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Conserved domains on  [gi|727177952|ref|WP_033641724|]
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MULTISPECIES: ABC transporter permease subunit [Serratia]

Protein Classification

ABC transporter permease( domain architecture ID 11471985)

ABC transporter permease containing duplicated transmembrane domains, is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020
PubMed:  18535149|25750732|24638992|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 1-573 0e+00

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 590.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952   1 MQNNRGTSVFRKSYLN--DFIVIAIGVFFIAFFIRAWGDMHGDFNEQNVSAISLDAWNLLYYSLRTSMRFLLGMAWSLLF 78
Cdd:COG4986    1 MTRRLFPANSTRRRPNrwDLAALLLVLALLVLLAYGAKQMTAPLAPGETPPISLDPANLPYYALRTTLRMFAALAASLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  79 SVVFAVLAARYAPLRRVILPFVNFMESVPLVGFLTFTTVYFLNLYPHSVMGLECTAIFAVFTGQAWNMMLTLYQTLRIVP 158
Cdd:COG4986   81 TFVYATLAAKSRRAEKILIPLLDILQSVPVLGFLSFTVTFFIALFPGSLLGVELAAIFAIFTSQAWNMAFSFYQSLRTVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 159 KELDEAARSFNYNPWQRFWRLEFIYSVPGLLWNAMVSQSAAWFALVASEAIPVGDRSVELPGVGSYIAEALAQQNVPAIL 238
Cdd:COG4986  161 RDLDEAARIFRLSGWQRFWRLELPFAMPGLVWNSMMSMSGGWFFLVASEAISVGNQDIRLPGIGSYLALAIAQGDLGAIG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 239 YAIVALAANIVLLDQLVFRPLVRYTARFKYEDvTANRALGNPWFYNSLAFSHVGAALGRTLRALADlWLFKLPRLWYALG 318
Cdd:COG4986  241 WAILAMLVVILLYDQLLFRPLVAWADKFRFEQ-TASEEAPRSWVLDLLRRSRLLRALGRPLGPLGR-ALLRLRLRLLPRA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 319 LHRLFRLAAKGNWLWRsLWYLGVVLACVWFGYRLWEY----FPKQYFAMLPEWMLLTTARVAAAMLLSVAIFTPLGVWIG 394
Cdd:COG4986  319 PRPPAVSRALSRWLDR-LWLALLALLVLYGLWRLLLFllteVGLSEVLHVFLLGLLTLLRVVVLIALASLIWVPVGVWIG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 395 LNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIYHQDLGWWAIPMIMLGTQWYVLFNVIAGVSAIPTQITEVSETFGLR 474
Cdd:COG4986  398 LRPRLARRLQPVAQFLASFPANLLFPVAVLLIVRFGLNPNIWLSPLMILGTQWYILFNVIAGASAIPNDLREAARNFGLR 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 475 RFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIQWGSTTLSATGLGAFISVVTDAGKNPESALGCAAMCALVALC 554
Cdd:COG4986  478 GWLWWRRLILPGIFPYYVTGAITASGGAWNASIVAEYVSWGDTTLQATGLGAYIAQATAAGDFPRILLGIAVMSLFVVLF 557

                        570
                 ....*....|....*....
gi 727177952 555 IIFVWQPLYRIAETKFKYD 573
Cdd:COG4986  558 NRLVWRPLYRLAERRYRLD 576
 
Name Accession Description Interval E-value
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 1-573 0e+00

