View
Concise Results
Standard Results
Full Results
pyruvate dehydrogenase (acetyl-transferring), homodimeric type [Chromobacterium violaceum]
Protein Classification
pyruvate dehydrogenase (acetyl-transferring), homodimeric type ( domain architecture ID 11457666 )
E1 component of the acetyl-transferring homodimeric-type pyruvate dehydrogenase multienzyme complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2
List of domain hits
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
3-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1958.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 3 ATFPD DIDP L ETQEW T E A L ES V LDN EG A ERA HF LLE KMV ER T RR R G AH LPF D ATT A Y Q NTIPV GK E AKS PG NH E M E H RIR 82
Cdd:COG2609 7 PSQLP DIDP Q ETQEW L E S L DA V IEE EG P ERA RY LLE RLL ER A RR S G VG LPF S ATT P Y I NTIPV EQ E PPY PG DE E L E R RIR 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 83 SI N RWNA A AMV L RA GK K DLE LGGHI A SF Q S S ATLY D VGFNHF W R AQNENQD GDL I YFQGH IA PG V YARAF M EGRLT AD Q M 162
Cdd:COG2609 87 SI I RWNA M AMV V RA NR K GGG LGGHI S SF A S A ATLY E VGFNHF F R GPDHPGG GDL V YFQGH AS PG I YARAF L EGRLT EE Q L 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 163 DNFRQEVDG Q GLSSYPHPWLM K DFWQFPTVSMGLGP LM AIYQARF L KYL ES RGL AK T MG RKVW C F C GDGEMDEPESLGAI 242
Cdd:COG2609 167 DNFRQEVDG K GLSSYPHPWLM P DFWQFPTVSMGLGP IN AIYQARF M KYL HN RGL KD T SD RKVW A F L GDGEMDEPESLGAI 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 243 AM AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGS R WDPLLA M DT K G L L K KRM D E C VDGDY 322
Cdd:COG2609 247 SL AARE K LDNL I FVINCNLQRLDGPVRGNGKIIQELEG V FRG A GWNV I KVIWGS E WDPLLA K DT D G A L V KRM N E T VDGDY 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 323 QT F K S KDG G YVREHFFGKYPEL REM VA N MSDE E IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG AS GE 402
Cdd:COG2609 327 QT Y K A KDG A YVREHFFGKYPEL KAL VA D MSDE D IW R LNRGGHDP R KVYAAY KA A V - EHK G Q PTVILAKTIKGYGMG EA GE 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 403 AK NI A HQ A KK M DLD S L RN FRDRF G IP V SDE D L PNV PYY L PAEDSPEMKY MR ERR A ALGGYLP A R KPVNH PL A VPELSAF D 482
Cdd:COG2609 406 GR NI T HQ Q KK L DLD D L KA FRDRF N IP I SDE Q L EEL PYY K PAEDSPEMKY LH ERR K ALGGYLP Q R RTKAE PL E VPELSAF A 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 483 A Q L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPIVPDE S RTFGMEG M FRQ Y GI W S TQ GQ N Y V P Q D H DQL MF YKESKD 562
Cdd:COG2609 486 A L L KG SG K RE I STTMAFVR I L NDLL KDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI Y S PV GQ L Y T P V D A DQL LY YKESKD 565
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 563 GQILQEGINE P GAM AD WIAA A TSY ANSSQ PMIPFYIYYSMFGFQR I GDLAWAAGD M RARGFL L G G TAGRTTLNGEGLQH E 642
Cdd:COG2609 566 GQILQEGINE A GAM SS WIAA G TSY STHGV PMIPFYIYYSMFGFQR V GDLAWAAGD Q RARGFL I G A TAGRTTLNGEGLQH Q 645
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 643 DGHSH IQ A GL IPNC I SYDP T FAYELAVIVQDG M RRMY A EQE D VFYY L T L MNENY VH PAMP A G A EEGILKGMYLL QD G - G D 721
Cdd:COG2609 646 DGHSH LL A ST IPNC V SYDP A FAYELAVIVQDG L RRMY G EQE N VFYY I T V MNENY AQ PAMP E G V EEGILKGMYLL KE G e G K 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 722 A K VK VQL M GSGTILREV M AAA D LL KA D F G IG AD I WSVTSFN Q LRRDG MEA ER H NLL N P TA E A R SS YV E Q Q LAG RN GPV I A 801
Cdd:COG2609 726 G K PR VQL L GSGTILREV L AAA E LL AE D W G VA AD V WSVTSFN E LRRDG LDV ER W NLL H P EE E P R VP YV T Q C LAG AE GPV V A 805
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 802 ATDY I R NYA DQIR AY VPGRY V VLGTDGFGRSD S R AN LR S FFEVDRY HVAL AAL S ALA RD GKID GAK VAEAI A KYGI KT DK 881
Cdd:COG2609 806 ATDY M R AVP DQIR PW VPGRY T VLGTDGFGRSD T R EA LR R FFEVDRY SIVV AAL K ALA DE GKID ASV VAEAI K KYGI DP DK 885
....*.
gi 1133852470 882 LPSWKV 887
Cdd:COG2609 886 PNPLTA 891
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
3-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1958.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 3 ATFPD DIDP L ETQEW T E A L ES V LDN EG A ERA HF LLE KMV ER T RR R G AH LPF D ATT A Y Q NTIPV GK E AKS PG NH E M E H RIR 82
Cdd:COG2609 7 PSQLP DIDP Q ETQEW L E S L DA V IEE EG P ERA RY LLE RLL ER A RR S G VG LPF S ATT P Y I NTIPV EQ E PPY PG DE E L E R RIR 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 83 SI N RWNA A AMV L RA GK K DLE LGGHI A SF Q S S ATLY D VGFNHF W R AQNENQD GDL I YFQGH IA PG V YARAF M EGRLT AD Q M 162
Cdd:COG2609 87 SI I RWNA M AMV V RA NR K GGG LGGHI S SF A S A ATLY E VGFNHF F R GPDHPGG GDL V YFQGH AS PG I YARAF L EGRLT EE Q L 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 163 DNFRQEVDG Q GLSSYPHPWLM K DFWQFPTVSMGLGP LM AIYQARF L KYL ES RGL AK T MG RKVW C F C GDGEMDEPESLGAI 242
Cdd:COG2609 167 DNFRQEVDG K GLSSYPHPWLM P DFWQFPTVSMGLGP IN AIYQARF M KYL HN RGL KD T SD RKVW A F L GDGEMDEPESLGAI 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 243 AM AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGS R WDPLLA M DT K G L L K KRM D E C VDGDY 322
Cdd:COG2609 247 SL AARE K LDNL I FVINCNLQRLDGPVRGNGKIIQELEG V FRG A GWNV I KVIWGS E WDPLLA K DT D G A L V KRM N E T VDGDY 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 323 QT F K S KDG G YVREHFFGKYPEL REM VA N MSDE E IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG AS GE 402
Cdd:COG2609 327 QT Y K A KDG A YVREHFFGKYPEL KAL VA D MSDE D IW R LNRGGHDP R KVYAAY KA A V - EHK G Q PTVILAKTIKGYGMG EA GE 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 403 AK NI A HQ A KK M DLD S L RN FRDRF G IP V SDE D L PNV PYY L PAEDSPEMKY MR ERR A ALGGYLP A R KPVNH PL A VPELSAF D 482
Cdd:COG2609 406 GR NI T HQ Q KK L DLD D L KA FRDRF N IP I SDE Q L EEL PYY K PAEDSPEMKY LH ERR K ALGGYLP Q R RTKAE PL E VPELSAF A 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 483 A Q L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPIVPDE S RTFGMEG M FRQ Y GI W S TQ GQ N Y V P Q D H DQL MF YKESKD 562
Cdd:COG2609 486 A L L KG SG K RE I STTMAFVR I L NDLL KDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI Y S PV GQ L Y T P V D A DQL LY YKESKD 565
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 563 GQILQEGINE P GAM AD WIAA A TSY ANSSQ PMIPFYIYYSMFGFQR I GDLAWAAGD M RARGFL L G G TAGRTTLNGEGLQH E 642
Cdd:COG2609 566 GQILQEGINE A GAM SS WIAA G TSY STHGV PMIPFYIYYSMFGFQR V GDLAWAAGD Q RARGFL I G A TAGRTTLNGEGLQH Q 645
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 643 DGHSH IQ A GL IPNC I SYDP T FAYELAVIVQDG M RRMY A EQE D VFYY L T L MNENY VH PAMP A G A EEGILKGMYLL QD G - G D 721
Cdd:COG2609 646 DGHSH LL A ST IPNC V SYDP A FAYELAVIVQDG L RRMY G EQE N VFYY I T V MNENY AQ PAMP E G V EEGILKGMYLL KE G e G K 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 722 A K VK VQL M GSGTILREV M AAA D LL KA D F G IG AD I WSVTSFN Q LRRDG MEA ER H NLL N P TA E A R SS YV E Q Q LAG RN GPV I A 801
Cdd:COG2609 726 G K PR VQL L GSGTILREV L AAA E LL AE D W G VA AD V WSVTSFN E LRRDG LDV ER W NLL H P EE E P R VP YV T Q C LAG AE GPV V A 805
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 802 ATDY I R NYA DQIR AY VPGRY V VLGTDGFGRSD S R AN LR S FFEVDRY HVAL AAL S ALA RD GKID GAK VAEAI A KYGI KT DK 881
Cdd:COG2609 806 ATDY M R AVP DQIR PW VPGRY T VLGTDGFGRSD T R EA LR R FFEVDRY SIVV AAL K ALA DE GKID ASV VAEAI K KYGI DP DK 885
....*.
