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Conserved domains on  [gi|1622865337|ref|XP_001084465|]
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kelch-like protein 35 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-154 8.71e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 160.32  E-value: 8.71e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  18 CAGRCHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaa 97
Cdd:cd18265     1 CSGPCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAA------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  98 aaLAVVLDYVYGAGVRLRkEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLA 154
Cdd:cd18265    75 --MEVLLDYMYGGGLRIQ-EDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
299-550 1.68e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 164.56  E-value: 1.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 299 IVVIGGCDRKGLLKlpFADAYHPESQRWTPLPSLPGHTRSEFAACALRNDVYVSGGHINSH-------DVWMFSSHLHTW 371
Cdd:COG3055    25 VYVAGGLSGGSASN--SFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANpsstplnDVYVYDPATNTW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 372 IKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSS-AAVASCAGQLFVIGGARQGG 450
Cdd:COG3055   103 TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSG 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 451 VNtdkvqcfdpkeDQWSLRSPAPFSQRCLEAISFEDTIYVMGGLM---SKIFTYDPGTDVWGEAAVLPSPVESCGVTVCD 527
Cdd:COG3055   183 FS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESgfsDEVEAYDPATNTWTALGELPTPRHGHAAVLTD 251

                         250       260
                  ....*....|....*....|...
gi 1622865337 528 GKVHILGGRDDHGESTDKVFTFD 550
Cdd:COG3055   252 GKVYVIGGETKPGVRTPLVTSAE 274
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 153-252 4.79e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


:

Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.51  E-value: 4.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  153 LALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQL 232
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 1622865337  233 RRLLEHVRLPLLSPAYFLEK 252
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
 
Name Accession Description Interval E-value
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-154 8.71e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 160.32  E-value: 8.71e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  18 CAGRCHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaa 97
Cdd:cd18265     1 CSGPCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAA------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  98 aaLAVVLDYVYGAGVRLRkEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLA 154
Cdd:cd18265    75 --MEVLLDYMYGGGLRIQ-EDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
299-550 1.68e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 164.56  E-value: 1.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 299 IVVIGGCDRKGLLKlpFADAYHPESQRWTPLPSLPGHTRSEFAACALRNDVYVSGGHINSH-------DVWMFSSHLHTW 371
Cdd:COG3055    25 VYVAGGLSGGSASN--SFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANpsstplnDVYVYDPATNTW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 372 IKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSS-AAVASCAGQLFVIGGARQGG 450
Cdd:COG3055   103 TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSG 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 451 VNtdkvqcfdpkeDQWSLRSPAPFSQRCLEAISFEDTIYVMGGLM---SKIFTYDPGTDVWGEAAVLPSPVESCGVTVCD 527
Cdd:COG3055   183 FS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESgfsDEVEAYDPATNTWTALGELPTPRHGHAAVLTD 251

                         250       260
                  ....*....|....*....|...
gi 1622865337 528 GKVHILGGRDDHGESTDKVFTFD 550
Cdd:COG3055   252 GKVYVIGGETKPGVRTPLVTSAE 274
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 153-252 4.79e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.51  E-value: 4.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  153 LALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQL 232
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 1622865337  233 RRLLEHVRLPLLSPAYFLEK 252
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 147-260 8.84e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 107.70  E-value: 8.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYFLEKVEADELLQ 260
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 153-254 2.53e-27

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 106.09  E-value: 2.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 153 LALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQL 232
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90       100
                  ....*....|....*....|..
gi 1622865337 233 RRLLEHVRLPLLSPAYFLEKVE 254
Cdd:pfam07707  82 PELLSAVRLPLLSPQYLLNLVE 103
PHA03098 PHA03098
kelch-like protein; Provisional
 139-555 4.98e-25

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 109.09  E-value: 4.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 139 CVRFLEGSLRAANSlALRRVAVAFslaplaercgrvLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAM 218
Cdd:PHA03098  110 CIDIYRFSFFYGCK-KLYSAAYNY------------IRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIII 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 219 RWVRHDAPARRGQLRRLLEHVRLPLLSPAYfLEKVEADELlqacGECRPLLLEARACFILGREAgaLRTRPRRFMDLAEV 298
Cdd:PHA03098  177 KWLTSKKNNKYKDICLILKVLRITFLSEEG-IKKLKRWKL----RIKKKKIVFNKRCIKIIYSK--KYNLNKILPRSSTF 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 299 IVVIGGCDRKGLLKLPFADAYHPESQRWTplpSLPGHTRSEFAACALRNDVYVSGGHIN----SHDVWMFSSHLHTWIKV 374
Cdd:PHA03098  250 GSIIYIHITMSIFTYNYITNYSPLSEINT---IIDIHYVYCFGSVVLNNVIYFIGGMNKnnlsVNSVVSYDTKTKSWNKV 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 375 ASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGQLFVIGGARQGGVNTD 454
Cdd:PHA03098  327 PELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLK 406

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 455 KVQCFDPKEDQWSLRSPAPFSQRCLEAISFEDTIYVMGGL--------MSKIFTYDPGTDVWGEAAVLPSPVESCGVTVC 526
Cdd:PHA03098  407 TVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyidnikvYNIVESYNPVTNKWTELSSLNFPRINASLCIF 486

                         410       420
                  ....*....|....*....|....*....
gi 1622865337 527 DGKVHILGGrDDHGESTDKVFTFDPSSGQ 555
Cdd:PHA03098  487 NNKIYVVGG-DKYEYYINEIEVYDDKTNT 514
Kelch smart00612
Kelch domain;
392-438 1.45e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.45e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622865337  392 QLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAG 438
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 31-70 8.98e-11

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 59.19  E-value: 8.98e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622865337  31 LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALF 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 383-425 1.75e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.08  E-value: 1.75e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622865337 383 RHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLP 425
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 42-82 5.41e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 44.99  E-value: 5.41e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622865337   42 DVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV 82
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEI 41
tRNA_cyclodipep TIGR04539
tRNA-dependent cyclodipeptide synthase; Members of this family take two aminoacylated tRNA ...
 156-249 3.76e-03

tRNA-dependent cyclodipeptide synthase; Members of this family take two aminoacylated tRNA molecules and produce a cyclic dipeptide with two peptide bonds. This enzyme therefore produces a type of nonribosomal peptide, but by a mechanism entirely different from the typical non-ribosomal peptide synthase (NRPS) that relies on adenylation to activate amino acids. Three characterized members of this family are the cyclodityrosine synthase of Mycobacterium tuberculosis (an essential gene), a cyclo(L-Phe-L-Leu) synthase from Streptomyces noursei involved in natural product biosynthesis, and cyclodileucine synthase YvmC from Bacillus licheniformis. Many cyclodipeptide synthases are found next to a cytochrome P450 that further modifies the product.


