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Conserved domains on  [gi|109128804|ref|XP_001082641|]
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cadherin-5 [Macaca mulatta]

Protein Classification

Cadherin_repeat and Cadherin_C domain-containing protein( domain architecture ID 11254411)

Cadherin_repeat and Cadherin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-255 8.15e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 157 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGRIVTiTKSLDREKQARYEIVVEARDa 233
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTGEITT-AKPLDREEQSSYTLTVTATD- 76

                         90       100
                 ....*....|....*....|..
gi 109128804 234 QGLRGDSGTATVLVTLQDINDN 255
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 717-776 8.38e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.61  E-value: 8.38e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  717 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 776
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
264-365 2.40e-24

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 2.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  264 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPthneGIIKPMKPLDYEYIQQYSFIVEATDP 343
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 109128804  344 tidlryLSPPAGNRAQVIINIT 365
Cdd:pfam00028  77 ------GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 378-476 2.97e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 2.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 378 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 454
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                         90       100
                 ....*....|....*....|..
gi 109128804 455 GTPtGKESIVQVHIEVLDENDN 476
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 483-577 1.26e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 483 PYQPKVCENAAHGQLVLQISAIDKDItPRNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 559
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*...
gi 109128804 560 DNGMPSRTGTSTLTVAVC 577
Cdd:cd11304   76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-150 7.88e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.88e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109128804    80 NAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 150
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-255 8.15e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 157 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGRIVTiTKSLDREKQARYEIVVEARDa 233
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTGEITT-AKPLDREEQSSYTLTVTATD- 76

                         90       100
                 ....*....|....*....|..
gi 109128804 234 QGLRGDSGTATVLVTLQDINDN 255
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 717-776 8.38e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.61  E-value: 8.38e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  717 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 776
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
264-365 2.40e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 2.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  264 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPthneGIIKPMKPLDYEYIQQYSFIVEATDP 343
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 109128804  344 tidlryLSPPAGNRAQVIINIT 365
Cdd:pfam00028  77 ------GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-369 3.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 264 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETnpthNEGIIKPMKPLDYEYIQQYSFIVEATDP 343
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDP----STGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*.
gi 109128804 344 TidlrylSPPAGNRAQVIINITDVDE 369
Cdd:cd11304   78 G------GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
157-250 1.43e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  157 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKGKEY--FAIDNSGRIVTITKSLDREKQARYEIVVEARDaQ 234
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATD-S 76

                          90
                  ....*....|....*.
gi 109128804  235 GLRGDSGTATVLVTLQ 250
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-257 5.31e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 5.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   175 TAVDADDptvGDHASVMYQILKG--KEYFAIDNSGRIVTITKSLDREKQARYEIVVEARDaQGLRGDSGTATVLVTLQDI 252
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                   ....*
gi 109128804   253 NDNFP 257
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 378-476 2.97e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 2.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 378 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 454
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                         90       100
                 ....*....|....*....|..
gi 109128804 455 GTPtGKESIVQVHIEVLDENDN 476
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
378-471 9.01e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 9.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  378 YHFQLKENQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDstg 455
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--- 77

                          90
                  ....*....|....*.
gi 109128804  456 tPTGKESIVQVHIEVL 471
Cdd:pfam00028  78 -GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 483-577 1.26e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 483 PYQPKVCENAAHGQLVLQISAIDKDItPRNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 559
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*...
gi 109128804 560 DNGMPSRTGTSTLTVAVC 577
Cdd:cd11304   76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 1.55e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   283 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPthneGIIKPMKPLDYEYIQQYSFIVEATDPTidlrylSPPAGNRAQVII 362
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTATVTI 71

                           90
                   ....*....|
gi 109128804   363 NITDV-DEPP 371
Cdd:smart00112  72 TVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-150 7.88e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.88e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109128804    80 NAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 150
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 396-478 5.82e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 5.82e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   396 AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKelDSTGTPtgKESIVQVHIEVLDEN 474
Cdd:smart00112   2 ATDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLDVN 77


                   ....
gi 109128804   475 DNAP 478
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-148 2.67e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 2.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  62 NTSLPHHVGKIKS----SVSRKNAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSS 137
Cdd:cd11304    9 NAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTAT 87

                         90
                 ....*....|.
gi 109128804 138 FTIKVHDVNDN 148
Cdd:cd11304   88 VTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
54-143 8.95e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 8.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   54 QMHIDEEKNT-SLPHHVGKI-KSSVSRKNAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGEN 131
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATdPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GPP 80

                          90
                  ....*....|..
gi 109128804  132 LETPSSFTIKVH 143
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
488-577 1.46e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  488 VCENAAHGQLVLQISAIDKDITPrNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVISDNGMP 564
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGP-NGRIFYSIlggGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 109128804  565 SRTGTSTLTVAVC 577
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 502-581 1.69e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   502 SAIDKDiTPRNVKFKFTLNTENNFTLTDNHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 581
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-255 8.15e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 8.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 157 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKG--KEYFAID-NSGRIVTiTKSLDREKQARYEIVVEARDa 233
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDpSTGEITT-AKPLDREEQSSYTLTVTATD- 76