gi 1133852470 882 LPSWKV 887
Cdd:COG2609 886 PNPLTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-887
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1931.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 1 MAATFPD DIDP L ETQEW T EAL E SV LDN EG A ERAH F LLE KMV ER T R RR G AH LP FD ATT A Y Q NTIPV GK E AKS PG NH E M E H R 80
Cdd:PRK09405 4 GSESQLN DIDP I ETQEW L EAL D SV IRE EG P ERAH Y LLE QLL ER A R EK G VS LP AS ATT P Y I NTIPV EE E PEY PG DL E L E R R 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 81 IRS IN RWNAAAMVLRA G KKDL E LGGHI A SF Q SSATLY D VGFNHF W RA Q NE NQD GDL IY FQGH IA PG V YARAF M EGRLT AD 160
Cdd:PRK09405 84 IRS YI RWNAAAMVLRA N KKDL G LGGHI S SF A SSATLY E VGFNHF F RA P NE PHG GDL VF FQGH AS PG I YARAF L EGRLT EE 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 161 Q M DNFRQEVDG Q GLSSYPHPWLM K DFWQFPTVSMGLGP L MAIYQARFLKYLE S RGL AK T MGR KVW C F C GDGEMDEPESLG 240
Cdd:PRK09405 164 Q L DNFRQEVDG K GLSSYPHPWLM P DFWQFPTVSMGLGP I MAIYQARFLKYLE N RGL KD T SDQ KVW A F L GDGEMDEPESLG 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 241 AI AM AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGSRWDPLLA M DT K G L L KKR M D E C VDG 320
Cdd:PRK09405 244 AI SL AARE K LDNL I FVINCNLQRLDGPVRGNGKIIQELEG I FRG A GWNV I KVIWGSRWDPLLA K DT S G K L VQL M N E T VDG 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 321 DYQT F K S KDG G YVREHFFGKYPE LREM VA N MSD EE IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG AS 400
Cdd:PRK09405 324 DYQT Y K A KDG A YVREHFFGKYPE TKAL VA D MSD DD IW A LNRGGHDP R KVYAAY KA A V - EHK G Q PTVILAKTIKGYGMG EA 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 401 GE A KNIAHQ A KK M DLD S L RN FRDRF G IP V SDE D L PNV PYY L P A EDSPE M KY MR ERR A ALGGYLPAR K P VNH PL A VP E LSA 480
Cdd:PRK09405 403 GE G KNIAHQ V KK L DLD D L KH FRDRF N IP I SDE Q L EKL PYY K P G EDSPE I KY LH ERR K ALGGYLPAR R P KFE PL E VP A LSA 482
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 481 F D A Q L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPI V PDE S RTFGMEG M FRQ Y GI WSTQ GQ N Y V P Q D H DQLM F YKES 560
Cdd:PRK09405 483 F E A L L KG SG E RE I STTMAFVR I L NILL KDK E IGKR I VPI I PDE A RTFGMEG L FRQ I GI YNPH GQ L Y T P V D R DQLM Y YKES 562
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 561 KDGQILQEGINE P GAMA D WIAAATSY ANSSQ PMIPFYIYYSMFGFQRIGDLAWAAGD M RARGFLLGGTAGRTTLNGEGLQ 640
Cdd:PRK09405 563 KDGQILQEGINE A GAMA S WIAAATSY STHGE PMIPFYIYYSMFGFQRIGDLAWAAGD Q RARGFLLGGTAGRTTLNGEGLQ 642
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 641 HEDGHSHI Q A GL IPNC I SYDP T FAYE L AVIVQDG M RRMY A EQE D VFYY L T L MNENY VH PAMP A GAEEGILKGMY L L QD -- 718
Cdd:PRK09405 643 HEDGHSHI L A ST IPNC V SYDP A FAYE V AVIVQDG L RRMY G EQE N VFYY I T V MNENY HQ PAMP E GAEEGILKGMY K L ET ae 722
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 719 G GDA K V KVQL M GSGTILREV MA AA DL L KA D F G IG AD I WSVTSFN Q L R RDG MEA ER H N L L N PT A E A R SS YV E Q Q L A G RN GP 798
Cdd:PRK09405 723 G KKG K P KVQL L GSGTILREV LE AA EI L AE D Y G VA AD V WSVTSFN E L A RDG QDV ER W N M L H PT E E P R VP YV T Q V L K G AE GP 802
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 799 V I AATDY IRNY A D QIRA Y VPG R YVVLGTDGFGRSD S R AN LR S FFEVD RYH V AL AAL S ALA RD G K ID GAK VAEAI A KYGI K 878
Cdd:PRK09405 803 V V AATDY MKLF A E QIRA F VPG D YVVLGTDGFGRSD T R EA LR R FFEVD AEY V VV AAL K ALA DE G E ID ASV VAEAI K KYGI D 882
....*....
