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Concise Results
Standard Results
Full Results
MULTISPECIES: argininosuccinate synthase [Citrobacter]
Protein Classification
argininosuccinate synthase ( domain architecture ID 10012360 )
argininosuccinate synthase reversibly catalyzes the ATP-dependent condensation of a citrulline with an aspartate to give argininosuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05370
PRK05370 argininosuccinate synthase; Validated
1-446
0e+00
argininosuccinate synthase; Validated
Pssm-ID: 235434
Cd Length: 447
Bit Score: 1010.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 1 M T TILKHLPVGQR I GIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCR K QLVAE 80
Cdd:PRK05370 1 M S TILKHLPVGQR V GIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCR A QLVAE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 81 GIAAIQCGAFH NT TGG L TYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTN A EL Q IYKPWLD T 160
Cdd:PRK05370 81 GIAAIQCGAFH IS TGG V TYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTN P EL K IYKPWLD Q 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 161 DFIDELGGR H EMSEF M IA C GFDYKMSVEKAYSTDSNMLGATHEAKDLE F LNS SV KIVNPIMGV K FWDE N V K I P AEEVTVR 240
Cdd:PRK05370 161 DFIDELGGR A EMSEF L IA H GFDYKMSVEKAYSTDSNMLGATHEAKDLE H LNS GI KIVNPIMGV A FWDE D V E I K AEEVTVR 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 241 FEQG H PVALNGKTFSD D VELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL L TGIHNEDTIEQY 320
Cdd:PRK05370 241 FEQG R PVALNGKTFSD P VELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL V TGIHNEDTIEQY 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 321 HAH GR Q LGRLLYQGRWFD S QALMLR DG LQRWVAS Q ITGEVTLELRRGNDYSILNTVS D NLTYKPERL T MEK G - DSV FSPD 399
Cdd:PRK05370 321 RIN GR R LGRLLYQGRWFD P QALMLR ES LQRWVAS A ITGEVTLELRRGNDYSILNTVS P NLTYKPERL S MEK V e SAA FSPD 400
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 501084815 400 DRIGQLTMRNLDITDTREKLF G YA QS GLLS ASS A T GLPQ V ENLENK G 446
Cdd:PRK05370 401 DRIGQLTMRNLDITDTREKLF I YA KT GLLS SGE A S GLPQ L ENLENK D 447
Name
Accession
Description
Interval
E-value
PRK05370
PRK05370 argininosuccinate synthase; Validated
1-446
0e+00
argininosuccinate synthase; Validated
Pssm-ID: 235434
Cd Length: 447
Bit Score: 1010.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 1 M T TILKHLPVGQR I GIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCR K QLVAE 80
Cdd:PRK05370 1 M S TILKHLPVGQR V GIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCR A QLVAE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 81 GIAAIQCGAFH NT TGG L TYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTN A EL Q IYKPWLD T 160
Cdd:PRK05370 81 GIAAIQCGAFH IS TGG V TYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTN P EL K IYKPWLD Q 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 161 DFIDELGGR H EMSEF M IA C GFDYKMSVEKAYSTDSNMLGATHEAKDLE F LNS SV KIVNPIMGV K FWDE N V K I P AEEVTVR 240
Cdd:PRK05370 161 DFIDELGGR A EMSEF L IA H GFDYKMSVEKAYSTDSNMLGATHEAKDLE H LNS GI KIVNPIMGV A FWDE D V E I K AEEVTVR 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 241 FEQG H PVALNGKTFSD D VELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL L TGIHNEDTIEQY 320
Cdd:PRK05370 241 FEQG R PVALNGKTFSD P VELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL V TGIHNEDTIEQY 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 321 HAH GR Q LGRLLYQGRWFD S QALMLR DG LQRWVAS Q ITGEVTLELRRGNDYSILNTVS D NLTYKPERL T MEK G - DSV FSPD 399
Cdd:PRK05370 321 RIN GR R LGRLLYQGRWFD P QALMLR ES LQRWVAS A ITGEVTLELRRGNDYSILNTVS P NLTYKPERL S MEK V e SAA FSPD 400
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 501084815 400 DRIGQLTMRNLDITDTREKLF G YA QS GLLS ASS A T GLPQ V ENLENK G 446
Cdd:PRK05370 401 DRIGQLTMRNLDITDTREKLF I YA KT GLLS SGE A S GLPQ L ENLENK D 447
argG
TIGR00032 argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ...
