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Conserved domains on  [gi|518684939|ref|WP_019846632|]
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methyl-accepting chemotaxis protein [Dickeya zeae]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1003728)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 1-563 0e+00

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15041:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 554  Bit Score: 599.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   1 MFRNIKIVTGLFSLLLALSLLQLVSYGFFFGAMKSDRNNFVVSQTLRKQSSELNSSWIALIQTRNTMNRAIARMIMETNN 80
Cdd:PRK15041   1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  81 IPSAGKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQ 160
Cdd:PRK15041  81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 161 DAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSAWVYIRRVLLQPLLRVITHLHHIATGDLTQS 240
Cdd:PRK15041 161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 241 LHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNA 320
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 321 DNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 401 GEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEM 480
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 481 DRVTQQNAVLVEQSANAAVSLEEQSDHLNHAVSLFRLHatpvqdSGKKRPVISTSGKTPSPLTLPGKAATAgayhDTG-N 559
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ------QQQQQQRETSAVVKTVTPATPRKMAVA----DSGeN 550


                 ....
gi 518684939 560 WETF 563
Cdd:PRK15041 551 WETF 554
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-563 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 599.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   1 MFRNIKIVTGLFSLLLALSLLQLVSYGFFFGAMKSDRNNFVVSQTLRKQSSELNSSWIALIQTRNTMNRAIARMIMETNN 80
Cdd:PRK15041   1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  81 IPSAGKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQ 160
Cdd:PRK15041  81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 161 DAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSAWVYIRRVLLQPLLRVITHLHHIATGDLTQS 240
Cdd:PRK15041 161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 241 LHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNA 320
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 321 DNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 401 GEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEM 480
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 481 DRVTQQNAVLVEQSANAAVSLEEQSDHLNHAVSLFRLHatpvqdSGKKRPVISTSGKTPSPLTLPGKAATAgayhDTG-N 559
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ------QQQQQQRETSAVVKTVTPATPRKMAVA----DSGeN 550


                 ....
gi 518684939 560 WETF 563
Cdd:PRK15041 551 WETF 554
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
58-517 4.20e-101

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 315.81  E-value: 4.20e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  58 IALIQTRNTMNRAIARMIMETNNIPSAGKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQ 137
Cdd:COG0840   44 ALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAAL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 138 QIVDLIKTQDVKTIQALPTQKMQDAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSA--WVYIR 215
Cdd:COG0840  124 LAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIilALLLS 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 216 RVLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRT 295
Cdd:COG0840  204 RSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGA 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 296 EQQSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVVS--------------TMKQISGSSQKI 361
Cdd:COG0840  284 EEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVEgieeiresveetaeTIEELGESSQEI 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 362 NDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTS---- 437
Cdd:COG0840  364 GEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEgsee 443

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 438 ----------AGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQSANAAVSLEEQSDH 507
Cdd:COG0840  444 veegvelveeAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEE 523

                        490
                 ....*....|
gi 518684939 508 LNHAVSLFRL 517
Cdd:COG0840  524 LQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 269-516 2.73e-72

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 231.79  E-value: 2.73e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   269 KVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVV 348
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   349 STMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLI------- 421
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   422 -------EDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQS 494
Cdd:smart00283 161 neavaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 518684939   495 ANAAVSLEEQSDHLNHAVSLFR 516
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 296-495 1.44e-62

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 204.39  E-value: 1.44e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 296 EQQSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQT 375
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 376 NILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDI 455
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 518684939 456 MGEISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQSA 495
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 327-484 1.86e-58

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 192.26  E-value: 1.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  327 SQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 406
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  407 AQRSAEAAREIKGLI--------------EDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQ 472
Cdd:pfam00015  81 AERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 518684939  473 VSQAVSEMDRVT 484
Cdd:pfam00015 161 VNQAVARMDQVT 172
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-563 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 599.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   1 MFRNIKIVTGLFSLLLALSLLQLVSYGFFFGAMKSDRNNFVVSQTLRKQSSELNSSWIALIQTRNTMNRAIARMIMETNN 80
Cdd:PRK15041   1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  81 IPSAGKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQ 160
Cdd:PRK15041  81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 161 DAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSAWVYIRRVLLQPLLRVITHLHHIATGDLTQS 240
Cdd:PRK15041 161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 241 LHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNA 320
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 321 DNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 401 GEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEM 480
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 481 DRVTQQNAVLVEQSANAAVSLEEQSDHLNHAVSLFRLHatpvqdSGKKRPVISTSGKTPSPLTLPGKAATAgayhDTG-N 559
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ------QQQQQQRETSAVVKTVTPATPRKMAVA----DSGeN 550


