPGDVEAGSVNANKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 109018062  475 LLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 527
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
84-165 2.10e-16

Acyl CoA binding protein;


:

Pssm-ID: 459982  Cd Length: 76  Bit Score: 73.79  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109018062   84 EELYGLALRFFKekdGKAFHSTYEEKLKLVALHKQVLMGPYNPdtcPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK 163
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCNT---PRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 109018062  164 LL 165
Cdd:pfam00887  75 LV 76
 
Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 397-527 6.05e-80

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 464028  Cd Length: 133  Bit Score: 245.85  E-value: 6.05e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109018062  397 VGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVS--ESSDDDEEEEENISSEEKAKKNANKP 474
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSesSDEEDEEEEEENPGDVEAGSVNANKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 109018062  475 LLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 527
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
84-165 2.10e-16

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 73.79  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109018062   84 EELYGLALRFFKekdGKAFHSTYEEKLKLVALHKQVLMGPYNPdtcPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK 163
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCNT---PRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 109018062  164 LL 165
Cdd:pfam00887  75 LV 76
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 107-175 1.42e-08

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 51.94  E-value: 1.42e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109018062 107 EEKLKLVALHKQVLMGPYNPDtCPevGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRcchLFSTY 175
Cdd:cd00435   22 EEKLQLYSLYKQATVGDCNTE-RP--GMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEE---LIAKY 84
 
Name Accession Description Interval E-value
GOLD_2 pfam13897
Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is ...
 397-527 6.05e-80

Golgi-dynamics membrane-trafficking; Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 464028  Cd Length: 133  Bit Score: 245.85  E-value: 6.05e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109018062  397 VGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVS--ESSDDDEEEEENISSEEKAKKNANKP 474
Cdd:pfam13897   1 VGRGEVVTVRVPTHPEGSYLFWEFATDHYDIGFGVYFEWTDPTSTAVSVHVSesSDEEDEEEEEENPGDVEAGSVNANKP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 109018062  475 LLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYT 527
Cdd:pfam13897  81 RLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKTLYYRVYYT 133
ACBP pfam00887
Acyl CoA binding protein;
84-165 2.10e-16

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 73.79  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109018062   84 EELYGLALRFFKekdGKAFHSTYEEKLKLVALHKQVLMGPYNPdtcPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK 163
Cdd:pfam00887   1 EEKFEAAAEFVK---KLKSKPSNEEKLELYGLYKQATVGDCNT---PRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74


                  ..
gi 109018062  164 LL 165
Cdd:pfam00887  75 LV 76
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 107-175 1.42e-08

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 51.94  E-value: 1.42e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109018062 107 EEKLKLVALHKQVLMGPYNPDtCPevGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRcchLFSTY 175
Cdd:cd00435   22 EEKLQLYSLYKQATVGDCNTE-RP--GMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEE---LIAKY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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