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Conserved domains on  [gi|1622942259|ref|XP_001085019|]
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LRP2-binding protein [Macaca mulatta]

Protein Classification

SEL1-like repeat protein( domain architecture ID 11434924)

SEL1-like repeat family protein may function as an adaptor protein for the assembly of macromolecular complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  16870393
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
41-256 3.76e-33

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 123.11  E-value: 3.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  41 ANLVDKALQLLKKRILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIEEKDHQATYQLGVMYYDGLGTILNSEKGVDYMKK 120
Cdd:COG0790    13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 121 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 198
Cdd:COG0790    93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622942259 199 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYK 256
Cdd:COG0790   162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 298-332 3.51e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.84  E-value: 3.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622942259  298 AMASFYHARCLQLGLGITRDEATAKHYYSKACRLN 332
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
41-256 3.76e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 123.11  E-value: 3.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  41 ANLVDKALQLLKKRILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIEEKDHQATYQLGVMYYDGLGTILNSEKGVDYMKK 120
Cdd:COG0790    13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 121 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 198
Cdd:COG0790    93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622942259 199 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYK 256
Cdd:COG0790   162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 209-243 1.28e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.78  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622942259  209 ESQGALGLMYLYGQGIRQDTEAALHCLREAAERGN 243
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 209-242 6.02e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.81  E-value: 6.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622942259 209 ESQGALGLMYLYGQGIRQDTEAALHCLREAAERG 242
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 37-241 2.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  37 HYSHANLVDKALQLLKKRILK--GDTLAYFLRGQLYFEEGWYEEALEQFE---EIEEKDHQATYQLGVMYYDGlgtiLNS 111
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKqpDNASLHNLLGAIYLGKGDLAKAREAFEkalSIEPDFFPAAANLARIDIQE----GNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 112 EKGVDYMKKIL-DSPCPKARHLKFAAAYNlgrayyegkgvKRSNEEAERLWLFAADNGNPKASVKAQSMLGLYYSTKEPK 190
Cdd:TIGR02917 516 DDAIQRFEKVLtIDPKNLRAILALAGLYL-----------RTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLK 584

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622942259 191 E----LEKAFYWHSEacgngNLESQGALGLMYLyGQGirqDTEAALHCLREAAER 241
Cdd:TIGR02917 585 KalaiLNEAADAAPD-----SPEAWLMLGRAQL-AAG---DLNKAVSSFKKLLAL 630
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 298-332 3.51e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.84  E-value: 3.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622942259  298 AMASFYHARCLQLGLGITRDEATAKHYYSKACRLN 332
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
41-256 3.76e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 123.11  E-value: 3.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  41 ANLVDKALQLLKKRILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIEEKDHQATYQLGVMYYDGLGTILNSEKGVDYMKK 120
Cdd:COG0790    13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 121 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 198
Cdd:COG0790    93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622942259 199 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYK 256
Cdd:COG0790   162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
135-331 9.08e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 111.56  E-value: 9.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 135 AAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQG 212
Cdd:COG0790    64 EAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQY 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 213 ALGLMYLYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYKMKF----FTKCVAFSKRIADydevhdipmiaqvtdc 288
Cdd:COG0790   140 NLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGvpkdPAKALEWYRKAAE---------------- 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1622942259 289 lpefisRGMAMASFYHARCLQLGLGITRDEATAKHYYSKACRL 331
Cdd:COG0790   204 ------QGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
45-241 5.00e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 109.63  E-value: 5.00e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  45 DKALQLLKKRILKGDTLAYFLRGQLYfEEGW-----YEEALEQFEEIEEKDH-QATYQLGVMYYDGLGTILNSEKGVDYM 118
Cdd:COG0790    48 AAAAAAAAAAAAAGGAEAQYNLGLMY-AEGRgvpkdYEKALEWFEKAAEQGDaEAQYNLGLMYEEGLGVPQDYAKALEWY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 119 KKildspcpKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAF 196
Cdd:COG0790   127 EK-------AAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA----QYNLGVLYENGRgvPKDPAKAL 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1622942259 197 YWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALHCLREAAER 241
Cdd:COG0790   196 EWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
135-336 4.15e-18