                 ....
gi 518684939 560 WETF 563
Cdd:PRK15041 551 WETF 554
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-563 0e+00

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 563.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   1 MFRNIKIVTGLFSLLLALSLLQLVSYGFFFGAMKSDRNNFVVSQTLRKQSSELNSSWIALIQTRNTMNRAIARMIMETNN 80
Cdd:PRK15048   1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  81 IPSAGKSaELIDVANQSLAQADKHFAAYAQIPLLPVQDAAlAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQ 160
Cdd:PRK15048  81 QQSNAKV-ELLDSARKTLAQAATHYKKFKSMAPLPEMVAT-SRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 161 DAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSAWVYIRRVLLQPLLRVITHLHHIATGDLTQS 240
Cdd:PRK15048 159 NAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 241 LHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNA 320
Cdd:PRK15048 239 LTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 321 DNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15048 319 DNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 401 GEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEM 480
Cdd:PRK15048 399 GEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEM 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 481 DRVTQQNAVLVEQSANAAVSLEEQSDHLNHAVSLFRLHATPVQdsgKKRPVISTSGKTPSPLTLPGKAATagayHDTgNW 560
Cdd:PRK15048 479 DRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLT---NKPQTPSRPASEQPPAQPRLRIAE----QDP-NW 550


                 ...
gi 518684939 561 ETF 563
Cdd:PRK15048 551 ETF 553
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
1-533 8.20e-140

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 415.62  E-value: 8.20e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   1 MFRNIKIVTGLFSLLLALSLLQLVSYGFFFGAMKSDRNNFVVSQTLRKQSSELNSSWIALIQTRNTMNRA--IARMIMET 78
Cdd:PRK09793   1 MFNRIRISTTLFLILILCGILQIGSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALNKAgtLTALSYPA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  79 NNIPSagksaeLIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQK 158
Cdd:PRK09793  81 DDIKT------LMTTARASLTQSTTLFKSFMAMTAGNEHVRALQKETEKSFARWHNDLEHQATWLESNQLSDFLTAPVQG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 159 MQDAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSAWVYIRRVLLQPLLRVITHLHHIATGDLT 238
Cdd:PRK09793 155 SQNAFDVNFEAWQLEINHVLEAASAQSQRNYQISALVFISMIIVAAIYISSALWWTRKMIVQPLAIIGSHFDSIAAGNLA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 239 QSLHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQ 318
Cdd:PRK09793 235 RPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQ 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 319 NADNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAV 398
Cdd:PRK09793 315 NADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAV 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 399 VAGEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVS 478
Cdd:PRK09793 395 VAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQAVS 474

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 518684939 479 EMDRVTQQNAVLVEQSANAAVSLEEQSDHLNHAVSLFRL--HATPVQDSGKKR--PVIS 533
Cdd:PRK09793 475 QMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTLeeHEVARHESAQLQiaPVVS 533
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
58-517 4.20e-101

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 315.81  E-value: 4.20e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  58 IALIQTRNTMNRAIARMIMETNNIPSAGKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQ 137
Cdd:COG0840   44 ALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAAL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 138 QIVDLIKTQDVKTIQALPTQKMQDAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSA--WVYIR 215
Cdd:COG0840  124 LAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIilALLLS 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 216 RVLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRT 295
Cdd:COG0840  204 RSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGA 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 296 EQQSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVVS--------------TMKQISGSSQKI 361
Cdd:COG0840  284 EEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVEgieeiresveetaeTIEELGESSQEI 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 362 NDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTS---- 437
Cdd:COG0840  364 GEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEgsee 443

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 438 ----------AGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQSANAAVSLEEQSDH 507
Cdd:COG0840  444 veegvelveeAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEE 523

                        490
                 ....*....|
gi 518684939 508 LNHAVSLFRL 517
Cdd:COG0840  524 LQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 269-516 2.73e-72

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 231.79  E-value: 2.73e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   269 KVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVV 348
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   349 STMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLI------- 421
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   422 -------EDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQS 494
Cdd:smart00283 161 neavaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 518684939   495 ANAAVSLEEQSDHLNHAVSLFR 516
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 296-495 1.44e-62

