NCBI Conserved Domain Search

Conserved domains on [gi|1348988274|ref|WP_104489117|]

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MULTISPECIES: PAS domain-containing sensor histidine kinase [Acinetobacter]

Protein Classification

sensor histidine kinase( domain architecture ID 11472018)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; similar to FlgS and FleS

CATH: 3.30.565.10

EC: 2.7.13.3

Gene Ontology: GO:0000156|GO:0005524|GO:0007165|GO:0004673|GO:0000155

PubMed: 10339418|10637609

SCOP: 4001957

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

187-514

2.41e-56

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 194.03 E-value: 2.41e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 187 SQSLELNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPDLFQLLQFDQLSNGEKFQ 266
Cdd:COG5000    80 EQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGK-PLEELLPELDLAELLREALERGWQE 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 267 FESQLSHFLIQIQVQKLVVPQQTlTLLVLQDarqINQRVQQLKLAALGQLSASIAHEIRNPLAAIVQA----NRLLAGSD 342
Cdd:COG5000   159 EIELTRDGRRTLLVRASPLRDDG-YVIVFDD---ITELLRAERLAAWGELARRIAHEIKNPLTPIQLSaerlRRKLADKL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 343 TDQQQMLSQMID---KQSQRIDKIIDDTLSMVKNKETTPVQIDLARFIPQ---LIQDDLADLASQIQVS-QPEPLQILFD 415
Cdd:COG5000   235 EEDREDLERALDtiiRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREvlaLYEPALKEKDIRLELDlDPDLPEVLAD 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 416 ESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEA 495
Cdd:COG5000   315 RDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEE 394

                         330       340
                  ....*....|....*....|
gi 1348988274 496 NRAKLRYV-EQKQGACFRIE 514
Cdd:COG5000   395 HGGTIELEsRPGGGTTFTIR 414

Name

Accession

Description

Interval

E-value

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

187-514

2.41e-56

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 194.03 E-value: 2.41e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 187 SQSLELNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPDLFQLLQFDQLSNGEKFQ 266
Cdd:COG5000    80 EQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGK-PLEELLPELDLAELLREALERGWQE 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 267 FESQLSHFLIQIQVQKLVVPQQTlTLLVLQDarqINQRVQQLKLAALGQLSASIAHEIRNPLAAIVQA----NRLLAGSD 342
Cdd:COG5000   159 EIELTRDGRRTLLVRASPLRDDG-YVIVFDD---ITELLRAERLAAWGELARRIAHEIKNPLTPIQLSaerlRRKLADKL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 343 TDQQQMLSQMID---KQSQRIDKIIDDTLSMVKNKETTPVQIDLARFIPQ---LIQDDLADLASQIQVS-QPEPLQILFD 415
Cdd:COG5000   235 EEDREDLERALDtiiRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREvlaLYEPALKEKDIRLELDlDPDLPEVLAD 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 416 ESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEA 495
Cdd:COG5000   315 RDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEE 394

                         330       340
                  ....*....|....*....|
gi 1348988274 496 NRAKLRYV-EQKQGACFRIE 514
Cdd:COG5000   395 HGGTIELEsRPGGGTTFTIR 414

PRK11360

two-component system sensor histidine kinase AtoS;

192-513

1.65e-34

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 137.41 E-value: 1.65e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 192 LNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPDLFQLLQF--DQLSNGEK---FQ 266
Cdd:PRK11360  257 LRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGK-PYSELFPPNTPFASPllDTLEHGTEhvdLE 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 267 FESQLSHFLIQIQV--QKLVVPQQTL--TLLVLQDA---RQINQRVQQLK-LAALGQLSASIAHEIRNPLAAI---VQAN 335
Cdd:PRK11360  336 ISFPGRDRTIELSVstSLLHNTHGEMigALVIFSDLterKRLQRRVARQErLAALGELVAGVAHEIRNPLTAIrgyVQIW 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 336 RLLAgSDTDQQQMLSQMIdKQSQRIDKIIDDTLSMVKNKETTPVQIDLARFIP---QLIQDdlADLASQIQVS---QPEP 409
Cdd:PRK11360  416 RQQT-SDPPSQEYLSVVL-REVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEevlQLFQT--AGVQARVDFEtelDNEL 491

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 410 LQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDT-VYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYL 488
Cdd:PRK11360  492 PPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGqVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLAL 571

                         330       340
                  ....*....|....*....|....*..
gi 1348988274 489 SHSFCEANRAKLRyVEQK--QGACFRI 513
Cdd:PRK11360  572 SQRIINAHGGDIE-VESEpgVGTTFTL 597

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

415-514

4.27e-23

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.87 E-value: 4.27e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274  415 DESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFST-----EISGTGLGLYLS 489
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTdkrsrKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*.
gi 1348988274  490 HSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:smart00387  82 KKLVELHGGEISVEsEPGGGTTFTIT 107

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

415-514

4.09e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 79.72 E-value: 4.09e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 415 DESQLRQVLINLIRNAQRHNAPDHPIELQLyRQQDTVYMDVKDYGSGVASHDIRYLFQPFFS---TEISGTGLGLYLSHS 491
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....
gi 1348988274 492 FCEANRAKLRYV-EQKQGACFRIE 514
Cdd:pfam02518  81 LVELLGGTITVEsEPGGGTTVTLT 104

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-514

9.25e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 70.18 E-value: 9.25e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNA--QRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEI--SGTGLGLYLSHSFCE 494
Cdd:cd16976     1 IQQVLMNLLQNAldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVE 80

                          90       100
                  ....*....|....*....|.
gi 1348988274 495 ANRAKLRYVEQKQ-GACFRIE 514
Cdd:cd16976    81 EHGGRLSVANEEGaGARFTFD 101

PEP_TPR_lipo

TIGR02917

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...

243-358

4.56e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.

Pssm-ID: 274350 [Multi-domain] Cd Length: 899 Bit Score: 39.68 E-value: 4.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 243 LYKVQPDLFQLLQFDQLSNGekfQFESQLSHFliqiqvQKLV--VPQQTLTLLVLQDArqinQRVQQLKLAALGQLSASI 320
Cdd:TIGR02917 596 AAPDSPEAWLMLGRAQLAAG---DLNKAVSSF------KKLLalQPDSALALLLLADA----YAVMKNYAKAITSLKRAL 662

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1348988274 321 AHEIRNPLAAIVQANRLLAGSDTDQQQMLSQMIDKQSQ 358
Cdd:TIGR02917 663 ELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHP 700

Name

Accession

Description

Interval

E-value

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

187-514

2.41e-56

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 194.03 E-value: 2.41e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 187 SQSLELNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPDLFQLLQFDQLSNGEKFQ 266
Cdd:COG5000    80 EQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGK-PLEELLPELDLAELLREALERGWQE 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 267 FESQLSHFLIQIQVQKLVVPQQTlTLLVLQDarqINQRVQQLKLAALGQLSASIAHEIRNPLAAIVQA----NRLLAGSD 342
Cdd:COG5000   159 EIELTRDGRRTLLVRASPLRDDG-YVIVFDD---ITELLRAERLAAWGELARRIAHEIKNPLTPIQLSaerlRRKLADKL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 343 TDQQQMLSQMID---KQSQRIDKIIDDTLSMVKNKETTPVQIDLARFIPQ---LIQDDLADLASQIQVS-QPEPLQILFD 415
Cdd:COG5000   235 EEDREDLERALDtiiRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREvlaLYEPALKEKDIRLELDlDPDLPEVLAD 314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 416 ESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEA 495
Cdd:COG5000   315 RDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEE 394

