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Conserved domains on  [gi|109098365|ref|XP_001084253|]
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inhibitor of nuclear factor kappa-B kinase-interacting protein isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
88-326 1.10e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    88 QLQSKISLISEKLESTE----SILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFQNITDFCKKSL 163
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKrelsSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   164 EEININtdifKSEAKHAHSRvtvqINSAEQEIKLLTERLKDLEDS-----------TLRNIRTVKRQEEEDLLRVEEQLG 232
Cdd:TIGR02169  751 QEIENV----KSELKELEAR----IEELEEDLHKLEEALNDLEARlshsripeiqaELSKLEEEVSRIEARLREIEQKLN 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   233 SDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHLPTIESAVR----SVLRVSQDLIGTEKKMEDLTMQMFNME 308
Cdd:TIGR02169  823 RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEeleaALRDLESRLGDLKKERDELEAQLRELE 902
                          250
                   ....*....|....*...
gi 109098365   309 DDMLKAVSEIMEMQKTLE 326
Cdd:TIGR02169  903 RKIEELEAQIEKKRKRLS 920
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
88-326 1.10e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    88 QLQSKISLISEKLESTE----SILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFQNITDFCKKSL 163
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKrelsSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   164 EEININtdifKSEAKHAHSRvtvqINSAEQEIKLLTERLKDLEDS-----------TLRNIRTVKRQEEEDLLRVEEQLG 232
Cdd:TIGR02169  751 QEIENV----KSELKELEAR----IEELEEDLHKLEEALNDLEARlshsripeiqaELSKLEEEVSRIEARLREIEQKLN 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   233 SDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHLPTIESAVR----SVLRVSQDLIGTEKKMEDLTMQMFNME 308
Cdd:TIGR02169  823 RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEeleaALRDLESRLGDLKKERDELEAQLRELE 902
                          250
                   ....*....|....*...
gi 109098365   309 DDMLKAVSEIMEMQKTLE 326
Cdd:TIGR02169  903 RKIEELEAQIEKKRKRLS 920
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
64-264 1.96e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.43  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365  64 QQSEKFAKVENQyqlLKLETNEFQQLQSKISLISEKLESTESILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQ 143
Cdd:PRK03918 197 EKEKELEEVLRE---INEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 144 RIQSLNEKFQNITDFCKKSLEEININTdiFKSEAKHAHSRVTVQINSAEQEIKLLTERLKDLEDSTLRnIRTVKRQEEED 223
Cdd:PRK03918 274 EIEELEEKVKELKELKEKAEEYIKLSE--FYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEER-LEELKKKLKEL 350
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 109098365 224 LLRVEEqlgsdTKAVEKLEEEQHALFARDEDLTNKLSDYEP 264
Cdd:PRK03918 351 EKRLEE-----LEERHELYEEAKAKKEELERLKKRLTGLTP 386
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
87-259 2.19e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.21  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    87 QQLQSKISLISEKLESTESILQEATSSMSLMT-QFEQEVSNLQDTMHGIQNNEEvltqRIQSLNEKFQNITDFCKKSLEE 165
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVQANgELEKASREETFARTALKNARL----DLRRLFDEKQSEKDKKNKALAE 675
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   166 inintdifkseakhAHSRVTVQINSAEQEIKLLTERLKDLEDSTLRNIRTVKRQEEEDLLRVEE----QLGSDTKAVEKL 241
Cdd:pfam12128  676 --------------RKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGaldaQLALLKAAIAAR 741
                          170
                   ....*....|....*....