13-420
0e+00
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987
Cd Length: 394
Bit Score: 617.11
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 13 RIGI A F SGGLDTS AA L L W M R Q KG AVPY AYTA NL GQP d E D D Y DAIP RR A M EYGAEN ARL ID C R KQL V AE - G I AAIQ CG AF H 91
Cdd:TIGR00032 1 KVVL A Y SGGLDTS VC L K W L R E KG YEVI AYTA DV GQP - E E D I DAIP EK A L EYGAEN HYT ID A R EEF V KD y G F AAIQ AN AF Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 92 NT T gglt Y FNT T P L G R AVTGTM LV A A M K ED G V N IWGD G S T Y KGND I ERF Y R YGL L T N AE L QIYK PW L D TD F I delgg R H E 171
Cdd:TIGR00032 80 EG T ---- Y PLS T A L A R PLIAKK LV E A A K KE G A N AVAH G C T G KGND Q ERF E R SIR L L N PD L KVIA PW R D LN F T ----- R E E 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 172 MS E FM I A CG FD Y K MS V EK A YS T D S N ML G ATH EA KD LE FL n S SVKIVNPI M GV KF W DE NVKIPA E E VT VR FEQG H PVALNG 251
Cdd:TIGR00032 151 EI E YA I Q CG IP Y P MS K EK P YS I D E N LW G RSI EA GI LE DP - S TEPPEDIY M WT KF P DE ATPDEP E V VT ID FEQG V PVALNG 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 252 KTF s D D VEL M LEAN R I G G R HG L G MS D Q IENRII EA KSR G IYEAPG M ALL H IA YER L L T GIHNE D TI E QYHAHGR Q LGR L L 331
Cdd:TIGR00032 230 VSL - D P VEL I LEAN E I A G K HG V G RI D I IENRII GL KSR E IYEAPG A ALL I IA HRD L E T LTLTR D VL E FKDIVEE Q YSE L I 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 332 YQG R WFD SQ A LM L r D GLQ R WVASQI TG E V TLE L RR GN DYS I LN T v S DNLT Y KP E RLT MEK g D S VF S P D D R IG QL TMR N L D 411
Cdd:TIGR00032 309 YQG L WFD PL A EA L - D AFI R KTQERV TG T V RVK L FK GN AIV I GR T - S PYSL Y DE E LVS MEK - D D VF D P R D A IG FI TMR G L Q 385
....*....
gi 501084815 412 I T D T REK LF 420
Cdd:TIGR00032 386 I K D Y REK KK 394
ArgG
COG0137 Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ...
12-418
1.27e-172
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907
Cd Length: 397
Bit Score: 489.57
E-value: 1.27e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 12 QRIGI A F SGGLDTS AALL W MRQ K - G AVPY A Y TA NL GQ pd ED D YD AI PRR A MEY GA EN A RLI D C R KQL V AEGIA - AI QCG A 89
Cdd:COG0137 1 KKVVL A Y SGGLDTS VIIP W LKE K y G YEVI A V TA DV GQ -- GE D LE AI EEK A LKL GA SK A YVV D A R EEF V EDYVF p AI KAN A 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 90 FH ntt G G l T Y FNT T P L G R AVTGTM LV AAMK E D G VNIWGD G S T Y KGND IE RF YRYGLLTNAE L Q I YK PW LDT D fide L GG R 169
Cdd:COG0137 79 LY --- E G - K Y PLG T A L A R PLIAKK LV EIAR E E G ADAVAH G C T G KGND QV RF ELAIRALAPD L K I IA PW REW D ---- L KS R 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 170 H E MS E FMIAC G FDYKMSV EK A YS T D S N ML G ATH E AKD LE FLNSSVK iv NPIMGVKFWD E NVKIPA E E VT VR FE Q G H PVAL 249
Cdd:COG0137 151 E E EI E YAEEH G IPVPATK EK P YS I D E N LW G RSI E GGE LE DPWNEPP -- EDAYEWTVSP E DAPDEP E Y VT IT FE K G V PVAL 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 250 NG KTF S D d VEL ML E A N R IGG R HG L G MS D QI ENR IIEA KSRG I YEAPG MAL L HI A YER L LTGIHNED T IEQYHAHGRQLGR 329
Cdd:COG0137 229 NG EKL S P - VEL IE E L N E IGG K HG V G RI D IV ENR LVGI KSRG V YEAPG ATI L IT A HRA L ESLTLDRE T LHFKDILDQKYAE 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 330 L L Y Q G R WF DSQALM L RDGLQR w VASQI TG E V T L E L RR GN d YSILNTV S DNLT Y KPERL T M E KG D s VF SPD D RI G QLTMRN 409
Cdd:COG0137 308 L V Y N G L WF SPLREA L DAFIDE - TQKRV TG T V R L K L YK GN - ATVVGRK S PYSL Y DEDLA T Y E ED D - VF DQK D AE G FIKLFG 384
....*....
gi 501084815 410 L DITDTREK 418
Cdd:COG0137 385 L PLRVAARV 393
ASS
cd01999 argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ...