                         330       340
                  ....*....|....*....|
gi 1348988274 496 NRAKLRYV-EQKQGACFRIE 514
Cdd:COG5000   395 HGGTIELEsRPGGGTTFTIR 414

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

191-513

3.44e-51

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 178.50 E-value: 3.44e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 191 ELNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPDLFQLLQFDQ--LSNGEKF-QF 267
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGR-PLAELFPEDSPLRELLEraLAEGQPVtER 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 268 ESQL-----SHFLIQIQVQKLV-VPQQTLTLLVLQD---ARQINQRVQQL-KLAALGQLSASIAHEIRNPLAAIVQANRL 337
Cdd:COG3852    80 EVTLrrkdgEERPVDVSVSPLRdAEGEGGVLLVLRDiteRKRLERELRRAeKLAAVGELAAGLAHEIRNPLTGIRGAAQL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 338 LAGS-DTDQQQMLSQMIDKQSQRIDKIIDDTLSMVKNKETTPVQIDLARFIPQLIQDDLADLASQIQVS---QPEPLQIL 413
Cdd:COG3852   160 LERElPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAPKNIRIVrdyDPSLPEVL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 414 FDESQLRQVLINLIRNAqRHNAPDHP-IELQLY----------RQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGT 482
Cdd:COG3852   240 GDPDQLIQVLLNLVRNA-AEAMPEGGtITIRTRverqvtlgglRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGT 318

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1348988274 483 GLGLYLSHSFCEANRAKLRYV-EQKQGACFRI 513
Cdd:COG3852   319 GLGLAIVQKIVEQHGGTIEVEsEPGKGTTFRI 350

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

295-514

2.95e-44

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 156.22 E-value: 2.95e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 295 LQDARQINQRVQQLKlaalGQLSASIAHEIRNPLAAIVQANRLL----AGSDTDQQQMLsQMIDKQSQRIDKIIDDTLSM 370
Cdd:COG2205     2 LEEALEELEELERLK----SEFLANVSHELRTPLTSILGAAELLldeeDLSPEERRELL-EIIRESAERLLRLIEDLLDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 371 VK----NKETTPVQIDLARFIPQLIqDDLADLASQIQVS-----QPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIE 441
Cdd:COG2205    77 SRlesgKLSLELEPVDLAELLEEAV-EELRPLAEEKGIRleldlPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTIT 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1348988274 442 LQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFF----STEISGTGLGLYLSHSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:COG2205   156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVEsEPGGGTTFTVT 233

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

295-514

1.29e-42

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 155.73 E-value: 1.29e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 295 LQDARQinQRVQQLKLAALGQLSASIAHEIRNPLAAIVQANRLL------AGSDTDQQQMLSQmIDKQSQRIDKIIDDTL 368
Cdd:COG4191   126 LRELQE--QLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLrrrledEPDPEELREALER-ILEGAERAAEIVRSLR 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 369 SMVKNKETTPVQIDLARFIPQ---LIQDDLAdlASQIQVS---QPEPLQILFDESQLRQVLINLIRNAqRH---NAPDHP 439
Cdd:COG4191   203 AFSRRDEEEREPVDLNELIDEaleLLRPRLK--ARGIEVEldlPPDLPPVLGDPGQLEQVLLNLLINA-IDameEGEGGR 279

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1348988274 440 IELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFST--EISGTGLGLYLSHSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:COG4191   280 ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTkpVGKGTGLGLSISYGIVEKHGGRIEVEsEPGGGTTFTIT 357

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

229-514

3.95e-41

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 150.83 E-value: 3.95e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 229 LLGINPLYAFDKYPLYKVQPDLFQLLQFDQLSNGEKFQFESQLSHFLIQIQVQKLVVPQQTLTLLVLQDARQINQRVQQL 308
Cdd:COG0642    26 LLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 309 KLAALGQLSASIAHEIRNPLAAIVQANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDTLSMVK----NKETTPVQIDLA 384
Cdd:COG0642   106 ANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRleagKLELEPEPVDLA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 385 RFIPQLIqDDLADLASQ--IQVS---QPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYG 459
Cdd:COG0642   186 ELLEEVV-ELFRPLAEEkgIELEldlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTG 264

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 460 SGVASHDIRYLFQPFF----STEISGTGLGLYLSHSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:COG0642   265 PGIPPEDLERIFEPFFrtdpSRRGGGTGLGLAIVKRIVELHGGTIEVEsEPGKGTTFTVT 324

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

166-514

1.56e-37

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 144.35 E-value: 1.56e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 166 IIYRFGQ---IAVRRFQILEHLNFSQSLELnrlkninryILEQTDMGYLVLDENCHIMVSNPAACHLLGINP-------- 234
Cdd:COG5809   116 IEGMLAIsrdITERKRMEEALRESEEKFRL---------IFNHSPDGIIVTDLDGRIIYANPAACKLLGISIeeligksi 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 235 LYAFDKYPLYKVQPDLFQLLQFDQL---------SNGEKFQFESQLSHFLIQIQVQKLVVpqqtltllVLQD---ARQIN 302
Cdd:COG5809   187 LELIHSDDQENVAAFISQLLKDGGIaqgevrfwtKDGRWRLLEASGAPIKKNGEVDGIVI--------IFRDiteRKKLE 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 303 QRVQQL-KLAALGQLSASIAHEIRNPLAAI---VQanrLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDTLSMVKNKETTP 378
Cdd:COG5809   259 ELLRKSeKLSVVGELAAGIAHEIRNPLTSLkgfIQ---LLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKY 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 379 VQIDLARFIPQLI-----QDDLADLasQIQ--VSQPEPLqILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDT- 450
Cdd:COG5809   336 EPKDLNTLIEEVIpllqpQALLKNV--QIEleLEDDIPD-ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDk 412

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1348988274 451 VYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEANRAKLRyVEQK--QGACFRIE 514
Cdd:COG5809   413 VVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKIT-VESEvgKGTTFSIT 477

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

145-514

9.96e-36

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 137.38 E-value: 9.96e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 145 LLDFSSLDRIGQSALLSFLFFIIYRFGQIAVRRFQILEHLNFSQSLELNRLKNINRYILEQTDMGYLVLDENchimvsnp 224
Cdd:COG5002     6 LLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLL-------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 225 aacHLLGINPLYAFDKYPLYKVQPDLFQLLQFDQLSNGEKFQFESQLSHFLIQIQVQKLVVPQQTLTLLVLQDARQINQR 304
Cdd:COG5002    78 ---LLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 305 VQQLKLA--ALGQLSASIAHEIRNPLAAI---VQANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDD--TLSMVKNKETT 377
Cdd:COG5002   155 ITELERLeqMRREFVANVSHELRTPLTSIrgyLELLLDGAADDPEERREYLEIILEEAERLSRLVNDllDLSRLESGELK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 378 --PVQIDLARFIPQLIqDDLADLASQIQVS-----QPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDT 450
Cdd:COG5002   235 leKEPVDLAELLEEVV-EELRPLAEEKGIEleldlPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQ 313

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1348988274 451 VYMDVKDYGSGVASHDIRYLFQPFF------STEISGTGLGLYLSHSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:COG5002   314 VRISVRDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVEsEPGKGTTFTIT 384

PRK11360

two-component system sensor histidine kinase AtoS;

