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Conserved domains on  [gi|492378347|ref|WP_005825315|]
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MULTISPECIES: smalltalk protein [Bacteroides]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF6486 super family cl41494
Family of unknown function (DUF6486); This family of proteins is functionally uncharacterized. ...
3-33 9.55e-04

Family of unknown function (DUF6486); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 30 amino acids in length. There is a conserved IAVASA sequence motif.


The actual alignment was detected with superfamily member pfam20096:

Pssm-ID: 455109  Cd Length: 31  Bit Score: 31.35  E-value: 9.55e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 492378347   3 ISKETWKDILKIVGTIIATIASVLGVQAMPL 33
Cdd:pfam20096  1 MKKSTWKIILKIIIAVATAILGALGVTSCMG 31
 
Name Accession Description Interval E-value
DUF6486 pfam20096
Family of unknown function (DUF6486); This family of proteins is functionally uncharacterized. ...
3-33 9.55e-04

Family of unknown function (DUF6486); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 30 amino acids in length. There is a conserved IAVASA sequence motif.


Pssm-ID: 437928  Cd Length: 31  Bit Score: 31.35  E-value: 9.55e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 492378347   3 ISKETWKDILKIVGTIIATIASVLGVQAMPL 33
Cdd:pfam20096  1 MKKSTWKIILKIIIAVATAILGALGVTSCMG 31
smalltalk NF033879
smalltalk protein; Smalltalk is a membrane-associated protein of very small size (less than 35 ...
4-31 1.11e-03

smalltalk protein; Smalltalk is a membrane-associated protein of very small size (less than 35 amino acids), found broadly in Bacteroides and Prevotella, both of which are prevalent in human gut microbiomes. Genomic context suggests a role in crosstalk in the gut microbiome, whether that involve toxins and immunity, signaling, or some other form of interaction. The family was identified and discussed by Sberro, et al., in a screen for overlooked small proteins encoded within human microbiomes, and named smalltalk here for its small size and cross-talk role.


Pssm-ID: 411442  Cd Length: 29  Bit Score: 31.29  E-value: 1.11e-03
                        10        20
                ....*....|....*....|....*...
gi 492378347  4 SKETWKDILKIVGTIIATIASVLGVQAM 31
Cdd:NF033879  1 KKSTWKKILKVIIAVATAIAGALGVQSC 28
 
Name Accession Description Interval E-value
DUF6486 pfam20096
Family of unknown function (DUF6486); This family of proteins is functionally uncharacterized. ...
3-33 9.55e-04

Family of unknown function (DUF6486); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 30 amino acids in length. There is a conserved IAVASA sequence motif.


Pssm-ID: 437928  Cd Length: 31  Bit Score: 31.35  E-value: 9.55e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 492378347   3 ISKETWKDILKIVGTIIATIASVLGVQAMPL 33
Cdd:pfam20096  1 MKKSTWKIILKIIIAVATAILGALGVTSCMG 31
smalltalk NF033879
smalltalk protein; Smalltalk is a membrane-associated protein of very small size (less than 35 ...
4-31 1.11e-03

smalltalk protein; Smalltalk is a membrane-associated protein of very small size (less than 35 amino acids), found broadly in Bacteroides and Prevotella, both of which are prevalent in human gut microbiomes. Genomic context suggests a role in crosstalk in the gut microbiome, whether that involve toxins and immunity, signaling, or some other form of interaction. The family was identified and discussed by Sberro, et al., in a screen for overlooked small proteins encoded within human microbiomes, and named smalltalk here for its small size and cross-talk role.


Pssm-ID: 411442  Cd Length: 29  Bit Score: 31.29  E-value: 1.11e-03
                        10        20
                ....*....|....*....|....*...
gi 492378347  4 SKETWKDILKIVGTIIATIASVLGVQAM 31
Cdd:NF033879  1 KKSTWKKILKVIIAVATAIAGALGVQSC 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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