gi 1133852470 879 T DK LPSWKV 887
Cdd:PRK09405 883 P DK ANPRTA 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
5-885
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1514.68
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 5 F P D D I DP L ETQEW T E A L E SVL DN EG AE RA HF LLE KMV E RT R RR G AHL P FDA TT A Y Q NTIPV GKEAKS PG NH E M E H RIRSI 84
Cdd:TIGR00759 2 Q P N D V DP I ETQEW L E S L D SVL AE EG PA RA RY LLE QLL E YA R EH G VPI P AGT TT D Y I NTIPV EEQPAY PG DL E L E R RIRSI 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 85 N RWNA A AMVLRA G KKDL E LGGHI ASFQ S S ATLY D VGFNHF W R AQN E NQD GDL IY FQGH I APG V YARAF M EGRLT AD Q M DN 164
Cdd:TIGR00759 82 I RWNA I AMVLRA N KKDL G LGGHI STYA S A ATLY E VGFNHF F R GHS E GGG GDL VF FQGH A APG I YARAF L EGRLT EE Q L DN 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 165 FRQEV D G Q GLSSYPHPWLM K DFWQFPTVSMGLGP LM AIYQARF L KYLE S RGL AK T MGR KVW C F C GDGEMDEPES L GAI AM 244
Cdd:TIGR00759 162 FRQEV Q G D GLSSYPHPWLM P DFWQFPTVSMGLGP IN AIYQARF M KYLE N RGL KD T GDQ KVW A F L GDGEMDEPES K GAI TF 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 245 AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELE GD FRG S GWNV L KV I WGS R WD P LLA M DT K G L L K K R M D E C VDGDYQT 324
Cdd:TIGR00759 242 AARE K LDNL T FVINCNLQRLDGPVRGNGKIIQELE SL FRG A GWNV I KV L WGS E WD A LLA R DT S G V L V K L M N E T VDGDYQT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 325 F K S KDG G YVREHFF GKY PEL REM VA N MSD EE IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG ASG E AK 404
Cdd:TIGR00759 322 Y K A KDG A YVREHFF NRT PEL KAL VA D MSD AD IW A LNRGGHDP R KVYAAY AA A Q - EHK G Q PTVILAKTIKGYGMG DAA E SR 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 405 N I AHQ A KK MDL D S L R NFRDRF GI P V SD EDLPNV PYY L P A E D SPE MK Y MRE RR A ALGGYLPAR KPVNHP L A VP E L SA F D A Q 484
Cdd:TIGR00759 401 N T AHQ V KK LEV D A L K NFRDRF EL P L SD AQVEEL PYY H P G E G SPE VR Y LLA RR Q ALGGYLPAR RTFAEH L T VP A L EF F G A L 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 485 L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPIVPDE S RTFGMEG M FRQ Y GI W S TQ GQ N Y V P Q D H D Q L MF YKESKDGQ 564
Cdd:TIGR00759 481 L KG SG E RE V STTMAFVR I L NKLL KDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI Y S PH GQ T Y T P V D A D S L LA YKESKDGQ 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 565 ILQEGINE P GAMA D WIAAATSYA NSSQ PMIPFYIYYSMFGFQRIGDL A WAA G D M RARGFLLG G TAGRTTLNGEGLQHEDG 644
Cdd:TIGR00759 561 ILQEGINE A GAMA S WIAAATSYA THGE PMIPFYIYYSMFGFQRIGDL C WAA A D Q RARGFLLG A TAGRTTLNGEGLQHEDG 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 645 HS HI QA GL IPNCI S YDP T FAYE L AVI VQ DG M RRMY A EQEDVFYY L T L MNENYV H P A MP A GAEEGILKG M Y LLQ -- DGGD A 722
Cdd:TIGR00759 641 HS LL QA AT IPNCI A YDP A FAYE V AVI ME DG L RRMY G EQEDVFYY V T V MNENYV Q P P MP E GAEEGILKG L Y RFE ts TEEK A 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 723 K VK VQL M GSG T I L R E V MA AA D LL K AD F G IGA D I WSVTSF NQ L R RDG MEA ER H NLL N PT AEA R S SYV E Q Q L AGRNG PVIA A 802
Cdd:TIGR00759 721 K GH VQL L GSG A I M R A V IE AA Q LL A AD W G VAS D V WSVTSF TE L A RDG HDV ER W NLL H PT ETP R V SYV A Q V L NEADA PVIA S 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 803 TDY I R NY A D QIR A YVP GR YV V LGTDGFGRSD S R A NLR S FFEVD RYH V A LAAL S ALA R DG K IDG AK VA E AIAKYGI KT DK L 882
Cdd:TIGR00759 801 TDY V R AF A E QIR P YVP RK YV T LGTDGFGRSD T R E NLR H FFEVD AKS V V LAAL Y ALA D DG E IDG DV VA D AIAKYGI DP DK A 880
...
gi 1133852470 883 PSW 885
Cdd:TIGR00759 881 NPV 883
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
76-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 732.57
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 76 E M E H RIRS IN RWNA A AMV L RA G KKDL EL GGHIA S F Q S S ATLY D VGFNHF W RA QN E NQD GDL I YFQGH IA PG V YARAF M EG 155
Cdd:cd02017 2 E I E R RIRS LI RWNA M AMV H RA N KKDL GI GGHIA T F A S A ATLY E VGFNHF F RA RG E GGG GDL V YFQGH AS PG I YARAF L EG 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 156 RLT AD Q M DNFRQEV D G Q GLSSYPHPWLM K DFW Q FPTVSMGLGP LM AIYQARF LK YLE S RGL AK T MGR KVW C F C GDGEMDE 235
Cdd:cd02017 82 RLT EE Q L DNFRQEV G G G GLSSYPHPWLM P DFW E FPTVSMGLGP IQ AIYQARF NR YLE D RGL KD T SDQ KVW A F L GDGEMDE 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 236 PESLGAI AM AARE G LDNL V FV I NCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGS R WD P LLA M D TK G L L KK RM D 315
Cdd:cd02017 162 PESLGAI GL AARE K LDNL I FV V NCNLQRLDGPVRGNGKIIQELEG I FRG A GWNV I KVIWGS K WD E LLA K D GG G A L RQ RM E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 316 E C VDGDYQT F K S KDG G YVREHFFGKYPEL REM V ANM SDE EI W N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGY 395
Cdd:cd02017 242 E T VDGDYQT L K A KDG A YVREHFFGKYPEL KAL V TDL SDE DL W A LNRGGHDP R KVYAAY KK A V - EHK G K PTVILAKTIKGY 320
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1133852470 396 G M GA S GE AK N I AHQ A KKM DL D S L RNF RDRFGIPVSDE D L PNV PYY L P A E D S P E M KY MR ERR A ALGG 461
Cdd:cd02017 321 G L GA A GE GR N H AHQ V KKM TE D E L KAL RDRFGIPVSDE Q L EEG PYY K P P E G S E E I KY LH ERR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
473-699
4.64e-118
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 358.27
E-value: 4.64e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 473 L AV P E L -- SA F DA Q LQS S GD RE F STTMAFVR M L GTIM KDK N IGK R VVPI V PDE S RTFGMEGMFRQ Y GI WSTQ GQ N Y V P Q D 550
Cdd:pfam17831 1 L EI P D L dd KI F AS Q TGG S KG RE I STTMAFVR I L NGLV KDK K IGK Q VVPI I PDE A RTFGMEGMFRQ L GI YTSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 551 HD Q L MFY K E S K D GQIL Q EGI N E P GAM AD WIAAATSY A N SSQPMI PFY I YYSMFGFQRIGDLAWAAGDM R ARGFL L GGTAG 630
Cdd:pfam17831 81 KG Q I MFY R E D K Q GQIL E EGI S E A GAM SA WIAAATSY S N HNTTLL PFY V YYSMFGFQRIGDLAWAAGDM Q ARGFL V GGTAG 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133852470 631 RTTLNGEGLQH E DGHSHIQA GL IPNC I SYDPT F A Y E L AVIVQDG MR RM Y A EQ E DV FYYLT L MNENY V HP 699
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQA ST IPNC R SYDPT Y A H E V AVIVQDG LK RM F A DK E NC FYYLT V MNENY E HP 229
Name
Accession
Description
Interval
E-value
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
3-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1958.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 3 ATFPD DIDP L ETQEW T E A L ES V LDN EG A ERA HF LLE KMV ER T RR R G AH LPF D ATT A Y Q NTIPV GK E AKS PG NH E M E H RIR 82