Pssm-ID: 275332  Cd Length: 220  Bit Score: 39.13  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 156 RRVAVAFSLAPLAERCGRVLrqAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRL 235
Cdd:TIGR04539  86 RRIRRALEAAGGAYPRVRVL--DLSELADNPAYRALLARVERAFAEDPEFRAACEEMSREVLAGRLKGGVEPTEEQLDAA 163

                          90
                  ....*....|....*...
gi 1622865337 236 LEHVR--LPLL--SPAYF 249
Cdd:TIGR04539 164 VRYLLaeLPFFldTPEIL 181
 
Name Accession Description Interval E-value
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-154 8.71e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 160.32  E-value: 8.71e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  18 CAGRCHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaa 97
Cdd:cd18265     1 CSGPCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAA------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  98 aaLAVVLDYVYGAGVRLRkEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLA 154
Cdd:cd18265    75 --MEVLLDYMYGGGLRIQ-EDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
299-550 1.68e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 164.56  E-value: 1.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 299 IVVIGGCDRKGLLKlpFADAYHPESQRWTPLPSLPGHTRSEFAACALRNDVYVSGGHINSH-------DVWMFSSHLHTW 371
Cdd:COG3055    25 VYVAGGLSGGSASN--SFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANpsstplnDVYVYDPATNTW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 372 IKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSS-AAVASCAGQLFVIGGARQGG 450
Cdd:COG3055   103 TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSG 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 451 VNtdkvqcfdpkeDQWSLRSPAPFSQRCLEAISFEDTIYVMGGLM---SKIFTYDPGTDVWGEAAVLPSPVESCGVTVCD 527
Cdd:COG3055   183 FS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESgfsDEVEAYDPATNTWTALGELPTPRHGHAAVLTD 251

                         250       260
                  ....*....|....*....|...
gi 1622865337 528 GKVHILGGRDDHGESTDKVFTFD 550
Cdd:COG3055   252 GKVYVIGGETKPGVRTPLVTSAE 274
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
326-574 8.15e-42

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 151.85  E-value: 8.15e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 326 WTPLPSLPGhTRSEFAACALRNDVYVSGGHIN---SHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ-GQLFAVGGFDG 401
Cdd:COG3055     3 WSSLPDLPT-PRSEAAAALLDGKVYVAGGLSGgsaSNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQdGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 402 ----LRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGQLFVIGGaRQGGVNTDKVQCFDPKEDQWSLRSPAPFSQR 477
Cdd:COG3055    82 anpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG-WDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 478 CLEA-ISFEDTIYVMGGlmskiFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDHgesTDKVFTFDPSSGQV 556
Cdd:COG3055   161 HLAAaVLPDGKILVIGG-----RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTW 232

                         250
                  ....*....|....*...
gi 1622865337 557 EAQPSLQRCTSSHGCVTI 574
Cdd:COG3055   233 TALGELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
370-543 1.23e-32

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 126.42  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 370 TWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLP-EAVSSAAVASCAGQLFVIGGARQ 448
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 449 ---GGVNTDKVQCFDPKEDQWSLRSPAPFSQRCLEAISFEDTIYVMGGLMSKIFT-----YDPGTDVWGEAAVLPSPVES 520
Cdd:COG3055    82 anpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVawvevYDPATGTWTQLAPLPTPRDH 161

                         170       180
                  ....*....|....*....|....
gi 1622865337 521 -CGVTVCDGKVHILGGRDDHGEST 543
Cdd:COG3055   162 lAAAVLPDGKILVIGGRNGSGFSN 185
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 153-252 4.79e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.51  E-value: 4.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  153 LALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQL 232
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 1622865337  233 RRLLEHVRLPLLSPAYFLEK 252
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 147-260 8.84e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 107.70  E-value: 8.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYFLEKVEADELLQ 260
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 147-225 1.52e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 105.67  E-value: 1.52e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDA 225
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 153-254 2.53e-27

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 106.09  E-value: 2.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 153 LALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQL 232
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90       100
                  ....*....|....*....|..
gi 1622865337 233 RRLLEHVRLPLLSPAYFLEKVE 254
Cdd:pfam07707  82 PELLSAVRLPLLSPQYLLNLVE 103
PHA03098 PHA03098
kelch-like protein; Provisional
 139-555 4.98e-25

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 109.09  E-value: 4.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 139 CVRFLEGSLRAANSlALRRVAVAFslaplaercgrvLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAM 218
Cdd:PHA03098  110 CIDIYRFSFFYGCK-KLYSAAYNY------------IRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIII 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 219 RWVRHDAPARRGQLRRLLEHVRLPLLSPAYfLEKVEADELlqacGECRPLLLEARACFILGREAgaLRTRPRRFMDLAEV 298
Cdd:PHA03098  177 KWLTSKKNNKYKDICLILKVLRITFLSEEG-IKKLKRWKL----RIKKKKIVFNKRCIKIIYSK--KYNLNKILPRSSTF 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 299 IVVIGGCDRKGLLKLPFADAYHPESQRWTplpSLPGHTRSEFAACALRNDVYVSGGHIN----SHDVWMFSSHLHTWIKV 374
Cdd:PHA03098  250 GSIIYIHITMSIFTYNYITNYSPLSEINT---IIDIHYVYCFGSVVLNNVIYFIGGMNKnnlsVNSVVSYDTKTKSWNKV 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 375 ASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGQLFVIGGARQGGVNTD 454
Cdd:PHA03098  327 PELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLK 406

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 455 KVQCFDPKEDQWSLRSPAPFSQRCLEAISFEDTIYVMGGL--------MSKIFTYDPGTDVWGEAAVLPSPVESCGVTVC 526
Cdd:PHA03098  407 TVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyidnikvYNIVESYNPVTNKWTELSSLNFPRINASLCIF 486