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 204.39  E-value: 1.44e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 296 EQQSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQT 375
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 376 NILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDI 455
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 518684939 456 MGEISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQSA 495
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 327-484 1.86e-58

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 192.26  E-value: 1.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  327 SQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 406
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  407 AQRSAEAAREIKGLI--------------EDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQ 472
Cdd:pfam00015  81 AERSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 518684939  473 VSQAVSEMDRVT 484
Cdd:pfam00015 161 VNQAVARMDQVT 172
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 44-175 1.32e-37

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 135.14  E-value: 1.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  44 QTLRKQSSELNSSWIALIQTRNTMNRAIARMIMETNNIPSAgKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAK 123
Cdd:cd19407    1 QQLRQQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGGA-AVAELLDQAKKSLAQAEKHFAQFKALPKLPGQDEALAA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 518684939 124 DIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQDAFQNSFDAYFRQND 175
Cdd:cd19407   80 ELEQSYQAYHDALAELIQFLEAGNIDAFLDQPTQGYQDAFEKAYNAYLAQNN 131
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 27-181 3.00e-29

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 112.78  E-value: 3.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   27 GFFFGAMKSDRNNFVVSQTLRKQS-SELNSSWIALIQTRNTMNRAIARMIMetnniPSAGKSAELIDVANQSLAQADKHF 105
Cdd:pfam02203   2 GLGLSGLSRSNDALREVYTNRLQQqAALADAWLLLLQARLTLNRAGIAALL-----PDAPDAAELLARARESLAQSDAAW 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518684939  106 AAYAQIPLLPVQDAALAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQDAFQNSFDAYFRQNDALNDSA 181
Cdd:pfam02203  77 KAYLALPRTPDEEEALAAELKAKYDALQDGLAPLIAALRAGDLDAFFDQPTQKIQPLFEALYNAYLALRKFQNDAA 152
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 44-182 2.40e-23

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 95.61  E-value: 2.40e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939    44 QTLRKQSSELNSSWIALIQTRNTMNRAIARMImeTNNIPSagKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAK 123
Cdd:smart00319   1 ATSSYQQAALSLSRVLLLQARNNLNRAGIRMM--QNNIGS--KAKKLMTAASESLKQAEKNYKSYENMTALPRADRALDA 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 518684939   124 DIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQDAFQNSFDAYFRQNDALNDSAV 182
Cdd:smart00319  77 ELKEKFQQYITALQELIQILGNGNLGAFFDQPTQGMQDGFDPAYRDWLQQAVALKGQAV 135
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
216-268 2.11e-09

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 53.41  E-value: 2.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 518684939   216 RVLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSLTDTVG 268
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
214-265 3.37e-09

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 52.63  E-value: 3.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 518684939  214 IRRVLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSLTD 265
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 43-258 4.45e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 59.31  E-value: 4.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  43 SQTLRKQSSELNSSWIALIQTRNTMN--RAIARMIMETNNIPSAgkSAELIDVANQSLAQADKHFAAYAqipLLPVQDAA 120
Cdd:COG4192  164 LQEASWQQTRLLDSVETTESLRNLQNelQLLLRLLAIENQIVSL--LREVAAARDQADVDNLFDRLQYL---KDELDRNL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 121 LAKDIDTHYQALRRVLQQIVDLIKTQD------------VKTIQALPTQ--KMQDAFQNSFDAYFRQNDALNDSAVTDSN 186
Cdd:COG4192  239 QALKNYPSTITLRQLIDELLAIGSGEGglpslrrdelaaQATLEALAEEnnSILEQLRTQISGLVGNSREQLVALNQETA 318

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518684939 187 QNYDYSIIVIAVCVLI-LIFATSSAWVYIRRVLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRH 258
Cdd:COG4192  319 QLVQQSGILLLAIALLsLLLAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRV 391
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 219-263 5.56e-09

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 52.06  E-value: 5.56e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 518684939 219 LQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSL 263
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
chemoreceptor_sensor cd00181
4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand ...
 44-175 3.26e-06

4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand binding sensor domain of chemoreceptors and related sensor histidine kinases forms homodimers and binds to ligands via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This family includes ligand binding sensor domain of several chemoreceptors, such as Escherichia coli Tar, Tsr, NarQ, NarX, Pseudomonas aeruginosa KinB, Rhodopseudomonas palustris histidine kinase HK9 chemoreceptors, Comamonas testosteroni CNB-2 MCP2201 and Anaeromyxobacter dehalogenans histidine kinase Adeh_2942, among others.