Cdd:COG2609 7 PSQLP DIDP Q ETQEW L E S L DA V IEE EG P ERA RY LLE RLL ER A RR S G VG LPF S ATT P Y I NTIPV EQ E PPY PG DE E L E R RIR 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 83 SI N RWNA A AMV L RA GK K DLE LGGHI A SF Q S S ATLY D VGFNHF W R AQNENQD GDL I YFQGH IA PG V YARAF M EGRLT AD Q M 162
Cdd:COG2609 87 SI I RWNA M AMV V RA NR K GGG LGGHI S SF A S A ATLY E VGFNHF F R GPDHPGG GDL V YFQGH AS PG I YARAF L EGRLT EE Q L 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 163 DNFRQEVDG Q GLSSYPHPWLM K DFWQFPTVSMGLGP LM AIYQARF L KYL ES RGL AK T MG RKVW C F C GDGEMDEPESLGAI 242
Cdd:COG2609 167 DNFRQEVDG K GLSSYPHPWLM P DFWQFPTVSMGLGP IN AIYQARF M KYL HN RGL KD T SD RKVW A F L GDGEMDEPESLGAI 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 243 AM AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGS R WDPLLA M DT K G L L K KRM D E C VDGDY 322
Cdd:COG2609 247 SL AARE K LDNL I FVINCNLQRLDGPVRGNGKIIQELEG V FRG A GWNV I KVIWGS E WDPLLA K DT D G A L V KRM N E T VDGDY 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 323 QT F K S KDG G YVREHFFGKYPEL REM VA N MSDE E IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG AS GE 402
Cdd:COG2609 327 QT Y K A KDG A YVREHFFGKYPEL KAL VA D MSDE D IW R LNRGGHDP R KVYAAY KA A V - EHK G Q PTVILAKTIKGYGMG EA GE 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 403 AK NI A HQ A KK M DLD S L RN FRDRF G IP V SDE D L PNV PYY L PAEDSPEMKY MR ERR A ALGGYLP A R KPVNH PL A VPELSAF D 482
Cdd:COG2609 406 GR NI T HQ Q KK L DLD D L KA FRDRF N IP I SDE Q L EEL PYY K PAEDSPEMKY LH ERR K ALGGYLP Q R RTKAE PL E VPELSAF A 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 483 A Q L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPIVPDE S RTFGMEG M FRQ Y GI W S TQ GQ N Y V P Q D H DQL MF YKESKD 562
Cdd:COG2609 486 A L L KG SG K RE I STTMAFVR I L NDLL KDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI Y S PV GQ L Y T P V D A DQL LY YKESKD 565
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 563 GQILQEGINE P GAM AD WIAA A TSY ANSSQ PMIPFYIYYSMFGFQR I GDLAWAAGD M RARGFL L G G TAGRTTLNGEGLQH E 642
Cdd:COG2609 566 GQILQEGINE A GAM SS WIAA G TSY STHGV PMIPFYIYYSMFGFQR V GDLAWAAGD Q RARGFL I G A TAGRTTLNGEGLQH Q 645
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 643 DGHSH IQ A GL IPNC I SYDP T FAYELAVIVQDG M RRMY A EQE D VFYY L T L MNENY VH PAMP A G A EEGILKGMYLL QD G - G D 721
Cdd:COG2609 646 DGHSH LL A ST IPNC V SYDP A FAYELAVIVQDG L RRMY G EQE N VFYY I T V MNENY AQ PAMP E G V EEGILKGMYLL KE G e G K 725
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 722 A K VK VQL M GSGTILREV M AAA D LL KA D F G IG AD I WSVTSFN Q LRRDG MEA ER H NLL N P TA E A R SS YV E Q Q LAG RN GPV I A 801
Cdd:COG2609 726 G K PR VQL L GSGTILREV L AAA E LL AE D W G VA AD V WSVTSFN E LRRDG LDV ER W NLL H P EE E P R VP YV T Q C LAG AE GPV V A 805
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 802 ATDY I R NYA DQIR AY VPGRY V VLGTDGFGRSD S R AN LR S FFEVDRY HVAL AAL S ALA RD GKID GAK VAEAI A KYGI KT DK 881
Cdd:COG2609 806 ATDY M R AVP DQIR PW VPGRY T VLGTDGFGRSD T R EA LR R FFEVDRY SIVV AAL K ALA DE GKID ASV VAEAI K KYGI DP DK 885
....*.
gi 1133852470 882 LPSWKV 887
Cdd:COG2609 886 PNPLTA 891
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-887
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1931.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 1 MAATFPD DIDP L ETQEW T EAL E SV LDN EG A ERAH F LLE KMV ER T R RR G AH LP FD ATT A Y Q NTIPV GK E AKS PG NH E M E H R 80
Cdd:PRK09405 4 GSESQLN DIDP I ETQEW L EAL D SV IRE EG P ERAH Y LLE QLL ER A R EK G VS LP AS ATT P Y I NTIPV EE E PEY PG DL E L E R R 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 81 IRS IN RWNAAAMVLRA G KKDL E LGGHI A SF Q SSATLY D VGFNHF W RA Q NE NQD GDL IY FQGH IA PG V YARAF M EGRLT AD 160
Cdd:PRK09405 84 IRS YI RWNAAAMVLRA N KKDL G LGGHI S SF A SSATLY E VGFNHF F RA P NE PHG GDL VF FQGH AS PG I YARAF L EGRLT EE 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 161 Q M DNFRQEVDG Q GLSSYPHPWLM K DFWQFPTVSMGLGP L MAIYQARFLKYLE S RGL AK T MGR KVW C F C GDGEMDEPESLG 240
Cdd:PRK09405 164 Q L DNFRQEVDG K GLSSYPHPWLM P DFWQFPTVSMGLGP I MAIYQARFLKYLE N RGL KD T SDQ KVW A F L GDGEMDEPESLG 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 241 AI AM AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGSRWDPLLA M DT K G L L KKR M D E C VDG 320
Cdd:PRK09405 244 AI SL AARE K LDNL I FVINCNLQRLDGPVRGNGKIIQELEG I FRG A GWNV I KVIWGSRWDPLLA K DT S G K L VQL M N E T VDG 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 321 DYQT F K S KDG G YVREHFFGKYPE LREM VA N MSD EE IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG AS 400
Cdd:PRK09405 324 DYQT Y K A KDG A YVREHFFGKYPE TKAL VA D MSD DD IW A LNRGGHDP R KVYAAY KA A V - EHK G Q PTVILAKTIKGYGMG EA 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 401 GE A KNIAHQ A KK M DLD S L RN FRDRF G IP V SDE D L PNV PYY L P A EDSPE M KY MR ERR A ALGGYLPAR K P VNH PL A VP E LSA 480
Cdd:PRK09405 403 GE G KNIAHQ V KK L DLD D L KH FRDRF N IP I SDE Q L EKL PYY K P G EDSPE I KY LH ERR K ALGGYLPAR R P KFE PL E VP A LSA 482
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 481 F D A Q L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPI V PDE S RTFGMEG M FRQ Y GI WSTQ GQ N Y V P Q D H DQLM F YKES 560
Cdd:PRK09405 483 F E A L L KG SG E RE I STTMAFVR I L NILL KDK E IGKR I VPI I PDE A RTFGMEG L FRQ I GI YNPH GQ L Y T P V D R DQLM Y YKES 562
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 561 KDGQILQEGINE P GAMA D WIAAATSY ANSSQ PMIPFYIYYSMFGFQRIGDLAWAAGD M RARGFLLGGTAGRTTLNGEGLQ 640
Cdd:PRK09405 563 KDGQILQEGINE A GAMA S WIAAATSY STHGE PMIPFYIYYSMFGFQRIGDLAWAAGD Q RARGFLLGGTAGRTTLNGEGLQ 642
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 641 HEDGHSHI Q A GL IPNC I SYDP T FAYE L AVIVQDG M RRMY A EQE D VFYY L T L MNENY VH PAMP A GAEEGILKGMY L L QD -- 718
Cdd:PRK09405 643 HEDGHSHI L A ST IPNC V SYDP A FAYE V AVIVQDG L RRMY G EQE N VFYY I T V MNENY HQ PAMP E GAEEGILKGMY K L ET ae 722
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 719 G GDA K V KVQL M GSGTILREV MA AA DL L KA D F G IG AD I WSVTSFN Q L R RDG MEA ER H N L L N PT A E A R SS YV E Q Q L A G RN GP 798
Cdd:PRK09405 723 G KKG K P KVQL L GSGTILREV LE AA EI L AE D Y G VA AD V WSVTSFN E L A RDG QDV ER W N M L H PT E E P R VP YV T Q V L K G AE GP 802
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 799 V I AATDY IRNY A D QIRA Y VPG R YVVLGTDGFGRSD S R AN LR S FFEVD RYH V AL AAL S ALA RD G K ID GAK VAEAI A KYGI K 878
Cdd:PRK09405 803 V V AATDY MKLF A E QIRA F VPG D YVVLGTDGFGRSD T R EA LR R FFEVD AEY V VV AAL K ALA DE G E ID ASV VAEAI K KYGI D 882
....*....