12-411
1.39e-144
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503
Cd Length: 386
Bit Score: 417.71
E-value: 1.39e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 12 QRIGI A F SGGLDTS AA L L W MRQK - G AVPY A Y TA N LGQ P DE DD yd A I PRR A MEY GA ENARLI D C R KQLVAEG I A - AI QCG A 89
Cdd:cd01999 1 KKVVL A Y SGGLDTS VI L K W LKEE y G YEVI A F TA D LGQ G DE EE -- E I EEK A LKL GA VKVYVV D L R EEFAEDY I F p AI KAN A 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 90 FHNTT gglt Y FNT T P L G R AVTGTM LV AAMK E D G VNIWGD G S T Y KGND IE RF YRYGLLTNAE L QIYK PW L D TD F idel GG R 169
Cdd:cd01999 79 IYEGR ---- Y PLG T A L A R PLIAKK LV EVAR E E G ATAVAH G C T G KGND QV RF ELAIKALAPD L KVIA PW R D WN F ---- LT R 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 170 H E MSEFMIAC G FDYKMSVE K A YS T D S N ML G ATH E AK DLE FLN ssvki VN P IMGVKF W DENVKIP --- A E E VT VR FE Q G H P 246
Cdd:cd01999 151 A E EIAYAKKH G IPVPVTKK K P YS I D E N LW G RSY E GG DLE DPW ----- NE P PEDAFE W TVSPEKA pde P E Y VT IE FE K G V P 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 247 VA L NG KTF s D D VEL MLEA N R I G GRHG L G MS D QI ENR IIEA KSRG I YEAPG MA LL HI A YER L LTGIHNEDTIEQYHAHG R Q 326
Cdd:cd01999 226 VA V NG EKL - D P VEL IEKL N E I A GRHG V G RI D IV ENR LVGI KSRG V YEAPG AT LL IK A HRD L EDLTLDREVLHFKDIVS R K 304
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 327 LGR L L Y Q G R WFD SQALM L RDGLQRWVAS q I TGEV T L E L RR GN DY s ILNTV S D N LT Y KP E RL T M E K GD s V F SPD D RI G QLT 406
Cdd:cd01999 305 YAE L V Y N G L WFD PLREA L EAFIDKTQER - V TGEV R L K L YK GN VI - VVGRE S P N SL Y SE E LA T Y E E GD - G F DQK D AE G FIK 381
....*
gi 501084815 407 MRN L D 411
Cdd:cd01999 382 IHG L Q 386
Arginosuc_synth
pfam00764 Arginosuccinate synthase; This family contains a PP-loop motif.
16-403
2.14e-59
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148
Cd Length: 386
Bit Score: 199.11
E-value: 2.14e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 16 I A F SGGLDTS AALL W MRQK G AVPY - A YTANL GQ P d ED D Y D AIPRR A MEY GA ENARL ID CRKQL V AEG I - A AIQ CG A FHNT 93
Cdd:pfam00764 2 L A Y SGGLDTS VCIP W LKEQ G GYEV i A VAVDV GQ G - GE D I D EAREK A LKL GA VKHYV ID AKEEF V EDY I f P AIQ AN A LYED 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 94 T gglt Y FNT T P L G R AVTGTM LV A A M K ED G VNIWGD G S T Y KGND IE RF YRYGLLTNAE L QIYK P WL D TDFI delgg R H E MS 173
Cdd:pfam00764 81 R ---- Y PLG T A L A R PLIAKK LV E A A K KE G ASAVAH G C T G KGND QV RF EVSFRSLAPD L KVIA P VR D PNLT ----- R E E EI 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 174 E FMIAC G FDYKMSVEKA YS T D S N ML G ATH EA KD LE FLNSS vkivn P IMGVKF W DENVKIP --- AEE V TVR FE Q G H PVAL N 250
Cdd:pfam00764 152 E YAEEH G IPIPVTKKSP YS I D E N LW G RSI EA GI LE DPWNA ----- P PEDIYE W TKDPAKA pde PDI V EIG FE K G V PVAL D 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 251 G KTF S D d V EL MLEA N R I G G R HG L G MS D QI E N R IIEA KSR G IYEAP GMAL L --- H IAY E R L - LT G -- IHNEDTIE Q yhahg 324
Cdd:pfam00764 227 G EPV S P - L EL IEKL N E I A G A HG V G RI D IV E D R LVGI KSR E IYEAP AATV L ita H RDL E N L t LT R ev LRFKRIVD Q ----- 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 325 r QLGR L L Y Q G R WF DS qalm L RDG L QRWVAS --- QI TG E V TLE L RR G NDY s I L NTV S DNLT Y KP E RLTMEK GD S v F SPD D R 401
Cdd:pfam00764 301 - KWAE L V Y D G L WF SP ---- L KEA L DAFIDK tqe RV TG T V RVK L HK G SAI - V L GRR S PYSL Y DE E LVSYDE GD T - F DQT D A 373
..