                         410       420
                  ....*....|....*....|....*....
gi 1622865337 527 DGKVHILGGrDDHGESTDKVFTFDPSSGQ 555
Cdd:PHA03098  487 NNKIYVVGG-DKYEYYINEIEVYDDKTNT 514
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 147-273 2.26e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 98.62  E-value: 2.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYFLEKVEADELLQACGECRPLLLEAR 273
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAK 127
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 147-272 2.99e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 98.18  E-value: 2.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYFLEKVEADELLQACGECRPLLLEA 272
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEA 126
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 151-253 2.74e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 91.99  E-value: 2.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 151 NSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRG 230
Cdd:cd18457     5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                          90       100
                  ....*....|....*....|...
gi 1622865337 231 QLRRLLEHVRLPLLSPAYFLEKV 253
Cdd:cd18457    85 YLPELLSKVRLPLLRPQFLTDRV 107
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 147-272 1.21e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 90.90  E-value: 1.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYFLEKVEADELLQACGECRPLLLEA 272
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEA 126
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 147-254 1.42e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 89.83  E-value: 1.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90       100
                  ....*....|....*....|....*...
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYFLEKVE 254
Cdd:cd18446    81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 168-248 5.30e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 85.46  E-value: 5.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 168 AERCGRVLRQA-------FAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRLLEHVR 240
Cdd:cd18444    16 AQGCTDLLKVAhnytmehFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLALIR 95


                  ....*...
gi 1622865337 241 LPLLSPAY 248
Cdd:cd18444    96 LPLLTPQF 103
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 147-249 2.05e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 80.88  E-value: 2.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18511     2 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVE 81

                          90       100
                  ....*....|....*....|...
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSPAYF 249
Cdd:cd18511    82 QRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 147-223 4.51e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 78.97  E-value: 4.51e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRH 223
Cdd:cd18463     2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-151 1.46e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 79.02  E-value: 1.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVpvaaEAPGTSPagaaAALAV 102
Cdd:cd18242     4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV----ELQGLTA----STMEI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFLEGSLRAAN 151
Cdd:cd18242    76 LLDFVYTETVHVTVENVQELLPAACL-LQLKGVKQACCEFLESQLDPSN 123
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 149-248 2.34e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 77.45  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 149 AANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPAR 228
Cdd:cd18468     2 PSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNR 81

                          90       100
                  ....*....|....*....|
gi 1622865337 229 RGQLRRLLEHVRLPLLSPAY 248
Cdd:cd18468    82 KQHIAELLAVVRLPFIHPSY 101
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-151 4.18e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 77.57  E-value: 4.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVpvaaEAPGTSPagaaAALAV 102
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLV----EINGILA----EAMDC 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFLEGSLRAAN 151
Cdd:cd18253    73 FLQYVYTGKVKITTENVQYLFETSSL-FQISPLRDACAKFLEEQLDPCN 120
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 147-246 3.03e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 71.87  E-value: 3.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18510     2 LHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQ 81

                          90       100
                  ....*....|....*....|
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSP 246
Cdd:cd18510    82 NRQKDLGMLLSYIRLPLLPP 101
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 147-246 3.76e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 71.31  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALgVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90       100
                  ....*....|....*....|
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSP 246
Cdd:cd18476    80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-155 3.82e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 72.71  E-value: 3.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV-------PVAAEapgtspag 95
Cdd:cd18267    23 YADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVnfhdsihPEVLE-------- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  96 aaaalaVVLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18267    95 ------LLLDYAYSSRVIINEENAESLLEAGDM-LEFQDIRDACAEFLEKNLHPTNCLGM 147
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 150-244 4.93e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 70.94  E-value: 4.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 150 ANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARR 229
Cdd:cd18516     4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                          90
                  ....*....|....*
gi 1622865337 230 GQLRRLLEHVRLPLL 244
Cdd:cd18516    84 KALPVLLESIRFRLM 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 167-246 7.62e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 70.53  E-value: 7.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 167 LAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLLSP 246
Cdd:cd18485    21 LSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRVQHLVELLKQVRLELVSP 100
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 147-244 1.17e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 69.87  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*...
gi 1622865337 227 ARRGQLRRLLEHVRLPLL 244
Cdd:cd18477    81 NRQKALPTVFESIRFRLL 98
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 147-246 1.16e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 67.35  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|
gi 1622865337 227 ARRGQLRRLLEHVRLPLLSP 246
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLPP 101
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 147-244 2.49e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 65.95  E-value: 2.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....*...
gi 1622865337 227 ARRGQLRRLLEHVRLPLL 244
Cdd:cd18517    81 NRVKSLGEIFDCIRFRLM 98
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-153 3.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 66.78  E-value: 3.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPgtspagaaAALAV 102
Cdd:cd18259    15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDP--------AVMES 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337 103 VLDYVYGAGVRLRKEDeAAAVLALAERLGVAGLREACVRFLEGSLRAANSL 153
Cdd:cd18259    87 LIDFAYTGKLTINQGN-VEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 147-245 3.54e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 65.53  E-value: 3.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18459     2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                          90
                  ....*....|....*....
gi 1622865337 227 ARRGQLRRLLEHVRLPLLS 245
Cdd:cd18459    82 ERRPHLPQVLQHVRLPLLS 100
PHA03098 PHA03098
kelch-like protein; Provisional
 299-484 4.67e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 71.72  E-value: 4.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 299 IVVIGGCDRKGLLKLpfADAYHPESQRWTPLPSLPgHTRSEFAACALRNDVYVSGG----HINSHDVWMFSSHLHTWIKV 374
Cdd:PHA03098  345 IYVIGGIYNSISLNT--VESWKPGESKWREEPPLI-FPRYNPCVVNVNNLIYVIGGisknDELLKTVECFSLNTNKWSKG 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 375 ASLHKGRWRHKMAVVQGQLFAVGGF---DGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGQLFVIGGARQGgV 451
Cdd:PHA03098  422 SPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYE-Y 500

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622865337 452 NTDKVQCFDPKEDQWSLRSPAPFSQRCLEAISF 484
Cdd:PHA03098  501 YINEIEVYDDKTNTWTLFCKFPKVIGSLEKNIF 533
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 147-242 1.01e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 64.25  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18448     2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQ 81

                          90
                  ....*....|....*.
gi 1622865337 227 ARRGQLRRLLEHVRLP 242
Cdd:cd18448    82 HRKRHLDDLLSQVRLP 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
417-574 1.47e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 68.26  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 417 TWAAAAPLPEAVSSAAVASCAGQLFVIGGARQGGVnTDKVQCFDPKEDQWSLRSPAPFSQRcleaisfedtiyvmgglms 496
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA-SNSFEVYDPATNTWSELAPLPGPPR------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 497 kiftydpgtdvWGEAAVLPspvescgvtvcDGKVHILGGRD---DHGESTDKVFTFDPSSGQVEAQPSLQRCTSSHGCVT 573
Cdd:COG3055    62 -----------HHAAAVAQ-----------DGKLYVFGGFTganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALL 119