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 82.28  E-value: 4.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 135 AAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQG 212
Cdd:COG0790    28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEA----QYNLGLMYAEGRgvPKDYEKALEWFEKAAEQGDAEAQY 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 213 ALGLMYLYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYKMKF----FTKCVAFSKRIADydevhdipmiaqvtdc 288
Cdd:COG0790   104 NLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGvpkdPAKAAEWYRKAAE---------------- 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622942259 289 lpefisRGMAMASFYHARCLQLGLGITRDEATAKHYYSKACRLNPALA 336
Cdd:COG0790   168 ------QGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADA 209
TPR COG0790
TPR repeat [General function prediction only];
157-336 1.60e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 63.41  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 157 AERLWLFAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALHCLR 236
Cdd:COG0790    12 AAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 237 EAAERGNVYAQGNLVEYYYK----MKFFTKCVAFSKRIADydevhdipmiaqvtdclpefisRGMAMASFYHARCLQLGL 312
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEglgvPQDYAKALEWYEKAAE----------------------QGDADAQYNLGLLYLNGE 149

                         170       180
                  ....*....|....*....|....
gi 1622942259 313 GITRDEATAKHYYSKACRLNPALA 336
Cdd:COG0790   150 GVPKDPAKAAEWYRKAAEQGDADA 173
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 209-243 1.28e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.78  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622942259  209 ESQGALGLMYLYGQGIRQDTEAALHCLREAAERGN 243
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 136-169 4.54e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 4.54e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622942259  136 AAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGN 169
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 209-242 6.02e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.81  E-value: 6.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622942259 209 ESQGALGLMYLYGQGIRQDTEAALHCLREAAERG 242
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 45-257 1.67e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  45 DKALQLLKKrILKGD---TLAYFLRGQLYFEEGWYEEALEQFEEIEEKDHQ---ATYQLGVMYYDGlgtiLNSEKGVDYM 118
Cdd:COG2956    25 DKAIDLLEE-ALELDpetVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeALLELAQDYLKA----GLLDRAEELL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 119 KKILDSPcPKARhlkfAAAYNLGRAYYEGKGVKRSNEEAERLwlfAADNGNpkaSVKAQSMLG-LYYSTKEPKE----LE 193
Cdd:COG2956   100 EKLLELD-PDDA----EALRLLAEIYEQEGDWEKAIEVLERL---LKLGPE---NAHAYCELAeLYLEQGDYDEaieaLE 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622942259 194 KAFYWHSEacgngNLESQGALGLMYLygqgIRQDTEAALHCLREAAER--GNVYAQGNLVEYYYKM 257
Cdd:COG2956   169 KALKLDPD-----CARALLLLAELYL----EQGDYEEAIAALERALEQdpDYLPALPRLAELYEKL 225
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 38-270 1.76e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  38 YSHANLVDKALQLLKKRILKGDT--LAYFLRGQLYFEEGWYEEALEQFEEIEEKDH---QATYQLGVMYYDglgtILNSE 112
Cdd:COG2956    52 YRRRGEYDRAIRIHQKLLERDPDraEALLELAQDYLKAGLLDRAEELLEKLLELDPddaEALRLLAEIYEQ----EGDWE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 113 KGVDYMKKILDSpCPKARHlkfaAAYNLGRAYYEgkgvKRSNEEAERLWLFAADNgNPKaSVKAQSMLG-LYYSTKEPKE 191
Cdd:COG2956   128 KAIEVLERLLKL-GPENAH----AYCELAELYLE----QGDYDEAIEALEKALKL-DPD-CARALLLLAeLYLEQGDYEE 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 192 LEKAFywhsEACGNGNLESQGAL-GLMYLYGQgiRQDTEAALHCLREAAERG-NVYAQGNLVEYYYKMKFFTKCVAFSKR 269
Cdd:COG2956   197 AIAAL----ERALEQDPDYLPALpRLAELYEK--LGDPEEALELLRKALELDpSDDLLLALADLLERKEGLEAALALLER 270


