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Conserved domains on  [gi|740849005|ref|WP_038634258|]
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MULTISPECIES: calcium/sodium antiporter [Citrobacter]

Protein Classification

sodium:calcium antiporter( domain architecture ID 11484916)

sodium:calcium antiporter facilitates Na(+)/Ca(2+) exchange

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 1-325 0e+00

putative calcium/sodium:proton antiporter; Provisional


:

Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 506.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   1 MLLATALLIIGLLLVVYGADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITN 80
Cdd:PRK10734   1 MLLATALLIIGLLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  81 ILLILGLSALIHPFTVHSDVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIARLAERQGNDTLTR 160
Cdd:PRK10734  81 ILLILGLAALIRPFTVHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIARLAERQGNDSLTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 161 EQIAELPREGGLPVAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIA 240
Cdd:PRK10734 161 EQLAELPREGGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 241 VGNIIGANIFNIVIVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRPRQIGRGAGALLTGGFIIWLAMLYWLS 320
Cdd:PRK10734 241 VGNIIGSNIFNIVIVLGLPALISPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGALLLGGFIVWLAMLYWLS 320


                 ....*
gi 740849005 321 PLLVG 325
Cdd:PRK10734 321 PILVE 325
 
Name Accession Description Interval E-value
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 1-325 0e+00

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 506.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   1 MLLATALLIIGLLLVVYGADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITN 80
Cdd:PRK10734   1 MLLATALLIIGLLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  81 ILLILGLSALIHPFTVHSDVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIARLAERQGNDTLTR 160
Cdd:PRK10734  81 ILLILGLAALIRPFTVHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIARLAERQGNDSLTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 161 EQIAELPREGGLPVAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIA 240
Cdd:PRK10734 161 EQLAELPREGGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 241 VGNIIGANIFNIVIVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRPRQIGRGAGALLTGGFIIWLAMLYWLS 320
Cdd:PRK10734 241 VGNIIGSNIFNIVIVLGLPALISPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGALLLGGFIVWLAMLYWLS 320


                 ....*
gi 740849005 321 PLLVG 325
Cdd:PRK10734 321 PILVE 325
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 2-312 2.70e-96

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 287.30  E-value: 2.70e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005    2 LLATALLIIGLLLVVYGADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNI 81
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   82 LLILGLSALIHPFTVHSDVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIARLAErqgNDTLTRE 161
Cdd:TIGR00367  81 LLILGLSAIFSPIIVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWVK---YDTYTEE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  162 QIAELPREGGLPVAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAV 241
Cdd:TIGR00367 158 NLDENNRRPQIFFSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740849005  242 GNIIGANIFNIVIVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRPrQIGRGAGALLTGGFIIW 312
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSM-KLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
19-316 1.62e-87

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 264.30  E-value: 1.62e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  19 ADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNILLILGLSALIHPFTVHS 98
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  99 DVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIArlaeRQGNDTLTREQIAELPREGGLPVAFLW 178
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRA----RKEPAWEEVEEELEEKPKMSLWKALLL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 179 LGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFNIVIVLGL 258
Cdd:COG0530  157 LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 740849005 259 PALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRpRQIGRGAGALLTGGFIIWLAML 316
Cdd:COG0530  237 GALITPIPVDPAVLSFDLPVMLAATLLLLGLLRTG-GRIGRWEGLLLLALYLAYLALL 293
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 174-318 7.10e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 92.67  E-value: 7.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  174 VAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFNIV 253
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740849005  254 IVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLC----WRRPRQIGRGAGALLTGGFIIWLAMLYW 318
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLllllLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
 
Name Accession Description Interval E-value
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 1-325 0e+00

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 506.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   1 MLLATALLIIGLLLVVYGADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITN 80
Cdd:PRK10734   1 MLLATALLIIGLLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  81 ILLILGLSALIHPFTVHSDVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIARLAERQGNDTLTR 160
Cdd:PRK10734  81 ILLILGLAALIRPFTVHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIARLAERQGNDSLTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 161 EQIAELPREGGLPVAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIA 240
Cdd:PRK10734 161 EQLAELPREGGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 241 VGNIIGANIFNIVIVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRPRQIGRGAGALLTGGFIIWLAMLYWLS 320
Cdd:PRK10734 241 VGNIIGSNIFNIVIVLGLPALISPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGALLLGGFIVWLAMLYWLS 320


                 ....*
gi 740849005 321 PLLVG 325
Cdd:PRK10734 321 PILVE 325
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 2-312 2.70e-96

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 287.30  E-value: 2.70e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005    2 LLATALLIIGLLLVVYGADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNI 81
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   82 LLILGLSALIHPFTVHSDVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIARLAErqgNDTLTRE 161
Cdd:TIGR00367  81 LLILGLSAIFSPIIVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWVK---YDTYTEE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  162 QIAELPREGGLPVAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAV 241
Cdd:TIGR00367 158 NLDENNRRPQIFFSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740849005  242 GNIIGANIFNIVIVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRPrQIGRGAGALLTGGFIIW 312
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSM-KLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
19-316 1.62e-87

