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Conserved domains on  [gi|510801963|ref|WP_016176752|]
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16S rRNA (guanine(966)-N(2))-methyltransferase RsmD [Enterococcus durans]

Protein Classification

RsmD family RNA methyltransferase( domain architecture ID 10002368)

RsmD family RNA methyltransferase similar to 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD, which specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:0003676|GO:0031167|GO:0008168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 1-185 1.19e-85

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 250.00  E-value: 1.19e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:COG0742    1 MRIIGGKARGRKLKVPKGPGTRPTTDRVREALFNILGPDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  81 KENIAITKEPEKFTTLKLDADKAIEKLAqlGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEK 160
Cdd:COG0742   81 RKNLEKLGLEDRARVIRGDALRFLKRLA--GEPFDLVFLDPPYAKGLLEKALELLAENGLLAPGGLIVVEHSKREELPEL 158

                        170       180
                 ....*....|....*....|....*
gi 510801963 161 ITCFEQIRKQTYGITSVTIYRKEDD 185
Cdd:COG0742  159 PAGLELLKERKYGDTRLSFYRREEE 183
 
Name Accession Description Interval E-value
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 1-185 1.19e-85

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 250.00  E-value: 1.19e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:COG0742    1 MRIIGGKARGRKLKVPKGPGTRPTTDRVREALFNILGPDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  81 KENIAITKEPEKFTTLKLDADKAIEKLAqlGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEK 160
Cdd:COG0742   81 RKNLEKLGLEDRARVIRGDALRFLKRLA--GEPFDLVFLDPPYAKGLLEKALELLAENGLLAPGGLIVVEHSKREELPEL 158

                        170       180
                 ....*....|....*....|....*
gi 510801963 161 ITCFEQIRKQTYGITSVTIYRKEDD 185
Cdd:COG0742  159 PAGLELLKERKYGDTRLSFYRREEE 183
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
1-181 1.85e-77

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 229.05  E-value: 1.85e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963    1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:pfam03602   1 MRIIGGKARGRKLKVPPGPGTRPTTDRVREALFNWLAPYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   81 KENIAITKEPEkfTTLKLDADKAIEKLAQLGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEK 160
Cdd:pfam03602  81 KENLQLLGLPG--AVLVMDALLALLRLAGKGPVFDIVFLDPPYAKGLIEEVLDLLAEKGWLKPNALIYVETEKRGELPEQ 158

                         170       180
                  ....*....|....*....|.
gi 510801963  161 ITCFEQIRKQTYGITSVTIYR 181
Cdd:pfam03602 159 PGNLELVREKKYGQTTLAFYQ 179
TIGR00095 TIGR00095
16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of ...
 2-180 2.79e-56

16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of uncharacterized bacterial proteins. Members are present in nearly every complete bacterial genome, always in a single copy. PSI-BLAST analysis shows homology to several families of SAM-dependent methyltransferases, including ribosomal RNA adenine dimethylases. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188022 [Multi-domain]  Cd Length: 190  Bit Score: 175.68  E-value: 2.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963    2 RVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIK 81
Cdd:TIGR00095  11 RIIGGQYRGRKLKVPPGPSTRPTTDRVRESLFNILRPDIVGAHFLDLFAGSGALGLEALSRGAASAVFVEQDRKVAQTLK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   82 ENIAITKEPEKFTTLKLDADKAIEKLAQLGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEKI 161
Cdd:TIGR00095  91 ENLSTLKKSGEQATVLNDAVRALLFLAKKQTPFDIIYLDPPFNRGLLEALLELLGENKWLNPKGLIVVEYDRENELPTVP 170

                         170
                  ....*....|....*....
gi 510801963  162 TCFEQIRKQTYGITSVTIY 180
Cdd:TIGR00095 171 ETWSLLRQKVYGQSALRLY 189
rsmD PRK10909
16S rRNA m(2)G966-methyltransferase; Provisional
 1-159 7.54e-26

16S rRNA m(2)G966-methyltransferase; Provisional


Pssm-ID: 236793  Cd Length: 199  Bit Score: 98.25  E-value: 7.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:PRK10909  13 IRIIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNWLAPVIVDARCLDCFAGSGALGLEALSRYAAGATLLEMDRAVAQQL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  81 KENIAitkepekftTLKLDA-----DKAIEKLAQLGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAV 155
Cdd:PRK10909  93 IKNLA---------TLKAGNarvvnTNALSFLAQPGTPHNVVFVDPPFRKGLLEETINLLEDNGWLADEALIYVESEVEN 163