gi 501084815 402 I G 403
Cdd:pfam00764 374 T G 375
Name
Accession
Description
Interval
E-value
PRK05370
PRK05370 argininosuccinate synthase; Validated
1-446
0e+00
argininosuccinate synthase; Validated
Pssm-ID: 235434
Cd Length: 447
Bit Score: 1010.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 1 M T TILKHLPVGQR I GIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCR K QLVAE 80
Cdd:PRK05370 1 M S TILKHLPVGQR V GIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCR A QLVAE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 81 GIAAIQCGAFH NT TGG L TYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTN A EL Q IYKPWLD T 160
Cdd:PRK05370 81 GIAAIQCGAFH IS TGG V TYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTN P EL K IYKPWLD Q 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 161 DFIDELGGR H EMSEF M IA C GFDYKMSVEKAYSTDSNMLGATHEAKDLE F LNS SV KIVNPIMGV K FWDE N V K I P AEEVTVR 240
Cdd:PRK05370 161 DFIDELGGR A EMSEF L IA H GFDYKMSVEKAYSTDSNMLGATHEAKDLE H LNS GI KIVNPIMGV A FWDE D V E I K AEEVTVR 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 241 FEQG H PVALNGKTFSD D VELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL L TGIHNEDTIEQY 320
Cdd:PRK05370 241 FEQG R PVALNGKTFSD P VELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL V TGIHNEDTIEQY 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 321 HAH GR Q LGRLLYQGRWFD S QALMLR DG LQRWVAS Q ITGEVTLELRRGNDYSILNTVS D NLTYKPERL T MEK G - DSV FSPD 399
Cdd:PRK05370 321 RIN GR R LGRLLYQGRWFD P QALMLR ES LQRWVAS A ITGEVTLELRRGNDYSILNTVS P NLTYKPERL S MEK V e SAA FSPD 400
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 501084815 400 DRIGQLTMRNLDITDTREKLF G YA QS GLLS ASS A T GLPQ V ENLENK G 446
Cdd:PRK05370 401 DRIGQLTMRNLDITDTREKLF I YA KT GLLS SGE A S GLPQ L ENLENK D 447
argG
TIGR00032 argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ...
13-420
0e+00
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987
Cd Length: 394
Bit Score: 617.11
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 13 RIGI A F SGGLDTS AA L L W M R Q KG AVPY AYTA NL GQP d E D D Y DAIP RR A M EYGAEN ARL ID C R KQL V AE - G I AAIQ CG AF H 91
Cdd:TIGR00032 1 KVVL A Y SGGLDTS VC L K W L R E KG YEVI AYTA DV GQP - E E D I DAIP EK A L EYGAEN HYT ID A R EEF V KD y G F AAIQ AN AF Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 92 NT T gglt Y FNT T P L G R AVTGTM LV A A M K ED G V N IWGD G S T Y KGND I ERF Y R YGL L T N AE L QIYK PW L D TD F I delgg R H E 171
Cdd:TIGR00032 80 EG T ---- Y PLS T A L A R PLIAKK LV E A A K KE G A N AVAH G C T G KGND Q ERF E R SIR L L N PD L KVIA PW R D LN F T ----- R E E 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 172 MS E FM I A CG FD Y K MS V EK A YS T D S N ML G ATH EA KD LE FL n S SVKIVNPI M GV KF W DE NVKIPA E E VT VR FEQG H PVALNG 251
Cdd:TIGR00032 151 EI E YA I Q CG IP Y P MS K EK P YS I D E N LW G RSI EA GI LE DP - S TEPPEDIY M WT KF P DE ATPDEP E V VT ID FEQG V PVALNG 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 252 KTF s D D VEL M LEAN R I G G R HG L G MS D Q IENRII EA KSR G IYEAPG M ALL H IA YER L L T GIHNE D TI E QYHAHGR Q LGR L L 331
Cdd:TIGR00032 230 VSL - D P VEL I LEAN E I A G K HG V G RI D I IENRII GL KSR E IYEAPG A ALL I IA HRD L E T LTLTR D VL E FKDIVEE Q YSE L I 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 332 YQG R WFD SQ A LM L r D GLQ R WVASQI TG E V TLE L RR GN DYS I LN T v S DNLT Y KP E RLT MEK g D S VF S P D D R IG QL TMR N L D 411
Cdd:TIGR00032 309 YQG L WFD PL A EA L - D AFI R KTQERV TG T V RVK L FK GN AIV I GR T - S PYSL Y DE E LVS MEK - D D VF D P R D A IG FI TMR G L Q 385
....*....
gi 501084815 412 I T D T REK LF 420
Cdd:TIGR00032 386 I K D Y REK KK 394
ArgG
COG0137 Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ...