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 264.30  E-value: 1.62e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  19 ADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNILLILGLSALIHPFTVHS 98
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  99 DVLRRELPLMLLVSILAASVLYDGQLSRSDGFFLLLLAVLWLLFIVKIArlaeRQGNDTLTREQIAELPREGGLPVAFLW 178
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRA----RKEPAWEEVEEELEEKPKMSLWKALLL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 179 LGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFNIVIVLGL 258
Cdd:COG0530  157 LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 740849005 259 PALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRpRQIGRGAGALLTGGFIIWLAML 316
Cdd:COG0530  237 GALITPIPVDPAVLSFDLPVMLAATLLLLGLLRTG-GRIGRWEGLLLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
194-320 8.16e-28

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 109.45  E-value: 8.16e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005 194 VDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFNIVIVLGLPALITPGEVNPMAFT 273
Cdd:COG0530    5 VRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVLR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 740849005 274 RDYSVMLLVSVIFALLCWrrPRQIGRGAGALLTGGFIIWLAMLYWLS 320
Cdd:COG0530   85 RDLPFLLLASLLLLALLL--DGTLSRIDGVILLLLYVLYLYYLIRRA 129
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
18-129 6.56e-25

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 101.75  E-value: 6.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  18 GADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNILLILGLSALIHPFTVH 97
Cdd:COG0530  167 GARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVD 246

                         90       100       110
                 ....*....|....*....|....*....|...
gi 740849005  98 SDVLRRELPLMLLVSILAASVLY-DGQLSRSDG 129
Cdd:COG0530  247 PAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEG 279
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 174-318 7.10e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 92.67  E-value: 7.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  174 VAFLWLGIALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFNIV 253
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740849005  254 IVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLC----WRRPRQIGRGAGALLTGGFIIWLAMLYW 318
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLllllLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 172-317 1.78e-21

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 92.39  E-value: 1.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  172 LPVAFLWLGIALIIMpmATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFN 251
Cdd:TIGR00367   2 LLIGYLILGLILLIY--GADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740849005  252 IVIVLGLPALITPGEVNPMAFTRDYSVMLLVSVIFALLCWRRprQIGRGAGALLTGGFIIWLAMLY 317
Cdd:TIGR00367  80 ILLILGLSAIFSPIIVDKDWLRRDILFYLLVSILLLFFGLDG--QISRIDGVVLLILYIVYLLFLV 143
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 17-120 4.70e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 74.18  E-value: 4.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   17 YGADRLVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNILLILGLSALIHPFTV 96
Cdd:pfam01699  15 VAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSALIGPVKV 94

                          90       100
                  ....*....|....*....|....
gi 740849005   97 HSDVLRRELPLMLLVSILAASVLY 120
Cdd:pfam01699  95 DSLLLKLDLGVLLLVALLLLLLLL 118
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 172-262 3.22e-10

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 61.16  E-value: 3.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   172 LPVAF-LWLGI------------------ALIIMPMATRMVVDNATVLANYFAMSELTIGLTVVAIGTSLPELATAIAGL 232
Cdd:TIGR00927  912 LPIVFpLWLTVpdvrrqearkffvitflgSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                           90       100       110
                   ....*....|....*....|....*....|
gi 740849005   233 RKGENDIAVGNIIGANIFNIVIVLGLPALI 262
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLL 1021
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 22-113 6.75e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 50.76  E-value: 6.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005    22 LVFAASILCRNFGIPPIIIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNILLILGLSAL-------IHPF 94
Cdd:TIGR00927  952 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLlfslingLQPV 1031

                           90       100
                   ....*....|....*....|....*
gi 740849005    95 TVHSD------VLrreLPLMLLVSI 113
Cdd:TIGR00927 1032 PVSSNglfcaiVL---LFLMLLFVI 1053
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 199-291 1.14e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 50.38  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005   199 VLANYFAMSELTIGLTVVAIGTSLPELATAIAGLRKGENDIAVGNIIGANIFNIVIVLGLPALITPGEVN----PMafTR 274
Cdd:TIGR00927  485 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNltwwPL--FR 562

                           90       100
                   ....*....|....*....|...
gi 740849005   275 DYS------VMLLVSVIFALLCW 291
Cdd:TIGR00927  563 DVSfyildlMMLILFFLDSLIAW 585
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 180-317 7.18e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 44.40  E-value: 7.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  180 GIALIIMPMATRMVVDnatvLANYFAmseLTIGL-------TVVAIGTSLPE-LATAIAGLRKGENDIAVGNIIGANIFN 251
Cdd:TIGR00845 760 VVSILMIGVLTAFIGD----LASHFG---CTIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVN 832

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005  252 IVIVLGLPALI---------TPGEVNPMafTRDYSVMLLvsVIFALLC-----WRRPRQIGRGAGA-----LLTGGFIIW 312
Cdd:TIGR00845 833 VFLGIGVAWSIaaiyhaangTQFKVSPG--TLAFSVTLF--TIFAFICigvllYRRRPEIGGELGGprtakLLTSALFVL 908


                  ....*
gi 740849005  313 LAMLY 317
Cdd:TIGR00845 909 LWLLY 913
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 23-90 2.96e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.59  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740849005    23 VFAA-SILCRNFGIPPI------------IIGMTVVSVGTSLPEIIVSVAASINGQLDLAVGTAIGSNITNILLILGLSA 89
Cdd:TIGR00927  467 VFVAlAIVCDEYFVPALgvitdklqisedVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCA 546


                   .
gi 740849005    90 L 90
Cdd:TIGR00927  547 L 547
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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