192-513

1.65e-34

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 137.41 E-value: 1.65e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 192 LNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPDLFQLLQF--DQLSNGEK---FQ 266
Cdd:PRK11360  257 LRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGK-PYSELFPPNTPFASPllDTLEHGTEhvdLE 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 267 FESQLSHFLIQIQV--QKLVVPQQTL--TLLVLQDA---RQINQRVQQLK-LAALGQLSASIAHEIRNPLAAI---VQAN 335
Cdd:PRK11360  336 ISFPGRDRTIELSVstSLLHNTHGEMigALVIFSDLterKRLQRRVARQErLAALGELVAGVAHEIRNPLTAIrgyVQIW 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 336 RLLAgSDTDQQQMLSQMIdKQSQRIDKIIDDTLSMVKNKETTPVQIDLARFIP---QLIQDdlADLASQIQVS---QPEP 409
Cdd:PRK11360  416 RQQT-SDPPSQEYLSVVL-REVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEevlQLFQT--AGVQARVDFEtelDNEL 491

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 410 LQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDT-VYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYL 488
Cdd:PRK11360  492 PPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGqVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLAL 571

                         330       340
                  ....*....|....*....|....*..
gi 1348988274 489 SHSFCEANRAKLRyVEQK--QGACFRI 513
Cdd:PRK11360  572 SQRIINAHGGDIE-VESEpgVGTTFTL 597

KinC

COG5807

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...

212-508

5.32e-34

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 131.83 E-value: 5.32e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 212 VLDENCHIMVSNPAACHLLGINplyafDKYPLYKVQPDLFQLLQFDQLSNGEKFqfESQLSHFLIQIQVQKLVV------ 285
Cdd:COG5807    42 FIDSKGEILECNDFAEDLYGLS-----QNEYIGKTFVEEKCILKDEQLYNKEAF--DRIEISYLTKNGEFDEIIypiyyk 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 286 -PQQTLTLLVLQDARQINQRVQQL----KLAALGQLSASIAHEIRNPLAAIVQANRLL-AGSDTDQQQMLSQMIDKQSQR 359
Cdd:COG5807   115 dGVILGLITVYRDITKRKEAEDKLlrseKLSVAGELAAGIAHEIRNPLTSIKGFLQLLqESREDSEREEYFNIIISEIDR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 360 IDKIIDDTLSMVKNKETTPVQIDLARFIPQLIqDDLADLASQIQVS-----QPEPLQILFDESQLRQVLINLIRNAQRHN 434
Cdd:COG5807   195 INTIITELLVLSKPKKFNFKKLNLNDVLEDVI-ALLSTEAILKNISikydlADDEPVINGDKNQLKQVFINLIKNAIEAM 273

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1348988274 435 APDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEANRAKLrYVEQKQG 508
Cdd:COG5807   274 ETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTI-EVESKPG 346

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

309-508

2.50e-28

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 117.91 E-value: 2.50e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 309 KLAALGQLSASIAHEIRNPLAAI---VQanrLLAGSDTDQQQMLSQMIDKQSqRIDKIIDDTLSMVKNKETTPVQIDlar 385
Cdd:COG5805   283 KLSIAGQLAAGIAHEIRNPLTSIkgfLQ---LLQPGIEDKEEYFDIMLSELD-RIESIISEFLALAKPQAVNKEKEN--- 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 386 fIPQLIQDDLADLASQ-------IQVSQPEPLQ-ILFDESQLRQVLINLIRNAqrhnapdhpIE---------LQLYRQQ 448
Cdd:COG5805   356 -INELIQDVVTLLETEailhniqIRLELLDEDPfIYCDENQIKQVFINLIKNA---------IEampnggtitIHTEEED 425

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 449 DTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEANRAKLRyVEQKQG 508
Cdd:COG5805   426 NSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTID-IDSKVG 484

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

295-513

5.41e-28

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 115.73 E-value: 5.41e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 295 LQDARQINQRVQQL-KLAALGQLSASIAHEIRNPLAAI---VQanrLLAGSDT--DQQQMLSQMIDKQSQRIDKIIDDTL 368
Cdd:COG5806   182 LIENILLRKELQRAeKLEVVSELAASIAHEVRNPLTVVrgfIQ---LLQEPELsdEKRKQYIRIALEELDRAEAIITDYL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 369 SMVKNKETTPVQIDLARFIPQLIQ--DDLADLAS-QIQVSQPEPLQILFDESQLRQVLINLIRNAqrhnapdhpIE---- 441
Cdd:COG5806   259 TFAKPQPEKLEKIDVSEELEHVIDvlSPYANMNNvEIQTELEPGLYIEGDRQKLQQCLINIIKNG---------IEampn 329

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1348988274 442 -----LQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEANRAKLRYVEQK-QGACFRI 513
Cdd:COG5806   330 ggtltIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVgKGTTFTI 407

KinD

COG5808

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...

300-489

6.52e-26

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 110.22 E-value: 6.52e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 300 QINQRVQQLKLAALGQLSASIAHEIRNPLAAIVQANRLLA-GSDTDQQQMLSQMIDKQSQRIDKIIDDTLsmVKNKETTP 378
Cdd:COG5808   228 RVIQEINTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQeKYPELEDQKYFDIIQEEIQRINQIVSEFL--VLGKPTAK 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 379 -VQIDLARfipQLIQDDLADLASQ-----IQVSQP---EPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQD 449
Cdd:COG5808   306 kLELDDLN---ELIEEILSIIDSEanlknIRVEKQsldEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDE 382

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1348988274 450 TVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLS 489
Cdd:COG5808   383 KAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVC 422

PRK10364

two-component system sensor histidine kinase ZraS;

291-522

1.64e-25

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 109.11 E-value: 1.64e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 291 TLLVLQDARQINQRVQQL--------KLAALGQLSASIAHEIRNPLAAIVQ-----ANRLLAGSdtdQQQMLSQMIDKQS 357
Cdd:PRK10364  207 SLLAFFWYRRYLRSRQLLqdemkrkeKLVALGHLAAGVAHEIRNPLSSIKGlakyfAERAPAGG---EAHQLAQVMAKEA 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 358 QRIDKIIDDTLSMVKNKETTPVQIDLARFIP---QLIQDDLADLASQIQVSQPEPLQ-ILFDESQLRQVLINLIRNAQRH 433
Cdd:PRK10364  284 DRLNRVVSELLELVKPTHLALQAVDLNDLINhslQLVSQDANSREIQLRFTANDTLPeIQADPDRLTQVLLNLYLNAIQA 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 434 NAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEANRAKLRYV-EQKQGACFR 512
Cdd:PRK10364  364 IGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVAsQEGKGATFT 443