                  .
gi 1622942259 270 I 270
Cdd:COG2956   271 Q 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 19-160 3.69e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  19 QCAAKNQKPFQWEKEKTDHYSHANLVDKALQLLKK--RILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIEEKD--HQAT 94
Cdd:COG2956   135 RLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKalKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDpdYLPA 214

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622942259  95 YQLGVMYYDGLGtilNSEKGVDYMKKILdspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERL 160
Cdd:COG2956   215 LPRLAELYEKLG---DPEEALELLRKAL------ELDPSDDLLLALADLLERKEGLEAALALLERQ 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-166 4.15e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  38 YSHANLVDKALQLLKK--RILKGDTLAYFLRGQLYFEEGWYEEALEQFE---EIEEKDHQATYQLGVMYYDgLGtilNSE 112
Cdd:COG0457    52 YLRLGRYEEALADYEQalELDPDDAEALNNLGLALQALGRYEEALEDYDkalELDPDDAEALYNLGLALLE-LG---RYD 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622942259 113 KGVDYMKKILdspcpkARHLKFAAAY-NLGRAYYEGKGVKRSNEEAERLWLFAAD 166
Cdd:COG0457   128 EAIEAYERAL------ELDPDDADALyNLGIALEKLGRYEEALELLEKLEAAALA 176
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 60-339 4.38e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 4.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  60 TLAYFLRGQLYFEEGWYEEALEQFEEIEEKDH---QATYQLGVMYYDgLGtilNSEKGVDYMKKILdspcpKARHLKFAA 136
Cdd:COG2956     8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPetvEAHLALGNLYRR-RG---EYDRAIRIHQKLL-----ERDPDRAEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 137 AYNLGRAYYEGKgvkrSNEEAERLWLFAADNgNPKASVKAQSMLGLYYSTkepKELEKAFYWHSEACGNGNLESQGALGL 216
Cdd:COG2956    79 LLELAQDYLKAG----LLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQE---GDWEKAIEVLERLLKLGPENAHAYCEL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 217 MYLYGQgiRQDTEAALHCLREA--AERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDevhdipmiaqvtdclPEFIS 294
Cdd:COG2956   151 AELYLE--QGDYDEAIEALEKAlkLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD---------------PDYLP 213

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1622942259 295 RGMAMASFYHARclqlglgitRDEATAKHYYSKACRLNPALADEL 339
Cdd:COG2956   214 ALPRLAELYEKL---------GDPEEALELLRKALELDPSDDLLL 249
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 135-168 5.49e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.12  E-value: 5.49e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622942259 135 AAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNG 168
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 37-241 2.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259  37 HYSHANLVDKALQLLKKRILK--GDTLAYFLRGQLYFEEGWYEEALEQFE---EIEEKDHQATYQLGVMYYDGlgtiLNS 111
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKqpDNASLHNLLGAIYLGKGDLAKAREAFEkalSIEPDFFPAAANLARIDIQE----GNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942259 112 EKGVDYMKKIL-DSPCPKARHLKFAAAYNlgrayyegkgvKRSNEEAERLWLFAADNGNPKASVKAQSMLGLYYSTKEPK 190
Cdd:TIGR02917 516 DDAIQRFEKVLtIDPKNLRAILALAGLYL-----------RTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLK 584

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622942259 191 E----LEKAFYWHSEacgngNLESQGALGLMYLyGQGirqDTEAALHCLREAAER 241
Cdd:TIGR02917 585 KalaiLNEAADAAPD-----SPEAWLMLGRAQL-AAG---DLNKAVSSFKKLLAL 630
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 298-332 3.51e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.84  E-value: 3.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622942259  298 AMASFYHARCLQLGLGITRDEATAKHYYSKACRLN 332
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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