                 ....
gi 510801963 156 ELPE 159
Cdd:PRK10909 164 GLPT 167
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 45-150 2.09e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.82  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  45 VLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAiTKEPEKFTTLKLDADKAIEKlaqLGKKFDYLFLDPPY- 123
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAA-ALLADNVEVLKGDAEELPPE---ADESFDVIISDPPLh 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 510801963 124 ----AKQQIIEQIekmsaLDLFKEEAVIVCE 150
Cdd:cd02440   78 hlveDLARFLEEA-----RRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 1-185 1.19e-85

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 250.00  E-value: 1.19e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:COG0742    1 MRIIGGKARGRKLKVPKGPGTRPTTDRVREALFNILGPDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  81 KENIAITKEPEKFTTLKLDADKAIEKLAqlGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEK 160
Cdd:COG0742   81 RKNLEKLGLEDRARVIRGDALRFLKRLA--GEPFDLVFLDPPYAKGLLEKALELLAENGLLAPGGLIVVEHSKREELPEL 158

                        170       180
                 ....*....|....*....|....*
gi 510801963 161 ITCFEQIRKQTYGITSVTIYRKEDD 185
Cdd:COG0742  159 PAGLELLKERKYGDTRLSFYRREEE 183
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
1-181 1.85e-77

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 229.05  E-value: 1.85e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963    1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:pfam03602   1 MRIIGGKARGRKLKVPPGPGTRPTTDRVREALFNWLAPYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   81 KENIAITKEPEkfTTLKLDADKAIEKLAQLGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEK 160
Cdd:pfam03602  81 KENLQLLGLPG--AVLVMDALLALLRLAGKGPVFDIVFLDPPYAKGLIEEVLDLLAEKGWLKPNALIYVETEKRGELPEQ 158

                         170       180
                  ....*....|....*....|.
gi 510801963  161 ITCFEQIRKQTYGITSVTIYR 181
Cdd:pfam03602 159 PGNLELVREKKYGQTTLAFYQ 179
TIGR00095 TIGR00095
16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of ...
 2-180 2.79e-56

16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of uncharacterized bacterial proteins. Members are present in nearly every complete bacterial genome, always in a single copy. PSI-BLAST analysis shows homology to several families of SAM-dependent methyltransferases, including ribosomal RNA adenine dimethylases. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188022 [Multi-domain]  Cd Length: 190  Bit Score: 175.68  E-value: 2.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963    2 RVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIK 81
Cdd:TIGR00095  11 RIIGGQYRGRKLKVPPGPSTRPTTDRVRESLFNILRPDIVGAHFLDLFAGSGALGLEALSRGAASAVFVEQDRKVAQTLK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   82 ENIAITKEPEKFTTLKLDADKAIEKLAQLGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAVELPEKI 161
Cdd:TIGR00095  91 ENLSTLKKSGEQATVLNDAVRALLFLAKKQTPFDIIYLDPPFNRGLLEALLELLGENKWLNPKGLIVVEYDRENELPTVP 170

                         170
                  ....*....|....*....
gi 510801963  162 TCFEQIRKQTYGITSVTIY 180
Cdd:TIGR00095 171 ETWSLLRQKVYGQSALRLY 189
rsmD PRK10909
16S rRNA m(2)G966-methyltransferase; Provisional
 1-159 7.54e-26

16S rRNA m(2)G966-methyltransferase; Provisional


Pssm-ID: 236793  Cd Length: 199  Bit Score: 98.25  E-value: 7.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   1 MRVISGEYGGRRLKSLSGPNTRPTTDKVKESIFNMIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKII 80
Cdd:PRK10909  13 IRIIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNWLAPVIVDARCLDCFAGSGALGLEALSRYAAGATLLEMDRAVAQQL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  81 KENIAitkepekftTLKLDA-----DKAIEKLAQLGKKFDYLFLDPPYAKQQIIEQIEKMSALDLFKEEAVIVCETDKAV 155
Cdd:PRK10909  93 IKNLA---------TLKAGNarvvnTNALSFLAQPGTPHNVVFVDPPFRKGLLEETINLLEDNGWLADEALIYVESEVEN 163


