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Conserved domains on  [gi|491387137|ref|WP_005245014|]
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MULTISPECIES: MFS transporter [Rhodococcus]

Protein Classification

MFS transporter( domain architecture ID 11457990)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0005886|GO:0016020|GO:0022857|GO:0055085
PubMed:  26098515|9529885|26758938|23403214
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-369 1.33e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.32  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 102 ALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSAPWDPAATEGVGarraaMSLTGGFGLGAGVAGVLAQWAPLPSV 181
Cdd:COG2814   93 AL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG-----AGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 182 LsYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARdlaipsAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLMSGNTG 261
Cdd:COG2814  167 F-LVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 262 GLPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVaasALTVPLALAAAVVLGCGYGMAMVS 341
Cdd:COG2814  240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPL 316

                        330       340
                 ....*....|....*....|....*...
gi 491387137 342 GLQEIQRIAGPDDLAGLTAVFYSLTYLG 369
Cdd:COG2814  317 LQALVAELAPPEARGRASGLYNSAFFLG 344
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-369 1.33e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.32  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 102 ALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSAPWDPAATEGVGarraaMSLTGGFGLGAGVAGVLAQWAPLPSV 181
Cdd:COG2814   93 AL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG-----AGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 182 LsYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARdlaipsAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLMSGNTG 261
Cdd:COG2814  167 F-LVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 262 GLPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVaasALTVPLALAAAVVLGCGYGMAMVS 341
Cdd:COG2814  240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPL 316

                        330       340
                 ....*....|....*....|....*...
gi 491387137 342 GLQEIQRIAGPDDLAGLTAVFYSLTYLG 369
Cdd:COG2814  317 LQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
24-369 4.42e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.75  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   24 VAATMFAVAWGGNEFTPLLGMYRA-DHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLA 102
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  103 LGADSaAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLtgGFGLGAGVAGVLAQWAPLPSVL 182
Cdd:pfam07690  81 FASSL-WLLLVLRVLQGLGAGALFPAALALIADWFP---PEERGRALGLVSAGFGL--GAALGPLLGGLLASLFGWRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  183 SYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTAAAAYAVlpSLMSGNTGG 262
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL--PLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  263 LPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGCGYGMAMVSG 342
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312

                         330       340
                  ....*....|....*....|....*..
gi 491387137  343 LQEIQRIAGPDDLAGLTAVFYSLTYLG 369
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLG 339
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 24-383 1.19e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.76  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  24 VAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLpAPFLTIAGSALLAL 103
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL-LGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 104 GADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGVGARRAAMSLTGGFGLGAGVAGVLAQWAPLPSVLs 183
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIA-----PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 184 YVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLMSGNTGGL 263
Cdd:cd17325  154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 264 PLAFSALMCMVGLGAGFAIQALGRKIDTPrnaRAVVVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGCGYGMAMVSGL 343
Cdd:cd17325  234 PAQIGLLFGAQGLASALSQPPAGKLSDRI---GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 491387137 344 QEIQRIAGPDDLAGLTAVFYSLTYLGFGT-PAVMAYLSETF 383
Cdd:cd17325  311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLgPLLGGFLYDAF 351
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 38-136 6.24e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 51.23  E-value: 6.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   38 FTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVL 117
Cdd:TIGR00710  24 YLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLAL-SNNIETLLVLRFV 102

                          90
                  ....*....|....*....
gi 491387137  118 CGIALGLGMAVGGSWVKEL 136
Cdd:TIGR00710 103 QAFGASAGSVISQALVRDI 121
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
47-129 2.48e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 43.00  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  47 ADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAgSALLALGADSAAMLIVGRVLCGIALGLGM 126
Cdd:PRK15402  41 EDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFIL-TCLAILLAQSIEQFTLLRFLQGIGLCFIG 119


                 ...
gi 491387137 127 AVG 129
Cdd:PRK15402 120 AVG 122
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-369 1.33e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.32  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 102 ALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSAPWDPAATEGVGarraaMSLTGGFGLGAGVAGVLAQWAPLPSV 181
Cdd:COG2814   93 AL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG-----AGLGLGPALGPLLGGLLADLFGWRWV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 182 LsYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARdlaipsAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLMSGNTG 261
Cdd:COG2814  167 F-LVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 262 GLPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVaasALTVPLALAAAVVLGCGYGMAMVS 341
Cdd:COG2814  240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPL 316