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 590.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952   1 MQNNRGTSVFRKSYLN--DFIVIAIGVFFIAFFIRAWGDMHGDFNEQNVSAISLDAWNLLYYSLRTSMRFLLGMAWSLLF 78
Cdd:COG4986    1 MTRRLFPANSTRRRPNrwDLAALLLVLALLVLLAYGAKQMTAPLAPGETPPISLDPANLPYYALRTTLRMFAALAASLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  79 SVVFAVLAARYAPLRRVILPFVNFMESVPLVGFLTFTTVYFLNLYPHSVMGLECTAIFAVFTGQAWNMMLTLYQTLRIVP 158
Cdd:COG4986   81 TFVYATLAAKSRRAEKILIPLLDILQSVPVLGFLSFTVTFFIALFPGSLLGVELAAIFAIFTSQAWNMAFSFYQSLRTVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 159 KELDEAARSFNYNPWQRFWRLEFIYSVPGLLWNAMVSQSAAWFALVASEAIPVGDRSVELPGVGSYIAEALAQQNVPAIL 238
Cdd:COG4986  161 RDLDEAARIFRLSGWQRFWRLELPFAMPGLVWNSMMSMSGGWFFLVASEAISVGNQDIRLPGIGSYLALAIAQGDLGAIG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 239 YAIVALAANIVLLDQLVFRPLVRYTARFKYEDvTANRALGNPWFYNSLAFSHVGAALGRTLRALADlWLFKLPRLWYALG 318
Cdd:COG4986  241 WAILAMLVVILLYDQLLFRPLVAWADKFRFEQ-TASEEAPRSWVLDLLRRSRLLRALGRPLGPLGR-ALLRLRLRLLPRA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 319 LHRLFRLAAKGNWLWRsLWYLGVVLACVWFGYRLWEY----FPKQYFAMLPEWMLLTTARVAAAMLLSVAIFTPLGVWIG 394
Cdd:COG4986  319 PRPPAVSRALSRWLDR-LWLALLALLVLYGLWRLLLFllteVGLSEVLHVFLLGLLTLLRVVVLIALASLIWVPVGVWIG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 395 LNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIYHQDLGWWAIPMIMLGTQWYVLFNVIAGVSAIPTQITEVSETFGLR 474
Cdd:COG4986  398 LRPRLARRLQPVAQFLASFPANLLFPVAVLLIVRFGLNPNIWLSPLMILGTQWYILFNVIAGASAIPNDLREAARNFGLR 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 475 RFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIQWGSTTLSATGLGAFISVVTDAGKNPESALGCAAMCALVALC 554
Cdd:COG4986  478 GWLWWRRLILPGIFPYYVTGAITASGGAWNASIVAEYVSWGDTTLQATGLGAYIAQATAAGDFPRILLGIAVMSLFVVLF 557

                        570
                 ....*....|....*....
gi 727177952 555 IIFVWQPLYRIAETKFKYD 573
Cdd:COG4986  558 NRLVWRPLYRLAERRYRLD 576
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 387-558 2.07e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.01  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  387 TPLGVWIGL--NPRLVKIFQPIIQILAAIPPNIFYP-LIAAFIAIYHQDLGWWAIPMIMLGTQWYVLFNVIAGVSAIPTQ 463
Cdd:pfam00528   2 IPLGIIAALrrGRRLDRLLRPLIDLLQALPSFVLAIlLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  464 ITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIqwgsttLSATGLGAFISVVTDAGKNPESALG 543
Cdd:pfam00528  82 LVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFL------GSWPGLGLLLIEAILGYDYPEIQGP 155

                         170
                  ....*....|....*
gi 727177952  544 CAAMCALVALCIIFV 558
Cdd:pfam00528 156 VLAAALILLLLNLLV 170
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 368-512 8.56e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 8.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 368 MLLTTARVAAAMLLSVAIFTPLGVWIGLNPRLV-KIFQPIIQILAAIPPNIFYPLIAAFIAIYH-----QDLGWWAIPMI 441
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLdRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgilPGLGLPALILA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727177952 442 MLGTQWYVLFNVIAGVSAIPTQITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVI 512
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151
PRK10160 PRK10160
taurine ABC transporter permease TauC;
373-512 1.75e-08

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 55.95  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 373 ARVAAAMLLSVAIFTPLGVWIGLNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIYHQDlgwwAIPMIMLGTQWYVLFN 452
Cdd:PRK10160  85 TRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETS----KILLIYLAIFAPVAMS 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 453 VIAGVSAIPTQITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVI 512
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELI 220
 
Name Accession Description Interval E-value
COG4986 COG4986
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ...
 1-573 0e+00

ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];