                 ....
gi 510801963 156 ELPE 159
Cdd:PRK10909 164 GLPT 167
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 35-122 1.68e-15

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 73.29  E-value: 1.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  35 MIGPYFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAITKEPEKFTTLKLDADKAIEKLAQLGKKF 114
Cdd:COG1092  210 RVAELAKGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFDWLRELAREGERF 289


                 ....*...
gi 510801963 115 DYLFLDPP 122
Cdd:COG1092  290 DLIILDPP 297
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 41-143 3.11e-11

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 58.81  E-value: 3.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  41 DGEEVLDLFSGSGGLAIEAVSRGCsHAVCVDKNYQALKIIKENIAITKePEKFTTLKLDAdkaiEKLAQLGKKFDYLFLD 120
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLGR-RVIGSDIDPKMVEGARENLEHYG-YEDADVIRGDA----RDLPLADESVDAIVTD 99

                         90       100
                 ....*....|....*....|...
gi 510801963 121 PPYAKQQiieQIEKMSALDLFKE 143
Cdd:COG1041  100 PPYGRSS---KISGEELLELYEK 119
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
39-122 1.28e-10

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 59.08  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  39 YFDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAITK-EPEKFTTLKLDADKAIEKLAQLGKKFDYL 117
Cdd:PRK15128 218 YVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKlDLSKAEFVRDDVFKLLRTYRDRGEKFDVI 297


                 ....*
gi 510801963 118 FLDPP 122
Cdd:PRK15128 298 VMDPP 302
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 45-150 2.09e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.82  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  45 VLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAiTKEPEKFTTLKLDADKAIEKlaqLGKKFDYLFLDPPY- 123
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAA-ALLADNVEVLKGDAEELPPE---ADESFDVIISDPPLh 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 510801963 124 ----AKQQIIEQIekmsaLDLFKEEAVIVCE 150
Cdd:cd02440   78 hlveDLARFLEEA-----RRLLKPGGVLVLT 103
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 42-137 4.43e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 48.63  E-value: 4.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  42 GEEVLDLFSGSGGLAIeAVSRGCSHAVCVDKNYQALKIIKENIAITkEPEKFTTLKLDADKAIEKLAQlGKKFDYLFLDP 121
Cdd:COG2265  234 GERVLDLYCGVGTFAL-PLARRAKKVIGVEIVPEAVEDARENARLN-GLKNVEFVAGDLEEVLPELLW-GGRPDVVVLDP 310

                         90
                 ....*....|....*...
gi 510801963 122 PY--AKQQIIEQIEKMSA 137
Cdd:COG2265  311 PRagAGPEVLEALAALGP 328
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 41-160 9.66e-07

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 47.55  E-value: 9.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  41 DGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAITKEPEKFTTLKLDADKAIEKLAqlgKKFDYLFLD 120
Cdd:COG2520  180 PGERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGDAREVAPELE---GKADRIIMN 256

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 510801963 121 PPYAKQQIIEqiekmSALDLFKEEAVI----VCETDKAVELPEK 160
Cdd:COG2520  257 LPHSADEFLD-----AALRALKPGGVIhyyeIVPEEDPFERAEE 295
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 42-101 2.20e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.79  E-value: 2.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   42 GEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAITKEPEKFtTLKLDAD 101
Cdd:pfam06325 162 GESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARL-EVYLPGD 220
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
40-83 1.63e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 40.66  E-value: 1.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 510801963  40 FDGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKEN 83
Cdd:COG2263   44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIAREN 87
PRK14967 PRK14967
putative methyltransferase; Provisional
 36-124 3.54e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.65  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  36 IGPyfdGEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAITKEPekFTTLKLDADKAIEklaqlGKKFD 115
Cdd:PRK14967  34 LGP---GRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVD--VDVRRGDWARAVE-----FRPFD 103


                 ....*....
gi 510801963 116 YLFLDPPYA 124
Cdd:PRK14967 104 VVVSNPPYV 112
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 45-118 4.15e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 37.93  E-value: 4.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 510801963   45 VLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAitKEPEKFTTLKLDAdkaiEKLAQLGKKFDYLF 118
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAA--EAGLNVEFVQGDA----EDLPFPDGSFDLVV 68
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 43-121 5.91e-04