                        330       340
                 ....*....|....*....|....*...
gi 491387137 342 GLQEIQRIAGPDDLAGLTAVFYSLTYLG 369
Cdd:COG2814  317 LQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
24-369 4.42e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.75  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   24 VAATMFAVAWGGNEFTPLLGMYRA-DHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLA 102
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  103 LGADSaAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLtgGFGLGAGVAGVLAQWAPLPSVL 182
Cdd:pfam07690  81 FASSL-WLLLVLRVLQGLGAGALFPAALALIADWFP---PEERGRALGLVSAGFGL--GAALGPLLGGLLASLFGWRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  183 SYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTAAAAYAVlpSLMSGNTGG 262
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL--PLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  263 LPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGCGYGMAMVSG 342
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312

                         330       340
                  ....*....|....*....|....*..
gi 491387137  343 LQEIQRIAGPDDLAGLTAVFYSLTYLG 369
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLG 339
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 24-383 1.19e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.76  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  24 VAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLpAPFLTIAGSALLAL 103
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL-LGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 104 GADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGVGARRAAMSLTGGFGLGAGVAGVLAQWAPLPSVLs 183
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIA-----PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 184 YVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLMSGNTGGL 263
Cdd:cd17325  154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 264 PLAFSALMCMVGLGAGFAIQALGRKIDTPrnaRAVVVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGCGYGMAMVSGL 343
Cdd:cd17325  234 PAQIGLLFGAQGLASALSQPPAGKLSDRI---GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 491387137 344 QEIQRIAGPDDLAGLTAVFYSLTYLGFGT-PAVMAYLSETF 383
Cdd:cd17325  311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLgPLLGGFLYDAF 351
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 22-351 7.92e-10

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 60.28  E-value: 7.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:cd17320    2 LLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 102 ALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwdpaategvGARRAAMS--LTGGFGLGAGVA----GVLAQW 175
Cdd:cd17320   82 AL-ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS-----------GAELAKIFslLMMILAIAPALApllgGLLLLF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 176 APLPSVLsYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLApWVFGTAAAAYAVLPSL 255
Cdd:cd17320  150 FGWRAIF-VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALG-LSFAGLFAYLAAAPFI 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 256 MSGNTGGLPLAFSALMCMVGLG---AGFAIQALGRKIDTPRNAR---AVVVSLVVVLAGMGVAAVAASALTVPLALAAAV 329
Cdd:cd17320  228 YIEQLGLSPAQFGLLFALNAIAlilGSLLNGRLVRRFGPRRLLRlglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFF 307

                        330       340
                 ....*....|....*....|..
gi 491387137 330 VLGCGYGMAMVSGLQEIQRIAG 351
Cdd:cd17320  308 GFGLIFPNATSLALEPFPHVAG 329
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 9-286 6.00e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 56.74  E-value: 6.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   9 MEVPEALASPRAWLLVAATMFAVAWGGNEFT---PLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRP 85
Cdd:COG0477    1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTivnVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  86 ILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGVGARRAAMSLTGGFGLG 165
Cdd:COG0477   81 VLLIGLLLFGLASLLCGL-APSPELLIAARALQGIGAGGLMPGALALIAELF-----PARERGRALGLWGAAIGLGLALG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 166 AGVAGVLAQWAPLPSVlsYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTA 245
Cdd:COG0477  155 PLLGGLLVAALGWRWI--FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLAL 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 491387137 246 AAAYAVLPSLMSGNTGGLPLAFSALMCMVGLGAGFAIQALG 286
Cdd:COG0477  233 LLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLA 273
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 22-130 1.03e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 56.81  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:cd17323    2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                         90       100
                 ....*....|....*....|....*....
gi 491387137 102 ALgADSAAMLIVGRVLCGIALGLGMAVGG 130
Cdd:cd17323   82 AL-APNIAMLIILRFLQGFFGSSPLAIGA 109
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 28-395 3.29e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.13  E-value: 3.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  28 MFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADS 107
Cdd:cd06174    5 FFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-APS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 108 AAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLTGGFGLGAGVAGVLAQWAPLPSVLSYVVH 187
Cdd:cd06174   84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFP---ERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 188 SAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLMSGNTGGLPLAF 267
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 268 SALMCMVGLGAGFAIQALGRKIdTPRNARAVVVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGCGYGMAMVSGLQEIQ 347
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLL-SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 491387137 348 RIAGPDDLAGLTAVFYSLTYLGFG-TPAVMAYLSETFPAVTYPRMFVFG 395
Cdd:cd06174  320 ELFPPEIRGTAFGLLNTFGFLGGAiGPLLAGFLLAATFGLTGAFLVLAV 368
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 22-371 3.68e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.86  E-value: 3.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:cd17324    2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 102 ALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGVGARRAAMSLTGGFGLGAGVAGVLAQWAPLPSV 181
Cdd:cd17324   82 AL-APSFALLLLARALAGLAHGGFWAIAAAYAADLV-----PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 182 lsYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLapwVFGTAAAAYAVLPSLMSGNTG 261
Cdd:cd17324  156 --FLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFL---LFGGFFALYTYLAPFLTDVPG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 262 GLPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVAASALtvpLALAAAVVLGCGYGMAMVS 341
Cdd:cd17324  231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPL---LLLVGLVLWGLGFFAAHSA 307

