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Conserved domains on  [gi|504406779|ref|WP_014593881|]
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MULTISPECIES: MFS transporter [Pantoea]

Protein Classification

MFS transporter( domain architecture ID 11487773)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
4-409 0e+00

MdfA family multidrug efflux MFS transporter;


:

Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 606.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   4 YQPISQLTGRIMLFPLAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPV 83
Cdd:PRK15402   1 LSPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  84 LLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAW 163
Cdd:PRK15402  81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 164 LTVGSWRSMFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPV 243
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 244 ILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYA 323
Cdd:PRK15402 241 ILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 324 FGGGMVNAGLYRLTLYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYFNGGVIWFSLINFISGVMWFGLVLMFLRERKR 403
Cdd:PRK15402 321 FGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPM 400


                 ....*.
gi 504406779 404 HAKVTP 409
Cdd:PRK15402 401 GNAHEG 406
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
4-409 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 606.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   4 YQPISQLTGRIMLFPLAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPV 83
Cdd:PRK15402   1 LSPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  84 LLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAW 163
Cdd:PRK15402  81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 164 LTVGSWRSMFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPV 243
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 244 ILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYA 323
Cdd:PRK15402 241 ILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 324 FGGGMVNAGLYRLTLYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYFNGGVIWFSLINFISGVMWFGLVLMFLRERKR 403
Cdd:PRK15402 321 FGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPM 400


                 ....*.
gi 504406779 404 HAKVTP 409
Cdd:PRK15402 401 GNAHEG 406
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 18-397 5.05e-69

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 222.84  E-value: 5.05e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  18 PLAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACIL 97
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  98 TTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFA 177
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 178 ACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYA 257
Cdd:cd17320  161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 258 LLQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLT 337
Cdd:cd17320  241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 338 LYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYfNGGVIWFSLINFISGVMWFGLVLMF 397
Cdd:cd17320  321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 33-362 2.26e-35

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 134.05  E-value: 2.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   33 DMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRF 112
Cdd:TIGR00710  22 DMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  113 VQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMP 192
Cdd:TIGR00710 102 VQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  193 ETAGDRTQSVAlPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFLAMIAGNV 272
Cdd:TIGR00710 182 ETLPYEARIQI-STYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGF 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  273 TLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTLYASDEGKGSVAAML 352
Cdd:TIGR00710 261 LNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALF 340

                         330
                  ....*....|
gi 504406779  353 GMVSILTLAI 362
Cdd:TIGR00710 341 GTLRLVLGAI 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-355 3.35e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 122.00  E-value: 3.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  19 LAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILT 98
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  99 TWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAA 178
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 179 CSAVAFLVLWRVMPETAGDRTQSvalpvLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYAL 258
Cdd:COG2814  173 LALLALLLLLRLLPESRPAARAR-----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 259 LQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAwpillGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTL 338
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGL-----LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322

                        330
                 ....*....|....*...
gi 504406779 339 -YASDEGKGSVAAMLGMV 355
Cdd:COG2814  323 eLAPPEARGRASGLYNSA 340
MFS_1 pfam07690
Major Facilitator Superfamily;
40-363 7.15e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.09  E-value: 7.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   40 LLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLC 119
Cdd:pfam07690  21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  120 FIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPETAGDR- 198
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRp 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  199 TQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPViLMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVV 278
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLS 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  279 GRMPIEQPVKFAAwpILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTL-YASDEGKGSVAAMLGMVSI 357
Cdd:pfam07690 260 DRLGRRRRLLLAL--LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGS 337


                  ....*.
gi 504406779  358 LTLAIG 363
Cdd:pfam07690 338 LGGALG 343
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
4-409 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 606.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   4 YQPISQLTGRIMLFPLAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPV 83
Cdd:PRK15402   1 LSPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  84 LLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAW 163
Cdd:PRK15402  81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 164 LTVGSWRSMFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPV 243
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 244 ILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYA 323
Cdd:PRK15402 241 ILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 324 FGGGMVNAGLYRLTLYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYFNGGVIWFSLINFISGVMWFGLVLMFLRERKR 403
Cdd:PRK15402 321 FGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPM 400


                 ....*.
gi 504406779 404 HAKVTP 409
Cdd:PRK15402 401 GNAHEG 406
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
12-404 2.66e-96

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 294.04  E-value: 2.66e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  12 GRIMLFPLAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFF 91
Cdd:PRK15403  12 AATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  92 ASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRS 171
Cdd:PRK15403  92 TLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKV 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 172 MFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGL 251
Cdd:PRK15403 172 LFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGM 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 252 SRMQYALLQLPVFLAMIAGNVTLSKVVgRMPIEQPVKFAAWPILLG-LSLALSATLIDAHSYLFITAGLSLYAFGGGMVN 330
Cdd:PRK15403 252 TTSQFAWTQVPVFGAVIVANAIVARFV-KDPTEPRFIWRAVPIQLVgLALLIVGNLLWPHVWLWSVLGTSLYAFGIGLIF 330

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504406779 331 AGLYRLTLYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYFNGGVIWFSLINFISGVMWFGLVLMFLRERKRH 404
Cdd:PRK15403 331 PTLFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVRQH 404
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 18-397 5.05e-69