                         250
                  ....*....|
gi 1348988274 513 IECsPVDVNK 522
Cdd:PRK10364  444 LWL-PVNITR 452

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

49-513

4.20e-23

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 102.56 E-value: 4.20e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274  49 RLYAASLVLYFIFSCAQLLYFRYVRHRIPLQLTLIFSVDVLVLSSLTFALDGPSLHLSLLFVIAIFAATLLLEKSKALFI 128
Cdd:COG4251    17 LLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 129 TLVAMICVTYQHFVGTLLDFSSLDRIGQSALLSFLFFIIYRFGQIAVRRFQILEHLNFSQSLELNRLKNINRYILEQTDM 208
Cdd:COG4251    97 LLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 209 GYLVLDENCHIMVSNPAACHLLGINPLYAFDKYPLYKVQPDLFQLLQFDQLSnGEKFQFESQLSHFLIQIQVQKLVVPQQ 288
Cdd:COG4251   177 ELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLL-LLLLLLLVLLLLLILLLLLLILVLELL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 289 TLTLLVLQDARQINQRVQQLKLA--ALGQLSASIAHEIRNPLAAIVQANRLL-----AGSDTDQQQMLsQMIDKQSQRID 361
Cdd:COG4251   256 ELRLELEELEEELEERTAELERSneELEQFAYVASHDLREPLRKISGFSQLLeedygDKLDEEGREYL-ERIRDAAERMQ 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 362 KIIDD--TLSMVKNKETTPVQIDLArfipQLIQDDLADLASQI-----QVSQPEPLQILFDESQLRQVLINLIRNAQRHN 434
Cdd:COG4251   335 ALIDDllAYSRVGRQELEFEPVDLN----ELLEEVLEDLEPRIeergaEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYS 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 435 APDHP--IELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFF----STEISGTGLGLYLSHSFCEANRAKLRYV-EQKQ 507
Cdd:COG4251   411 RPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQrlhsRDEYEGTGIGLAIVKKIVERHGGRIWVEsEPGE 490


                  ....*.
gi 1348988274 508 GACFRI 513
Cdd:COG4251   491 GATFYF 496

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

415-514

4.27e-23

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.87 E-value: 4.27e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274  415 DESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFST-----EISGTGLGLYLS 489
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTdkrsrKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*.
gi 1348988274  490 HSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:smart00387  82 KKLVELHGGEISVEsEPGGGTTFTIT 107

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

118-514

3.11e-19

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 89.52 E-value: 3.11e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 118 LLLEKSKALFITLVAMICVTYQHFVGTLLDFSSLDRIGQSALLSFLFFIIYRFGQIAVRRFQILEHLNFSQSLELNRLKN 197
Cdd:COG3290     5 LLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 198 INRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLyafdKYPLYKVQPDLFQLLQFDQlsngekfqfESQLSHFLIQ 277
Cdd:COG3290    85 EREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAI----GRPIDEVLAEVLETGERDE---------EILLNGRVLV 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 278 IQVQKLVVPQQTL-TLLVLQDARQINQRVQQLKLA-ALGQLSASIAHEIRNPLAAIVQanrLLagsDTDQQQMLSQMIDK 355
Cdd:COG3290   152 VNRVPIRDDGRVVgAVATFRDRTELERLEEELEGVkELAEALRAQRHDFRNHLHTISG---LL---QLGEYDEALEYIDE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 356 QSQRIDKIIDDTLSMVKNkettpvqIDLArfipQLIQDDLADLASQ-IQVS---QPEPLQILFDESQLRQVLINLIRNA- 430
Cdd:COG3290   226 ISEELQELIDSLLSRIGN-------PVLA----ALLLGKAARARERgIDLTidiDSDLPDLPLSDTDLVTILGNLLDNAi 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 431 ---QRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEIS-GTGLGLYLSHSFCEANRAKLRY-VEQ 505
Cdd:COG3290   295 eavEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGeGRGLGLALVKQIVEKYGGTIEVeSEE 374


                  ....*....
gi 1348988274 506 KQGACFRIE 514
Cdd:COG3290   375 GEGTVFTVR 383

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

294-491

3.12e-18

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 87.82 E-value: 3.12e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 294 VLQDARQI-NQRVQQLKLAALGQLSASIAHEIRNPLAAI----VQANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDTL 368
Cdd:COG4192   413 IEKNLRQTqDELIQAAKMAVVGQTMTSLAHELNQPLNAMsmylFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLR 492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 369 SMVKNKETTPVQIDLArfipQLIQDDLADLAS-----QIQVSQPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQ 443
Cdd:COG4192   493 QFSRKSDTPLQPVDLR----QVIEQAWELVESrakpqQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVD 568

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1348988274 444 LYRQQDTVYMDVKDYGSGVASHDirYLFQPFFSTEISGTGLGLYLSHS 491
Cdd:COG4192   569 LLSNAENLRVAISDNGNGWPLVD--KLFTPFTTTKEVGLGLGLSICRS 614

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

415-514

4.09e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 79.72 E-value: 4.09e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 415 DESQLRQVLINLIRNAQRHNAPDHPIELQLyRQQDTVYMDVKDYGSGVASHDIRYLFQPFFS---TEISGTGLGLYLSHS 491
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....
gi 1348988274 492 FCEANRAKLRYV-EQKQGACFRIE 514
Cdd:pfam02518  81 LVELLGGTITVEsEPGGGTTVTLT 104

PRK11100

sensory histidine kinase CreC; Provisional

319-486

3.75e-17

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 84.13 E-value: 3.75e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 319 SIAHEIRNPLAAIVQANRLLAGS-DTDQQQMLSQMIDKQSQRIDKIIDD--TLSMVKNKET--TPVQIDLARFIPQLIQD 393
Cdd:PRK11100  262 TLTHELKSPLAAIRGAAELLQEDpPPEDRARFTGNILTQSARLQQLIDRllELARLEQRQEleVLEPVALAALLEELVEA 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 394 DLADLAS-QIQVS-QPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLF 471
Cdd:PRK11100  342 REAQAAAkGITLRlRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIF 421

                         170       180
                  ....*....|....*....|
gi 1348988274 472 QPFFS-----TEISGTGLGL 486
Cdd:PRK11100  422 ERFYSlprpaNGRKSTGLGL 441

PRK13837

two-component system VirA-like sensor kinase;

296-495

5.42e-16

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 81.26 E-value: 5.42e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 296 QDARQINQRVQQL-KLAALGQLSASIAHEIRNPLAAI-----VQANRLLAGSDT-DQQQMLSQMIDKQSQRIDKIIddTL 368
Cdd:PRK13837  432 TERDALERRLEHArRLEAVGTLASGIAHNFNNILGAIlgyaeMALNKLARHSRAaRYIDEIISAGARARLIIDQIL--AF 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 369 SMVKNKETTPVQIDlarfipqliqDDLADLASQIQVSQPEPLQILFDES-----------QLRQVLINLIRNAQRHNAPD 437
Cdd:PRK13837  510 GRKGERNTKPFDLS----------ELVTEIAPLLRVSLPPGVELDFDQDqepavvegnpaELQQVLMNLCSNAAQAMDGA 579

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1348988274 438 HPIELQLYRQQ---------------DTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFCEA 495
Cdd:PRK13837  580 GRVDISLSRAKlrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSA 652

PRK15347

two component system sensor kinase;

295-514

1.89e-15

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 79.69 E-value: 1.89e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 295 LQDARQINQRVQQLKLAALgqlsASIAHEIRNPLAAIVQANRLLAGSDTDQQQMlsQMIDKQSQRIDK---IIDDTL--- 368
Cdd:PRK15347  384 LAEAKQRAEQANKRKSEHL----TTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSllaIINNLLdfs 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 369 -----SMVKNKETTPvqidlarfIPQLIQDDLADLASQIQ---------VSQPEPLQILFDESQLRQVLINLIRNAQRHn 434
Cdd:PRK15347  458 riesgQMTLSLEETA--------LLPLLDQAMLTIQGPAQsksltlrtfVGAHVPLYLHLDSLRLRQILVNLLGNAVKF- 528

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 435 APDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTE--ISGTGLGLYLShsfceANRAKLRYVEQK------ 506
Cdd:PRK15347  529 TETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADthSQGTGLGLTIA-----SSLAKMMGGELTlfstpg 603