                        330       340       350
                 ....*....|....*....|....*....|
gi 491387137 342 GLQEIQRIAgPDDLAGLTAVFYSLTYLGFG 371
Cdd:cd17324  308 LQTRVLRLA-PEARGLASSLYLAAYNLGGA 336
Sugar_tr pfam00083
Sugar (and other) transporter;
45-139 8.71e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 53.82  E-value: 8.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   45 YRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLAL--GADSAAMLIVGRVLCGIAL 122
Cdd:pfam00083  37 SVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAakGKWSVYQLIVGRVLVGIGV 116

                          90
                  ....*....|....*..
gi 491387137  123 GLGMAVGGSWVKELSSA 139
Cdd:pfam00083 117 GGASVLAPMYISEIAPK 133
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 47-175 1.79e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.59  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  47 ADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGM 126
Cdd:cd17365   27 QDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF-AQSVLQLALLRFLTGLGLGAAM 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491387137 127 AVGGSWVKELSSAPWdpaategvgaRRAAMSLT-GGFGLGAGVAGVLAQW 175
Cdd:cd17365  106 PNAITLVSEYAPARR----------RSLAVTLMfCGYPLGAALGGFLAAA 145
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 38-136 6.24e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 51.23  E-value: 6.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   38 FTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVL 117
Cdd:TIGR00710  24 YLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLAL-SNNIETLLVLRFV 102

                          90
                  ....*....|....*....
gi 491387137  118 CGIALGLGMAVGGSWVKEL 136
Cdd:TIGR00710 103 QAFGASAGSVISQALVRDI 121
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-139 6.84e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 6.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   5 RESPMEVPEALASPRAWLLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRR 84
Cdd:COG2814  194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491387137  85 PILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSA 139
Cdd:COG2814  274 RLLLIGLLLLALGLLLLAL-AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 38-397 8.78e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.67  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  38 FTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVL 117
Cdd:cd17489   15 LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL-ATSVALLLVLRLI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 118 CGIALGLGMAVGGSWVKELSsapwdPAATEGVGARRAAMSLTGGFGLGAGVAGVLAQWAPLPSVLSYVVHSAIAVAAAVA 197
Cdd:cd17489   94 HGIGWGAFTTAAATLVADII-----PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 198 LWRAPETRAAQPVSERVSLARDLAIPSAahkrflFVIAPLAPwvfgTAAAAYAVLPSLMS--GNTGGLPLAFSALMCMvG 275
Cdd:cd17489  169 LVKDPPPVAAEEAEAGTRAFRRLVEKKV------LPPALILF----LASIAYGAISTFLPlyAAERGISNAGLFFTVY-A 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 276 LGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVAASAltvPLALAAAVVLGCGYGMAMVSGLQEIQRIAGPDDL 355
Cdd:cd17489  238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSP---WMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRR 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 491387137 356 AGLTAVFYSLTYLGFG-TPAVMAYLSETFpavTYPRMFVFGTV 397
Cdd:cd17489  315 GAANGTFFIFFDLGIGlGGLLLGLVAELF---GYRAMFLLAAV 354
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 21-387 1.53e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  21 WLLVAATMFAvAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSAL 100
Cdd:cd06173    2 RLLWLAQLLS-ALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 101 LALGADSAAMLIVGRVLCGIALGLGMAVGG----SWVKELSSAPWDPAAtegvgARRAAMSLTGGFGLGAGVAGVLAQWA 176
Cdd:cd06173   81 LALLALLGSLSLWLLLVLAFLLGIASAFFGparqALLPELVPKEQLVRA-----NALNSLATQLARIIGPALGGLLVALL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 177 PLPSVLSYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHKRFLFVIAPLAPWVFGTAAAAYAVLPSLM 256
Cdd:cd06173  156 GPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 257 SGNTGGLPLAFSALMCMVGLGAGFAIQALGRKIDTPRNARAVVVSLVVVLAGMGVAAVAASaltVPLALAAAVVLGCGYG 336
Cdd:cd06173  236 KEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS---LWLLLAALFLLGLAGG 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491387137 337 MAMVSGLQEIQRIAGPDDLAGLTAVFYSLTYLGF-GTPAVMAYLSETFPAVT 387
Cdd:cd06173  313 LFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMpLGALLAGLLADALGLSA 364
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 72-140 2.59e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 49.19  E-value: 2.59e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491387137  72 LLGGPLSDRLGRRPILLPAPFLTIAGSALLAlGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSAP 140
Cdd:cd17360   53 AIGGWLNDRFGRRPCILLADALFTIGAIVMA-AAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPR 120
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 42-139 2.79e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 49.10  E-value: 2.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  42 LGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIA 121
Cdd:cd17359   24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAF-SPNFTIFIIARIIGGLA 102