gi 1133852470 879 T DK LPSWKV 887
Cdd:PRK09405 883 P DK ANPRTA 891
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
2-887
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1624.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 2 AA TFPD DIDP L ET Q EW T EAL ES V LDNE G A ERA HF LL EKMV ER TRR RG AH LP FDA TT A Y Q NTIPV GKEAKS PG NHEM E H R I 81
Cdd:PRK13012 13 AA AQLP DIDP Q ET A EW L EAL DA V VAHA G P ERA RY LL DRLL ER AAA RG IA LP GLL TT P Y V NTIPV DQQPPY PG DLAL E E R L 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 82 RS I N RWNA A AMV L RA GKKDL ELGGHIAS FQ S S A T L YD VGFNHF W R AQNENQD GDL I YFQ G H I APG V YARAF M EGRL TAD Q 161
Cdd:PRK13012 93 AA I I RWNA L AMV V RA NRAYG ELGGHIAS YA S A A D L FE VGFNHF F R GRDDAGG GDL V YFQ P H S APG I YARAF L EGRL SEE Q 172
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 162 M D N FRQE VD G Q GLSSYPHPWLM K DFWQFPT V SMG L GP LM AIYQARF LK YL ES RGL AK T M GRKVW C F C GDGEMDEPES LG A 241
Cdd:PRK13012 173 L D H FRQE IG G P GLSSYPHPWLM P DFWQFPT G SMG I GP IN AIYQARF MR YL QH RGL KD T S GRKVW G F F GDGEMDEPES IA A 252
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 242 IAM AAREGLDNLVFVINCNLQRLDGPVRGNG K IIQELE GD FRG S GWNV L KV I WGS R WD P L L A M DT K G L L KK R MD E C VDG D 321
Cdd:PRK13012 253 LSL AAREGLDNLVFVINCNLQRLDGPVRGNG R IIQELE AL FRG A GWNV I KV L WGS D WD A L F A R DT T G A L VR R FA E T VDG Q 332
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 322 Y QTFK SK DG G Y V REHFFG KY PEL REM VA NM SDE E I WN L N RGGHDP H KVYAAY HE A THNA n G R PTVILAKT I KGYGMG AS G 401
Cdd:PRK13012 333 F QTFK AN DG A Y N REHFFG QD PEL AAL VA HL SDE D I DR L K RGGHDP R KVYAAY AA A VRHK - G Q PTVILAKT K KGYGMG EA G 411
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 402 E AKNIA HQ A KK M D LDS L RN FRDRF GI P V SDE D L PNV P Y Y L PAEDSPEM K Y MRE RRAALGGYLP A R KPVNH PL A VP E LSAF 481
Cdd:PRK13012 412 E GRMTT HQ Q KK L D VEA L KA FRDRF RL P L SDE Q L EQL P F Y K PAEDSPEM R Y LHA RRAALGGYLP R R RTAAP PL P VP P LSAF 491
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 482 DAQLQSS G DR E F STTMAFVRMLG TIM KDK NI G K R V VPIV P DE S RTFGM EGM FRQ Y GI W S TQ GQ N Y V P Q D HDQ L MF Y K E S K 561
Cdd:PRK13012 492 AQFALGA G GK E M STTMAFVRMLG NLL KDK AL G P R I VPIV A DE A RTFGM ANL FRQ V GI Y S PL GQ L Y E P E D AGS L LY Y R E A K 571
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 562 DGQIL Q EGI N E P GA MAD WIAAATSY ANSSQ PM I PFYIYYSMFGFQR I GDL A WAA G D M RARGFLLG G TAGRTTL N GEGLQH 641
Cdd:PRK13012 572 DGQIL E EGI T E A GA ISS WIAAATSY SVHGL PM L PFYIYYSMFGFQR V GDL I WAA A D Q RARGFLLG A TAGRTTL G GEGLQH 651
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 642 E DGHSH IQ A GL IPNC IS YDP T FAYELAVIV Q DGMRRM YA EQEDVFYYLT L MNENY VH PA M P A GAEEGILKGMY L L QDGGD 721
Cdd:PRK13012 652 Q DGHSH LL A ST IPNC RA YDP A FAYELAVIV D DGMRRM LE EQEDVFYYLT V MNENY AQ PA L P E GAEEGILKGMY R L AAAAE 731
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 722 A K v K VQL M GSG T ILREV M AAA D LL KA D F G IG AD I WSVTSF NQ LRRDG ME AER H NLL N P TA EAR SS YV E Q Q LAG RN GPV I A 801
Cdd:PRK13012 732 A P - R VQL L GSG A ILREV L AAA R LL AD D W G VD AD V WSVTSF TE LRRDG LA AER A NLL G P AE EAR VP YV T Q C LAG TR GPV V A 810
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 802 ATDY I R NYAD QIRA Y VP G RYV V LGTDGFGRSD S RA N LR S FFEVDR YHVA LAAL S ALA R DG KIDGAK VAEAI AK YGI KT DK 881
Cdd:PRK13012 811 ATDY V R AVPE QIRA F VP A RYV T LGTDGFGRSD T RA A LR R FFEVDR HSIV LAAL K ALA D DG EVERTV VAEAI ER YGI DD DK 890
....*.