Pssm-ID: 438624 [Multi-domain]  Cd Length: 119  Bit Score: 46.35  E-value: 3.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  44 QTLRKQSSELNSSWIALIQTRNTMNRAIARMImetnnipsagksAELIDVANQSLAQADKHfaaYAQIPLLPVQDAALAK 123
Cdd:cd00181    1 QEIRQQASAISSLESLVLQARVTLRAEALTGV------------EELGDALIRALKQTAAV---LAQFRALTRDPPEAEA 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 518684939 124 DIDTHYQALRRVLQQIVDLIKTQDVKTI--QALPTQKMQDAFQNSFDAYFRQND 175
Cdd:cd00181   66 EILDKVQDYQKALAALIPALLERGAESAlfDQSEAQGGLELLLSLLQQLTAAGI 119
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 191-263 5.30e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 48.80  E-value: 5.30e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518684939 191 YSIIVIAVCVLILIFATSSAWVYIRRvLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSL 263
Cdd:COG5000    7 FLLLLLLIALLLLLLALWLALLLARR-LTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL 78
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
58-504 5.14e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 46.26  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  58 IALIQTRNTMNRAIARMIMETNNIPSAGKSAELIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQ 137
Cdd:COG2770   77 LLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 138 QIVDLIKTQDVKTIQALPTQKMQDAFQNSFDAYFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSAWVYIRRV 217
Cdd:COG2770  157 LLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRI 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 218 LlQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQ 297
Cdd:COG2770  237 T-RPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLL 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 298 QSASLVETAASMEQLTATVKQNADNARHASQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNI 377
Cdd:COG2770  316 LLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALL 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 378 LALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMG 457
Cdd:COG2770  396 AALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLL 475

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 518684939 458 EISCASEEQSRGIDQVSQAVSEMDRVTQQNAVLVEQSANAAVSLEEQ 504
Cdd:COG2770  476 AALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLE 522
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 90-507 1.16e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 44.87  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939  90 LIDVANQSLAQADKHFAAYAQIPLLPVQDAALAKDIDTHYQALRRVLQQIVDLIKTQDVKTIQALPTQKMQDAFQNSFDA 169
Cdd:COG3850   11 LLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 170 YFRQNDALNDSAVTDSNQNYDYSIIVIAVCVLILIFATSSA---WVYIRRVLLQPLLRVITHLHHIATGDLTQSLHIEAK 246
Cdd:COG3850   91 SLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLAlllAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 247 NEIGQLAESVRHMQQSLTDTVGKVRTSADEIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTATVKQNADNARHA 326
Cdd:COG3850  171 DELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAE 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 327 SQLARDASDTAHKGLQVVDNVVSTMKQISGSSQKINDITALIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 406
Cdd:COG3850  251 SELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLL 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 407 AQRSAEAAREIKGLIEDSVNRVHEGSVLVTSAGETMGELVKAVSRVTDIMGEISCASEEQSRGIDQVSQAVSEMDRVTQQ 486
Cdd:COG3850  331 IALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGV 410

                        410       420
                 ....*....|....*....|.
gi 518684939 487 NAVLVEQSANAAVSLEEQSDH 507
Cdd:COG3850  411 AGEGGLVVLIVSIIAGGEAIA 431
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 239-337 5.22e-04

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 41.89  E-value: 5.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939   239 QSLHIEAKNEIGQLAESVRHMQQSLTDTVGKVRTSAD---EIYRSASEIAGGNSDLSSRTEQQSASLVETAASMEQLTAT 315
Cdd:smart00283 150 ESLIKEIQEETNEAVAAMEESSSEVEEGVELVEETGDaleEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQV 229

                           90       100
                   ....*....|....*....|..
gi 518684939   316 VKQNADNARHASQLARDASDTA 337
Cdd:smart00283 230 TQETAAMSEEISAAAEELSGLA 251
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
194-263 2.13e-03

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 40.81  E-value: 2.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518684939 194 IVIAVCVLILIFATssawVYIRRVLLQPLLRVITHLHHIATGDLTQSLHIEAKNEIGQLAESVRHMQQSL 263
Cdd:PRK10600 129 VFAVFMALLLVFTI----IWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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