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 222.84  E-value: 5.05e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  18 PLAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACIL 97
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  98 TTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFA 177
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 178 ACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYA 257
Cdd:cd17320  161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 258 LLQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLT 337
Cdd:cd17320  241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 338 LYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYfNGGVIWFSLINFISGVMWFGLVLMF 397
Cdd:cd17320  321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 33-362 2.26e-35

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 134.05  E-value: 2.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   33 DMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRF 112
Cdd:TIGR00710  22 DMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  113 VQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMP 192
Cdd:TIGR00710 102 VQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  193 ETAGDRTQSVAlPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFLAMIAGNV 272
Cdd:TIGR00710 182 ETLPYEARIQI-STYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGF 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  273 TLSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTLYASDEGKGSVAAML 352
Cdd:TIGR00710 261 LNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALF 340

                         330
                  ....*....|
gi 504406779  353 GMVSILTLAI 362
Cdd:TIGR00710 341 GTLRLVLGAI 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-355 3.35e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 122.00  E-value: 3.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  19 LAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILT 98
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  99 TWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAA 178
Cdd:COG2814   93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 179 CSAVAFLVLWRVMPETAGDRTQSvalpvLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYAL 258
Cdd:COG2814  173 LALLALLLLLRLLPESRPAARAR-----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 259 LQLPVFLAMIAGNVTLSKVVGRMPIEQPVKFAAwpillGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTL 338
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGL-----LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322

                        330
                 ....*....|....*...
gi 504406779 339 -YASDEGKGSVAAMLGMV 355
Cdd:COG2814  323 eLAPPEARGRASGLYNSA 340
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
15-231 1.32e-30

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 120.79  E-value: 1.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  15 MLFPLAMvlyefatyiahDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASA 94
Cdd:PRK11102   1 MLMPLAI-----------DMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  95 CILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFW 174
Cdd:PRK11102  70 AVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFW 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504406779 175 LFAACSAVAFLVLWRVMPET-AGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVF 231
Cdd:PRK11102 150 VLALAAILAAALVFFFIPETlPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSF 207
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
29-245 4.89e-23

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 99.97  E-value: 4.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  29 YIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFV 108
Cdd:PRK11043  19 FLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 109 SLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMA-LMANVALLAPLAgPLAGAAWLTVGSWRSMFWLFAACSAVAFLVL 187
Cdd:PRK11043  99 VLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFAtIMPLVALSPALA-PLLGAWLLNHFGWQAIFATLFAITLLLILPT 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504406779 188 WRVMPETAGDRTQSVALpvlarNYGRLLKDRQ-----VMYGS-----FAiglvfipiltWVALSPVIL 245
Cdd:PRK11043 178 LRLKPSKKARKQSQDAL-----TFKQLLKSKTylgnvLIFAAcsaafFA----------WLTGSPFIL 230
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 26-394 7.42e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 93.02  E-value: 7.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQ 105
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 106 QFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFL 185
Cdd:cd17325   86 QLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 186 VLWRVMPETAG-DRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVF 264
Cdd:cd17325  166 LALLLLPEPRPpPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 265 LAMIAGNVTLSKVVGRMPIEQPVKFAAWPILLGLSLALSATlidahSYLFITAGLSLYAFGGGMVNAGLY-RLTLYASDE 343
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPATLaLLADIVPPE 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504406779 344 GKGSVAAMLGMVSILTLAIG----IELAKHFYFNGGVIWFSLINFISGVMWFGLV 394
Cdd:cd17325  321 GRGTAMGLFNTAFSLGMVLGpllgGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 26-351 3.84e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 91.07  E-value: 3.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQ 105
Cdd:cd17324    9 FAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 106 QFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFL 185
Cdd:cd17324   89 LLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 186 VLWRVMPETAGDRTQSvalPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFL 265
Cdd:cd17324  169 LLWRLLPSLPPKKPGS---LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 266 AMIAGNVTLSKVVGRMPIeqpvKFAAWPILLGLSLALSATLIdAHSYLFITAGLSLYAFGGGMVNAGLYRLTLYASDEGK 345
Cdd:cd17324  246 AGVVGSPLAGRLADRGGR----RALLIALLLLAAALLLLTLL-GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320


                 ....*.
gi 504406779 346 GSVAAM 351
Cdd:cd17324  321 GLASSL 326
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 44-397 4.45e-20

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 91.09  E-value: 4.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  44 AEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGA 123
Cdd:cd17474   27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 124 VGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGaAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPETagdRTQSVA 203
Cdd:cd17474  107 LALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG-GLLAAISWRYPFFLLAALIPVAFLAILFLLPEP---KEKAKS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 204 LPVLARNYGRLLKDRQVMYGSFAIGLVFIPIL-TWVALSPVILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMP 282
Cdd:cd17474  183 SSATKLRDLKKALRGRGLLTFLVSAFLYFFLYfAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRF 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 283 IEQPVKFAAWPILLGLSLALSAtlidAHSYLFITAGLSLYAFGGGMVNAGL-YRLTLYASDEGKGSVAAMLGMVSILTLA 361
Cdd:cd17474  263 GARRILVIGLLLYALSLLLLGF----VPSLALLLIAIVLFGLGLGLNLPLLtTLVTELAPEEERGTASSLYNFVRFLGQA 338