Pssm-ID: 444010 [Multi-domain]  Cd Length: 576  Bit Score: 590.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952   1 MQNNRGTSVFRKSYLN--DFIVIAIGVFFIAFFIRAWGDMHGDFNEQNVSAISLDAWNLLYYSLRTSMRFLLGMAWSLLF 78
Cdd:COG4986    1 MTRRLFPANSTRRRPNrwDLAALLLVLALLVLLAYGAKQMTAPLAPGETPPISLDPANLPYYALRTTLRMFAALAASLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  79 SVVFAVLAARYAPLRRVILPFVNFMESVPLVGFLTFTTVYFLNLYPHSVMGLECTAIFAVFTGQAWNMMLTLYQTLRIVP 158
Cdd:COG4986   81 TFVYATLAAKSRRAEKILIPLLDILQSVPVLGFLSFTVTFFIALFPGSLLGVELAAIFAIFTSQAWNMAFSFYQSLRTVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 159 KELDEAARSFNYNPWQRFWRLEFIYSVPGLLWNAMVSQSAAWFALVASEAIPVGDRSVELPGVGSYIAEALAQQNVPAIL 238
Cdd:COG4986  161 RDLDEAARIFRLSGWQRFWRLELPFAMPGLVWNSMMSMSGGWFFLVASEAISVGNQDIRLPGIGSYLALAIAQGDLGAIG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 239 YAIVALAANIVLLDQLVFRPLVRYTARFKYEDvTANRALGNPWFYNSLAFSHVGAALGRTLRALADlWLFKLPRLWYALG 318
Cdd:COG4986  241 WAILAMLVVILLYDQLLFRPLVAWADKFRFEQ-TASEEAPRSWVLDLLRRSRLLRALGRPLGPLGR-ALLRLRLRLLPRA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 319 LHRLFRLAAKGNWLWRsLWYLGVVLACVWFGYRLWEY----FPKQYFAMLPEWMLLTTARVAAAMLLSVAIFTPLGVWIG 394
Cdd:COG4986  319 PRPPAVSRALSRWLDR-LWLALLALLVLYGLWRLLLFllteVGLSEVLHVFLLGLLTLLRVVVLIALASLIWVPVGVWIG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 395 LNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIYHQDLGWWAIPMIMLGTQWYVLFNVIAGVSAIPTQITEVSETFGLR 474
Cdd:COG4986  398 LRPRLARRLQPVAQFLASFPANLLFPVAVLLIVRFGLNPNIWLSPLMILGTQWYILFNVIAGASAIPNDLREAARNFGLR 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 475 RFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIQWGSTTLSATGLGAFISVVTDAGKNPESALGCAAMCALVALC 554
Cdd:COG4986  478 GWLWWRRLILPGIFPYYVTGAITASGGAWNASIVAEYVSWGDTTLQATGLGAYIAQATAAGDFPRILLGIAVMSLFVVLF 557

                        570
                 ....*....|....*....
gi 727177952 555 IIFVWQPLYRIAETKFKYD 573
Cdd:COG4986  558 NRLVWRPLYRLAERRYRLD 576
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 368-528 2.57e-21

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 93.67  E-value: 2.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 368 MLLTTARVAAAMLLSVAIFTPLGVWIGLNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIyhqdlGWWA-IPMIMLGTQ 446
Cdd:COG0600   63 LLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWFGI-----GEASkIFVIFLGAF 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 447 WYVLFNVIAGVSAIPTQITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIQwgsttlSATGLGA 526
Cdd:COG0600  138 FPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAWIGLVVAELLG------ASSGLGY 211


                 ..
gi 727177952 527 FI 528
Cdd:COG0600  212 LI 213
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 48-265 2.27e-17

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 82.12  E-value: 2.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  48 SAISLDAWNLLYYSLRTSM-RFLLGMAWSLLFSVVFAVLAARYAPLRRVILPFVNFMESVPLVGFLTFTTVYFlnlyphs 126
Cdd:COG0600   49 ALVELLASGELWEHLLASLlRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWF------- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 127 vmGL-ECTAIFAVFTGQAWNMMLTLYQTLRIVPKELDEAARSFNYNPWQRFWRLEFIYSVPGLLWNAMVSQSAAWFALVA 205
Cdd:COG0600  122 --GIgEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAWIGLVV 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 206 SEAIPVGDrsvelpGVGSYIAEALAQQNVPAILYAIVALAANIVLLDQLvFRPLVRYTAR 265
Cdd:COG0600  200 AELLGASS------GLGYLILDARQLLDTDLVFAAILVIGLLGLLLDLL-LRLLERRLLR 252
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 387-558 2.07e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.01  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  387 TPLGVWIGL--NPRLVKIFQPIIQILAAIPPNIFYP-LIAAFIAIYHQDLGWWAIPMIMLGTQWYVLFNVIAGVSAIPTQ 463
Cdd:pfam00528   2 IPLGIIAALrrGRRLDRLLRPLIDLLQALPSFVLAIlLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  464 ITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIqwgsttLSATGLGAFISVVTDAGKNPESALG 543
Cdd:pfam00528  82 LVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFL------GSWPGLGLLLIEAILGYDYPEIQGP 155

                         170
                  ....*....|....*
gi 727177952  544 CAAMCALVALCIIFV 558
Cdd:pfam00528 156 VLAAALILLLLNLLV 170
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 368-512 8.56e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 8.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 368 MLLTTARVAAAMLLSVAIFTPLGVWIGLNPRLV-KIFQPIIQILAAIPPNIFYPLIAAFIAIYH-----QDLGWWAIPMI 441
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLdRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgilPGLGLPALILA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727177952 442 MLGTQWYVLFNVIAGVSAIPTQITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVI 512
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151
PRK10160 PRK10160
taurine ABC transporter permease TauC;
373-512 1.75e-08