                         90
                 ....*....|....*...
gi 491387137 122 LGLGMAVGGSWVKELSSA 139
Cdd:cd17359  103 VGGASALVPMYIAEVAPA 120
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
22-397 2.84e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.11  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGG-NEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSAL 100
Cdd:COG2223    7 LLLATLAFFLAFGVwYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 101 LALgADSAAMLIVGRVLCGIALGLGMAVGGSWVkelssAPWDPAATEGVGARRAAMSLTGGFGLGAGVAGVLAQWAPLPS 180
Cdd:COG2223   87 LAL-AVSYWLLLLLGLLLGIGGGGSFAVGIALV-----SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 181 VLSYVVHSAIAVAAAVALWrAPETRAAQPVSERVSLARDLAIpsAAHKRFLFviapLAPWVFGTAAAAYAV---LPSLMS 257
Cdd:COG2223  161 AFLILGILLLVVAVLAWLF-LRDPPAGAAAAAKASLRDQLEA--LRDPRFWL----LSLLYFGTFGSFIGFsswLPPYLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 258 GNTGGLPLAFSALMCMVGLGAGFAIQALGRKIDtpRNARAVVVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGCGYGM 337
Cdd:COG2223  234 DQFGLSAATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491387137 338 AMVSGLQEIQRIAGPDDLAGLTAVFYSLTYLG-FGTPAVMAYLSETFPAVTYPRMFVFGTV 397
Cdd:COG2223  312 GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGgFLGPLLFGALLDATGSYTAAFLVFAVLA 372
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-176 3.52e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  14 ALASPRAWLLVAATMFaVAWGGNEFTPLLGMYRADH--GFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAP 91
Cdd:COG2211  223 ALLKNRPFLLLLLAYL-LFFLALALVAALLLYYFKYvlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  92 FLTIAGSALLAL-GADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGVGARRAA-------MSLTGGFG 163
Cdd:COG2211  302 LLAALGLLLLFFlGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVV-----DYDEWKTGRRREGlyfgiftFAIKLGQA 376

                        170
                 ....*....|...
gi 491387137 164 LGAGVAGVLAQWA 176
Cdd:COG2211  377 LAGALAGLLLALF 389
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 50-139 5.61e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 47.95  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  50 GFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAVG 129
Cdd:cd17315   30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL-APNVWVLIVGRFLLGLGVGLASVLV 108

                         90
                 ....*....|
gi 491387137 130 GSWVKELSSA 139
Cdd:cd17315  109 PLYISEIAPA 118
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 49-140 5.72e-06

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 48.12  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  49 HGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAV 128
Cdd:cd17362   34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGL-APSYPVLLVGRLIYGVGIGLAMHA 112