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 504406779 362 IGIELAKHFYFNGGVIWFSLINFISGVMWFGLVLMF 397
Cdd:cd17474  339 VGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 21-398 1.01e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 89.79  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  21 MVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTW 100
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 101 VSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLT--VGSWRSMFWLFAA 178
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 179 CSAVAFLVLWRVMPETAGDRTQSVALPVLARN---YGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQ 255
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 256 YALLQLPVFLAMIAGNVTLSKVVGRMPIEQPVkfaaWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYR 335
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL----LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504406779 336 L-TLYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYfnGGVIWFSLINFISGVMWFGLVLMFL 398
Cdd:cd06174  317 LiAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
40-363 7.15e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.09  E-value: 7.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   40 LLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLC 119
Cdd:pfam07690  21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  120 FIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPETAGDR- 198
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRp 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  199 TQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPViLMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVV 278
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLS 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  279 GRMPIEQPVKFAAwpILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTL-YASDEGKGSVAAMLGMVSI 357
Cdd:pfam07690 260 DRLGRRRRLLLAL--LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGS 337


                  ....*.
gi 504406779  358 LTLAIG 363
Cdd:pfam07690 338 LGGALG 343
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 26-195 1.70e-18

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 86.48  E-value: 1.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQ 105
Cdd:cd17323    9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 106 QFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFL 185
Cdd:cd17323   89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLI 168

                        170
                 ....*....|
gi 504406779 186 VLWRVMPETA 195
Cdd:cd17323  169 LIFLFLPIVL 178
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 26-283 1.61e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 82.55  E-value: 1.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQ 105
Cdd:COG0477   24 FLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 106 QFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFL 185
Cdd:COG0477  104 LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 186 VLWRVmPETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFL 265
Cdd:COG0477  184 LRLRL-PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262

                        250
                 ....*....|....*...
gi 504406779 266 AMIAGNVTLSKVVGRMPI 283
Cdd:COG0477  263 LLLLLLLLLLALLLALLL 280
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
12-275 4.81e-17

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 81.99  E-value: 4.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  12 GRIMLFPLAMVLYeFATYIahDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFF 91
Cdd:PRK10473   2 SRFLLCSFALVLL-YPAGI--DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  92 ASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRS 171
Cdd:PRK10473  79 IIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 172 MFWLFAACSAVAFLVLWRVMPET-AGDRTQSVALPVLARnygRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEG 250
Cdd:PRK10473 159 LFYTMAAMGILVLLLSLFILKETrPARAPAASSKPRENS---ESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMG 235

                        250       260
                 ....*....|....*....|....*
gi 504406779 251 LSRMQYALLQlpVFLAMIAGNVTLS 275
Cdd:PRK10473 236 FSRGEYAIIM--ALTAGVSMTVSFS 258
2_A_01_02 TIGR00880
Multidrug resistance protein;
57-194 5.06e-17

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 77.30  E-value: 5.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   57 LTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEA 136
Cdd:TIGR00880   4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 504406779  137 LAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPET 194
Cdd:TIGR00880  84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-407 1.45e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 80.70  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  19 LAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILT 98
Cdd:COG2223    8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  99 TWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAA 178
Cdd:COG2223   88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 179 CSAVAFLVLWRVMPETAGDRTQSVALPVlaRNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYAL 258
Cdd:COG2223  168 LLLVVAVLAWLFLRDPPAGAAAAAKASL--RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 259 LQLPVFLAMIAGNVTLSKVVGRMPIeqpvKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLT- 337
Cdd:COG2223  246 LAALFALLGALGRPLGGWLSDRIGG----RRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVp 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 338 LYASDEGKGSVAAMLGMVSILTLAIGIELAKHFYFNGGVIWFSLInFISGVMWFGLVLMFLRERKRHAKV 407
Cdd:COG2223  322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFL-VFAVLALVALVLTLLLYRRPRRAA 390
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 42-364 2.10e-16

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 79.91  E-value: 2.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  42 VTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFI 121
Cdd:cd17321   22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 122 GAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFlvlwrvmpetagdrtqs 201
Cdd:cd17321  102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVAL----------------- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 202 valpVLARNYGRllkdrqVMYGSFAIGLVFIPILTWValsPVILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRM 281
Cdd:cd17321  165 ----LLARTFSG------AVLAAFLLGAALGGLLFLL---PLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 282 PIEQPVKFAAwpILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTLYASDEGK-GSVAAMLGMVSILTL 360
Cdd:cd17321  232 GPRLVLVAGL--LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKaGAASGILNTARQLGG 309


                 ....
gi 504406779 361 AIGI 364
Cdd:cd17321  310 ALGV 313
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-394 8.11e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.21  E-value: 8.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  13 RIMLFPLAMVLYeFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFA 92
Cdd:COG2271    8 RWRILALLFLAY-FLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  93 SACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSM 172
Cdd:COG2271   87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 173 FWLFAACSAVAFLVlwrvmpetagdrtqsvalpvlarnygrllkdrQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLS 252
Cdd:COG2271  167 FLILGLPGLLLALL--------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 253 RMQYALLQLPVFLAMIAGNVTLSKVVGRMpIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAG 332
Cdd:COG2271  215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRL-GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504406779 333 LYrLTLYASDEGKGSVAAMLGMVSILTLAIGI----ELAKHFYFNGGVIWFSLINFISGVMWFGLV 394
Cdd:COG2271  294 AL-AAELFPKKARGTASGLVNTFGFLGGALGPllvgYLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 52-396 1.40e-13