                  .
gi 1622865337 574 I 574
Cdd:COG3055   120 L 120
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 175-248 1.59e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 64.01  E-value: 1.59e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 175 LRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLLSPAY 248
Cdd:cd18469    31 LLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 147-245 1.63e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 63.87  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90
                  ....*....|....*....
gi 1622865337 227 ARRGQLRRLLEHVRLPLLS 245
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLS 99
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-76 4.65e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 63.49  E-value: 4.65e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18254     5 HPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRE 58
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 149-224 1.19e-11

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 60.50  E-value: 1.19e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337 149 AANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHD 224
Cdd:cd18508     2 ATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
Kelch smart00612
Kelch domain;
392-438 1.45e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.45e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622865337  392 QLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAG 438
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 2.19e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 61.19  E-value: 2.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  28 LQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVpvaaEAPGTSPagaaAALAVVLDYV 107
Cdd:cd18240     5 CNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVY----KIPGVSP----EMMELIIEYA 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622865337 108 YGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAAN 151
Cdd:cd18240    77 YTRTVPI-TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 147-245 2.84e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 60.35  E-value: 2.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*....
gi 1622865337 227 ARRGQLRRLLEHVRLPLLS 245
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLLS 99
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-84 8.19e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 58.33  E-value: 8.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622865337  40 LTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPV 84
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIEL 45
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 31-70 8.98e-11

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 59.19  E-value: 8.98e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622865337  31 LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALF 40
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-73 9.69e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 59.18  E-value: 9.69e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAG 73
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSG 58
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 147-221 1.06e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 57.78  E-value: 1.06e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWV 221
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 147-244 1.14e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 58.66  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*...
gi 1622865337 227 ARRGQLRRLLEHVRLPLL 244
Cdd:cd18460    81 HRQHFWPELLQHVRLPFV 98
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 383-425 1.75e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.08  E-value: 1.75e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622865337 383 RHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLP 425
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 147-224 2.25e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 56.85  E-value: 2.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVA-RHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHD 224
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAkDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-155 2.63e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 58.26  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  27 VLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaaLAVVLDY 106
Cdd:cd18268    10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDV--------LDQIVDY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337 107 VYgAGVRLRKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18268    82 VY-TGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-91 3.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 58.18  E-value: 3.02e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGT 91
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDI 71
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 149-236 3.23e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 56.94  E-value: 3.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 149 AANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPAR 228
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                  ....*...
gi 1622865337 229 RGQLRRLL 236
Cdd:cd18455    82 KVHLKDLM 89
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 149-243 4.56e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 56.60  E-value: 4.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 149 AANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPAR 228
Cdd:cd18447     4 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 83

                          90
                  ....*....|....*
gi 1622865337 229 RGQLRRLLEHVRLPL 243
Cdd:cd18447    84 QPYMVDILAKVRFPL 98
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 4.56e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 57.53  E-value: 4.56e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18224     9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLF 56
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 150-246 6.27e-10

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 56.33  E-value: 6.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 150 ANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARR 229
Cdd:cd18466     4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                          90
                  ....*....|....*..
gi 1622865337 230 GQLRRLLEHVRLPLLSP 246
Cdd:cd18466    84 KHVVEVLEPVRFPLLPP 100
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-88 7.14e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 56.80  E-value: 7.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVP---VAAEA 88
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEidfVSPEA 76
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-72 1.27e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 56.11  E-value: 1.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAA 72
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSS 50
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-71 1.49e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 55.93  E-value: 1.49e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA 71
Cdd:cd18250     4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFA 52
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 179-244 1.97e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 54.81  E-value: 1.97e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337 179 FAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLL 244
Cdd:cd18464    32 FTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRLALL 97
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-241 2.83e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 54.29  E-value: 2.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                          90
                  ....*....|....*
gi 1622865337 227 ARRGQLRRLLEHVRL 241
Cdd:cd18479    81 SRSQYLSSVLSQIRI 95
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-73 3.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 55.20  E-value: 3.44e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAG 73
Cdd:cd18276     4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCG 54
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-153 3.49e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 55.19  E-value: 3.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  28 LQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaaLAVVLDYV 107
Cdd:cd18237     9 MGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDI--------IELLVEFA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622865337 108 YGAGVRLRKEDeAAAVLALAERLGVAGLREACVRFLEGSLRAANSL 153
Cdd:cd18237    81 YTARISVNSNN-VQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 153-244 4.61e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 53.76  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 153 LALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDaPARRGQL 232
Cdd:cd18465     7 LNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASA 85

                          90
                  ....*....|..
gi 1622865337 233 RRLLEHVRLPLL 244
Cdd:cd18465    86 SHVLCHIRFPLM 97
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 151-244 4.69e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 53.83  E-value: 4.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 151 NSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRG 230
Cdd:cd18515     4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHC 83