                         90
                 ....*....|..
gi 491387137 129 GGSWVKELSSAP 140
Cdd:cd17362  113 APVYIAETSPSH 124
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
7-379 5.87e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.95  E-value: 5.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   7 SPMEVPEALASPRAWLLVAATMFAVAWGGNEFT---PLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGR 83
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITsvgPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  84 RPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKElsSAPWDPAATEGVgarrAAMSLTGGFG 163
Cdd:COG2807   83 ERTLLLALLLLAAGLLLRSL-APSVALLLAGTALIGAGIAVGNVLLPGLIKR--WFPDRVGLMTGL----YTAAMGLGAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 164 LGAGVAGVLAQWAPLPSVLSYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLAIPSAAHkrflfviapLAPWVFG 243
Cdd:COG2807  156 LAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWL---------LTLFFGL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 244 TAAAAYAV---LPSL-----MSGNTGGLplaFSALMCMVGLGAGFAIQALGRKIDTPRnaravvVSLVVVLAGMGVAAVA 315
Cdd:COG2807  227 QSLLYYAVvawLPPIlrdagLSAATAGL---LLSLFQLAGIPGSLLVPLLADRLGDRR------PLLLLLGLLGLAGLLG 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137 316 ASALTVPLALAAAVVLGCGYGMAMVSGLQEIQRIAGPDDLAG-LTAVFYSLTYLGFGT-PAVMAYL 379
Cdd:COG2807  298 LLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAaLSGMAQSVGYLLAALgPLLVGAL 363
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 19-182 5.99e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 47.94  E-value: 5.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  19 RAWLLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGS 98
Cdd:cd17478  195 RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  99 ALLALGadSAAMLIVGRVLCGIALGLGMAVGGSWVKELssapwdpaATEGVGarrAAMSLTGGFGLGAG-----VAGVLA 173
Cdd:cd17478  275 LLFLLT--PGIWSYILLVLAGFLLFASFPVTVVLAQEL--------LPGNVG---LASGLMMGLSFGLGgigapVLGALA 341


                 ....*....
gi 491387137 174 QWAPLPSVL 182
Cdd:cd17478  342 DAFGLESVL 350
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-128 6.75e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 6.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   2 TVVRESPMEVPEALASPRAWLLvAATMFAVAWGGNEFTPLLGMY-RADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDR 80
Cdd:COG2223  189 AAAKASLRDQLEALRDPRFWLL-SLLYFGTFGSFIGFSSWLPPYlVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR 267

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491387137  81 LGRRPILLPAPFLTIAGSALLALGADSAAMLIVGRVLCGIALGLGMAV 128
Cdd:COG2223  268 IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 21-176 1.01e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  21 WLLVAATMFAVAwGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSAL 100
Cdd:cd17474    2 YAVFFATLLAVL-GVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137 101 LALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLtgGFGLGAGVAGVLAQWA 176
Cdd:cd17474   81 CGL-SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFE---GGERAKAMGLYEAALGL--GIAVGPLLGGLLAAIS 150
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 72-183 1.06e-05

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 47.26  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  72 LLGGPLSDRLGRRPILLPAPFLTIAGSAL--LALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGV 149
Cdd:cd17357   67 FISAFLANRFGRKNGLLISNALLVVSSLLmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEIS-----PSELRGA 141