                  ....*...
gi 1348988274 507 QGACFRIE 514
Cdd:PRK15347  604 VGSCFSLV 611

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-514

9.25e-15

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 70.18 E-value: 9.25e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNA--QRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEI--SGTGLGLYLSHSFCE 494
Cdd:cd16976     1 IQQVLMNLLQNAldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVE 80

                          90       100
                  ....*....|....*....|.
gi 1348988274 495 ANRAKLRYVEQKQ-GACFRIE 514
Cdd:cd16976    81 EHGGRLSVANEEGaGARFTFD 101

glnL

PRK11073

nitrogen regulation protein NR(II);

211-516

1.15e-14

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 75.50 E-value: 1.15e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 211 LVLDENCHIMVSNPAACHLLGINPLYAFDkYPLykvqPDLFQLLQFD------QLSNGEKFQfESQLShFLIQIQVQKLV 284
Cdd:PRK11073   21 LLLDDDLAIHYANPAAQQLLAQSSRKLFG-TPL----PELLSYFSLNielmreSLQAGQGFT-DNEVT-LVIDGRSHILS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 285 VPQQTLT-LLVLQDARQI-NQR------VQQLKLAALGQLSASIAHEIRNPLAAIVQANRLLAGSDTDQQ-QMLSQMIDK 355
Cdd:PRK11073   94 LTAQRLPeGMILLEMAPMdNQRrlsqeqLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPAlTEYTKVIIE 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 356 QSQRIDKIIDDTLSMVKNKETTPVQI-DLARFIPQLIQDDLADLASQIQVSQPEPLQILFDESQLRQVLINLIRNA---- 430
Cdd:PRK11073  174 QADRLRNLVDRLLGPQRPGTHVTESIhKVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNAlqal 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 431 -QRHNA------PDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSFceanraklryV 503
Cdd:PRK11073  254 gPEGGTitlrtrTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNL----------I 323

                         330
                  ....*....|...
gi 1348988274 504 EQKQGacfRIECS 516
Cdd:PRK11073  324 DQHSG---KIEFT 333

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

295-486

9.74e-14

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 73.43 E-value: 9.74e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 295 LQDARQINQRVQQLKLAALGQ--LSASIAHEIRNPLAAIVQANRLLAGSDTDQQQMlsQMIDKQSQRIDKIIDDTLSMVK 372
Cdd:PRK09470  223 RQAGASFNQMVTALERMMTSQqrLLSDISHELRTPLTRLQLATALLRRRQGESKEL--ERIETEAQRLDSMINDLLVLSR 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 373 N-------KETTPvqidlarfIPQLIQDDLADL---ASQIQ-----VSQPEPLQILFDESQLRQVLINLIRNAQRHNapD 437
Cdd:PRK09470  301 NqqknhleRETFK--------ANSLWSEVLEDAkfeAEQMGksltvSAPPGPWPINGNPNALASALENIVRNALRYS--H 370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1348988274 438 HPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFST------EISGTGLGL 486
Cdd:PRK09470  371 TKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGL 425

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

417-513

6.35e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 65.14 E-value: 6.35e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 417 SQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEI--SGTGLGLYLSHSFCE 494
Cdd:cd16943     2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQ 81

                          90       100
                  ....*....|....*....|
gi 1348988274 495 ANRAKLRYVEQK-QGACFRI 513
Cdd:cd16943    82 KHGGTIRVASVPgGGTRFTI 101

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-512

2.44e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 63.18 E-value: 2.44e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRN---AQRHNAPDhPIELQLYRQQDT---VYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLSHSF 492
Cdd:cd16920     1 IQQVLINLVRNgieAMSEGGCE-RRELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSI 79

                          90       100
                  ....*....|....*....|..
gi 1348988274 493 CEANRAKLrYVEQKQ--GACFR 512
Cdd:cd16920    80 IEAHGGRL-SVESPAggGATFQ 100

envZ

PRK09467

osmolarity sensor protein; Provisional

316-486

1.88e-11

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 66.09 E-value: 1.88e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 316 LSASIAHEIRNPLAAIvqanRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDTLSMVKN-KETTPVQIDLARFIPQLIQDD 394
Cdd:PRK09467  232 LMAGVSHDLRTPLTRI----RLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVIAAE 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 395 lADLASQIQVS-QPEPLQILFDESQLRQVLINLIRNAQRHNAPDhpIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQP 473
Cdd:PRK09467  308 -SGYEREIETAlQPGPIEVPMNPIAIKRALANLVVNAARYGNGW--IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQP 384

                         170
                  ....*....|....*..
gi 1348988274 474 FFSTEI----SGTGLGL 486
Cdd:PRK09467  385 FTRGDSargsSGTGLGL 401

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

415-495

7.01e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 59.40 E-value: 7.01e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 415 DESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEIS------GTGLGLYL 488
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAI 80


                  ....*..
gi 1348988274 489 SHSFCEA 495
Cdd:cd16946    81 CHNIALA 87

PRK10604

sensor protein RstB; Provisional

296-522

1.27e-10

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 63.47 E-value: 1.27e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 296 QDARQINQRVQQLKlaalgQLSASIAHEIRNPLAaivqanRL---LAGSD---TDQQQMLSQMIDKqsqrIDKIIDDTLS 369
Cdd:PRK10604  200 QMADNINALIASKK-----QLIDGIAHELRTPLV------RLryrLEMSDnlsAAESQALNRDIGQ----LEALIEELLT 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 370 MVK----NKETTPVQIDLarfiPQLIQDDLADLAS-----QIQVSQPEPLQIL-FDESQLRQVLINLIRNAQRHNapDHP 439
Cdd:PRK10604  265 YARldrpQNELHLSEPDL----PAWLSTHLADIQAvtpekTVRLDTPHQGDYGaLDMRLMERVLDNLLNNALRYA--HSR 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 440 IELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEIS------GTGLGLYLSHSFCEANRAKLRyVEQKQ--GACF 511
Cdd:PRK10604  339 VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSrdratgGCGLGLAIVHSIALAMGGSVN-CDESElgGARF 417

                         250
                  ....*....|.
gi 1348988274 512 RIeCSPVDVNK 522
Cdd:PRK10604  418 SF-SWPVWHNL 427

PRK09303

histidine kinase;

292-511

2.03e-10

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 62.66 E-value: 2.03e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 292 LLVLqdaRQINQRVQQlKLAALGQLSASIAHEIRNPLAA---------IVQANRLLAGSDTDQQQMLSQmIDKQSQRIDK 362
Cdd:PRK09303  134 LFVL---RQENETLLE-QLKFKDRVLAMLAHDLRTPLTAaslaletleLGQIDEDTELKPALIEQLQDQ-ARRQLEEIER 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 363 IIDDTLSMVKNKETT----PVQIDLARfIPQLIQDDLADL----ASQIQVSQPEPLQILF-DESQLRQVLINLIRNAQRH 433
Cdd:PRK09303  209 LITDLLEVGRTRWEAlrfnPQKLDLGS-LCQEVILELEKRwlakSLEIQTDIPSDLPSVYaDQERIRQVLLNLLDNAIKY 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 434 NAPDHPIELQ-LYRQQDTVYMDVKDYGSGVASHDIRYLFQPFF----STEISGTGLGLYLSHSFCEANRAKLRYV-EQKQ 507
Cdd:PRK09303  288 TPEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWVDsEPGQ 367