                          90
                  ....*....|....
gi 1622865337 231 QLRRLLEHVRLPLL 244
Cdd:cd18515    84 YLSELLQTVRLALL 97
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-76 5.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 54.22  E-value: 5.70e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337  28 LQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18238     3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAE 51
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-147 6.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 53.97  E-value: 6.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVpVAAEAPGTSpagaaaaLAV 102
Cdd:cd18235     4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRV-TLQDVDGKA-------LLL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAvlalaerLGVAGL------REACVRFLEGSL 147
Cdd:cd18235    76 LIDYVYTAEIQVTEENVQVL-------LPAANLlqltdvRDACCDFLQSQL 119
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-76 7.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 53.94  E-value: 7.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRE 54
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 147-244 9.27e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 52.92  E-value: 9.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*...
gi 1622865337 227 ARRGQLRRLLEHVRLPLL 244
Cdd:cd18514    81 KRKDYLPELLRNVRLALL 98
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 151-228 1.11e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 52.33  E-value: 1.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865337 151 NSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPAR 228
Cdd:cd18480     5 NCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-153 1.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 53.29  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  22 CHAQRVLQTLNTYRRSGTLTDVVLRAG-GRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVaaeapgtsPAGAAAAL 100
Cdd:cd18252     3 SHPADFLDAFRTFYLDGLFTDITLQCAsGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKL--------SGIDHDIL 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622865337 101 AVVLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFLEGSLRAANSL 153
Cdd:cd18252    75 EALVNYVYTSQICITERNVQSLLEAADL-LQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-144 1.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 52.73  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  28 LQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEapGTSPagaaAALAVVLDYV 107
Cdd:cd18245     2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELE--GISV----EVMEEILDYI 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1622865337 108 YGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLE 144
Cdd:cd18245    76 YTGQIKL-SEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-77 1.78e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 52.93  E-value: 1.78e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPER 77
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEK 55
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-72 1.78e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 53.04  E-value: 1.78e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  23 HAQRVLQTLNTYRRSG-TLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAA 72
Cdd:cd18207     9 HSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSA 59
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-84 1.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 53.15  E-value: 1.79e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRD----FPCHRAALSAASAYFHNLFAAGRPERGPAVVPV 84
Cdd:cd18248     4 HTKEAFQIMNELRLSQQLCDVTLKVKYQDpkeeFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPI 69
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-155 2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 52.68  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAG-GRDFPCHRAALSAASAYFHNLFAAGRPE---RGPAVVPVAAEApgtspagaaa 98
Cdd:cd18274     5 HACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTEstqKEVRIVGVEAES---------- 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  99 aLAVVLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18274    75 -MHLVLDYAYTSRVTL-TEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-83 3.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 52.56  E-value: 3.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVP 83
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSP 62
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-155 6.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 51.75  E-value: 6.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLR--------AGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspa 94
Cdd:cd18273     9 HARALLAQLKSFYDARLLTDVTIEvngpgsgpGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSES--- 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  95 gaaaaLAVVLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18273    86 -----MALIIDYCYTGRVTL-SEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-82 6.65e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 51.38  E-value: 6.65e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV 82
Cdd:cd18327     8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA 67
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-70 9.52e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 51.00  E-value: 9.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622865337  27 VLQT-LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18236    10 VLQNgLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMF 54
PLN02153 PLN02153
epithiospecifier protein
 333-572 9.76e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 54.22  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 333 PGhTRSEFAACALRNDVYVSGGHI--NSH---DVWMFSSHLHTW-IKVASLHKGRWRH---KMAVVQGQLFAVGGFDGLR 403
Cdd:PLN02153   20 PG-PRCSHGIAVVGDKLYSFGGELkpNEHidkDLYVFDFNTHTWsIAPANGDVPRISClgvRMVAVGTKLYIFGGRDEKR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 404 RLHSVERYDPFSNTWAAAAPL-----PEAVSSAAVASCAGQLFVIGGARQGGVntdkvqcfdpkedqwsLRSPAPFsqRC 478
Cdd:PLN02153   99 EFSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGL----------------MKTPERF--RT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 479 LEAISFEDtiyvmgglmskiftydpgtdvwGEAAVLPSPVES------CGVTVCDGKVHIL---------GGRDDHgeST 543
Cdd:PLN02153  161 IEAYNIAD----------------------GKWVQLPDPGENfekrggAGFAVVQGKIWVVygfatsilpGGKSDY--ES 216

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1622865337 544 DKVFTFDPSSG---QVE---AQPSlQRCTSSHGCV 572
Cdd:PLN02153  217 NAVQFFDPASGkwtEVEttgAKPS-ARSVFAHAVV 250
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-71 1.18e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 50.73  E-value: 1.18e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337  18 CAGRCHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA 71
Cdd:cd18261     6 CQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFS 59
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-77 1.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 50.57  E-value: 1.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRD--FPCHRAALSAASAYFHNLFAAGRPER 77
Cdd:cd18239     6 HSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEQ 62
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-242 1.96e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 49.09  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*..
gi 1622865337 227 ARRGQLRRLLEH-VRLP 242
Cdd:cd18483    81 KREMHLPEIFAKcIRMP 97
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-156 2.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 50.06  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaaLAV 102
Cdd:cd18337     6 HAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNA--------LWA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 103 VLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLALR 156
Cdd:cd18337    78 LVQYAYTGRLEL-KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-76 2.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 50.28  E-value: 2.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18266     8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMRE 61
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-89 2.33e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 49.88  E-value: 2.33e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAP 89
Cdd:cd18328     8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTP 74
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-115 2.97e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 49.10  E-value: 2.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFaAGRPERGPAVV--PVAAEAPGTSPagaaaal 100
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF-TDQLKNNVSVInlDPEIEPEGFRI------- 73

                          90
                  ....*....|....*
gi 1622865337 101 avVLDYVYGAGVRLR 115
Cdd:cd18215    74 --LLDFMYTSRLNLR 86
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 173-249 3.45e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 48.58  E-value: 3.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337 173 RVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPlLSPAYF 249
Cdd:cd18462    27 RIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIECAYDLLSSIKLD-LDEIYL 102
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-83 3.66e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 49.26  E-value: 3.66e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  27 VLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRP---ERGPAVVP 83
Cdd:cd18290    14 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSavvELPAAVQP 73
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-156 3.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 49.27  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPgtspagaaAALAV 102
Cdd:cd18336     2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDP--------DALKA 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 103 VLDYVYgAGVRLRKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLALR 156
Cdd:cd18336    74 LVHYAY-TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-81 5.01e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 49.05  E-value: 5.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHnLFAAGRPERGPAV 81
Cdd:cd18194     6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKRDLV 63
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-155 5.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 48.68  E-value: 5.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  22 CHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPgtspagaaAALA 101
Cdd:cd18271     6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSP--------KAVK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 102 VVLDYVYGAGVRLRkEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18271    78 AFLDYAYTGKAEIT-DDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-143 6.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 48.52  E-value: 6.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTSPagaaaalav 102
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEP--------- 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFL 143
Cdd:cd18277    81 LIQFAYTAKLILSKDNVDEVCKCVEF-LSVHNIEESCFQFL 120
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 9.33e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 48.22  E-value: 9.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMF 53
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-68 1.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 47.14  E-value: 1.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622865337  27 VLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHN 68
Cdd:cd18210     8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHD 49
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-135 1.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 47.58  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTS-----PAGAA 97
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPErvlelPGVKA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1622865337  98 AALAVVLDYVYGAGVRLRKEDEAAAVLALAERLGVAGL 135
Cdd:cd18195    81 GVFSDVLNFIYSSRVALPGSAAAKELGAAGKRLGIPFL 118
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-155 1.72e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 47.52  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  21 RCHAQRVLQT-LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaa 99
Cdd:cd18340     7 RLYQQTLLQDgLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDV-------- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337 100 LAVVLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18340    79 MGKILHYIYTSEIEI-TEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-71 1.79e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 46.79  E-value: 1.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA 71
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFT 49
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 1.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 46.85  E-value: 1.84e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF 52
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-84 1.87e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 47.12  E-value: 1.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPV 84
Cdd:cd18251     6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLI 67
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-76 2.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 47.30  E-value: 2.25e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18270     9 YAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSE 62
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 179-236 2.58e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 45.75  E-value: 2.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865337 179 FAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRLL 236
Cdd:cd18458    34 FSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENRRQYLEALL 91
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-143 2.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 46.86  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFaAGRPERGPAV-VPVAAEAPGTSPagaaaala 101
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQAL-VGQTENDLVVsLPEEVTARGFGP-------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1622865337 102 vVLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFL 143
Cdd:cd18278    85 -LLQFAYTAKLLLSRENIQEVIRCAEF-LRMHNLEDSCFRFL 124
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-73 2.60e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 46.29  E-value: 2.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAG 73
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDG 51
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-82 2.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 47.10  E-value: 2.86e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622865337  21 RCHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV 82
Cdd:cd18264     9 KSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVI 70
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-93 3.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 46.39  E-value: 3.31e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFaAGRPERGPAV--VPVAAEAPGTSP 93
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF-SGRVGEGVSVltLPSGLEARGFQL 73
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-155 3.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 46.63  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  21 RCHAQRVLQT-LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaa 99
Cdd:cd18269     7 RLYQQTLLQDgLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDV-------- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337 100 LAVVLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18269    79 MGMILKYLYTSEIDL-NDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-70 5.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 45.73  E-value: 5.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622865337  26 RVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18247     5 SGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMF 49
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 42-82 5.41e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 44.99  E-value: 5.41e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622865337   42 DVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV 82
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEI 41
PHA03098 PHA03098
kelch-like protein; Provisional
 289-430 7.64e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 48.61  E-value: 7.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 289 PRRFMDLAEV---IVVIGGCDrKGLLKLPFADAYHPESQRWTPLPSLPghtRSEFAACAL--RNDVYVSGG--HINSHDV 361
Cdd:PHA03098  379 PRYNPCVVNVnnlIYVIGGIS-KNDELLKTVECFSLNTNKWSKGSPLP---ISHYGGCAIyhDGKIYVIGGisYIDNIKV 454

