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Conserved domains on  [gi|647262427|ref|WP_025710493|]
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MULTISPECIES: 1-acylglycerol-3-phosphate O-acyltransferase [Klebsiella]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 1-244 1.44e-160

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member PRK15018:

Pssm-ID: 473073  Cd Length: 245  Bit Score: 444.46  E-value: 1.44e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   1 MLFIFRVIFVVIYCIVVCILGCLYCLFSPRNPKHVATFGHLFGRLSPVFGLKVELRKPADAESYGNAIYIANHQNNYDMV 80
Cdd:PRK15018   1 MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  81 TASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNAFKKRKISFWMFPEGTRSRGRGLLPFK 160
Cdd:PRK15018  81 TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 161 TGAFHAAIAAGVPIIPVCVSNTSNKIKLNRWNNGLVIVEMLPPVDTTQFGKDNVRALATHCRELMAAKIAELDNEVAERE 240
Cdd:PRK15018 161 TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE 240


                 ....
gi 647262427 241 AAGK 244
Cdd:PRK15018 241 AAGK 244
 
Name Accession Description Interval E-value
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 1-244 1.44e-160

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 444.46  E-value: 1.44e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   1 MLFIFRVIFVVIYCIVVCILGCLYCLFSPRNPKHVATFGHLFGRLSPVFGLKVELRKPADAESYGNAIYIANHQNNYDMV 80
Cdd:PRK15018   1 MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  81 TASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNAFKKRKISFWMFPEGTRSRGRGLLPFK 160
Cdd:PRK15018  81 TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 161 TGAFHAAIAAGVPIIPVCVSNTSNKIKLNRWNNGLVIVEMLPPVDTTQFGKDNVRALATHCRELMAAKIAELDNEVAERE 240
Cdd:PRK15018 161 TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE 240


                 ....
gi 647262427 241 AAGK 244
Cdd:PRK15018 241 AAGK 244
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 50-180 5.34e-61

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 187.94  E-value: 5.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   50 GLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNrTKAHGTIA 129
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDREN-IRAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 647262427  130 EVVNAFKKRKISFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 32-237 9.75e-59

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 185.21  E-value: 9.75e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  32 PKHVATFGHLFGR-LSPVFGLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWL 110
Cdd:COG0204    9 RRFRYRLVRLWARlLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 111 TGNLLIDRNNRTKAHGTIAEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKI-KLN 189
Cdd:COG0204   89 LGAIPVDRSKRRAALRALRQAVEALKAGE-SLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALpKGF 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 647262427 190 RWNNGLVIVEMLPPVDTTQFGKDNVRALATHCRELMAAKIAELDNEVA 237
Cdd:COG0204  168 LPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 48-222 2.78e-42

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 142.02  E-value: 2.78e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  48 VFGLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGT 127
Cdd:cd07989    7 LLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 128 IAEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT--SNKIKLNRWNNGLVIVEMLPPVD 205
Cdd:cd07989   87 LREAIEALKEGE-SVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTwgSLPKGKKLPRPGRVTVRIGEPIP 165

                        170
                 ....*....|....*....
gi 647262427 206 TTQFG--KDNVRALATHCR 222
Cdd:cd07989  166 PEGLElaEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 52-180 3.75e-40

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 134.71  E-value: 3.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   52 KVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQA---PTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTI 128
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 647262427  129 AEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:pfam01553  81 EYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 67-182 2.61e-33

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 116.69  E-value: 2.61e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427    67 AIYIANHQNNYDMVTASNIVQ---APTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNAFKKRKiSFW 143
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPrklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGE-WLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 647262427   144 MFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT 182
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
 
Name Accession Description Interval E-value
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 1-244 1.44e-160

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 444.46  E-value: 1.44e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   1 MLFIFRVIFVVIYCIVVCILGCLYCLFSPRNPKHVATFGHLFGRLSPVFGLKVELRKPADAESYGNAIYIANHQNNYDMV 80
Cdd:PRK15018   1 MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  81 TASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNAFKKRKISFWMFPEGTRSRGRGLLPFK 160
Cdd:PRK15018  81 TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 161 TGAFHAAIAAGVPIIPVCVSNTSNKIKLNRWNNGLVIVEMLPPVDTTQFGKDNVRALATHCRELMAAKIAELDNEVAERE 240
Cdd:PRK15018 161 TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE 240