gi 109098365   242 EEEQHA-LFARDEDLTNKL 259
Cdd:pfam12128  742 RSGAKAeLKALETWYKRDL 760
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
119-326 2.62e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 119 QFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFQNItdfcKKSLEEININTDifksEAKHAHSRVTVQINSAEQEIKLL 198
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAELAELEAELEEL----RLELEELELELE----EAQAEEYELLAELARLEQDIARL 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 199 TERLKDLEDSTLRN---IRTVKRQEEEDLLRVEEQLGSDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEEckthlpt 275
Cdd:COG1196  308 EERRRELEERLEELeeeLAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE------- 380
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109098365 276 IESAVRSVLRVSQDLIGTEKKMEDLTMQMFNMEDDMLKAVSEIMEMQKTLE 326
Cdd:COG1196  381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALA 431
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
88-326 1.10e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    88 QLQSKISLISEKLESTE----SILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFQNITDFCKKSL 163
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKrelsSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   164 EEININtdifKSEAKHAHSRvtvqINSAEQEIKLLTERLKDLEDS-----------TLRNIRTVKRQEEEDLLRVEEQLG 232
Cdd:TIGR02169  751 QEIENV----KSELKELEAR----IEELEEDLHKLEEALNDLEARlshsripeiqaELSKLEEEVSRIEARLREIEQKLN 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   233 SDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHLPTIESAVR----SVLRVSQDLIGTEKKMEDLTMQMFNME 308
Cdd:TIGR02169  823 RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEeleaALRDLESRLGDLKKERDELEAQLRELE 902
                          250
                   ....*....|....*...
gi 109098365   309 DDMLKAVSEIMEMQKTLE 326
Cdd:TIGR02169  903 RKIEELEAQIEKKRKRLS 920
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
67-348 6.53e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 6.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    67 EKFAKVENQYQLLKLETNEFQQLQSKISLISEKLEST-ESILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQRI 145
Cdd:TIGR02168  705 KELEELEEELEQLRKELEELSRQISALRKDLARLEAEvEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEI 784
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   146 QSLNEKFQNITDFCKKSLEEININTDIFKSEAKHAHsRVTVQINSAEQEIKLLTERLKDLEDStlrnirtvKRQEEEDLL 225
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAELTLLNEEAA-NLRERLESLERRIAATERRLEDLEEQ--------IEELSEDIE 855
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   226 RVEEQLGSDTKAVEKLEEE-QHALFARDEdltnklsdyepkveeckthlptiesavrsvlrVSQDLIGTEKKMEDLTMQM 304
Cdd:TIGR02168  856 SLAAEIEELEELIEELESElEALLNERAS--------------------------------LEEALALLRSELEELSEEL 903
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 109098365   305 FNMEDDMLKAVSEIMEMQKTLEgiQYDNRILKMQNELDVLKEKV 348
Cdd:TIGR02168  904 RELESKRSELRRELEELREKLA--QLELRLEGLEVRIDNLQERL 945
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
68-328 1.41e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    68 KFAKVENQYQLLKLETNEFQQLQSK----ISLISEKLESTESILQEATSSMslmTQFEQEVSNLQDTMHGIQNNEEVLTQ 143
Cdd:TIGR02168  275 EVSELEEEIEELQKELYALANEISRleqqKQILRERLANLERQLEELEAQL---EELESKLDELAEELAELEEKLEELKE 351
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   144 RIQSLNEKFQNITDFcKKSLEEININTDIFKSEAKHAHSRVTVQINSAEQEIKLLTERLKDLEDstlRNIRTVKRQEEED 223
Cdd:TIGR02168  352 ELESLEAELEELEAE-LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLED---RRERLQQEIEELL 427
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   224 LLRVEEQLGSDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEEckthlptIESAVRSVLRVSQDLIGTEKKMEDltmq 303
Cdd:TIGR02168  428 KKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDAAERELAQLQARLDSLER---- 496
                          250       260
                   ....*....|....*....|....*
gi 109098365   304 MFNMEDDMLKAVSEIMEMQKTLEGI 328
Cdd:TIGR02168  497 LQENLEGFSEGVKALLKNQSGLSGI 521
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
64-349 1.64e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    64 QQSEKFAKVENQYQLLKLE--TNEFQQLQSKISLISEKLESTESILQEATSsmsLMTQFEQEVSNLQDTMHGIQNNEEVL 141
Cdd:TIGR02168  210 EKAERYKELKAELRELELAllVLRLEELREELEELQEELKEAEEELEELTA---ELQELEEKLEELRLEVSELEEEIEEL 286