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491387137 150 GARRAAMSLTGGFglgagvagVLAQWAPLPSVLS 183
Cdd:cd17357  142 LGSLTQIGVTLGI--------LLGQVFGLPSVLG 167
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 72-137 1.19e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.18  E-value: 1.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137  72 LLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELS 137
Cdd:cd17358   59 LLSGKLADRIGRKRTLLISAIPCILGWLLIAF-AKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIA 123
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 21-395 1.45e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  21 WLLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFL-TIAGSA 99
Cdd:cd17473    2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLyGIGGVA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 100 llALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLTGGFGLGAGvaGVLAQWAPLP 179
Cdd:cd17473   82 --GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFE---GEERAKMLGLQSAAMSLGGVVFLLLG--GALAEIGWRA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 180 SVLSYVVHSAIAVAAAVALWRAPETRAAQPVSERVSLARDLaipsaahkrfLFVIAPLAPWVFGTAAAAYAV---LPSLM 256
Cdd:cd17473  155 PFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALP----------WKRVLPIYFLAFLAMLLFYVIpiqLPFLL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 257 SGNTGGLPLAFS---ALMCMVGLGAGFAIQALGRKIDTPRnaravvVSLVVVLAGMGVAAVAASALTVPLALAAAVVLGC 333
Cdd:cd17473  225 QERGGGSAALIGlalAIASLAGAIGALLFGRLKRRLGKRR------LLAIGFALMALGFLLLALASGLWVVLLGAILAGL 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491387137 334 GYGMAMVSGLQEIQRIAGPDDLAGLTAVFYSLTYLG-FGTPAVMAYLSETFPAVTYPRMFVFG 395
Cdd:cd17473  299 GFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqFLSPLVLGPLVNLTGGLSGAFLILGV 361
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 47-176 1.67e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.58  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   47 ADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGM 126
Cdd:TIGR00895  45 AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAL-ATNVTQLLILRFLAGLGLGGLM 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 491387137  127 AVGGSWVKELSSAPWdpaategvgaRRAAMSLTG-GFGLGAGVAGVLAQWA 176
Cdd:TIGR00895 124 PNLNALVSEYAPKRF----------RGTAVGLMFcGYPIGAAVGGFLAGWL 164
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-172 2.77e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.01  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  19 RAWLLVAATMFAVAWGGNEFTPLLGMYRadHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGS 98
Cdd:cd17321  171 SGAVLAAFLLGAALGGLLFLLPLYLQGV--LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137  99 ALLAL--GADSAAMLIVGRVLCGIalGLGMAVGGSWVKELSSApwdPAATEGVGARRAAMSLTGGFGLGAGVAGVL 172
Cdd:cd17321  249 LLLALlgADSSVWLLLPGLVLLGL--GLGLFATPLTNAALSSV---PKEKAGAASGILNTARQLGGALGVALLGAL 319
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 48-125 2.94e-05

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 46.09  E-value: 2.94e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491387137  48 DHGFSPVTVDLFLFAyvvgiVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLAlGADSAAMLIVGRVLCGIALGLG 125
Cdd:cd17361   50 DQLLQLFTSSLYLAG-----LVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNA-AAQNIAMLIVGRILLGFGVGFG 121
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 10-182 3.45e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.62  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  10 EVPEALASPRAWLLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLP 89
Cdd:cd17324  190 SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  90 APFLTIAGSALLALGADSAAMlIVGRVLCGIALGLGMAVGGSWVKELSSApwdpaategvgARRAAMSLTG-----GFGL 164
Cdd:cd17324  270 LLLLAAALLLLTLLGPSPLLL-LVGLVLWGLGFFAAHSALQTRVLRLAPE-----------ARGLASSLYLaaynlGGAL 337

                        170
                 ....*....|....*...
gi 491387137 165 GAGVAGVLAQWAPLPSVL 182
Cdd:cd17324  338 GAALGGLVLDHGGWAGVG 355
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 21-174 6.25e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 6.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  21 WLLVAATMFAVAwGGNEFTPLLGMYRADH-GFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSA 99
Cdd:cd17329    2 WVLLIGSFLNRL-GFFMVWPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491387137 100 LLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLtgGFGLGAGVAGVLAQ 174
Cdd:cd17329   81 LLGF-AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT---PENRTRAFSLLYWAINL--GVAIGPLLGGLLLL 149
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 58-139 1.18e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 44.25  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   58 LFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLAL--GADSAAMLIVGRVLCGIALGLGMAVGGSWVKE 135
Cdd:TIGR00879  75 LVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLaaFALSVEMLIVGRVLLGIGVGIASALVPMYLSE 154


                  ....
gi 491387137  136 LSSA 139
Cdd:TIGR00879 155 IAPK 158
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 20-175 1.53e-04

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 43.39  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   20 AWLLVAATMFAVAWGgnEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSA 99
Cdd:pfam12832 204 IIFFLAAFLLGFSHG--PFYTFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWL 281