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 71.48  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  52 WVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGIslCFIGAVGYAAIQE 131
Cdd:cd17472   33 LIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 132 AFEEALAVRIMALMANV----ALLAPLAGPLAGAAWltvgSWRSMFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVl 207
Cdd:cd17472  111 LTREENRTKAMALIGASigiaFAISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKK- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 208 arNYGRLLKDRQVMYGSFAIGLV-FIPILTWVALSpvILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMPIEQP 286
Cdd:cd17472  186 --KLKKLLKNKRLLRLDFSIFILhFVLMAFFYILP--LLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQ 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 287 VKFAAWpilLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRL-TLYASDEGKGSVAAMLGMVSILTLAIGIE 365
Cdd:cd17472  262 VFVSSI---LLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLvSKIAPKEYRGTAMGIYNTSQFLGSFLGGA 338

                        330       340       350
                 ....*....|....*....|....*....|.
gi 504406779 366 LAKHFYFNGGVIWFSLINFISGVMWFGLVLM 396
Cdd:cd17472  339 LGGLLWGLLGYSSVFLTILILALLWLLVSFL 369
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 34-349 1.60e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 71.45  E-value: 1.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  34 MIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFV 113
Cdd:cd17504   14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 114 QGISLCFIGaVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLvlwrvmpe 193
Cdd:cd17504   94 QGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA-------- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 194 tagdrtqsvALPVLARnygRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDE----GLSRMQYALLQLPVFLAMIA 269
Cdd:cd17504  165 ---------LVPLIDL---RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 270 GnvtlSKVVGRMPIEQPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTLYASDEGKGSVA 349
Cdd:cd17504  233 A----GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIA 308
emrD PRK11652
multidrug transporter EmrD;
37-218 3.46e-13

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 70.32  E-value: 3.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  37 PGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGI 116
Cdd:PRK11652  29 PAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 117 SLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPETag 196
Cdd:PRK11652 109 GTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPET-- 186

                        170       180
                 ....*....|....*....|..
gi 504406779 197 dRTQSVALPVLARNYGRLLKDR 218
Cdd:PRK11652 187 -RPADARRTRVLASYRTLLSNR 207
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 44-367 2.31e-12

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 67.99  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  44 AEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGA 123
Cdd:cd17503   24 GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 124 VGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFlvlwrvmpetagdrtqsVA 203
Cdd:cd17503  104 LAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL-----------------LL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 204 LPVLARnygRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMPi 283
Cdd:cd17503  167 APLLDL---RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 284 eqPVKFAAWPILLGLSLALSATLIDAHS-YLFITAGLSLYAFGGGMVNAGLYRLTLYASDEGK-GSVAAMLGMVSILTLA 361
Cdd:cd17503  243 --PRLLLLAGLLLLALGTLLLAFLTPDTsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQiGDATALFNTIRQLGGS 320


                 ....*.
gi 504406779 362 IGIELA 367
Cdd:cd17503  321 IGTALL 326
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 21-284 1.59e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 65.33  E-value: 1.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  21 MVLYEFATYIAHDMIQPGMLL-VTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTT 99
Cdd:cd17329    4 LLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 100 WVSDIQQFVSLRFVQGISLCFIGAVGYAAI-----QEAFEEALAVRIMALMANVALlaplaGPLAGaAWLTVGSWRSMFW 174
Cdd:cd17329   84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIadvttPENRTRAFSLLYWAINLGVAI-----GPLLG-GLLLLYSFRLLFL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 175 LFAACSAVAFLVLWRVMPETAGDRTQSVALPVLaRNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRM 254
Cdd:cd17329  158 AAAVLFLLAALVLLFLLPETRPKRRAAEKTEIL-RGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236

                        250       260       270
                 ....*....|....*....|....*....|
gi 504406779 255 QYALLQLPVFLAMIAGNVTLSKVVGRMPIE 284
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFRLR 266
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 43-195 8.26e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 63.09  E-value: 8.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  43 TAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIG 122
Cdd:cd17371   26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 123 AVGYAAIQEAFEEALAVRIMALMAN--------VALLAPLAGPLAGAAWltvgSWRSMFWlFAACSAVAFLVLWRVMPET 194
Cdd:cd17371  106 AAGAALMAEYVPARHRGKALGYVQSgwavgwllATLLAALLFPLLPPEI----AWRVLFL-LGALPALLVLFIRRFVKEP 180


                 .
gi 504406779 195 A 195
Cdd:cd17371  181 P 181
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 26-190 2.21e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.84  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQ 105
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 106 QFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFL 185
Cdd:cd17489   86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165