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865337 362 W----MFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSS 430
Cdd:PHA03098  455 YniveSYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGS 527
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-156 8.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 45.42  E-value: 8.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaaLAV 102
Cdd:cd18335     2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNA--------LWD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 103 VLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAANSLALR 156
Cdd:cd18335    74 LVQFAYTGCLEL-KEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-70 8.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 44.66  E-value: 8.44e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622865337  40 LTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18234     1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMF 31
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-68 9.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 44.84  E-value: 9.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHN 68
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHD 46
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-147 9.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 45.06  E-value: 9.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVaAEAPGTSpagaaaaLAV 102
Cdd:cd18338     4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRI-KEVDGWT-------LKM 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAvlalaerLGVAGL------REACVRFLEGSL 147
Cdd:cd18338    76 LIDYVYTAEIQVTEENVQVL-------LPAAGLlqlqdvKKTCCEFLESQL 119
PHA02713 PHA02713
hypothetical protein; Provisional
 319-448 9.82e-06

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 48.47  E-value: 9.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 319 YHPESQRWTPLPSLPGHTRSeFAACALRNDVYVSGGH----INSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLF 394
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIIN-YASAIVDNEIIIAGGYnfnnPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIY 355

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 395 AVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGQLFVIGGARQ 448
Cdd:PHA02713  356 AIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTE 409
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 9.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 44.84  E-value: 9.84e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELF 49
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-87 1.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 45.04  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAE 87
Cdd:cd18196     4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSE 68
Kelch smart00612
Kelch domain;
298-347 1.14e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.14e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622865337  298 VIVVIGGCDRKGLLKLpfADAYHPESQRWTPLPSLPgHTRSEFAACALRN 347
Cdd:smart00612   1 KIYVVGGFDGGQRLKS--VEVYDPETNKWTPLPSMP-TPRSGHGVAVING 47
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 40-82 1.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 43.69  E-value: 1.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622865337  40 LTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV 82
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVII 43
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-151 1.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 44.65  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRpergpaVVPVAAEAPGTspagaaaalAV 102
Cdd:cd18243    15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSINN------LVLQGCSSIGL---------RL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337 103 VLDYVYGAGVRLrKEDEAAAVLALAERLGVAGLREACVRFLEGSLRAAN 151
Cdd:cd18243    80 VLEYLYTANVTL-SLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-153 1.55e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 44.89  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  21 RCHAQRVLQT-LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAaeapgtspAGAAAA 99
Cdd:cd18272    12 RSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELK--------DVSESV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 100 LAVVLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFLEGSLRAANSL 153
Cdd:cd18272    84 FQLLVDYIYHGTVKLRVEELQETYEVADM-YQLTALFEECSRFLARTVQVRNCL 136
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 429-467 1.56e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622865337 429 SSAAVASCAGQLFVIGGaRQGGVNTDKVQCFDPKEDQWS 467
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGG-FDGNQSLNSVEVYDPETNTWS 40
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-143 1.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 44.16  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVaaeAPGTspagaaaaLAV 102
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGEGI---SPST--------FKQ 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFL 143
Cdd:cd18218    70 LLDFVYGESVEVQPGELRPLLEAARA-LEVESLEEACWRAL 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 337-377 1.77e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622865337 337 RSEFAACALRNDVYVSGGHIN---SHDVWMFSSHLHTWIKVASL 377
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGnqsLNSVEVYDPETNTWSKLPSM 45
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 151-202 1.97e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 42.26  E-value: 1.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622865337 151 NSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLAD 202
Cdd:cd14733     4 NCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 147-228 2.01e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 43.41  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 147 LRAANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAP 226
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ..
gi 1622865337 227 AR 228
Cdd:cd18451    81 ER 82
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-71 3.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 43.28  E-value: 3.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA 71
Cdd:cd18219     4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS 52
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 151-244 3.22e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 43.21  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 151 NSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWvrHDAP--AR 228
Cdd:cd18461     5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY--HYTPeqVE 82

                          90       100
                  ....*....|....*....|.
gi 1622865337 229 RGQLR-----RLLEHVRLPLL 244
Cdd:cd18461    83 KDQVSlqeppKLLEAVRFPLM 103
PLN02193 PLN02193
nitrile-specifier protein
 349-467 3.76e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.49  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 349 VYVSGGHINSHD---VWMFSSHLHTWIKVASLHKG---RWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAA 422
Cdd:PLN02193  231 LYVFGGRDASRQyngFYSFDTTTNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCS 310