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 55.95  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 373 ARVAAAMLLSVAIFTPLGVWIGLNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIYHQDlgwwAIPMIMLGTQWYVLFN 452
Cdd:PRK10160  85 TRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETS----KILLIYLAIFAPVAMS 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 453 VIAGVSAIPTQITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVI 512
Cdd:PRK10160 161 ALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAELI 220
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 79-251 2.35e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 54.23  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952   79 SVVFAVLAARY--APLRRVILPFVNFMESVPLVGFLTFTTVYFLNLYPHSVMGlecTAIFAVFTGQAWNMMLTLYQTLRI 156
Cdd:pfam00528   1 GIPLGIIAALRrgRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGIL---PAIILALLGWAGYARLIRRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  157 VPKELDEAARSFNYNPWQRFWRLEFIYSVPGLLWNAMVSQSAAWFALVASEAIpvgdrsVELPGVGSYIAEALAQQNVPA 236
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFL------GSWPGLGLLLIEAILGYDYPE 151

                         170
                  ....*....|....*
gi 727177952  237 ILYAIVALAANIVLL 251
Cdd:pfam00528 152 IQGPVLAAALILLLL 166
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 69-250 8.76e-08

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 52.67  E-value: 8.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  69 LLGMAWSLLFSVVFAVLAARYA-PLRRVILPFVNFMESVP-LVGFLTFTTVYFLNLYPHSVMGLECTAIFAVFTGQAWNM 146
Cdd:cd06261    9 LIATLLALVLGLLLGIILARKRgKLDRLLRRIIDLLLSLPsLVLGLLLVLLFGVLLGWGILPGLGLPALILALLLIAPFA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 147 MLTLYQTLRIVPKELDEAARSFNYNPWQRFWRLEFIYSVPGLLWNAMVSQSAAWFALVASEAIPVGDRSVelPGVGSYIA 226
Cdd:cd06261   89 RLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG--PGTGLLLI 166

                        170       180
                 ....*....|....*....|....
gi 727177952 227 EALAQQNVPAILYAIVALAANIVL 250
Cdd:cd06261  167 FAILFPGDLGVAAAVALILLLLSL 190
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 69-250 2.95e-06

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 48.51  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952  69 LLGMAWSLLFSVVFAVLAARYAPLRRVILPFVNFMESVPLVGFLTFttvyflnLYPhsVMGL-ECTAIFAvftgqawnmm 147
Cdd:COG1174   28 LLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLAL-------LIP--LLGIgPAPAIIA---------- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 148 LTLYQTLRI----------VPKELDEAARSFNYNPWQRFWRLEFIYSVPGLLW---NAMVsQSAAWFALVAseaiPVGdr 214
Cdd:COG1174   89 LVLYALLPIlrntytglrsVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAgirTAAV-QNIGTATLAA----LIG-- 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 727177952 215 sveLPGVGSYIAEALAQQNVP-----AILYAIVALAANIVL 250
Cdd:COG1174  162 ---AGGLGDLIFDGLQLNNTAlilagAILVALLALLVDLLL 199
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 375-555 7.98e-06

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 46.97  E-value: 7.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 375 VAAAMLLSVAIFTPLGVWIGLNPRLVKIFQPIIQILAAIPPnifYPLIAAFIAIYhqDLGWW-AIPMIMLGTQWYVLFNV 453
Cdd:COG1174   27 VLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPS---LALLALLIPLL--GIGPApAIIALVLYALLPILRNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 454 IAGVSAIPTQITEVSETFGLRRFRWWRYYMLPAIFPYIVTGIISAAggawnsaiaaeVIQWGSTTLSAT----GLGAFIs 529
Cdd:COG1174  102 YTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAA-----------VQNIGTATLAALigagGLGDLI- 169

                        170       180
                 ....*....|....*....|....*...
gi 727177952 530 vvTD--AGKNPESALGCAAMCALVALCI 555
Cdd:COG1174  170 --FDglQLNNTALILAGAILVALLALLV 195
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
389-516 4.16e-04

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 42.23  E-value: 4.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727177952 389 LGVWIGLNPRLVKIFQPIIQILAAIPPNIFYPLIAAFIAIYHQDlgwwAIPMIMLGTQWYVLFNVIAGVSAIPTQITEVS 468
Cdd:PRK11365  83 LGLISGLSRWGERLLDTSIQMLRNVPHLALIPLVILWFGIDESA----KIFLVALGTLFPIYINTWHGIRNIDRGLVEMA 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727177952 469 ETFGLRRFRWWRYYMLPAIFPYIVTGIISAAGGAWNSAIAAEVIQWGS 516
Cdd:PRK11365 159 RSYGLSGIPLFIHVILPGALPSIMVGVRFALGLMWLTLIVAETISANS 206
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 136-189 2.78e-03

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 40.13  E-value: 2.78e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727177952 136 FAVFTGQAWN----MMLTLYQTLRIVPKELDEAARSFNYNPWQRFWRLEFIYSVPGLL 189
Cdd:COG1176  155 FAVVIGLVYVylpfMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGII 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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