12-418
1.27e-172
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907
Cd Length: 397
Bit Score: 489.57
E-value: 1.27e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 12 QRIGI A F SGGLDTS AALL W MRQ K - G AVPY A Y TA NL GQ pd ED D YD AI PRR A MEY GA EN A RLI D C R KQL V AEGIA - AI QCG A 89
Cdd:COG0137 1 KKVVL A Y SGGLDTS VIIP W LKE K y G YEVI A V TA DV GQ -- GE D LE AI EEK A LKL GA SK A YVV D A R EEF V EDYVF p AI KAN A 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 90 FH ntt G G l T Y FNT T P L G R AVTGTM LV AAMK E D G VNIWGD G S T Y KGND IE RF YRYGLLTNAE L Q I YK PW LDT D fide L GG R 169
Cdd:COG0137 79 LY --- E G - K Y PLG T A L A R PLIAKK LV EIAR E E G ADAVAH G C T G KGND QV RF ELAIRALAPD L K I IA PW REW D ---- L KS R 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 170 H E MS E FMIAC G FDYKMSV EK A YS T D S N ML G ATH E AKD LE FLNSSVK iv NPIMGVKFWD E NVKIPA E E VT VR FE Q G H PVAL 249
Cdd:COG0137 151 E E EI E YAEEH G IPVPATK EK P YS I D E N LW G RSI E GGE LE DPWNEPP -- EDAYEWTVSP E DAPDEP E Y VT IT FE K G V PVAL 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 250 NG KTF S D d VEL ML E A N R IGG R HG L G MS D QI ENR IIEA KSRG I YEAPG MAL L HI A YER L LTGIHNED T IEQYHAHGRQLGR 329
Cdd:COG0137 229 NG EKL S P - VEL IE E L N E IGG K HG V G RI D IV ENR LVGI KSRG V YEAPG ATI L IT A HRA L ESLTLDRE T LHFKDILDQKYAE 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 330 L L Y Q G R WF DSQALM L RDGLQR w VASQI TG E V T L E L RR GN d YSILNTV S DNLT Y KPERL T M E KG D s VF SPD D RI G QLTMRN 409
Cdd:COG0137 308 L V Y N G L WF SPLREA L DAFIDE - TQKRV TG T V R L K L YK GN - ATVVGRK S PYSL Y DEDLA T Y E ED D - VF DQK D AE G FIKLFG 384
....*....
gi 501084815 410 L DITDTREK 418
Cdd:COG0137 385 L PLRVAARV 393
ASS
cd01999 argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ...
12-411
1.39e-144
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503
Cd Length: 386
Bit Score: 417.71
E-value: 1.39e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 12 QRIGI A F SGGLDTS AA L L W MRQK - G AVPY A Y TA N LGQ P DE DD yd A I PRR A MEY GA ENARLI D C R KQLVAEG I A - AI QCG A 89
Cdd:cd01999 1 KKVVL A Y SGGLDTS VI L K W LKEE y G YEVI A F TA D LGQ G DE EE -- E I EEK A LKL GA VKVYVV D L R EEFAEDY I F p AI KAN A 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 90 FHNTT gglt Y FNT T P L G R AVTGTM LV AAMK E D G VNIWGD G S T Y KGND IE RF YRYGLLTNAE L QIYK PW L D TD F idel GG R 169
Cdd:cd01999 79 IYEGR ---- Y PLG T A L A R PLIAKK LV EVAR E E G ATAVAH G C T G KGND QV RF ELAIKALAPD L KVIA PW R D WN F ---- LT R 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 170 H E MSEFMIAC G FDYKMSVE K A YS T D S N ML G ATH E AK DLE FLN ssvki VN P IMGVKF W DENVKIP --- A E E VT VR FE Q G H P 246
Cdd:cd01999 151 A E EIAYAKKH G IPVPVTKK K P YS I D E N LW G RSY E GG DLE DPW ----- NE P PEDAFE W TVSPEKA pde P E Y VT IE FE K G V P 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 247 VA L NG KTF s D D VEL MLEA N R I G GRHG L G MS D QI ENR IIEA KSRG I YEAPG MA LL HI A YER L LTGIHNEDTIEQYHAHG R Q 326
Cdd:cd01999 226 VA V NG EKL - D P VEL IEKL N E I A GRHG V G RI D IV ENR LVGI KSRG V YEAPG AT LL IK A HRD L EDLTLDREVLHFKDIVS R K 304
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 327 LGR L L Y Q G R WFD SQALM L RDGLQRWVAS q I TGEV T L E L RR GN DY s ILNTV S D N LT Y KP E RL T M E K GD s V F SPD D RI G QLT 406
Cdd:cd01999 305 YAE L V Y N G L WFD PLREA L EAFIDKTQER - V TGEV R L K L YK GN VI - VVGRE S P N SL Y SE E LA T Y E E GD - G F DQK D AE G FIK 381
....*
gi 501084815 407 MRN L D 411
Cdd:cd01999 382 IHG L Q 386
Arginosuc_synth
pfam00764 Arginosuccinate synthase; This family contains a PP-loop motif.