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337 423 PLPEAVSS---AAVASCAGQLFVIGGARqgGVNTDKVQCFDPKEDQWS 467
Cdd:PLN02193  311 TPGDSFSIrggAGLEVVQGKVWVVYGFN--GCEVDDVHYYDPVQDKWT 356
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-85 4.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 43.48  E-value: 4.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  27 VLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERG--PAVVPVA 85
Cdd:cd18289    16 VLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFelPATVPPA 76
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-155 4.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 43.30  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  42 DVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVAAEAPGTspagaaaaLAVVLDYVYGAGVRLrKEDEAA 121
Cdd:cd18341    29 DCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNI--------MDMILKYLYSAEIDL-NDGNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622865337 122 AVLALAERLGVAGLREACVRFLEGSLRAANSLAL 155
Cdd:cd18341   100 DIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-71 6.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 42.47  E-value: 6.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA 71
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFS 49
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-72 6.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 42.48  E-value: 6.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAA 72
Cdd:cd18212     6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAD 55
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 42-84 7.74e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 41.89  E-value: 7.74e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622865337  42 DVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPV 84
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCD 62
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-66 8.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 42.23  E-value: 8.59e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622865337  27 VLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYF 66
Cdd:cd18227    12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYF 51
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-70 1.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 42.19  E-value: 1.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622865337  22 CHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18213     3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIF 51
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-83 1.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 41.77  E-value: 1.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  24 AQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE-RGPAVVP 83
Cdd:cd18229     2 SKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEiEVPPVVP 62
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 1.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 41.91  E-value: 1.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF 48
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-147 1.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 42.02  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPVaAEAPGTSpagaaaaLAV 102
Cdd:cd18339     4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEI-KDVDGQT-------LSK 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622865337 103 VLDYVYGAGVRLRKEDEAAAVLALAErLGVAGLREACVRFLEGSL 147
Cdd:cd18339    76 LIDYIYTAEIEVTEENVQVLLPAASL-LQLMDVRQNCCDFLQSQL 119
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-78 1.34e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 42.11  E-value: 1.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHnLFAAGRPERG 78
Cdd:cd18956     6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGG 60
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-67 1.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 41.94  E-value: 1.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFH 67
Cdd:cd18325     6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH 50
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-67 1.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 42.33  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFH 67
Cdd:cd18324     6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFH 50
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-84 1.62e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 41.34  E-value: 1.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865337  28 LQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVVPV 84
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQL 57
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 150-223 2.69e-04

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 39.64  E-value: 2.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622865337 150 ANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRH 223
Cdd:cd18503     4 DNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 3.39e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 40.57  E-value: 3.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18192     4 HSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMF 51
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-88 3.78e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 39.88  E-value: 3.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA---AGRPERGPAVVPVAAEA 88
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLgsnGPLPPLSLEVTPVGWEA 69
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 3.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 40.23  E-value: 3.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18331     7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIF 54
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-77 4.68e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 40.58  E-value: 4.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPER 77
Cdd:cd18323     6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKR 60
Kelch smart00612
Kelch domain;
349-391 4.73e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 4.73e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1622865337  349 VYVSGGHINSHD---VWMFSSHLHTWIKVASLHKGRWRHKMAVVQG 391
Cdd:smart00612   2 IYVVGGFDGGQRlksVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 41-90 5.86e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 39.24  E-value: 5.86e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622865337  41 TDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGrPERGpAVVPVAAEAPG 90
Cdd:cd18283     3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSS-PGYG-AEIPVDLPTAG 50
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-156 6.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 39.77  E-value: 6.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  31 LNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV-PVAAEAPGTspagaaaaLAVVLDYVYG 109
Cdd:cd18293     6 LHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHT--------LLKLVDFLYT 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622865337 110 AGVRLRKEDeAAAVLALAERLGVAGLREACvrfLEGSLRAANSLALR 156
Cdd:cd18293    78 SELEVSSEE-AQDVLAAARRLQISELESLC---LEGGKLVKAPPGRR 120
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
406-557 7.11e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.54  E-value: 7.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 406 HSVERYDPFSNTWAA-AAPLPEAVSSAAVASCAGQLFViggarqGGVNTDKVQCFDPKEDQWS-LRSPAPFSQ-RCLeAI 482
Cdd:COG4257   123 NRIGRLDPATGEVTEfPLPTGGAGPYGIAVDPDGNLWV------TDFGANAIGRIDPDTGTLTeYALPTPGAGpRGL-AV 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337 483 SFEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSPVESCGVTVC-DGKVHIlggrDDHGesTDKVFTFDPSSGQVE 557
Cdd:COG4257   196 DPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVDgDGRVWF----AESG--ANRIVRFDPDTELTE 265
Kelch smart00612
Kelch domain;
488-528 7.30e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 7.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1622865337  488 IYVMGGLMSKIFT-----YDPGTDVWGEAAVLPSPVESCGVTVCDG 528
Cdd:smart00612   2 IYVVGGFDGGQRLksvevYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-73 7.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 39.53  E-value: 7.50e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622865337  22 CHAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAG 73
Cdd:cd18287     4 DHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGG 55
PHA02713 PHA02713
hypothetical protein; Provisional
 424-573 8.51e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 42.30  E-value: 8.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 424 LPEAVSSAAVASCAGQLFVIGGARQGGVNTDKVQCFDpKEDQWSLRSPAPFSQRCLEAIS-FEDTIYVMGG-----LMSK 497
Cdd:PHA02713  290 IPNHIINYASAIVDNEIIIAGGYNFNNPSLNKVYKIN-IENKIHVELPPMIKNRCRFSLAvIDDTIYAIGGqngtnVERT 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 498 IFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDH-----------------GESTDKVFTFDPSSGQVEAQP 560
Cdd:PHA02713  369 IECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHidytsvhhmnsidmeedTHSSNKVIRYDTVNNIWETLP 448

                         170
                  ....*....|...
gi 1622865337 561 SLQRCTSSHGCVT 573
Cdd:PHA02713  449 NFWTGTIRPGVVS 461
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 151-245 9.26e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 39.05  E-value: 9.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 151 NSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLE-LAPDEVAALLADPALGVARQEAVFEAAMRWVRHdAPARR 229
Cdd:cd18475     5 NYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQ-SPERE 83