                  ....
gi 1348988274 508 GACF 511
Cdd:PRK09303  368 GSCF 371

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

419-514

3.99e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 57.12 E-value: 3.99e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNAQRHNAPDHpIELQLYRQQDT-----VYMDVKDYGSGVASHDIRYLFQPFFSTEIS------GTGLGLY 487
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGE-VTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSttrkygGTGLGLA 79

                          90       100
                  ....*....|....*....|....*...
gi 1348988274 488 LSHSFCEANRAKLRYV-EQKQGACFRIE 514
Cdd:cd16922    80 ISKKLVELMGGDISVEsEPGQGSTFTFT 107

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-513

5.89e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 56.57 E-value: 5.89e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNAQRHnAPDHpIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFF------STEISGTGLGLYLSHSF 492
Cdd:cd16949     1 LARALENVLRNALRY-SPSK-ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERA 78

                          90       100
                  ....*....|....*....|..
gi 1348988274 493 CEANRAKLRYVEQK-QGACFRI 513
Cdd:cd16949    79 IEQHGGKIKASNRKpGGLRVRI 100

PRK10490

sensor protein KdpD; Provisional

280-513

6.79e-10

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 61.98 E-value: 6.79e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 280 VQKLVVPQQ-----TLTLLVLQ--DARQINQRVQQLKLAA-----LGQLSASIAHEIRNPL------AAIVQANRLLAGS 341
Cdd:PRK10490  619 LRQLMIPEQqrlleTFTLLIANalERLTLTASEEQARLASereqlRNALLAALSHDLRTPLtvlfgqAEILTLDLASEGS 698

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 342 DTDQQqmLSQmIDKQSQRIDKIIDDTLSMVK--------NKETTPVQidlarfipQLIQDDLADLAS-----QIQVSQPE 408
Cdd:PRK10490  699 PHARQ--ASE-IRQQVLNTTRLVNNLLDMARiqsggfnlRKEWLTLE--------EVVGSALQMLEPglsghPINLSLPE 767

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 409 PLQILF-DESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFF----STEISGTG 483
Cdd:PRK10490  768 PLTLIHvDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFArgnkESAIPGVG 847

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1348988274 484 LGLYLSHSFCEANRAKLrYVE--QKQGACFRI 513
Cdd:PRK10490  848 LGLAICRAIVEVHGGTI-WAEnrPEGGACFRV 878

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

312-372

7.01e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 54.91 E-value: 7.01e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1348988274 312 ALGQLSASIAHEIRNPLAAIV-QANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDTLSMVK 372
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRgYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

312-372

8.54e-10

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 54.88 E-value: 8.54e-10

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1348988274  312 ALGQLSASIAHEIRNPLAAIV-QANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDTLSMVK 372
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRgYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62

PRK11466

hybrid sensory histidine kinase TorS; Provisional

279-514

1.55e-09

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 60.69 E-value: 1.55e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 279 QVQKLVVPQQTLTLLVLQdARQINQRVQQLKLAALgqlsASIAHEIRNPLAAIVQANRLLAGSD-TDQQQMLSQMIDKQS 357
Cdd:PRK11466  415 QVKARTAELQELVIEHRQ-ARAEAEKASQAKSAFL----AAMSHEIRTPLYGILGTAQLLADNPaLNAQRDDLRAITDSG 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 358 QRIDKIIDDTL----------SMVKNKET-TPVQI--DLARFIPQLIQDDLADLASQIQVSQPEPLQilFDESQLRQVLI 424
Cdd:PRK11466  490 ESLLTILNDILdysaieaggkNVSVSDEPfEPRPLleSTLQLMSGRVKGRPIRLATDIADDLPTALM--GDPRRIRQVIT 567

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 425 NLIRNAQRHNAPDHpIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPF--FSTEISGTGLGLYLSHSFCEANRAKLRY 502
Cdd:PRK11466  568 NLLSNALRFTDEGS-IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSA 646

                         250
                  ....*....|...
gi 1348988274 503 VEQ-KQGACFRIE 514
Cdd:PRK11466  647 TSTpEVGSCFCLR 659

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

317-501

1.56e-09

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 60.17 E-value: 1.56e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 317 SASIAHEIRNPLAAIVQANRlLAGSDTDQQQMLSQMID---KQSQRIDKIIDDTLSMvknkettpVQIDLARFIPQLIQD 393
Cdd:PRK09835  266 SADIAHEIRTPITNLITQTE-IALSQSRSQKELEDVLYsnlEELTRMAKMVSDMLFL--------AQADNNQLIPEKKML 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 394 DLAD-----------LASQIQVS---QPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYG 459
Cdd:PRK09835  337 DLADevgkvfdffeaWAEERGVElrfVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPG 416

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1348988274 460 SGVASHDIRYLFQPFFSTEIS------GTGLGLYLSHSFCEANRAKLR 501
Cdd:PRK09835  417 TPIAPEHLPRLFDRFYRVDPSrqrkgeGSGIGLAIVKSIVVAHKGTVA 464

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

310-372

1.65e-09

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 53.76 E-value: 1.65e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1348988274 310 LAALGQLSASIAHEIRNPLAAIVQANRLLA--GSDTDQQQMLSQMIDKQSQRIDKIIDDTLSMVK 372
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEeeLLDDEEQREYLERIREEAERLLRLINDLLDLSR 65

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

415-513

3.13e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.60 E-value: 3.13e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 415 DESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFS-----TEISGTGLGLYLS 489
Cdd:cd16948     2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTgengrNFQESTGMGLYLV 81

                          90       100
                  ....*....|....*....|....*
gi 1348988274 490 HSFCEANRAKLRY-VEQKQGACFRI 513
Cdd:cd16948    82 KKLCDKLGHKIDVeSEVGEGTTFTI 106

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

401-495

7.45e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 54.06 E-value: 7.45e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 401 QIQVSQPE-PLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEI 479
Cdd:cd16947     2 QVEINIPDrPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81

                          90       100
                  ....*....|....*....|..
gi 1348988274 480 S------GTGLGLYLSHSFCEA 495
Cdd:cd16947    82 SrnsakqGNGLGLTITKRLAES 103

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

415-513

1.03e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.92 E-value: 1.03e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 415 DESQLRQVLINLIRNAQR--HNAPDHPIELQLYRQQDTVY---MDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYLS 489
Cdd:cd16944     1 DTTQISQVLTNILKNAAEaiEGRPSDVGEVRIRVEADQDGrivLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80

                          90       100
                  ....*....|....*....|....*
gi 1348988274 490 HSFCEANRAKLRYVEQK-QGACFRI 513
Cdd:cd16944    81 KKIMEEHGGRISLSNREaGGACIRI 105

PRK10618

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

159-493

4.01e-08

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 56.09 E-value: 4.01e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 159 LLSFLFFIIYRFGQIAVRRFQIleHLNFSQSLELNRLKNINRYILEQTDMGYLVLD-ENCHIMVSNPAACHLLginplya 237
Cdd:PRK10618  307 LLNLGLLALSLFGYYTFRHQYG--RPTESMSHELRILRALNEEIVSNLPLGLLVYDfESNRTVISNKIADHLL------- 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 238 fdkyplykvqP--DLFQLLQFDQLSNG-----------EKFQFESQLSH----FLIQIQVQKLVVPQQtltllvLQDARQ 300
Cdd:PRK10618  378 ----------PhlNLQKITTMAEQHQGviqatinnelyEIRMFRSQLAPrtqlFLLRDQDREVLVNKK------LQQAQR 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 301 INQRVQQlklaALGQLSASIAHEIRNPLAAIVQ-ANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIDDT--LSMVKNKETT 377
Cdd:PRK10618  442 EYEKNQQ----ARKAFLQNIGDELKQPLQSLAQlAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIqlLNMLETQDWK 517