16-403
2.14e-59
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148
Cd Length: 386
Bit Score: 199.11
E-value: 2.14e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 16 I A F SGGLDTS AALL W MRQK G AVPY - A YTANL GQ P d ED D Y D AIPRR A MEY GA ENARL ID CRKQL V AEG I - A AIQ CG A FHNT 93
Cdd:pfam00764 2 L A Y SGGLDTS VCIP W LKEQ G GYEV i A VAVDV GQ G - GE D I D EAREK A LKL GA VKHYV ID AKEEF V EDY I f P AIQ AN A LYED 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 94 T gglt Y FNT T P L G R AVTGTM LV A A M K ED G VNIWGD G S T Y KGND IE RF YRYGLLTNAE L QIYK P WL D TDFI delgg R H E MS 173
Cdd:pfam00764 81 R ---- Y PLG T A L A R PLIAKK LV E A A K KE G ASAVAH G C T G KGND QV RF EVSFRSLAPD L KVIA P VR D PNLT ----- R E E EI 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 174 E FMIAC G FDYKMSVEKA YS T D S N ML G ATH EA KD LE FLNSS vkivn P IMGVKF W DENVKIP --- AEE V TVR FE Q G H PVAL N 250
Cdd:pfam00764 152 E YAEEH G IPIPVTKKSP YS I D E N LW G RSI EA GI LE DPWNA ----- P PEDIYE W TKDPAKA pde PDI V EIG FE K G V PVAL D 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 251 G KTF S D d V EL MLEA N R I G G R HG L G MS D QI E N R IIEA KSR G IYEAP GMAL L --- H IAY E R L - LT G -- IHNEDTIE Q yhahg 324
Cdd:pfam00764 227 G EPV S P - L EL IEKL N E I A G A HG V G RI D IV E D R LVGI KSR E IYEAP AATV L ita H RDL E N L t LT R ev LRFKRIVD Q ----- 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 325 r QLGR L L Y Q G R WF DS qalm L RDG L QRWVAS --- QI TG E V TLE L RR G NDY s I L NTV S DNLT Y KP E RLTMEK GD S v F SPD D R 401
Cdd:pfam00764 301 - KWAE L V Y D G L WF SP ---- L KEA L DAFIDK tqe RV TG T V RVK L HK G SAI - V L GRR S PYSL Y DE E LVSYDE GD T - F DQT D A 373
..
gi 501084815 402 I G 403
Cdd:pfam00764 374 T G 375
PRK00509
PRK00509 argininosuccinate synthase; Provisional
13-400
2.01e-56
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 191.43
E-value: 2.01e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 13 RIGI A F SGGLDTS AALL W MRQK - G AVPY A Y TA NL GQ pd EDDYDA I PRR A MEY GA ENARLI D C R KQL V AEGIA - AI QCG A F 90
Cdd:PRK00509 4 KVVL A Y SGGLDTS VIIK W LKET y G CEVI A F TA DV GQ -- GEELEP I REK A LKS GA SEIYVE D L R EEF V RDYVF p AI RAN A L 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 91 hnttgglt Y FNTT PLG ---- R AVTGTM LV AAMKED G VNIWGD G S T Y KGND IE RF --- Y r YG L lt NAE L QIYK PW LDT D F i 163
Cdd:PRK00509 82 -------- Y EGKY PLG tala R PLIAKK LV EIARKE G ADAVAH G C T G KGND QV RF elg I - AA L -- APD L KVIA PW REW D L - 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 164 del GG R H E MSEFMIAC G FDYKMSVEKA YS T D S N MLGATH E AKD LE FLNSSVK ------ I V N P img VKFW DE nvkip A E E V 237
Cdd:PRK00509 150 --- KS R E E LIAYAEEH G IPIPVTKKSP YS I D A N LWHRSI E GGI LE DPWNEPP edvyew T V S P --- EDAP DE ----- P E Y V 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 238 TVR FE Q G H PVA L NG KTF S D d V EL ML E A N RIG G R HG L G MS D QI ENR IIEA KSRG I YE A PG MAL L HI A YER L -- LT ---- GI 311
Cdd:PRK00509 219 EIE FE K G V PVA I NG EAL S P - A EL IE E L N ELA G K HG I G RI D IV ENR LVGI KSRG V YE T PG GTI L IK A HRA L es LT ldre VA 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 312 H NE D TI E QYH A H grqlgr L L Y Q G R WF DS ----- QA LM lr D GL Q RW V asqi TGEV T L E L RR GN DY s ILNTV S D N LT Y KPER 386
Cdd:PRK00509 298 H FK D EL E PKY A E ------ L V Y N G L WF SP lreal QA FI -- D ET Q EH V ---- TGEV R L K L YK GN AI - VVGRK S P N SL Y DEDL 364
410
....*....|....