                          90
                  ....*....|....*.
gi 1622865337 230 GQLRRLLEHVRLPLLS 245
Cdd:cd18475    84 NEAYQVLSNIHFPLIP 99
Kelch_6 pfam13964
Kelch motif;
381-425 1.02e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 1.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622865337 381 RWRHKMAVVQGQLFAVGGFDGLRRLHS-VERYDPFSNTWAAAAPLP 425
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLP 47
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 177-242 1.09e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.56  E-value: 1.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865337 177 QAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDaPARRGQLRRLLEHVRLP 242
Cdd:cd18449    31 KNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQFAAKLMENIRFP 95
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-88 1.20e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 39.15  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865337  37 SGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAA---GRPE---RGPAVVPVAAEA 88
Cdd:cd18295    16 QGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwkDKREinlKHPLVNPDAFRA 73
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-76 1.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 39.17  E-value: 1.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  26 RVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18201     7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKE 57
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 41-66 1.45e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 38.78  E-value: 1.45e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622865337  41 TDVVLRAGGRDFPCHRAALSAASAYF 66
Cdd:cd18286    18 SDITIKVDGKTFKAHRCILCARSSYF 43
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 150-224 1.45e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 38.32  E-value: 1.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865337 150 ANSLALRRVAVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHD 224
Cdd:cd18470     4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD 78
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-82 1.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 38.65  E-value: 1.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPERGPAVV 82
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTV 63
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-73 1.97e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 38.47  E-value: 1.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAG 73
Cdd:cd18220     8 YSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALS 58
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-68 2.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 38.49  E-value: 2.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622865337  27 VLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHN 68
Cdd:cd18222    12 VLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRD 53
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-70 2.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 38.04  E-value: 2.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622865337  24 AQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVML 47
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 2.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 38.86  E-value: 2.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18246    22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMF 69
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 2.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 38.26  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNIL 48
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-77 2.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 38.30  E-value: 2.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622865337  32 NTYRRSGTLTDVVL---RAGGRDFPCHRAALSAASAYFHNL----FAAGRPER 77
Cdd:cd18241    15 NEQRKQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLlsgqFSESRSGR 67
Kelch smart00612
Kelch domain;
439-473 3.11e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 3.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622865337  439 QLFVIGGaRQGGVNTDKVQCFDPKEDQWSLRSPAP 473
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMP 34
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-86 3.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 37.74  E-value: 3.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622865337  24 AQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLFAAGRPE-RGPAVVPVAA 86
Cdd:cd18208     9 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDiEIPSVVSVQS 72
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 521-563 3.63e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 3.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622865337 521 CGVTVCDGKVHILGGRdDHGESTDKVFTFDPSSGQVEAQPSLQ 563
Cdd:pfam01344   5 AGVVVVGGKIYVIGGF-DGNQSLNSVEVYDPETNTWSKLPSMP 46
tRNA_cyclodipep TIGR04539
tRNA-dependent cyclodipeptide synthase; Members of this family take two aminoacylated tRNA ...
 156-249 3.76e-03

tRNA-dependent cyclodipeptide synthase; Members of this family take two aminoacylated tRNA molecules and produce a cyclic dipeptide with two peptide bonds. This enzyme therefore produces a type of nonribosomal peptide, but by a mechanism entirely different from the typical non-ribosomal peptide synthase (NRPS) that relies on adenylation to activate amino acids. Three characterized members of this family are the cyclodityrosine synthase of Mycobacterium tuberculosis (an essential gene), a cyclo(L-Phe-L-Leu) synthase from Streptomyces noursei involved in natural product biosynthesis, and cyclodileucine synthase YvmC from Bacillus licheniformis. Many cyclodipeptide synthases are found next to a cytochrome P450 that further modifies the product.


Pssm-ID: 275332  Cd Length: 220  Bit Score: 39.13  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 156 RRVAVAFSLAPLAERCGRVLrqAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWVRHDAPARRGQLRRL 235
Cdd:TIGR04539  86 RRIRRALEAAGGAYPRVRVL--DLSELADNPAYRALLARVERAFAEDPEFRAACEEMSREVLAGRLKGGVEPTEEQLDAA 163

                          90
                  ....*....|....*...
gi 1622865337 236 LEHVR--LPLL--SPAYF 249
Cdd:TIGR04539 164 VRYLLaeLPFFldTPEIL 181
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-69 3.92e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 37.64  E-value: 3.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNL 69
Cdd:cd18334     4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL 50
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 39-71 4.32e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 37.27  E-value: 4.32e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622865337  39 TLTDVVLRAGGRDFPCHRAALSAASAYFHNLFA 71
Cdd:cd18296    16 SFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLR 48
PHA02790 PHA02790
Kelch-like protein; Provisional
 349-535 4.97e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 39.64  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 349 VYVSGGHINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGfdgLRRLHSVERYDPFSNTWAAAAPLP 425
Cdd:PHA02790  274 VYLIGGWMNNeihNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGG---LPNPTSVERWFHGDAAWVNMPSLL 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865337 426 EAVSSAAVASCAGQLFVIGGARQGGVNTDKVQcfdPKEDQWSLrSPA---PFSQRCleAISFEDTIYVMGGLMSKIFTYd 502
Cdd:PHA02790  351 KPRCNPAVASINNVIYVIGGHSETDTTTEYLL---PNHDQWQF-GPStyyPHYKSC--ALVFGRRLFLVGRNAEFYCES- 423

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622865337 503 pgTDVWGEAAVLPSPVESCGVTVCDGKVHILGG 535
Cdd:PHA02790  424 --SNTWTLIDDPIYPRDNPELIIVDNKLLLIGG 454
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 297-333 4.98e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 4.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622865337 297 EVIVVIGGCDRKGLLKLpfADAYHPESQRWTPLPSLP 333
Cdd:pfam01344  12 GKIYVIGGFDGNQSLNS--VEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-69 5.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 37.19  E-value: 5.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNL 69
Cdd:cd18333     4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSL 50
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 40-76 5.44e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 36.96  E-value: 5.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622865337  40 LTDVVLRA-GGRDFPCHRAALSAASAYFHNLFAAGRPE 76
Cdd:cd18302     5 LYDVTIVSeDGKEFPCHKCVLVARLEYFHSMLSSSWIE 42
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-70 5.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 36.79  E-value: 5.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYFHNLF 70
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLF 48
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-66 7.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 36.66  E-value: 7.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622865337  23 HAQRVLQTLNTYRRSGTLTDVVLRAGGRDFPCHRAALSAASAYF 66
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYF 44
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 159-221 8.03e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 35.25  E-value: 8.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865337 159 AVAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVAALLADPALGVARQEAVFEAAMRWV 221
Cdd:cd18493    12 AKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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