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 378 PVQidlARFIPQ-LIQDDLADLASQIQVS--------QPEPLQILF-DESQLRQVLINLIRNA-----------QRHNAP 436
Cdd:PRK10618  518 PEQ---ELFSLQdLIDEVLPEVLPAIKRKglqllihnHLKAEQLRIgDRDALRKILLLLLNYAitttaygkitlEVDQDE 594

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1348988274 437 DHPielqlyrqqDTVYMDVKDYGSGVASHDIRYLFQPFFSTEIS-----GTGLGLYLSHSFC 493
Cdd:PRK10618  595 SSP---------DRLTIRILDTGAGVSIKELDNLHFPFLNQTQGdrygkASGLTFFLCNQLC 647

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-513

4.42e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 51.28 E-value: 4.42e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNAQRHnaPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEIS------GTGLGLYLSHSF 492
Cdd:cd16939     1 MARALDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSrdratgGFGLGLAIVHRV 78

                          90       100
                  ....*....|....*....|..
gi 1348988274 493 CEANRAKLRYVEQKQ-GACFRI 513
Cdd:cd16939    79 ALWHGGHVECDDSELgGACFRL 100

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

292-490

8.41e-08

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 54.63 E-value: 8.41e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 292 LLVLQDARQINQrvqqLKlAALGQLSASIAHEIRNPLAaivqanrLLAG--SDTDQQQMLSQMIDK-------QSQRIDK 362
Cdd:PRK11006  188 LMVARDVTQMHQ----LE-GARRNFFANVSHELRTPLT-------VLQGylEMMQDQPLEGALREKalhtmreQTQRMEG 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 363 IIDDTLSMVKnKETTPvQIDLARF--IPQLIQ------DDLADLASQIQVSQPEPLQILFDESQLRQVLINLIRNAQRHN 434
Cdd:PRK11006  256 LVKQLLTLSK-IEAAP-TIDLNEKvdVPMMLRvlereaQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHT 333

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1348988274 435 APDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFF------STEISGTGLGL-----YLSH 490
Cdd:PRK11006  334 PEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLGLaivkhALSH 400

PRK10841

two-component system sensor histidine kinase RcsC;

318-494

1.02e-07

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 54.98 E-value: 1.02e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 318 ASIAHEIRNPLAAIV------QANRLLAGSDtdqqQMLSQMiDKQSQRIDKIIDDTLSMVKnKETTPVQIDLARFIPQ-- 389
Cdd:PRK10841  452 ATVSHELRTPLYGIIgnldllQTKELPKGVD----RLVTAM-NNSSSLLLKIISDILDFSK-IESEQLKIEPREFSPRev 525

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 390 ---LIQDDLA-----DLASQIQVSQPEPLQILFDESQLRQVLINLIRNAQRHNAPDHpIELQLYRQQDTVYMDVKDYGSG 461
Cdd:PRK10841  526 inhITANYLPlvvkkRLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVG 604

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1348988274 462 VASHDIRYLFQPFF------STEISGTGLGLylshSFCE 494
Cdd:PRK10841  605 IPAKEVVRLFDPFFqvgtgvQRNFQGTGLGL----AICE 639

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

318-489

1.93e-07

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 53.79 E-value: 1.93e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 318 ASIAHEIRNPLAAIVQANRLLAGSDTDQQQMlSQM--IDKQSQRIDKIIDDTLSMVK---NK-ETTPVQIDLARFIPQL- 390
Cdd:PRK11091  288 STISHELRTPLNGIVGLSRILLDTELTAEQR-KYLktIHVSAITLGNIFNDIIDMDKmerRKlQLDNQPIDFTDFLADLe 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 391 ----IQDDLADLASQIQVSQPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHD 466
Cdd:PRK11091  367 nlsgLQAEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDE 446

                         170       180       190
                  ....*....|....*....|....*....|
gi 1348988274 467 IRYLFQPFFSTEIS-------GTGLGLYLS 489
Cdd:PRK11091  447 LDKIFAMYYQVKDShggkpatGTGIGLAVS 476

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-514

3.01e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 48.54 E-value: 3.01e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEIS----GTGLGLYLSHSFCE 494
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSrnteGAGLGLSIAKAIIE 80

                          90       100
                  ....*....|....*....|
gi 1348988274 495 ANRAKLRYVEQKQGACFRIE 514
Cdd:cd16923    81 LHGGSASAEYDDNHDLFKVR 100

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-486

3.85e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 48.21 E-value: 3.85e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1348988274 419 LRQVLINLIRNAQRHNAPDhpIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTE----ISGTGLGL 486
Cdd:cd16950     1 LKRVLSNLVDNALRYGGGW--VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDnargTSGTGLGL 70

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

415-514

4.35e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.23 E-value: 4.35e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 415 DESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGT-----GLGLYLS 489
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIA 80

                          90       100
                  ....*....|....*....|....*..
gi 1348988274 490 HSFCEANRAKLrYVE--QKQGACFRIE 514
Cdd:cd16975    81 KNLVEKHGGSL-IIEnsQKGGAEVTVK 106

PRK10755

two-component system sensor histidine kinase PmrB;

301-486

4.35e-07

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 51.89 E-value: 4.35e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 301 INQRVQQLK--LAALGQLSASIAHEIRNPLAAIVQANRLLAGSDTDQQQMLSQMIDKQSQRIDKIIddTLSMVKNKETTP 378
Cdd:PRK10755  123 LNQLVSRLTstLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHTVEQLL--QLARAGQSFSSG 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 379 --VQIDLARFIPQLIQDDLADLASQIQV-----SQPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTV 451
Cdd:PRK10755  201 hyQTVKLLEDVILPSQDELSEMLEQRQQtlllpESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGA 280

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1348988274 452 YMDVKDYGSGVASHDIRYLFQPF--FSTEISGTGLGL 486
Cdd:PRK10755  281 VLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGL 317

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-515

5.60e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 48.17 E-value: 5.60e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNAQRHNAP-----------DHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLY 487
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGsggeiilrtrtQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80

                          90       100
                  ....*....|....*....|....*...
gi 1348988274 488 LSHSFceanraklryVEQKQGacfRIEC 515
Cdd:cd16918    81 IAQNI----------VSQHGG---VIEC 95

PRK09959

acid-sensing system histidine kinase EvgS;

312-488

9.05e-07

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 52.04 E-value: 9.05e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274  312 ALGQLSASIAHEIRNPLAAIVQANRLLAGSDTDQQQMLS--QMIDKQSQRIDKIIDDTLSMVK----NKETTPVQIDlar 385
Cdd:PRK09959   711 AKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEaiSLAYATGQSLLGLIGEILDVDKiesgNYQLQPQWVD--- 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274  386 fIPQLIQDDL---------ADLASQIQVSQPEPLQILFDESQLRQVLINLIRNAQRHNAPDH-PIELQLYRQQD---TVY 452
Cdd:PRK09959   788 -IPTLVQNTChsfgaiaasKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDnhaVIK 866

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1348988274  453 MDVKDYGSGVASHDIRYLFQPFFST----EISGTGLGLYL 488
Cdd:PRK09959   867 MTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMI 906

PRK11086

sensory histidine kinase DcuS; Provisional

415-488

1.21e-05

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 47.99 E-value: 1.21e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1348988274 415 DESQ---LRQVLINLIRNA--QRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISGTGLGLYL 488
Cdd:PRK11086  427 DEDQvheLITILGNLIENAleAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYL 505