gi 1133852470 882 L P S W K V 887
Cdd:PRK13012 891 T P P W E V 896
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
5-885
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1514.68
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 5 F P D D I DP L ETQEW T E A L E SVL DN EG AE RA HF LLE KMV E RT R RR G AHL P FDA TT A Y Q NTIPV GKEAKS PG NH E M E H RIRSI 84
Cdd:TIGR00759 2 Q P N D V DP I ETQEW L E S L D SVL AE EG PA RA RY LLE QLL E YA R EH G VPI P AGT TT D Y I NTIPV EEQPAY PG DL E L E R RIRSI 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 85 N RWNA A AMVLRA G KKDL E LGGHI ASFQ S S ATLY D VGFNHF W R AQN E NQD GDL IY FQGH I APG V YARAF M EGRLT AD Q M DN 164
Cdd:TIGR00759 82 I RWNA I AMVLRA N KKDL G LGGHI STYA S A ATLY E VGFNHF F R GHS E GGG GDL VF FQGH A APG I YARAF L EGRLT EE Q L DN 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 165 FRQEV D G Q GLSSYPHPWLM K DFWQFPTVSMGLGP LM AIYQARF L KYLE S RGL AK T MGR KVW C F C GDGEMDEPES L GAI AM 244
Cdd:TIGR00759 162 FRQEV Q G D GLSSYPHPWLM P DFWQFPTVSMGLGP IN AIYQARF M KYLE N RGL KD T GDQ KVW A F L GDGEMDEPES K GAI TF 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 245 AARE G LDNL V FVINCNLQRLDGPVRGNGKIIQELE GD FRG S GWNV L KV I WGS R WD P LLA M DT K G L L K K R M D E C VDGDYQT 324
Cdd:TIGR00759 242 AARE K LDNL T FVINCNLQRLDGPVRGNGKIIQELE SL FRG A GWNV I KV L WGS E WD A LLA R DT S G V L V K L M N E T VDGDYQT 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 325 F K S KDG G YVREHFF GKY PEL REM VA N MSD EE IW N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGYGMG ASG E AK 404
Cdd:TIGR00759 322 Y K A KDG A YVREHFF NRT PEL KAL VA D MSD AD IW A LNRGGHDP R KVYAAY AA A Q - EHK G Q PTVILAKTIKGYGMG DAA E SR 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 405 N I AHQ A KK MDL D S L R NFRDRF GI P V SD EDLPNV PYY L P A E D SPE MK Y MRE RR A ALGGYLPAR KPVNHP L A VP E L SA F D A Q 484
Cdd:TIGR00759 401 N T AHQ V KK LEV D A L K NFRDRF EL P L SD AQVEEL PYY H P G E G SPE VR Y LLA RR Q ALGGYLPAR RTFAEH L T VP A L EF F G A L 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 485 L QS SG D RE F STTMAFVR M L GTIM KDK N IGKR V VPIVPDE S RTFGMEG M FRQ Y GI W S TQ GQ N Y V P Q D H D Q L MF YKESKDGQ 564
Cdd:TIGR00759 481 L KG SG E RE V STTMAFVR I L NKLL KDK E IGKR I VPIVPDE A RTFGMEG L FRQ I GI Y S PH GQ T Y T P V D A D S L LA YKESKDGQ 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 565 ILQEGINE P GAMA D WIAAATSYA NSSQ PMIPFYIYYSMFGFQRIGDL A WAA G D M RARGFLLG G TAGRTTLNGEGLQHEDG 644
Cdd:TIGR00759 561 ILQEGINE A GAMA S WIAAATSYA THGE PMIPFYIYYSMFGFQRIGDL C WAA A D Q RARGFLLG A TAGRTTLNGEGLQHEDG 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 645 HS HI QA GL IPNCI S YDP T FAYE L AVI VQ DG M RRMY A EQEDVFYY L T L MNENYV H P A MP A GAEEGILKG M Y LLQ -- DGGD A 722
Cdd:TIGR00759 641 HS LL QA AT IPNCI A YDP A FAYE V AVI ME DG L RRMY G EQEDVFYY V T V MNENYV Q P P MP E GAEEGILKG L Y RFE ts TEEK A 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 723 K VK VQL M GSG T I L R E V MA AA D LL K AD F G IGA D I WSVTSF NQ L R RDG MEA ER H NLL N PT AEA R S SYV E Q Q L AGRNG PVIA A 802
Cdd:TIGR00759 721 K GH VQL L GSG A I M R A V IE AA Q LL A AD W G VAS D V WSVTSF TE L A RDG HDV ER W NLL H PT ETP R V SYV A Q V L NEADA PVIA S 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 803 TDY I R NY A D QIR A YVP GR YV V LGTDGFGRSD S R A NLR S FFEVD RYH V A LAAL S ALA R DG K IDG AK VA E AIAKYGI KT DK L 882
Cdd:TIGR00759 801 TDY V R AF A E QIR P YVP RK YV T LGTDGFGRSD T R E NLR H FFEVD AKS V V LAAL Y ALA D DG E IDG DV VA D AIAKYGI DP DK A 880
...
gi 1133852470 883 PSW 885
Cdd:TIGR00759 881 NPV 883
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
6-887
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1185.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 6 P DD I DP L ET Q EW TE AL ES V LDNE GAERA HF LL EKMVERTR R R G AHL P FDAT T A Y Q NTI P V GK E AKS PG NHEM E H R IRS I N 85
Cdd:TIGR03186 3 H DD T DP Q ET A EW LD AL DG V VAHA GAERA QY LL AQLAAHAA R L G LAP P AAGA T P Y V NTI A V DQ E PPY PG DLQL E E R LAA I L 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 86 RWNA A AMV L RA GKKDL ELGGHIAS FQ S S A T L YD VGFNHF W RA QNENQD GDL I YFQ G H I APGVYARAF M EG R L TAD Q MDNF 165
Cdd:TIGR03186 83 RWNA L AMV V RA NRAYG ELGGHIAS YA S A A D L FE VGFNHF F RA AGDASG GDL V YFQ P H S APGVYARAF L EG F L SDA Q LAHY 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 166 RQE VD G Q GL S SYPHPWLM K DFWQFPT V SMG L GP LM AIYQARF LK YL ES RGLA K T M GRKVW C F C GDGEMDEPES L GA IAM A 245
Cdd:TIGR03186 163 RQE IA G P GL C SYPHPWLM P DFWQFPT G SMG I GP IN AIYQARF MR YL QN RGLA R T E GRKVW G F F GDGEMDEPES I GA LSL A 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 246 ARE G LDNLVFVINCNLQRLDGPVRGNG K II Q ELE GD F R G S GWNV L KV I WGS R WD P L L A M D TK G L L KKRMDEC VDG DY QTF 325
Cdd:TIGR03186 243 ARE R LDNLVFVINCNLQRLDGPVRGNG R II D ELE SQ F A G A GWNV I KV L WGS D WD A L F A R D AT G A L ARAFAHT VDG QF QTF 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 326 KSK DG G Y V R EH FFG KY P E L REM VA NM SDE E I WN L N RGGHD PH K V YAAY HE A THN a N GRPTVILAKT I KG Y GMGA S G EAKN 405
Cdd:TIGR03186 323 SAN DG A Y N R AR FFG QD P A L AAL VA HL SDE D I DR L R RGGHD AR K L YAAY DR A VRH - E GRPTVILAKT M KG F GMGA I G QGRM 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 406 IA HQ A KK M D LDS L RN FRDRF GI P V SD E D LPNVPY Y L P A EDS P EM K Y MRE RRAALGGYLP A R KP - VN H P LAVP E L SAFDAQ 484
Cdd:TIGR03186 402 TT HQ Q KK L D VEA L LA FRDRF RL P L SD A D VEQLKF Y K P D EDS A EM R Y LHA RRAALGGYLP R R RT a AT H A LAVP A L PSWGRF 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 485 LQSSGDR E F STTMA F VRMLG TIM KD KNI G K R V VPIV P DE S RTFGM EGM FRQ Y GI W S TQ GQ N Y V P Q D HDQLMF Y K E SK DGQ 564
Cdd:TIGR03186 482 ALDAEGK E M STTMA I VRMLG ALL KD AEL G P R I VPIV A DE A RTFGM ANL FRQ V GI Y S PL GQ R Y E P E D LGSMLY Y R E DT DGQ 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 565 IL Q EGI N E P GA MAD WIAAATSY ANSSQ PM I PFYIYYSMFGFQRIGDL A WAA G D M RARGFL L G G T A G R TTL N GEGLQH E DG 644
Cdd:TIGR03186 562 IL E EGI S E A GA ISS WIAAATSY SVHDL PM L PFYIYYSMFGFQRIGDL I WAA A D Q RARGFL I G A T S G K TTL G GEGLQH Q DG 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 645 H SH IQ A GLI PNC ISY DP T FAYE L AVIV QD GMR R M YAE Q E D V FYYLT LM NENY VH P AM P AGAEE ---- GILKGMY L L QDGG 720
Cdd:TIGR03186 642 T SH LA A STV PNC RAW DP A FAYE V AVIV DE GMR E M LER Q R D E FYYLT VT NENY AQ P SL P EDRLD avrr GILKGMY P L DPAA 721
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 721 D A KVK VQL M GSG T IL R EV M AAA D LL KA D F GI G A DI WSVTSF NQ L R RDG ME AER HNL L NPTAEAR S SY V E Q Q L AGRN GPVI 800
Cdd:TIGR03186 722 L A AAR VQL L GSG A IL G EV Q AAA R LL RD D W GI D A AV WSVTSF TE L A RDG RA AER AQR L GDAERPP S PH V A Q A L GATQ GPVI 801
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 801 AATDY I R NYADQ IRAYVP G RYV V LGTDGFGRSD S RA N LR S FFEVDR YHVAL AAL S ALA R DG KIDGAK V AE AIA K YG IK - T 879
Cdd:TIGR03186 802 AATDY V R AVPEL IRAYVP R RYV T LGTDGFGRSD T RA A LR A FFEVDR ASIVI AAL Q ALA D DG LVARDV V RQ AIA R YG KA a T 881
....*...