                 ....*
gi 504406779 186 VLWRV 190
Cdd:cd17489  166 LVFLV 170
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 57-195 9.19e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.06  E-value: 9.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   57 LTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEE- 135
Cdd:TIGR00895  58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKr 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504406779  136 --ALAVRIMAL-----MANVALLAPLAGPLAGaawltvgsWRSMFWLFAACSAVAFLVLWRVMPETA 195
Cdd:TIGR00895 138 frGTAVGLMFCgypigAAVGGFLAGWLIPVFG--------WRSLFYVGGIAPLLLLLLLMRFLPESI 196
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 42-188 3.12e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.98  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  42 VTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFI 121
Cdd:cd17365   25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504406779 122 GAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLW 188
Cdd:cd17365  105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 58-187 3.83e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 57.57  E-value: 3.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  58 TAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEAL 137
Cdd:cd17502   37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 504406779 138 AVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVL 187
Cdd:cd17502  117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL 166
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
30-363 3.25e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.25  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  30 IAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVS 109
Cdd:COG0738   22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 110 LRFVQGISLCFIGAVGYAAIQEAFEEAlAVRIMALMANVALLAPLAGPLAGAAWLTVG---SWRSMFWLFAACSAVAFLV 186
Cdd:COG0738  102 ALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 187 LWRV-MPETAGDRTQSVAlpvLARNYGRLLKDRQVMYGSFAIGLVFIP---ILTWvalSPVILMRDEGLSRMQYALLQLP 262
Cdd:COG0738  181 FLRSkLPEIEEEEEEAAG---SAASLKSLLKNPRLLLGGLAIFLYVGAegaIGDW---LPLYLKDVLGLSEATAALGLSL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 263 VFLAMIAGNVTLSKVVGRMPIEQPVKFAAwpillGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTLYASD 342
Cdd:COG0738  255 FWGGMTIGRFLGGFLLKRFGPVRLLRLSA-----LLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG 329

                        330       340
                 ....*....|....*....|.
gi 504406779 343 EGKGSVAAMLGMVSILTLAIG 363
Cdd:COG0738  330 KRTAAAVSAVLIMGIVGGAIG 350
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 41-203 3.41e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.89  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  41 LVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCF 120
Cdd:cd17473   25 IAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 121 IGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGaAWLTVGSWRSMFWLFAACSAVAFLVlWRVMPETAGDRTQ 200
Cdd:cd17473  105 IMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLG-GALAEIGWRAPFLVYLLALPVLILV-LLFLPEPARKSKS 182


                 ...
gi 504406779 201 SVA 203
Cdd:cd17473  183 AAS 185
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 34-363 5.75e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.16  E-value: 5.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  34 MIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLF------GILFFASACILTTWVSDIQQF 107
Cdd:cd06173   17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllraLLAAVLALLALLGSLSLWLLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 108 VSLrFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVL 187
Cdd:cd06173   97 VLA-FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 188 WRVMPETAGDRTQSVALPVLARNYG--RLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFL 265
Cdd:cd06173  176 LFIRRPPPAAPGESSSLLLRDLREGlrYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 266 AMIAGNVTLSKVVGRMPieqPVKFAAWPILLGLSLALSATLidAHSYLFITAGLSLYAFGGGMVNAGLYRLT-LYASDEG 344
Cdd:cd06173  256 GALLGALLLGRLSKRRR---RGRLLLIGALLLGLALLVLGL--SPSLWLLLAALFLLGLAGGLFNVPLNTLLqLRVPDEL 330

                        330
                 ....*....|....*....
gi 504406779 345 KGSVAAMLGMVSILTLAIG 363
Cdd:cd06173  331 RGRVFSVYNALNSGAMPLG 349
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 46-337 1.39e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.99  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  46 FNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVG 125
Cdd:cd17316   31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 126 YAAIQEAFEEALAVRIMALMANV----ALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMpetagdrtqs 201
Cdd:cd17316  111 STYVAEFAPSKRRGFALGLLQSGwalgALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRRTL---------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 202 valpvlarnygrllkdrQVMYGSFAIGLVFIPILTWValsPVILMRDEGLSRMQYALLQLPVFLAMIAGNVT---LSKVV 278
Cdd:cd17316  181 -----------------LLILLWFFISFGYYGLTTFL---PTYLQTVLGLSPATSSLYLLLISLGALVGALIaglLSDRI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504406779 279 GRMPIeqpvkfAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLT 337
Cdd:cd17316  241 GRKKT------LVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYL 293
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 52-192 1.67e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.58  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  52 WVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQE 131
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504406779 132 AFEEAlavriMALMANVALLAPLAGPLAGAAWLT--VGSWRsmfWLFAACS--AVAFLVLWRVMP 192
Cdd:cd17317  106 IVGPK-----YRSFVGILFGLFWALGYMLLALLAylIRDWR---WLQLAISlpGLLFLLLLWWLP 162
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 40-189 3.72e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.85  E-value: 3.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  40 LLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLC 119
Cdd:cd06173  233 LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGG 312

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 120 FIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWR 189
Cdd:cd06173  313 LFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
44-282 5.40e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.41  E-value: 5.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  44 AEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGA 123
Cdd:COG2807   46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 124 VGYAAIQEAFEE----ALAVRIMALMANVALLAPLAGPLAGAAwltvgSWRSMFWLFAACSAVAFLVLWRVMPETAGDRT 199
Cdd:COG2807  126 LLPGLIKRWFPDrvglMTGLYTAAMGLGAALAAGLTVPLAAAL-----GWRGALAVWALLALLALLLWLPLLRRRPAAAA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 200 QSVAlpvlARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMrDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVG 279
Cdd:COG2807  201 AAPA----AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275