gi 501084815 387 L T M E KG D s V FSPD D 400
Cdd:PRK00509 365 A T Y E ED D - V YDQK D 377
PLN00200
PLN00200 argininosuccinate synthase; Provisional
16-410
2.78e-52
argininosuccinate synthase; Provisional
Pssm-ID: 177791
Cd Length: 404
Bit Score: 180.71
E-value: 2.78e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 16 I A F SGGLDTS AA L L W M R QK - G AVPYAY TA NL GQ PD E D d YDAIPRR A MEY GA ENARLI D C R KQL V AEG I - AAIQCG A FHNT 93
Cdd:PLN00200 10 L A Y SGGLDTS VI L K W L R EN y G CEVVCF TA DV GQ GI E E - LEGLEAK A KAS GA KQLVVK D L R EEF V RDY I f PCLRAN A IYEG 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 94 T gglt Y FNT T PLG R AVTGTML V AAM KE D G VNIWGD G S T Y KGND IE RF YR -- YG L lt N A EL QIYK PW LDT D FI delg GR HE 171
Cdd:PLN00200 89 K ---- Y LLG T SMA R PLIAKAM V DIA KE V G ADAVAH G A T G KGND QV RF EL tf FA L -- N P EL KVVA PW REW D IK ---- GR ED 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 172 MS E FMIACGFDYKMSVEKA YS T D S N MLGATH E AKD LE ---------- F LN S svki V N P imgvkfwd E NVKIPA E EVTVR F 241
Cdd:PLN00200 159 LI E YAKKHNIPVPVTKKSI YS R D R N LWHISY E GDI LE dpanepkedm F MM S ---- V S P -------- E AAPDQP E YIEIE F 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 242 E Q G H PVA L NGKT F S D d VE L MLEA N R IGG R HG L G MS D QI ENR IIEA KSRG I YE A PG MAL L HI A YER L LTGIHNED T IEQYH 321
Cdd:PLN00200 227 E K G L PVA I NGKT L S P - AT L LTKL N E IGG K HG I G RI D MV ENR FVGM KSRG V YE T PG GTI L FA A HRE L ESLTLDRE T MQVKD 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 322 AHGRQLGR L L Y Q G R WFD SQALMLRDGLQR w VASQI TG E V T L E L RR GN d Y S ILNTV S DNLT Y KPERLTM E K G DSVFSPD D - 400
Cdd:PLN00200 306 SLALKYAE L V Y N G F WFD PERESMDAFMEK - ITETT TG S V R L K L YK GN - V S VAGRK S PYSL Y RQDISSF E E G GGIYNQA D a 383
410
....*....|....