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 39.47  E-value: 5.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 510801963  43 EEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIAITKEPEKFTTLKlDADKAiekLAQLGKKFDYLFLDP 121
Cdd:COG1867   59 ISYLDALAASGIRGLRYALEVGIKVTLNDIDPEAVELIRENLELNGLEDVEVYNR-DANAL---LHELGRRFDVVDLDP 133
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
42-85 8.48e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 38.59  E-value: 8.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 510801963  42 GEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIA 85
Cdd:PRK00517 120 GKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAE 163
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 31-121 8.55e-04

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 39.13  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  31 SIFNMIGPYFDGEEVLDLFSGSG--GLAIeAVSRGCSHAVCVDKNYQALKIIKENIAITkepekfttlKLDADKAIEK-- 106
Cdd:PRK04338  47 LVLRAFGPKLPRESVLDALSASGirGIRY-ALETGVEKVTLNDINPDAVELIKKNLELN---------GLENEKVFNKda 116

                         90
                 ....*....|....*..
gi 510801963 107 --LAQLGKKFDYLFLDP 121
Cdd:PRK04338 117 naLLHEERKFDVVDIDP 133
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
42-85 1.40e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 38.23  E-value: 1.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 510801963  42 GEEVLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIA 85
Cdd:COG2264  149 GKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAVEAARENAE 192
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 45-123 1.88e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.82  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  45 VLDLFSGSG--GLAIeAVSRGCSHAVCVDKNYQALKIIKENIAITKEPEKFTTLKLDADKAIEKlaqlGKKFDYLFLDPP 122
Cdd:COG2890  116 VLDLGTGSGaiALAL-AKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPG----DGRFDLIVSNPP 190


                 .
gi 510801963 123 Y 123
Cdd:COG2890  191 Y 191
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
45-85 1.95e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 37.71  E-value: 1.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 510801963  45 VLDLFSGSGGLAIEAVSRGCSHAVCVDKNYQALKIIKENIA 85
Cdd:COG4076   39 VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIA 79
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 42-143 2.28e-03

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 36.93  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   42 GEEVLDLFSGSGGLAIEAVSRGCShAVCVDKNYQALKIIKENIAITKEPEKFTTLKLDADKAIEKLaQLGK-KFDYLFLD 120
Cdd:pfam09445   1 ATRILDVFCGGGGNTIQFANVFDS-VISIDINLEHLACAQHNAEVYGVSDRIWLIHGDWFELLAKL-KFEKiKYDCVFAS 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 510801963  121 PP-----YAKQQ---IIEQIEKMSALDLFKE 143
Cdd:pfam09445  79 PPwggpsYKKQNvydLENKLQPYGLSQLLKE 109
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 41-85 3.99e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 37.07  E-value: 3.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 510801963  41 DGEEVLDLFSGSGGLAIEAvSRGC--SHAVCVDKNYQALKIIKENIA 85
Cdd:COG2242  247 PGDVLWDIGAGSGSVSIEA-ARLApgGRVYAIERDPERAALIRANAR 292
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 41-162 4.79e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 35.86  E-value: 4.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963   41 DGEEVLDLFSGSGGLAIEAVSRGCSHA--VCVDKNYQALKIIKENIAiTKEPEKFTTLKLDadkaIEKLAQL--GKKFDY 116
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQ-KLGFDNVEFEQGD----IEELPELleDDKFDV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 510801963  117 LF----LDPPYAKQQIIEQIEKmsaldLFKEE-AVIVCETDKAVELPEKIT 162
Cdd:pfam13847  78 VIsncvLNHIPDPDKVLQEILR-----VLKPGgRLIISDPDSLAELPAHVK 123
PRK14968 PRK14968
putative methyltransferase; Provisional
 41-123 5.00e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.03  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510801963  41 DGEEVLDLFSGSGGLAIEAVSRGCShAVCVDKNYQALKIIKENIAITK-EPEKFTTLKLDADKAIEklaqlGKKFDYLFL 119
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNGKK-VVGVDINPYAVECAKCNAKLNNiRNNGVEVIRSDLFEPFR-----GDKFDVILF 96


                 ....
gi 510801963 120 DPPY 123
Cdd:PRK14968  97 NPPY 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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