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   142 TQRIQSLNEKfqnitdfckksleeinintdifkseakhahsrvtvqINSAEQEIKLLTERLKDLEDSTLR---NIRTVKR 218
Cdd:TIGR02168  287 QKELYALANE------------------------------------ISRLEQQKQILRERLANLERQLEEleaQLEELES 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   219 QEEED---LLRVEEQLGSDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHL------------------PTIE 277
Cdd:TIGR02168  331 KLDELaeeLAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVaqlelqiaslnneierleARLE 410
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 109098365   278 SAVRSVLRVSQDLIGTEKKMEDLTMQMFNMEDDMLKAvsEIMEMQKTLEGIQ-----YDNRILKMQNELDVLKEKVH 349
Cdd:TIGR02168  411 RLEDRRERLQQEIEELLKKLEEAELKELQAELEELEE--ELEELQEELERLEealeeLREELEEAEQALDAAERELA 485
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
64-264 1.96e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.43  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365  64 QQSEKFAKVENQyqlLKLETNEFQQLQSKISLISEKLESTESILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQ 143
Cdd:PRK03918 197 EKEKELEEVLRE---INEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 144 RIQSLNEKFQNITDFCKKSLEEININTdiFKSEAKHAHSRVTVQINSAEQEIKLLTERLKDLEDSTLRnIRTVKRQEEED 223
Cdd:PRK03918 274 EIEELEEKVKELKELKEKAEEYIKLSE--FYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEER-LEELKKKLKEL 350
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 109098365 224 LLRVEEqlgsdTKAVEKLEEEQHALFARDEDLTNKLSDYEP 264
Cdd:PRK03918 351 EKRLEE-----LEERHELYEEAKAKKEELERLKKRLTGLTP 386
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
87-259 2.19e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.21  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    87 QQLQSKISLISEKLESTESILQEATSSMSLMT-QFEQEVSNLQDTMHGIQNNEEvltqRIQSLNEKFQNITDFCKKSLEE 165
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVQANgELEKASREETFARTALKNARL----DLRRLFDEKQSEKDKKNKALAE 675
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   166 inintdifkseakhAHSRVTVQINSAEQEIKLLTERLKDLEDSTLRNIRTVKRQEEEDLLRVEE----QLGSDTKAVEKL 241
Cdd:pfam12128  676 --------------RKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGaldaQLALLKAAIAAR 741
                          170
                   ....*....|....*....
gi 109098365   242 EEEQHA-LFARDEDLTNKL 259
Cdd:pfam12128  742 RSGAKAeLKALETWYKRDL 760
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
119-326 2.62e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 119 QFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFQNItdfcKKSLEEININTDifksEAKHAHSRVTVQINSAEQEIKLL 198
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAELAELEAELEEL----RLELEELELELE----EAQAEEYELLAELARLEQDIARL 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 199 TERLKDLEDSTLRN---IRTVKRQEEEDLLRVEEQLGSDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEEckthlpt 275
Cdd:COG1196  308 EERRRELEERLEELeeeLAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE------- 380
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109098365 276 IESAVRSVLRVSQDLIGTEKKMEDLTMQMFNMEDDMLKAVSEIMEMQKTLE 326
Cdd:COG1196  381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALA 431
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
61-340 4.77e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 38.93  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   61 FVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKLESTESILQEATSsmslmtqfeqEVSNLQDTMHGIQNNEEV 140
Cdd:pfam05483 245 LLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTK----------ELEDIKMSLQRSMSTQKA 314
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365  141 LTQRIQSLNEKFQNITDFCKKSLEEINintdifksEAKHAHSRVTVQINSA------------------EQEIKLLTERL 202
Cdd:pfam05483 315 LEEDLQIATKTICQLTEEKEAQMEELN--------KAKAAHSFVVTEFEATtcsleellrteqqrleknEDQLKIITMEL 386
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365  203 K----DLEDST-LRNIRTVKRQEEEDLLRVEEQLGSDTKAVEKLEEEqhaLFARDEDLTNKLSDYEPKVEECKTHLPTIE 277
Cdd:pfam05483 387 QkkssELEEMTkFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEE---LKGKEQELIFLLQAREKEIHDLEIQLTAIK 463
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109098365  278 SAVRSVLRVSQDLiGTEKKMEDLTMQMFNMEDDML-----KAVSEIMEMQKTLEGIQYDNRILKMQNE 340