                 ...
gi 504406779 280 RMP 282
Cdd:COG2807  276 RLG 278
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
39-363 7.89e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.06  E-value: 7.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  39 MLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYG-----RRPVLLFGILFFASACILTTWVSDIQQFVSLRFV 113
Cdd:COG2211   34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 114 QGISLCFigAVGYAAIQEAF------------EEALAVRIMALMANVALLAPLAGPLAGAAWL---TVGSWRSMFWLFAA 178
Cdd:COG2211  114 LVTYLLL--GLAYTLVNIPYsalgaeltpdyeERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdAALGYRLTALIFAV 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 179 CSAVAFLVLWRVMPETAGDRTQSVAlpvLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYAL 258
Cdd:COG2211  192 LGLLAFLLTFFGTKERPVPEEEKVS---LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGL 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 259 LQLPVFLAMIAGNVTLSKVVGRMPieqPVKFAAWPILLGLSLALSATLIDAHSYLFITAGLSLYAFGGGMVNAGLYRLTL 338
Cdd:COG2211  269 LLALYFLAALLGAPLWPRLAKRFG---KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345

                        330       340       350
                 ....*....|....*....|....*....|...
gi 504406779 339 YASDEGK--------GSVAAMLGMVSILTLAIG 363
Cdd:COG2211  346 DVVDYDEwktgrrreGLYFGIFTFAIKLGQALA 378
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 44-393 9.61e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 50.26  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  44 AEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGA 123
Cdd:cd17319   31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 124 VGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPETAGdrtqsva 203
Cdd:cd17319  111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWG------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 204 lpvlarnygrllkdrqVMYGSFAIGLVFIPILTWValsPVILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRMPI 283
Cdd:cd17319  184 ----------------LALGYFGINYALYGLLTWL---PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 284 EQPVKFAAWPILLGLSLALSATLidAHSYLFITAGLSLYAFGGGMVNAGLYRL-TLYASDEGKGSVAAMLGMVS-----I 357
Cdd:cd17319  245 GARRLVIIIGLLLAAVGLLLAYL--TTSPVVAVILLSLAGFGIGAASPVFWSLpADLLPGEAAATAGGLINSGGnlggfV 322

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 504406779 358 LTLAIGIELAKHFYFNGGVIWFSLINFISGVMWFGL 393
Cdd:cd17319  323 APLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 45-187 1.21e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 50.25  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  45 EFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSD-IQQFVSLRFVQGISLCFIGA 123
Cdd:cd17477  217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGlPLALLVLLFLWGGAAGPLYT 296

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504406779 124 VGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVL 187
Cdd:cd17477  297 LALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 52-194 2.90e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 49.10  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  52 WVSTSLtayLLGGVVLQWLLGPLSDKYGRRPVLLF-GILFFASAcILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQ 130
Cdd:cd17359   40 LVVSSA---LLGAAIGALFAGRLADRFGRRKTLLIsAVLFFISA-LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIA 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504406779 131 EA------------FEEALAVRIMALMANVALLAplagPLAGAAWLTVGSWRSMFWLfAACSAVAFLVLWRVMPET 194
Cdd:cd17359  116 EVapaeirgrlvslNQLMIVFGQLLAYIVNYLIA----NAGGADWLGAEGWRWMLGL-EAIPAILFLLGMLFIPES 186
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 26-232 3.15e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 48.70  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGM-LLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDK-YGRRPVLLFGILFFASACILTTWVSD 103
Cdd:cd17471    6 LLTGLAGAFVLPYLsLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 104 IQQFVslrfvqgISLCFIGAVGYAAIQEAF----------EEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMF 173
Cdd:cd17471   86 YWVLL-------LVGVVLLSLGAAAFPQLFalareyadrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504406779 174 WLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLarnyGRLLKDRQVMYGSFAIGLVFI 232
Cdd:cd17471  159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSL----VKAPVNRRLLLLFAAFTLLFA 213
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 39-280 3.19e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 48.81  E-value: 3.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  39 MLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFV-QGIS 117
Cdd:cd17355   26 IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlGGGG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 118 LCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFA----ACSAVAFLVLWRVMPE 193
Cdd:cd17355  106 AGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAllalLVLVPVLLLLRRRPAD 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 194 TAGDRTQSVALPVLARNYGRLLKDRQ--VMYGSFAIGLVfipILTWVALSPVILMRDEGLSRMQYALLQLPVFLAMIAGN 271
Cdd:cd17355  186 LALRAYDDASPASPGSTLKEALRSASfwLLALAFFLCGF---AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGR 262


                 ....*....
gi 504406779 272 VTLSKVVGR 280
Cdd:cd17355  263 LLSGWLGDR 271
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 49-194 1.03e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 47.25  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  49 GAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCfIGAVGYAA 128
Cdd:cd17388   36 AATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGA-TGAVAAAY 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504406779 129 IQEAFEEALAVRIMALMANVALLAPLAGPLAGaAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPET 194
Cdd:cd17388  115 IADVTPPEQRARNFGLLGAAFGLGFIAGPALG-GLLGEISPRAPFLVAAGLNGLNFLLGLFVLPES 179
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 57-281 1.85e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 46.46  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  57 LTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEE- 135
Cdd:cd17475   37 LSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPr 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 136 ----ALAVRIMALMANVALLAPLAGPLAGAAwltvgSWRSMFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLARNY 211
Cdd:cd17475  117 erglAMGIRQTGVPLGGALAAALLPPLALHY-----GWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 212 GRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRM 281
Cdd:cd17475  192 KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRV 261
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 52-187 2.34e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 46.47  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  52 WVSTsltAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGaVGYAAIQE 131
Cdd:cd06179   36 WIST---AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQG-LGAAVASE 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504406779 132 AFEEALAVRIMALMANVALLAPLAGPLAGAAWL--TVGSWRSMFWLFAACSAVAFLVL 187
Cdd:cd06179  112 LVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALILL 169
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 30-188 5.28e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 5.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  30 IAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVS 109
Cdd:cd17477   10 LGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFL 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504406779 110 LRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWrsMFWLFAACSAVAFLVLW 188
Cdd:cd17477   90 LRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLLALVPLL 166
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 58-192 1.20e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.72  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  58 TAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGyAAIQEAFEEAL 137
Cdd:cd17330   41 SSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ-AYIADITDEEE 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504406779 138 AVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMP 192
Cdd:cd17330  120 RAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 41-195 7.64e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 7.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   41 LVTAEFNVGaewvstsltaYLLGGVVLqwllGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCF 120
Cdd:TIGR00898 131 LTQSCFFVG----------VLLGSFVF----GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGG 196