gi 1133852470 880 DKL P S W KV 887
Cdd:TIGR03186 882 SRA P P W ER 889
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
76-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 732.57
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 76 E M E H RIRS IN RWNA A AMV L RA G KKDL EL GGHIA S F Q S S ATLY D VGFNHF W RA QN E NQD GDL I YFQGH IA PG V YARAF M EG 155
Cdd:cd02017 2 E I E R RIRS LI RWNA M AMV H RA N KKDL GI GGHIA T F A S A ATLY E VGFNHF F RA RG E GGG GDL V YFQGH AS PG I YARAF L EG 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 156 RLT AD Q M DNFRQEV D G Q GLSSYPHPWLM K DFW Q FPTVSMGLGP LM AIYQARF LK YLE S RGL AK T MGR KVW C F C GDGEMDE 235
Cdd:cd02017 82 RLT EE Q L DNFRQEV G G G GLSSYPHPWLM P DFW E FPTVSMGLGP IQ AIYQARF NR YLE D RGL KD T SDQ KVW A F L GDGEMDE 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 236 PESLGAI AM AARE G LDNL V FV I NCNLQRLDGPVRGNGKIIQELEG D FRG S GWNV L KVIWGS R WD P LLA M D TK G L L KK RM D 315
Cdd:cd02017 162 PESLGAI GL AARE K LDNL I FV V NCNLQRLDGPVRGNGKIIQELEG I FRG A GWNV I KVIWGS K WD E LLA K D GG G A L RQ RM E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 316 E C VDGDYQT F K S KDG G YVREHFFGKYPEL REM V ANM SDE EI W N LNRGGHDP H KVYAAY HE A T h NAN G R PTVILAKTIKGY 395
Cdd:cd02017 242 E T VDGDYQT L K A KDG A YVREHFFGKYPEL KAL V TDL SDE DL W A LNRGGHDP R KVYAAY KK A V - EHK G K PTVILAKTIKGY 320
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1133852470 396 G M GA S GE AK N I AHQ A KKM DL D S L RNF RDRFGIPVSDE D L PNV PYY L P A E D S P E M KY MR ERR A ALGG 461
Cdd:cd02017 321 G L GA A GE GR N H AHQ V KKM TE D E L KAL RDRFGIPVSDE Q L EEG PYY K P P E G S E E I KY LH ERR H ALGG 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
473-699
4.64e-118
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 358.27
E-value: 4.64e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 473 L AV P E L -- SA F DA Q LQS S GD RE F STTMAFVR M L GTIM KDK N IGK R VVPI V PDE S RTFGMEGMFRQ Y GI WSTQ GQ N Y V P Q D 550
Cdd:pfam17831 1 L EI P D L dd KI F AS Q TGG S KG RE I STTMAFVR I L NGLV KDK K IGK Q VVPI I PDE A RTFGMEGMFRQ L GI YTSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 551 HD Q L MFY K E S K D GQIL Q EGI N E P GAM AD WIAAATSY A N SSQPMI PFY I YYSMFGFQRIGDLAWAAGDM R ARGFL L GGTAG 630
Cdd:pfam17831 81 KG Q I MFY R E D K Q GQIL E EGI S E A GAM SA WIAAATSY S N HNTTLL PFY V YYSMFGFQRIGDLAWAAGDM Q ARGFL V GGTAG 160
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133852470 631 RTTLNGEGLQH E DGHSHIQA GL IPNC I SYDPT F A Y E L AVIVQDG MR RM Y A EQ E DV FYYLT L MNENY V HP 699
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQA ST IPNC R SYDPT Y A H E V AVIVQDG LK RM F A DK E NC FYYLT V MNENY E HP 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
86-396
2.62e-21
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 94.11
E-value: 2.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 86 R WNAAA MV LR AG kkdlel G GH IASFQ S S A TLYD V GFNHFWRA ----- QNE N Q D gdli Y F --- Q GH IA P GV YA RAFME G R L 157
Cdd:cd02012 4 R RLSID MV QK AG ------ S GH PGGSL S A A DILA V LYFKVLKY dpadp KWP N R D ---- R F vls K GH AS P AL YA VLALA G Y L 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 158 TADQMDN FRQ ev D G qgl S SY P - HP wlmk DFWQF P T V SMGL G P L --------- MA IYQ arfl K Y L ESRG laktmgr K V WCF 227
Cdd:cd02012 74 PEEDLKT FRQ -- L G --- S RL P g HP ---- EYGLT P G V EVTT G S L gqglsvavg MA LAE ---- K L L GFDY ------- R V YVL 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 228 C GDGE MD E PESLG A IAM A AREG LDNL VFVINC N LQRL DGP VR g NGKIIQE L EGD F RGS GWNV LK V I wgsrwdpllamdtk 307
Cdd:cd02012 134 L GDGE LQ E GSVWE A ASF A GHYK LDNL IAIVDS N RIQI DGP TD - DILFTED L AKK F EAF GWNV IE V D -------------- 198
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 308 gllkkrmdecvdgdyqtfkskdggyvrehffgkypelremvanmsdeeiwnlnrg GHD PHKVY AA YH EA THN a N G R PT V I 387
Cdd:cd02012 199 ------------------------------------------------------- GHD VEEIL AA LE EA KKS - K G K PT L I 222
....*....