                 ....
gi 647262427 241 AAGK 244
Cdd:PRK15018 241 AAGK 244
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 50-180 5.34e-61

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 187.94  E-value: 5.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   50 GLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNrTKAHGTIA 129
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDREN-IRAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 647262427  130 EVVNAFKKRKISFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 32-237 9.75e-59

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 185.21  E-value: 9.75e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  32 PKHVATFGHLFGR-LSPVFGLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWL 110
Cdd:COG0204    9 RRFRYRLVRLWARlLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 111 TGNLLIDRNNRTKAHGTIAEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKI-KLN 189
Cdd:COG0204   89 LGAIPVDRSKRRAALRALRQAVEALKAGE-SLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALpKGF 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 647262427 190 RWNNGLVIVEMLPPVDTTQFGKDNVRALATHCRELMAAKIAELDNEVA 237
Cdd:COG0204  168 LPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 48-222 2.78e-42

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 142.02  E-value: 2.78e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  48 VFGLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGT 127
Cdd:cd07989    7 LLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 128 IAEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT--SNKIKLNRWNNGLVIVEMLPPVD 205
Cdd:cd07989   87 LREAIEALKEGE-SVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTwgSLPKGKKLPRPGRVTVRIGEPIP 165

                        170
                 ....*....|....*....
gi 647262427 206 TTQFG--KDNVRALATHCR 222
Cdd:cd07989  166 PEGLElaEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 52-180 3.75e-40

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 134.71  E-value: 3.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427   52 KVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQA---PTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTI 128
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 647262427  129 AEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:pfam01553  81 EYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 67-182 2.61e-33

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 116.69  E-value: 2.61e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427    67 AIYIANHQNNYDMVTASNIVQ---APTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNAFKKRKiSFW 143
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPrklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGE-WLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 647262427   144 MFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT 182
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 68-229 6.34e-17

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 76.49  E-value: 6.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  68 IYIANHQNNYDMVTASnIVQAPTVtVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVN-AFKKRKISFWMFP 146
Cdd:cd07991   27 IIVANHTSFIDPLILF-SDLFPSI-VAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKErATDPNWPPILIFP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 147 EGTRSRGRGLLPFKTGAFhaaiAAGVPIIPVCV---------SNTSNKIK--------LNRWNNgLVIVEMLPPVDTTQf 209
Cdd:cd07991  105 EGTTTNGKALIMFKKGAF----EPGVPVQPVAIrypnkfvdaFWNSSGYSslmylfrlLTQPAN-VLEVEFLPVYTPSE- 178

                        170       180
                 ....*....|....*....|
gi 647262427 210 GKDNVRALATHCRELMAAKI 229
Cdd:cd07991  179 EGEDPKEFANRVRLIMANKL 198
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 50-226 2.16e-16

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 74.76  E-value: 2.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  50 GLKVELRKPADAESYGNAIYIANHQNNYDM-----VTASNIVQAPTVTVGKKSLLWIPFFGQLywltGNLLIDRNNRTKA 124
Cdd:cd06551   11 FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGlilflLLERGLRRDVYGLMDEELLERYPFFTRL----GAFSVDRDSPRSA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 125 HGTIAEVVNAFKKRKISFWMFPEGTRSRGR-GLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKIKlnRWNNGLVIVEMLPP 203
Cdd:cd06551   87 AKSLKYVARLLSKPGSVVWIFPEGTRTRRDkRPLQFKPGVAHLAEKAGVPIVPVALRYTFELFE--QFPEIFVRIGPPIP 164