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504406779  121 IGAVGYAAIQEaFEEALAVRIMALMANVAlLAPLAGPLAGAAWLtVGSWRsmfWLFAACSA--VAFLVLWRVMPETA 195
Cdd:TIGR00898 197 IWVQAVVLNTE-FLPKKQRAIVGTLIQVF-FSLGLVLLPLVAYF-IPDWR---WLQLAVSLptFLFFLLSWFVPESP 267
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 72-281 1.17e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  72 GPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEAL---AVRIM-ALMAN 147
Cdd:PRK11551  71 GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLrgtAVSLMyCGVPF 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 148 VALLAPLAGPLAGAAwltvGSWRSMFWLFAACSAVAFLVLWRVMPETAGDRTQSVALPVLARNYGRLLKDRQVM------ 221
Cdd:PRK11551 151 GGALASVIGVLAAGD----AAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATatlllw 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 222 YGSFAIGLVFIPILTWVALspviLMRDEGLSRMQYALLQLPVFLAMIAGNVTLSKVVGRM 281
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLPS----LLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL 282
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 13-188 1.51e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  13 RIMLFPLAMVLYEFATYIAHDMIQPGmlLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFA 92
Cdd:cd17316  177 RRTLLLILLWFFISFGYYGLTTFLPT--YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  93 SACILTTWV--SDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWR 170
Cdd:cd17316  255 ILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334

                        170
                 ....*....|....*...
gi 504406779 171 SMFWLFAACSAVAFLVLW 188
Cdd:cd17316  335 GVPALILALLAIVALIVA 352
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 44-217 1.61e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 40.30  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  44 AEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGA 123
Cdd:cd17328   27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 124 VGYAAIQEAFEE-----ALAVRIMALMANVALLAPLAGPLAGAAwltvGSWRSMFWLFAACSAVAFLVLWRVMPE-TAGD 197
Cdd:cd17328  107 IAPTIIADLFPKekrtrALGVFYFAIPLGSGLGYVVGGLVAQAT----GGWRWAFRVTGVLGVLLAILLLLFVREpPRGA 182

                        170       180
                 ....*....|....*....|
gi 504406779 198 RTQSVALPVLARNYGRLLKD 217
Cdd:cd17328  183 AEGGVMAKSTATSFLADLKA 202
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 61-194 1.97e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.86  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  61 LLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGIslcFIGAVGYAA---IQEAFEEAL 137
Cdd:cd17315   44 LLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGL---GVGLASVLVplyISEIAPAKI 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 138 AVRIMA---LMANVALLAPLAGPLAGAAWLTVGsWRSMFWLfAACSAVAFLVLWRVMPET 194
Cdd:cd17315  121 RGALGTlnqLMITFGILLAYLLGLALSLSPPGW-WRLMFAL-AAVPALLQLLLMFFLPES 178
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 24-195 2.09e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 39.97  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  24 YEFATYIahdmiqPGMLLVTAEFNVGAewVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLL-FGILFFASACILTTWVS 102
Cdd:cd17367  240 YTWTTYL------QKFLVNTAGFSKGD--ATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLfFGIGGTLATVPLLSALD 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 103 DIQQFVSLRFVQGISLCFIgaVGYAAIQEA-FEEALAVRIMALmaNVALLAPLAGPLAG------AAWL-TVGSWRSMFW 174
Cdd:cd17367  312 HTDSPYTAFALVLVGLVFL--SGYTSINAVvKAELFPTHVRAL--GVGLPYALAVAIFGgtapyvALWLkSIGHEWVFFW 387

                        170       180
                 ....*....|....*....|.
gi 504406779 175 LFAACSAVAFLVLWRvMPETA 195
Cdd:cd17367  388 YVAGLIAISLVVYLR-MPETR 407
Sugar_tr pfam00083
Sugar (and other) transporter;
73-196 2.61e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 39.95  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779   73 PLSDKYGRRPVLLFGI-------LFFASACILTTWVSDIQQFVSLRFVQGISLCF---IGAVGYAAIQEAFEEALAVRIM 142
Cdd:pfam00083 309 FLVDRFGRRPLLLLGAagmaicfVILGIVALLGVSKSDWAGIVAIVFIALFIAFFamgWGPVPWVIVSELFPLSVRSKAM 388