gi 1133852470 388 L AKTIKG Y G 396
Cdd:cd02012 223 I AKTIKG K G 231
PRK05899
PRK05899 transketolase; Reviewed
77-832
2.50e-16
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 83.26
E-value: 2.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 77 ME HRIRSI N -- R WNAAAM V LR A G kkdlel G GH IASFQSS A TLYD V GFNH F W R ----- AQNE N Q D g DLIYFQ GH IAPGV Y A 149
Cdd:PRK05899 5 ME LLQLLA N ai R VLSIDA V QK A N ------ S GH PGMPMGA A DIAY V LWTR F L R hdpkn PKWP N R D - RFVLSA GH GSMLL Y S 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 150 RAFME G - R L TA D QMD NFRQ evdgqg L S S - Y P - HP wlmk DFWQF P T V SMGL GPL --------- MA I y QARF L KY L ES R GLA 217
Cdd:PRK05899 78 LLHLA G y D L SI D DLK NFRQ ------ L G S k T P g HP ---- EYGHT P G V ETTT GPL gqglanavg MA L - AEKY L AA L FN R PGL 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 218 KTMGRKVWCF CGDG EMD E PE S LG A IAM A AREG L D NL VFVINC N - LQ r L DGP VR gn G KIIQELEGD F RGS GW N V L kviwgs 296
Cdd:PRK05899 147 DIVDHYTYVL CGDG DLM E GI S HE A CSL A GHLK L G NL IVIYDD N r IS - I DGP TE -- G WFTEDVKKR F EAY GW H V I ------ 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 297 rwdpllamdtkgllkkrmde C VD gdyqtfkskdggyvrehffgkypelremvanmsdeeiwnlnrg GHD PHKVY AA YH EA 376
Cdd:PRK05899 218 -------------------- E VD ------------------------------------------- GHD VEAID AA IE EA 234
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 377 T hn A NGR PT V I L AKTI K G Y gm GA SG - E AKNIA H q AKKMDLDSLRNFRDRF G I pvsdedlpnvpyylpaedspemkymr ER 455
Cdd:PRK05899 235 K -- A STK PT L I I AKTI I G K -- GA PN k E GTHKV H - GAPLGAEEIAAAKKEL G W -------------------------- DY 283
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 456 R A A L G GY L P A RKPVN hplav PEL SAFD A Q L QS S gdrefsttmafvrmlgtimkdknigkrvvpivp DESRTF G MEG mfrq 535
Cdd:PRK05899 284 R K A S G KA L N A LAKAL ----- PEL VGGS A D L AG S --------------------------------- NNTKIK G SKD ---- 321
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 536 ygiwstqgqnyvpqdhdqlm F YK E SKD G QILQE G IN E p G AMA dwi A A A TSY A NSS q PM IPF --------- Y iyys MFGFQ 606
Cdd:PRK05899 322 -------------------- F AP E DYS G RYIHY G VR E - F AMA --- A I A NGL A LHG - GF IPF ggtflvfsd Y ---- ARNAI 372
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 607 R IGD L awaagd M RARGFLLG gtagrt T LNGE G LQ h EDG HS H i Q ----- A G L -- IPN CISYD P TF A Y E L A VIVQ dgmrrm Y 679
Cdd:PRK05899 373 R LAA L ------ M KLPVIYVF ------ T HDSI G VG - EDG PT H - Q pveql A S L ra IPN LTVIR P AD A N E T A AAWK ------ Y 432
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 680 A - E QE D VFYY L T L MNE N Y vh P AMPA - GA EEG IL KG M Y L L Q D GG D akvk V Q L MGS G TILREVMA AAD L L K A D f GI GADIW S 757
Cdd:PRK05899 433 A l E RK D GPSA L V L TRQ N L -- P VLER t AQ EEG VA KG G Y V L R D DP D ---- V I L IAT G SEVHLALE AAD E L E A E - GI KVRVV S 505
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1133852470 758 VT S FNQL - RR D gm E A ERHNL L NPTAE AR SS y VE qqlagrngpvi A AT dyirny AD QIRA YV PGRYV VLG T D G FG R S 832
Cdd:PRK05899 506 MP S TELF d EQ D -- A A YKESV L PAAVT AR VA - VE ----------- A GV ------ AD GWYK YV GLDGK VLG I D T FG A S 561
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
141-444
2.24e-07
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 53.93
E-value: 2.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 141 GH IAPGV Y ARAFME G - R L TADQMDN FRQ evdg Q G LSSYP HP wlmk D F WQFPT V SMGL GPL --------- MAI YQ arflky 210
Cdd:pfam00456 63 GH GSMLL Y SLLHLT G y D L SMEDLKS FRQ ---- L G SKTPG HP ---- E F GHTAG V EVTT GPL gqgianavg MAI AE ------ 128
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 211 les R G LA K T MG R -------- KVWC F C GDG EMD E PE S LG A IAM A ARE GL D NL VFVINC N LQRL DG PVRGN gk IIQELEGD F 282
Cdd:pfam00456 129 --- R N LA A T YN R pgfdivdh YTYV F L GDG CLM E GV S SE A SSL A GHL GL G NL IVFYDD N QISI DG ETKIS -- FTEDTAAR F 203
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 283 RGS GW N V LK V I wgsrwdpllamdtkgllkkrmdecvdgdyqtfkskdggyvrehffgkypelremvanmsdeeiwnlnr G 362
Cdd:pfam00456 204 EAY GW H V IE V E -------------------------------------------------------------------- D 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 363 GHD PHKVY AA YH EA t HNANGR PT V I LAK T IK GYG MGAS g EAKNIA H Q A k KMDL D SLRNFRDRF G IP vsdedl P NV P YYL P 442
Cdd:pfam00456 216 GHD VEAIA AA IE EA - KAEKDK PT L I KCR T VI GYG SPNK - QGTHDV H G A - PLGA D EVAALKQKL G WD ------ P YK P FEI P 286
..
gi 1133852470 443 AE 444
Cdd:pfam00456 287 AE 288
PTZ00089
PTZ00089 transketolase; Provisional
141-432
2.73e-05
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain]
Cd Length: 661
Bit Score: 47.75
E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 141 GH IAPGV Y ARAFME G R - L TADQMD NFRQ EV dgqgl S SY P - HP wlmk DFWQF P T V SMGL GPL - MA I YQ A RF L K y LESRG LA 217
Cdd:PTZ00089 67 GH ASALL Y SMLHLT G Y d L SMEDLK NFRQ LG ----- S RT P g HP ---- ERHIT P G V EVTT GPL g QG I AN A VG L A - IAEKH LA 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 218 KTMG R -------- K V WCF CGDG EMD E PE S LG A IAM A ARE GL DN L VFVINC N LQRL DG PV rg NGKIIQEL E GDFRGS GW N V 289
Cdd:PTZ00089 137 AKFN R pghpifdn Y V YVI CGDG CLQ E GV S QE A LSL A GHL GL EK L IVLYDD N KITI DG NT -- DLSFTEDV E KKYEAY GW H V 214
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 290 LK V IW G SR wdpllam D TK GL L K krmdecvdgdyqtfkskdggyvrehffgkypelremvanmsdeeiwnlnrgghdphkv 369
Cdd:PTZ00089 215 IE V DN G NT ------- D FD GL R K ---------------------------------------------------------- 229
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1133852470 370 ya A YH EA THN a N G R P TV I LA KT IK GYG MGAS G EA K ni A H Q A KKM D l DSLRNFRDR FG IP ------ VS D E 432
Cdd:PTZ00089 230 -- A IE EA KKS - K G K P KL I IV KT TI GYG SSKA G TE K -- V H G A PLG D - EDIAQVKEL FG LD pekkfh VS E E 292
TPP_enzymes
cd00568 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
193-303
1.26e-04
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain]
Cd Length: 168
Bit Score: 43.40
E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 193 S MG L G PLM AI YQ A RFLK ylesrglaktm G R K V W C FC GDG EMD ep ESLGAI A M A A R E GL d NLVF V INC N -------- L Q RL 264
Cdd:cd00568 47 A MG Y G LPA AI GA A LAAP ----------- D R P V V C IA GDG GFM -- MTGQEL A T A V R Y GL - PVIV V VFN N ggygtirm H Q EA 112
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1133852470 265 DGPV R GN G KIIQEL eg DF ---- RGS G WNVLK V IWGSRWDPL LA 303
Cdd:cd00568 113 FYGG R VS G TDLSNP -- DF aala EAY G AKGVR V EDPEDLEAA LA 153
IlvB
COG0028 Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ...
205-286
8.65e-03
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439799 [Multi-domain]
Cd Length: 548
Bit Score: 39.76
E-value: 8.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133852470 205 AR F L K ------ Y L E S R GL A k TMG --------------- R K V WCFC GDG -- E M depe S L GAI A M A A R E GL DNL V F V I N c N l 261
Cdd:COG0028 394 AR Y L R frrprr F L T S G GL G - TMG yglpaaigaklarpd R P V VAIT GDG gf Q M ---- N L QEL A T A V R Y GL PVK V V V L N - N - 466
90 100
....*....|....*....|....*
gi 1133852470 262 QR L dgpvr G NGKII QEL EGDF R G SG 286
Cdd:COG0028 467 GG L ----- G MVRQW QEL FYGG R Y SG 486
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