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491387137  100 LLALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdPAATEGVG-ARRAAMSLTGGFGLGAGVAGVLAQW 175
Cdd:pfam12832 282 LYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIF-----PGSLQGTGqALYSGLYFGLGGALGSLIGGQLWDL 353
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 62-124 1.64e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.77  E-value: 1.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491387137  62 AYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSaLLALGADSAAMLIVGRVLCGIALGL 124
Cdd:cd06179   40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS-IVAGTAKSVNMLIGGQALIGIGAGT 101
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 5-139 2.19e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   5 RESPMEVPEALASPRAWLLVAATMFAVAwgGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRR 84
Cdd:cd17370  187 RKKSKKTSLKKLPKAFWLYLLAVALFAL--GNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRK 264

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491387137  85 PiLLPAPFLTIAGSALLALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSA 139
Cdd:cd17370  265 K-LLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
47-129 2.48e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 43.00  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  47 ADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAgSALLALGADSAAMLIVGRVLCGIALGLGM 126
Cdd:PRK15402  41 EDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFIL-TCLAILLAQSIEQFTLLRFLQGIGLCFIG 119


                 ...
gi 491387137 127 AVG 129
Cdd:PRK15402 120 AVG 122
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 64-137 2.66e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.01  E-value: 2.66e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491387137  64 VVGIVPA-----LLLGGPLSDRLGRRPILLPAPFLTIAGSALLALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELS 137
Cdd:cd17356   50 IVSIVNLgsffgALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVA 128
MFS_1 pfam07690
Major Facilitator Superfamily;
13-163 2.76e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137   13 EALASPRAWLLVAATMFAVAWGGneFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPF 92
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFG--LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491387137   93 LTIAGSALLALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSAPWDPAATeGVGARRAAMSLTGGFG 163
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGT-ASGLYNTAGSLGGALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
22-173 3.06e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLGMY-RADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSAL 100
Cdd:COG2271  183 WLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALAL 262

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491387137 101 LALG-ADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSsapwdpaateGVGARRAAMSLTGGFGLGAGVAGVLA 173
Cdd:COG2271  263 LLLAlLPSPALAIALLFLAGFGLGGAFGLLWALAAELF----------PKKARGTASGLVNTFGFLGGALGPLL 326
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 46-176 3.11e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.55  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  46 RADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLG 125
Cdd:cd17321   23 ARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL-APSLAFLIAARALQGIGAAAI 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137 126 MAVGGSWVKELSSApwdpaategvGARRAAMSLTG-----GFGLGAGVAGVLAQWA 176
Cdd:cd17321  102 MPASLALIAATFPG----------ERRGRALGLWGavvgiGAALGPLLGGLLLELF 147
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 40-175 3.56e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 3.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  40 PLLGMYRADHGFSPVTVDLFLFAYvvGIVPalLLGGP----LSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGR 115
Cdd:cd17390   17 PLLSTHIRSLGASPTVIGLIGSVY--GALQ--LFSSPlvgsWSDVVGRRPVLLICLLLTALGYVLLGF-STSLALLFLSR 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 116 VLCGIaLGLGMAVGGSWVKELSSapwDPAATEGVGARRAAMSLtgGFGLGAGVAGVLAQW 175
Cdd:cd17390   92 IPLGI-FKHTQSLCKAYLSDLVS---EQERSRVLGRFNAASSL--GFILGPVVGGHLAET 145
emrD PRK11652
multidrug transporter EmrD;
75-130 7.65e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 41.43  E-value: 7.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137  75 GPLSDRLGRRPILLPAPFLTIAGsALLALGADSAAMLIVGRVLcgiaLGLGMAVGG 130
Cdd:PRK11652  64 GPLSDRVGRRPVILVGMSIFILG-TLVALFAHSLTVLIAASAI----QGLGTGVGG 114
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 54-128 8.28e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 41.45  E-value: 8.28e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491387137  54 VTVDLFLFAYVVGIvpalLLGGPLSDRLGRRPILLPAPFLTIAGSALLALG--ADSAAMLIVGRVLCGIALGLGMAV 128
Cdd:cd17432   54 LTVSIFPLGGLFGS----LLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSkiAKSFEMIIVGRFLVGINAGISLNV 126
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-176 9.01e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.38  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  19 RAWLLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGS 98
Cdd:COG0738    8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491387137  99 ALLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELssapwdpaateGVGARRAAMSLTGGF-GLGAGVAGVLAQWA 176
Cdd:COG0738   88 LLFAL-APSYPLLLLALFLLGLGLGLLDVAANPYVAAL-----------GPETAASRLNLLHAFfSLGALLGPLLGGLL 154
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 62-120 9.61e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.01  E-value: 9.61e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491387137  62 AYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGI 120
Cdd:cd17502   38 AYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL-APNMTMLIVGRAIQGI 95
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 22-136 1.18e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGNEFTPLLgmYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALL 101
Cdd:cd17316  183 ILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491387137 102 A-LGADSAAMLIVGRVLCGIALGLGMAVGGSWVKEL 136
Cdd:cd17316  261 FyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
47-123 2.20e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.00  E-value: 2.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491387137  47 ADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALGADSAAMLIvGRVLCGIALG 123
Cdd:PRK10473  31 ADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLA-GRFLQGIGAG 106
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 38-178 2.44e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  38 FTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVL 117
Cdd:cd17330   18 VLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL-SRNLWLLFLARFL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491387137 118 CGIaLGLGMAVGGSWVKELSSAPWDPAATEGVGArraamSLTGGFGLGAGVAGVLAQWAPL 178
Cdd:cd17330   97 DGL-TGGNVSVAQAYIADITDEEERAKAFGIISA-----AFGLGFILGPALGGFLSTPYGY 151
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
40-115 2.51e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.88  E-value: 2.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137  40 PLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGR 115
Cdd:PRK11043  27 PAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLW-VESAAQLLVLR 101
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 72-139 2.81e-03