PRK10549

two-component system sensor histidine kinase BaeS;

318-501

1.26e-05

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 47.71 E-value: 1.26e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 318 ASIAHEIRNPLAaiVQANRLLAGSDTDQQQMLSQMIDKQSQ--RIDKIIDD--TLSM------VKNKETTPV----QIDL 383
Cdd:PRK10549  245 ADISHELRTPLA--VLRGELEAIQDGVRKFTPESVASLQAEvgTLTKLVDDlhQLSLsdegalAYRKTPVDLvpllEVAG 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 384 ARFipqliQDDLADLASQIQVSQPEPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVA 463
Cdd:PRK10549  323 GAF-----RERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVS 397

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1348988274 464 SHDIRYLFQPFFSTEIS------GTGLGLYLSHSFCEANRAKLR 501
Cdd:PRK10549  398 DEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRII 441

PRK10337

sensor protein QseC; Provisional

297-486

1.48e-05

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 47.34 E-value: 1.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 297 DARQINQRVQQLkLAALGQLSASI--------------AHEIRNPLAAI-VQANRL-LAGSDTD-QQQMLSQM---IDKQ 356
Cdd:PRK10337  208 NATGVPSEVRPL-VEALNQLFARThammvrerrftsdaAHELRSPLAALkVQTEVAqLSDDDPQaRKKALLQLhagIDRA 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 357 SQRIDKIIddTLSMVKN----KETTPVQIDlarfipQLIQDDLADL-----ASQIQV--SQPEPLQILFDESQLRQVLI- 424
Cdd:PRK10337  287 TRLVDQLL--TLSRLDSldnlQDVAEIPLE------DLLQSAVMDIyhtaqQAGIDVrlTLNAHPVIRTGQPLLLSLLVr 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1348988274 425 NLIRNAQRHNAPDHPIELQLyrqqDTVYMDVKDYGSGVASHDIRYLFQPFF---STEISGTGLGL 486
Cdd:PRK10337  359 NLLDNAIRYSPQGSVVDVTL----NARNFTVRDNGPGVTPEALARIGERFYrppGQEATGSGLGL 419

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

425-513

1.88e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 43.43 E-value: 1.88e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 425 NLIRNA----QRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFST-EISGTGLGLYLSHSFCEANRAK 499
Cdd:cd16915     7 NLIDNAldalAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTkGQGERGIGLALVRQSVERLGGS 86

                          90
                  ....*....|....*
gi 1348988274 500 LRYVEQKQ-GACFRI 513
Cdd:cd16915    87 ITVESEPGgGTTFSI 101

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-486

6.61e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 42.06 E-value: 6.61e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1348988274 419 LRQVLINLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFS-----TEISGTGLGL 486
Cdd:cd16945     5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGL 77

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

401-514

7.21e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 42.62 E-value: 7.21e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 401 QIQVSQPEPLQILFDESQLRQVLINLIRNAQRHNapDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQ--PFFSTE 478
Cdd:cd16954    20 SISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQrgQRLDEQ 97

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1348988274 479 ISGTGLGLYLSHSFCEANRAKLRYVEQKQG-ACFRIE 514
Cdd:cd16954    98 RPGQGLGLAIAKEIVEQYGGELSLSDSPLGgARFEVV 134

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

408-486

1.21e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 41.62 E-value: 1.21e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 408 EPLQILFDESQLRQVLINLIRNAQRHNAPDHPIELQLyRQQDTVYMDVKDYGSGVASHDIRYLFQPFF---STEISGTGL 484
Cdd:cd16940     3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGL 81


                  ..
gi 1348988274 485 GL 486
Cdd:cd16940    82 GL 83

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

449-513

1.91e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 41.21 E-value: 1.91e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1348988274 449 DTVYMDVKDYGSGVASHDIRYLFQPFFST-EI-SGTGLGLYLSHSFCEANRAKLR-YVEQKQGACFRI 513
Cdd:cd16919    46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTTkEVgKGTGLGLSMVYGFVKQSGGHLRiYSEPGVGTTVRI 113

HATPase_c_2

pfam13581

Histidine kinase-like ATPase domain;

390-513

4.31e-04

Histidine kinase-like ATPase domain;

Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 40.35 E-value: 4.31e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 390 LIQDDLADLASQIQVSQPEPLQIL--FDEsqlrqVLINLIRNAQRHNaPDHPIELQLYRQQDTVYMDVKDYGSGVASHDI 467
Cdd:pfam13581  10 AARRVLEAVLRRAGLPEELLDEVElaVGE-----ACTNAVEHAYREG-PEGPVEVRLTSDGGGLVVTVADSGPPFDPLTL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1348988274 468 RYLFQPFFSTEISGTGLGLYLSHSFCEAnrakLRYVEQKQGACFRI 513
Cdd:pfam13581  84 PPPDLEEPDEDRKEGGRGLALIRGLMDD----VEYTRGGEGNTVRM 125

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

419-514

9.88e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 39.09 E-value: 9.88e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 419 LRQVLINLIRNAQRHNAPDH-PIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEISG------TGLGLYLSHS 491
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQ 80

                          90       100
                  ....*....|....*....|....*...
gi 1348988274 492 FCEAN----RAKLRYV-EQKQGACFRIE 514
Cdd:cd16953    81 IIEAHggisVAENHNQpGQVIGARFTVQ 108

HATPase_LytS-like

cd16957

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

421-487

1.03e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.

Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 38.56 E-value: 1.03e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1348988274 421 QVLI-NLIRNAQRHNAPDHPIELQLYRQQDTVYMDVKDYGSGVASHDIRYLFQPFFSTEiSGTGLGLY 487
Cdd:cd16957     7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE-KGTGTALE 73

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

187-317

1.80e-03

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 40.91 E-value: 1.80e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 187 SQSLELNRLKNINRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINPLYAFDKyPLYKVQPD--LFQLLQFDQLSNGEK 264
Cdd:COG3829     1 AEELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGK-NVTELIPNspLLEVLKTGKPVTGVI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1348988274 265 FQFESQLSHFLIQIQVqklVVPQQTLT--LLVLQDARQINQRVQQLKLAALGQLS 317
Cdd:COG3829    80 QKTGGKGKTVIVTAIP---IFEDGEVIgaVETFRDITELKRLERKLREEELERGL 131

PEP_TPR_lipo

TIGR02917

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...

243-358

4.56e-03

Pssm-ID: 274350 [Multi-domain] Cd Length: 899 Bit Score: 39.68 E-value: 4.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1348988274 243 LYKVQPDLFQLLQFDQLSNGekfQFESQLSHFliqiqvQKLV--VPQQTLTLLVLQDArqinQRVQQLKLAALGQLSASI 320
Cdd:TIGR02917 596 AAPDSPEAWLMLGRAQLAAG---DLNKAVSSF------KKLLalQPDSALALLLLADA----YAVMKNYAKAITSLKRAL 662

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1348988274 321 AHEIRNPLAAIVQANRLLAGSDTDQQQMLSQMIDKQSQ 358
Cdd:TIGR02917 663 ELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHP 700

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

199-234

9.52e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 35.07 E-value: 9.52e-03

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1348988274  199 NRYILEQTDMGYLVLDENCHIMVSNPAACHLLGINP 234
Cdd:smart00091   3 LRAILESLPDGIFVLDLDGRILYANPAAEELLGYSP 38

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01