gi 501084815 401 ---- R IGQ L TM R NL 410
Cdd:PLN00200 384 agfi R LYA L RL R TR 397
PRK13820
PRK13820 argininosuccinate synthase; Provisional
13-368
2.29e-31
argininosuccinate synthase; Provisional
Pssm-ID: 237521
Cd Length: 394
Bit Score: 123.89
E-value: 2.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 13 RIGI A F SGGLDTS AALLWMRQ K gavp Y A Y ------ T ANL GQP D E D d YDAIPRR A MEY G AEN a RL ID CRKQLVAEG I A - AI 85
Cdd:PRK13820 4 KVVL A Y SGGLDTS VCVPLLKE K ---- Y G Y devitv T VDV GQP E E E - IKEAEEK A KKL G DKH - YT ID AKEEFAKDY I F p AI 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 86 QCG A FHNT tgglt Y FNT T P L G R AVTGTML V AAMKED G VNIWGD G S T Y KGND IE RF --- Y R ygllt NAE L QIYK P wldtdf 162
Cdd:PRK13820 78 KAN A LYEG ----- Y PLG T A L A R PLIAEKI V EVAEKE G ASAIAH G C T G KGND QL RF eav F R ----- ASD L EVIA P ------ 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 163 I D EL G - G R HEMS E FMIAC G FDYKMSV EK AY S T D S N MLGATH E AKD LE fl NSSVKIVNP I MG vkf W DEN --- VKIPA E E V T 238
Cdd:PRK13820 142 I R EL N l T R EWEI E YAKEK G IPVPVGK EK PW S I D E N LWSRSI E GGK LE -- DPAFEPPEE I YA --- W TVS ped APDEP E I V E 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 239 VR FE Q G H PVA L NG KTF s D D VEL MLEA N R I G G R HG L G MS D QI E N R IIEA KSR GI YE A P GMAL L --- H I A Y E R L - LT gi HN E 314
Cdd:PRK13820 217 IE FE E G V PVA I NG EKM - D G VEL IRKL N E I A G K HG V G RT D MM E D R VLGL KSR EN YE H P AATV L lta H K A L E Q L v LT -- RE E 293
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501084815 315 ---- DTIEQ yhahgr QLGR L L Y Q G RWFDS qalm LR DG L QRWVA --- SQI TG E VT LE L RR G N 368
Cdd:PRK13820 294 lkfk EIVDS ------ KWAE L A Y E G LVDEP ---- LR ED L NAFID ktq ERV TG T VT VK L YK G S 344
PRK04527
PRK04527 argininosuccinate synthase; Provisional
12-382
2.42e-26
argininosuccinate synthase; Provisional
Pssm-ID: 235305
Cd Length: 400
Bit Score: 109.92
E-value: 2.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 12 QR I GI AFSGGLDTS AALLWMRQK G AVPYAYT A NL G QP D EDDY D A I PR RA M E Y GA ENARLI D C r KQLVA EG IAA -- IQ cga 89
Cdd:PRK04527 3 KD I VL AFSGGLDTS FCIPYLQER G YAVHTVF A DT G GV D AEER D F I EK RA A E L GA ASHVTV D G - GPAIW EG FVK pl VW --- 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 90 fhntt G G LT Y FNTT PL GRAVTGTMLV AA M K --- E D G VN I WGD G S T YK GND IE RF YR y GLLTNAEL QI YK P WLDTD fi D E L 166
Cdd:PRK04527 79 ----- A G EG Y QGQY PL LVSDRYLIVD AA L K rae E L G TR I IAH G C T GM GND QV RF DL - AVKALGDY QI VA P IREIQ -- K E H 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 167 GG - R HEMSEFMIAC GF DYKMS v E KAY STDS N M LG A T HEAKDLE flnssv KIVN P IM G VKF W - DENVKI P A E EV TV R -- F E 242
Cdd:PRK04527 151 TQ t R AYEQKYLEER GF GVRAK - Q KAY TINE N L LG V T MSGGEID ------ RWEA P GE G ARG W c APRSAW P T E AL TV T ik F V 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 243 Q G HP VAL N GK TFS d DVELMLEA N RIGGRH G L G MSDQIENRI I EA K S R GIY EAPG MAL L HI A YER L ---- LT GIH N edtie 318
Cdd:PRK04527 224 E G EA VAL D GK PLP - GAQILAKL N KLFAQY G V G RGVYTGDTV I GL K G R IVF EAPG LVS L LT A HRA L edav LT KQQ N ----- 297
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501084815 319 QYHAH - G R QLGR L L Y Q G RWF D S qalm L RDGLQRWVA S --- QIT GEVTLE L R R G ------- NDYSI LN tv S DNL TY 382
Cdd:PRK04527 298 RFKPD v A R KWVE L V Y E G FYH D P ---- L KTDIEAFLK S sqa KVN GEVTLE T R G G rvdavav RSPHL LN -- S KGA TY 366
TilS
COG0037 tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]; tRNA ...
3-55
7.57e-03
tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]; tRNA(Ile)-lysidine synthase TilS/MesJ is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 439807 [Multi-domain]
Cd Length: 235
Bit Score: 37.89
E-value: 7.57e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 501084815 3 T I LKH -- L PV G Q RI GI A F SGG L D t S A ALL ----- WM R QK G AVPY A YTANL G QPD E D D Y DA 55
Cdd:COG0037 5 A I RDY rl L EP G D RI LV A V SGG K D - S L ALL hllak LR R RL G FELV A VHVDH G LRE E S D E DA 63
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