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 39.69  E-value: 2.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491387137  72 LLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSA 139
Cdd:cd17437   50 LAAGRTSDWIGRRYTIALAALIFFVGALLMGV-APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPA 116
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 22-183 4.03e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  22 LLVAATMFAVAWGGneFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLpAPFLTIAGSALL 101
Cdd:cd17477    1 LLLSVALLGLGSGL--LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFA-AGAAITAVSVLL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137 102 ALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELssapwdpaATEGVGARRAA---MSLTGGFGLGAGVAGVLAQWAPL 178
Cdd:cd17477   78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL--------ATNENRGRVLGlysTVLGLGFALGPLLLALVGTAGAL 149


                 ....*
gi 491387137 179 PSVLS 183
Cdd:cd17477  150 PFLIA 154
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 63-175 6.57e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 38.55  E-value: 6.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  63 YVVGIVPALLLGGPLSDRLGRRPILLPApFLTIAGSALLALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKElssapWD 142
Cdd:cd17446   42 YMAGVLVGAIVFGGLSDRFGRRPLLIWS-YLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVE-----WM 115

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491387137 143 PAATEGVGARRAAMSLTGGFGLGAGVAGVLAQW 175
Cdd:cd17446  116 PTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDW 148
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 11-146 7.08e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 7.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  11 VPEALASPRAWLLVAATMFAVAWGGNEFTPLLGMYRADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPA 90
Cdd:cd06174  196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI 275

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491387137  91 PFLTIAGSALLALGADSAAMLIVGRVLCGIALGLGMAVGGSWVKELSSAPWDPAAT 146
Cdd:cd06174  276 GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 75-136 7.63e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 38.35  E-value: 7.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491387137  75 GPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIalGLGMAVGGSWVKEL 136
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAY-ATSIYGLILGRALQGS--GAISSVVMALLADL 111
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-129 7.73e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.30  E-value: 7.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  13 EALASPRAWLLVAATMFAVA--WGGNEFTPLLGMyrADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPA 90
Cdd:COG0738  205 SLLKNPRLLLGGLAIFLYVGaeGAIGDWLPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLS 282

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491387137  91 PFLTIAGSALLALGADSAAMLIvgrvlCGIALGLGMAVG 129
Cdd:COG0738  283 ALLAAVGLLLALLAPGPWLALI-----GLALVGLGLSLM 316
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 46-126 8.48e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 38.02  E-value: 8.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491387137  46 RADHGFSPVTVDLFLFAYVVGIVPALLLGGPLSDRLGRRPILLPAPFLTIAGSALLALgADSAAMLIVGRVLCGIALGLG 125
Cdd:PRK11551  42 AQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQ-AWDFPSLLVARLLTGVGLGGA 120


                 .
gi 491387137 126 M 126
Cdd:PRK11551 121 L 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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