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Conserved domains on  [gi|1622969170|ref|XP_001086432|]
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sperm protein associated with the nucleus on the X chromosome N2-like [Macaca mulatta]

Protein Classification

SPAN-X domain-containing protein( domain architecture ID 10538540)

SPAN-X domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-93 7.78e-34

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


:

Pssm-ID: 400025  Cd Length: 94  Bit Score: 114.64  E-value: 7.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170   1 MERPTSSTNGEKMKSPCESNNKkNDEMQEAPNRVLAPKQSFQKAKTVEYLTVIVYYYRKGKKINSNQLENDQSQENSINP 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNA-NDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINP 79

                          90
                  ....*....|...
gi 1622969170  81 GQEEEDEDLDSSE 93
Cdd:pfam07458  80 LQMEEEEFMEIRE 92
CobT2 super family cl34772
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 83-167 1.25e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG4547:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 44.01  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170  83 EEEDEDLDSSELSSQEDEDLYSSEISSQEDEDLDSSEGSSQgyedlDSFEISSQEDEDlfsSEISSQEDEDPDLSEGSSQ 162
Cdd:COG4547   209 EELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEA-----EDAEASGDDAEE---GESEAAEAESDEMAEEAEG 280


                  ....*
gi 1622969170 163 EGEED 167
Cdd:COG4547   281 EDSEE 285
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-93 7.78e-34

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 114.64  E-value: 7.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170   1 MERPTSSTNGEKMKSPCESNNKkNDEMQEAPNRVLAPKQSFQKAKTVEYLTVIVYYYRKGKKINSNQLENDQSQENSINP 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNA-NDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINP 79

                          90
                  ....*....|...
gi 1622969170  81 GQEEEDEDLDSSE 93
Cdd:pfam07458  80 LQMEEEEFMEIRE 92
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 83-167 1.25e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 44.01  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170  83 EEEDEDLDSSELSSQEDEDLYSSEISSQEDEDLDSSEGSSQgyedlDSFEISSQEDEDlfsSEISSQEDEDPDLSEGSSQ 162
Cdd:COG4547   209 EELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEA-----EDAEASGDDAEE---GESEAAEAESDEMAEEAEG 280


                  ....*
gi 1622969170 163 EGEED 167
Cdd:COG4547   281 EDSEE 285
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-93 7.78e-34

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 114.64  E-value: 7.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170   1 MERPTSSTNGEKMKSPCESNNKkNDEMQEAPNRVLAPKQSFQKAKTVEYLTVIVYYYRKGKKINSNQLENDQSQENSINP 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNA-NDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINP 79

                          90
                  ....*....|...
gi 1622969170  81 GQEEEDEDLDSSE 93
Cdd:pfam07458  80 LQMEEEEFMEIRE 92
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 83-167 1.25e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 44.01  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170  83 EEEDEDLDSSELSSQEDEDLYSSEISSQEDEDLDSSEGSSQgyedlDSFEISSQEDEDlfsSEISSQEDEDPDLSEGSSQ 162
Cdd:COG4547   209 EELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEA-----EDAEASGDDAEE---GESEAAEAESDEMAEEAEG 280


                  ....*
gi 1622969170 163 EGEED 167
Cdd:COG4547   281 EDSEE 285
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 67-165 4.58e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 39.39  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969170  67 QLENDQSQENsinpgQEEEDEDLDSSELSSQEDEDLYSSEISSQEDEDLDSSEGSSQgyedldsfeisSQEDEDLFSSEI 146
Cdd:COG4547   206 DLAEELGEDE-----DEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGD-----------DAEEGESEAAEA 269

                          90
                  ....*....|....*....
gi 1622969170 147 SSQEDEDPDLSEGSSQEGE 165
Cdd:COG4547   270 ESDEMAEEAEGEDSEEPGE 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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