                         90       100
                 ....*....|....*....|..
gi 109128804 234 QGLRGDSGTATVLVTLQDINDN 255
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 717-776 8.38e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 97.61  E-value: 8.38e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  717 ADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 776
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
264-365 2.40e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 2.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  264 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPthneGIIKPMKPLDYEYIQQYSFIVEATDP 343
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|..
gi 109128804  344 tidlryLSPPAGNRAQVIINIT 365
Cdd:pfam00028  77 ------GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-369 3.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 264 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETnpthNEGIIKPMKPLDYEYIQQYSFIVEATDP 343
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDP----STGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*.
gi 109128804 344 TidlrylSPPAGNRAQVIINITDVDE 369
Cdd:cd11304   78 G------GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
157-250 1.43e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  157 FNASVPESSAVGTSVISVTAVDADDptvGDHASVMYQILKGKEY--FAIDNSGRIVTITKSLDREKQARYEIVVEARDaQ 234
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATD-S 76

                          90
                  ....*....|....*.
gi 109128804  235 GLRGDSGTATVLVTLQ 250
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-257 5.31e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 5.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   175 TAVDADDptvGDHASVMYQILKG--KEYFAIDNSGRIVTITKSLDREKQARYEIVVEARDaQGLRGDSGTATVLVTLQDI 252
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDV 76


                   ....*
gi 109128804   253 NDNFP 257
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 378-476 2.97e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 2.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 378 YHFQLKENQKKP-LIGTVLAMDPDAARHS-IGYSIRRTSDKGqFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELdst 454
Cdd:cd11304    2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPStGEITTAKPLDREEQSSYTLTVTATDG--- 77

                         90       100
                 ....*....|....*....|..
gi 109128804 455 GTPtGKESIVQVHIEVLDENDN 476
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
378-471 9.01e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 9.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  378 YHFQLKENQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDstg 455
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--- 77

                          90
                  ....*....|....*.
gi 109128804  456 tPTGKESIVQVHIEVL 471
Cdd:pfam00028  78 -GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 483-577 1.26e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804 483 PYQPKVCENAAHGQLVLQISAIDKDItPRNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVIS 559
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIvsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                         90
                 ....*....|....*...
gi 109128804 560 DNGMPSRTGTSTLTVAVC 577
Cdd:cd11304   76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 1.55e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   283 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPthneGIIKPMKPLDYEYIQQYSFIVEATDPTidlrylSPPAGNRAQVII 362
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTATVTI 71

                           90
                   ....*....|
gi 109128804   363 NITDV-DEPP 371
Cdd:smart00112  72 TVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-150 7.88e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.88e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109128804    80 NAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSSFTIKVHDVNDNWP 150
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 396-478 5.82e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 5.82e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   396 AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKelDSTGTPtgKESIVQVHIEVLDEN 474
Cdd:smart00112   2 ATDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLDVN 77


                   ....
gi 109128804   475 DNAP 478
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-148 2.67e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 2.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  62 NTSLPHHVGKIKS----SVSRKNAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGENLETPSS 137
Cdd:cd11304    9 NAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTAT 87

                         90
                 ....*....|.
gi 109128804 138 FTIKVHDVNDN 148
Cdd:cd11304   88 VTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
54-143 8.95e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 8.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   54 QMHIDEEKNT-SLPHHVGKI-KSSVSRKNAKYLLKGEFVDKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDtGEN 131
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATdPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GPP 80

                          90
                  ....*....|..
gi 109128804  132 LETPSSFTIKVH 143
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
488-577 1.46e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  488 VCENAAHGQLVLQISAIDKDITPrNVKFKFTL---NTENNFTLtdnHDNTANITVKyGQFDREHTKVHFLPVVISDNGMP 564
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGP-NGRIFYSIlggGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 109128804  565 SRTGTSTLTVAVC 577
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 502-581 1.69e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804   502 SAIDKDiTPRNVKFKFTLNTENNFTLTDNHDNTANITVKyGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 581
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-148 2.05e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.95  E-value: 2.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109128804  62 NTSLPHHVGKIKSSV---SRKNAKYLLKG-EFVDKVFRVDAETGDVFAIERLDRENISEYHLTaVIVDKDTGENLETPSS 137
Cdd:cd00031    9 GRSRGSFRVSIPTDLiasSGEIIKISAAGkEALPSWLHWEPHSGILEGLEKLDREDKGVHYIS-VSAASLGANVPQTSSV 87

                         90
                 ....*....|.
gi 109128804 138 FTIKVHDVNDN 148
Cdd:cd00031   88 FSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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