                        170       180
                 ....*....|....*....|...
gi 647262427 204 VDTTQFGKDNVRALATHCRELMA 226
Cdd:cd06551  165 YAETALGEELAAELANRLTRLLD 187
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 39-177 2.59e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 65.70  E-value: 2.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  39 GHLFGRLSpvfGLKVELRKPADAEsygNAIYIANHQNNYD---MVTASNIVQAPTVTVGKKSLLWIPFFGQLYWLtGNLL 115
Cdd:cd07988    1 ARLLLRLS---GWRIEGEPPNKPK---FVVIGAPHTSNWDfvlGLLAAFALGLKISFLGKHSLFKPPLGPFMRWL-GGIP 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 647262427 116 IDRNNRTkahGTIAEVVNAFKKR-KISFWMFPEGTRSRGRgllPFKTGAFHAAIAAGVPIIPV 177
Cdd:cd07988   74 VDRSRAG---GLVEQVVEEFRRReEFVLAIAPEGTRSKVD---KWKTGFYHIARGAGVPILLV 130
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 46-207 7.67e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 65.52  E-value: 7.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  46 SPVFGLKVELRK--PADAESygnAIYIANHQNNYDMVTASNIvQAPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTK 123
Cdd:PLN02901  32 SPFYKIEVEGLEnlPSPDEP---AVYVSNHQSFLDIYTLFHL-GRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 124 AHGTIAEVVNAFKKrKISFWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKIKLNR---WNNGLVIVEM 200
Cdd:PLN02901 108 QLECLKRCMELLKK-GASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNGKegiLNPGSVKVVI 186


                 ....*..
gi 647262427 201 LPPVDTT 207
Cdd:PLN02901 187 HPPIEGS 193
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 45-168 4.44e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 63.03  E-value: 4.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  45 LSPVFGLKVELRKPADAESYGNAIYIANHQNNYDMVTASNIVQAPTVTVG-----KKSLLWIPFFGQLYWLTGNLLIDRN 119
Cdd:cd07990    4 FEWLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLGRlkivlKDSLKYPPLGGWGWQLGEFIFLKRK 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427 120 NrTKAHGTIAEVVNAFKKRKISFWM--FPEGTR----SRGRG---------------LLPfKTGAFHAAI 168
Cdd:cd07990   84 W-EKDEKTIKRQLKRLKDSPEPFWLliFPEGTRfteeKKERSqefaeknglpplkhvLLP-RTKGFVAIL 151
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 38-177 2.96e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 49.57  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  38 FGHLFGRLSPVFGLKVELRKPADAESYGNAIYIANHQNNY-DMVTASNIVQAPTVTVGKKSLLWIPFFGQLYWLTGNLLI 116
Cdd:cd07992    1 VRLLSRVILRIYFRRITVVGRENVPKDGPVIFLGNHPNALiDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 647262427 117 DRNNRTKAHG--------TIAEVVNAFKKRKiSFWMFPEGTRSRGRGLLPFKTGAFHAAIAA------GVPIIPV 177
Cdd:cd07992   81 YRPKDLARGGigkisnaaVFDAVGEALKAGG-AIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVPV 154
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 130-180 3.37e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 40.63  E-value: 3.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 647262427 130 EVVNAFKKRKISFWMFPEGTRSRGRGLLPFKTG-------AFHAAIAAGVPIIPVCVS 180
Cdd:cd07993   92 EYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGllsvvveAYLKGSVPDVLIVPVSIS 149
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 50-174 5.70e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 40.49  E-value: 5.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647262427  50 GLKVELRkpADAESYG-----NAIYIANHQNNYDMVTASNIVQ-----APTVTVGKKSLLWIPFFGQLYWLTGNLLIDRn 119
Cdd:PLN02380  66 GVKVQLY--ADEETFElmgkeHALVISNHRSDIDWLVGWILAQrsgclGSALAVMKKSSKFLPVIGWSMWFSEYVFLER- 142

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 647262427 120 NRTKAHGTIAEVVNAFKKRKISFW--MFPEGTRSRGRGLLpfktGAFHAAIAAGVPI 174
Cdd:PLN02380 143 SWAKDENTLKSGFQRLKDFPRPFWlaLFVEGTRFTQAKLL----AAQEYAASRGLPV 195
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 144-177 7.96e-03

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 37.21  E-value: 7.96e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 647262427 144 MFPEGTRSR-GRgLLPFKTG-------AFHAAIAAGVPIIPV 177
Cdd:COG2937  287 YFIEGGRSRtGR-LLPPKTGmlsmtvqAFLRGARRPVVFVPV 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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