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 504406779  143 ALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLWRVMPETAG 196
Cdd:pfam00083 389 ALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKG 442
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
 63-119 2.94e-03

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 39.52  E-value: 2.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 504406779  63 GGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLC 119
Cdd:PLN00028  83 GSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLA 139
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 26-281 3.16e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  26 FATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQ 105
Cdd:cd17333    6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 106 QFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRiMALMANVALLAPLAGPLAGAAWLTVGSWRSmfWLFAACSAVAFL 185
Cdd:cd17333   86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSELSWS--WAYLIIGLIYLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 186 VLWRVM----PETAGDRTQSVALPVLARNYGRLLKDRQVMYGSFAIGLVFIPILTWVALSPVILMRDEGLSRMQYALLQL 261
Cdd:cd17333  163 LAILILltlfPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS 242

                        250       260
                 ....*....|....*....|
gi 504406779 262 PVFLAMIAGNVTLSKVVGRM 281
Cdd:cd17333  243 GFWVGITIGRLLGGPISRRI 262
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 40-188 3.19e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.45  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  40 LLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLC 119
Cdd:cd17324  223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504406779 120 FIGAVGYAAIQEAFEEALAvRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLVLW 188
Cdd:cd17324  303 AAHSALQTRVLRLAPEARG-LASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 54-188 3.51e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.43  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  54 STSLTAYLLG---GVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQ 130
Cdd:cd17369  264 STVLLAVLIAsvvAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQA 343

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504406779 131 EAFEEALAVRI----MALMANV-ALLAPLAGPL-AGAAWLTVGSWRSMFWLFAACSAVAFLVLW 188
Cdd:cd17369  344 AFLAELFPTRVrytgASLGYQLgAILGGGFAPLiATALVAATGSWWPVALYLAALAVISLVAAL 407
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 22-191 3.85e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.16  E-value: 3.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  22 VLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTW- 100
Cdd:cd17341    5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALa 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 101 VSDIQQFVSLRFVQGISLCfIGAVGYAAIQEAFEEA---LAVRIMALMANV-ALLAPLAGPLAGAAWLTVGS---WRSMF 173
Cdd:cd17341   85 VSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEkigGAAGGIAGAGNMgVAVSQLLAPLIAGAIVFDGGfvgWRNAF 163

                        170
                 ....*....|....*...
gi 504406779 174 WLFAACSAVAFLVLWRVM 191
Cdd:cd17341  164 FVPGILLAIAAVLVLLFG 181
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
19-189 5.70e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 5.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  19 LAMVLYEFATYIAHDMIQPGMLL-VTAEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACIL 97
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  98 TTWV--SDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEA------------LAVRIMALMANVALLAPLAGPLAGAAW 163
Cdd:COG2211  311 LFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrreglyFGIFTFAIKLGQALAGALAGLLLALFG 390

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 504406779 164 LTVGSWRS----------MFWLFAACSAVAFLVLWR 189
Cdd:COG2211  391 YVAGAAQSpsaltgirllFFLLPAVLLLLAALLLLF 426
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 19-189 7.72e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.40  E-value: 7.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  19 LAMVLYEFATYIAHDMIQPGMLLVTAEFNVGAEWVST----SLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASA 94
Cdd:cd17391  204 ISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFisglVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  95 CILTTWVSDIQQFVSLRFVQGISLCFIGAVGYAAIQEAFEEALAVRIMALMANVALLAPLAGPLAGAAWLTVGSWRSMFW 174
Cdd:cd17391  284 YIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFV 363

                        170
                 ....*....|....*
gi 504406779 175 LFAACSAVAFLVLWR 189
Cdd:cd17391  364 VTALLVLLNAIWSFI 378
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 44-271 8.07e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 37.97  E-value: 8.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  44 AEFNVGAEWVSTSLTAYLLGGVVLQWLLGPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSL-RFVQGISLCF-- 120
Cdd:cd17490   24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIaRFLSGIAAATwv 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779 121 IGAVGYAAIQEAFEEALAVRIMALMANVA-LLAPLAGPLAGAAWltvgSWRSMFWLFAACSAVAFLVLWRVMPETAGDRT 199
Cdd:cd17490  104 SFTVLYASYFPPDEAAKAMGLINLVNNLGqLIAFLIGGLIAEHF----GMRAPFLLAALAGVLGFILSLFIKEERREKKP 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504406779 200 QSVALpvlaRNYGRLLKDRQVMYGSF-AIGLVFIPILTWVALSPVIlMRDEGLSRMQYALLQLPVFLAMIAGN 271
Cdd:cd17490  180 VLTEL----KELLSVLKDKKLLFFSLlAILQQMITFSTTFGFTPLI-AKQLGASSFQLGLLSIIYLLPNALAS 247
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 72-186 9.87e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.01  E-value: 9.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504406779  72 GPLSDKYGRRPVLLFGILFFASACILTTWVSDIQQFVSLRFVQGISLCFI-GAVGYAAIQEAFEE---ALAVRIMALMAN 147
Cdd:cd17391   57 GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVpNATALIASQTPKEKsgwALGTLSTGVVAG 136

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 504406779 148 VallapLAGPLAGAAWLTVGSWRSMFWLFAACSAVAFLV 186
Cdd:cd17391  137 T-----LIGPLLGGFLADLFGIRNVFFITGGLLFLAFLL 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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