Cdd:pfam05483 464 TSEEHYLKEVEDL-KTELEKEKLKNIELTAHCDKLllenkELTQEASDMTLELKKHQEDIINCKKQEE 530
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
63-280 5.12e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 39.05  E-value: 5.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    63 FQQSEKFAKVENQYQLLKLETNEFQQLQ-SKISLISEKLESTESILQEATSSMSLMTQFEQEVSNLQDTMhgIQNNEEVL 141
Cdd:pfam12128  311 SAADAAVAKDRSELEALEDQHGAFLDADiETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRR--RSKIKEQN 388
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   142 TQRIQSLNEKFQNITDFCKKSLEEININTDIFKSEAKHAHSRVTVQINSAEQEIKLLTERLKDLEDSTlrnirtvkrQEE 221
Cdd:pfam12128  389 NRDIAGIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQA---------TAT 459
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 109098365   222 EDLLrveEQLGSDTKAVEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHLPTIESAV 280
Cdd:pfam12128  460 PELL---LQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRL 515
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
52-268 6.37e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365  52 LGTCLGLAWFVFQQSEKFAKVENqyqllkletnEFQQLQSKISLISEKLESTEsilQEATSSMSLMTQFEQEVSNLQDTM 131
Cdd:COG4942    5 LLLALLLALAAAAQADAAAEAEA----------ELEQLQQEIAELEKELAALK---KEEKALLKQLAALERRIAALARRI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 132 HGIQNNEEVLTQRIQSLNEKFQNItdfcKKSLEE-----------------ININTDIFKSEAKHAHSRVTVQINSAEQE 194
Cdd:COG4942   72 RALEQELAALEAELAELEKEIAEL----RAELEAqkeelaellralyrlgrQPPLALLLSPEDFLDAVRRLQYLKYLAPA 147
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 109098365 195 IKLLTERLKDlEDSTLRNIRTVKRQEEEDLLRVEEQLGSDTKAVEKLEEEQHALFARdedLTNKLSDYEPKVEE 268
Cdd:COG4942  148 RREQAEELRA-DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLAR---LEKELAELAAELAE 217
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
92-267 6.97e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.60  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365  92 KISLISEKLESTESILQEATSSMSLMTQFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFQNITDFckKSLEEININTD 171
Cdd:COG4717   65 KPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLY--QELEALEAELA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365 172 IFKSEAKHAHSRVTvQINSAEQEIKLLTERLKDLEDSTLRNIRTVKRQEEEDLLRVEEQLGSDTKAVEKLEEEQHALFAR 251
Cdd:COG4717  143 ELPERLEELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221
                        170
                 ....*....|....*.
gi 109098365 252 DEDLTNKLSDYEPKVE 267
Cdd:COG4717  222 LEELEEELEQLENELE 237
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
79-249 7.50e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 7.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    79 LKLETNEFQQLQSKISLISEKLESTESILQEATSSMSlmtQFEQEVSNLQDTMHGIQNNEEVLTQRIQSLNEKFqnitdf 158
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRS---ELRRELEELREKLAQLELRLEGLEVRIDNLQERL------ 945
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   159 ckksLEEININTDIFKSEakhaHSRVTVQINSAEQEIKLLTERLKDLEDSTLRNIRTVKRQEE---------EDLLRVEE 229
Cdd:TIGR02168  946 ----SEEYSLTLEEAEAL----ENKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKErydfltaqkEDLTEAKE 1017
                          170       180
                   ....*....|....*....|
gi 109098365   230 QLgsdTKAVEKLEEEQHALF 249
Cdd:TIGR02168 1018 TL---EEAIEEIDREARERF 1034
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
88-248 7.96e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.51  E-value: 7.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365    88 QLQSKISLISEKLESTESILQEATSSMSLMTQFEQEVSNLQDTMhgiqnneEVLTQRIQSLNEKFQNITDFCKK------ 161
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL-------EDLRAELEEVDKEFAETRDELKDyrekle 395
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109098365   162 ----SLEEININTDIFKSEAKHAHSRVT---VQINSAEQEIKLLTERLKDLEDStLRNIRTVKRQEEEDLLRVEEQLGSD 234
Cdd:TIGR02169  396 klkrEINELKRELDRLQEELQRLSEELAdlnAAIAGIEAKINELEEEKEDKALE-IKKQEWKLEQLAADLSKYEQELYDL 474
                          170
                   ....*....|....
gi 109098365   235 TKAVEKLEEEQHAL 248
Cdd:TIGR02169  475 KEEYDRVEKELSKL 488
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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