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Conserved domains on  [gi|491327000|ref|WP_005184962|]
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sensor histidine kinase [Yersinia intermedia]

Protein Classification

sensor histidine kinase( domain architecture ID 11485193)

two-component system sensor histidine kinase with a PAS sensor and/or ligand binding domain functions as a protein kinase that phosphorylates a target protein in response to various signals, similar to Escherichia coli sensor histidine kinase DcuS and Bacillus subtilis sensor histidine kinase MalK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-535 0e+00

sensory histidine kinase DcuS; Provisional


:

Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 934.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   1 MNNATTAAKQKVPLRLSTTITLMVSGVIVSVLLVVHTLFFIQLSQMAQDSLQNKAVAVARALSFSPTIINGLSDPAAGQQ 80
Cdd:PRK11086   1 RHSLPYMKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  81 IQAYVSEVQKANGLLFIVVTDIKGIRYSHPNPEMIGQHFIGNDLLPALAGKENIAINRGVLERALRIFIPVYEPHGKQIG 160
Cdd:PRK11086  81 IQTYAEAVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 161 VVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDTN 240
Cdd:PRK11086 161 VVAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 241 SRITVVNHEARRLFKQSGPMENLLLSNASKYWPVRLYLQQVLETGIARRDEEINFNGSILLTNTVPVIVKGDIIGAIATF 320
Cdd:PRK11086 241 GEVTLINDEAKRLFNYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 321 RDKTEVSQLMQRLTGMVHYADALRAQSHEFMNKLHVILGLLHMKYYQQLEDYIVKTSNNYQAEIGSLLRKVKSPVIAGFL 400
Cdd:PRK11086 321 RDKTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 401 LGKINRARDLGITLSISDDSLLPDTDNEQVTTTLITVLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIA 480
Cdd:PRK11086 401 LGKISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIA 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491327000 481 SELQSRIFDNGFSTKGTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPY 535
Cdd:PRK11086 481 PDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPW 535
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-535 0e+00

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 934.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   1 MNNATTAAKQKVPLRLSTTITLMVSGVIVSVLLVVHTLFFIQLSQMAQDSLQNKAVAVARALSFSPTIINGLSDPAAGQQ 80
Cdd:PRK11086   1 RHSLPYMKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  81 IQAYVSEVQKANGLLFIVVTDIKGIRYSHPNPEMIGQHFIGNDLLPALAGKENIAINRGVLERALRIFIPVYEPHGKQIG 160
Cdd:PRK11086  81 IQTYAEAVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 161 VVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDTN 240
Cdd:PRK11086 161 VVAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 241 SRITVVNHEARRLFKQSGPMENLLLSNASKYWPVRLYLQQVLETGIARRDEEINFNGSILLTNTVPVIVKGDIIGAIATF 320
Cdd:PRK11086 241 GEVTLINDEAKRLFNYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 321 RDKTEVSQLMQRLTGMVHYADALRAQSHEFMNKLHVILGLLHMKYYQQLEDYIVKTSNNYQAEIGSLLRKVKSPVIAGFL 400
Cdd:PRK11086 321 RDKTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 401 LGKINRARDLGITLSISDDSLLPDTDNEQVTTTLITVLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIA 480
Cdd:PRK11086 401 LGKISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIA 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491327000 481 SELQSRIFDNGFSTKGTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPY 535
Cdd:PRK11086 481 PDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPW 535
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 159-536 7.06e-113

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 340.67  E-value: 7.06e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 159 IGVVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEP-YEISNLFEQRNAMLQSIKEGVIAV 237
Cdd:COG3290   21 LLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLlEEIARLVEEREAVLESIREGVIAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 238 DTNSRITVVNHEARRLFKQSGPMEnlllsnaskywPVRLYLQQVLETGiaRRDEEINFNGSILLTNTVPVIVKGDIIGAI 317
Cdd:COG3290  101 DRDGRITLINDAARRLLGLDAIGR-----------PIDEVLAEVLETG--ERDEEILLNGRVLVVNRVPIRDDGRVVGAV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 318 ATFRDKTEVSQLMQRLTGMVHYADALRAQSHEFMNKLHVILGLLHMKYYQQLEDYIVKTSNNYQAEIGSLLRKVKSPVIA 397
Cdd:COG3290  168 ATFRDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 398 GFLLGKINRARDLGITLSISDDSLLPDTdnEQVTTTLITVLGNLIENAMDAIGNL--SQREINVSFHYQNGRVHCVVSDD 475
Cdd:COG3290  248 ALLLGKAARARERGIDLTIDIDSDLPDL--PLSDTDLVTILGNLLDNAIEAVEKLpeEERRVELSIRDDGDELVIEVEDS 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491327000 476 GPGIASELQSRIFDNGFSTK-GTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPYN 536
Cdd:COG3290  326 GPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 3.66e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 113.54  E-value: 3.66e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQ--REINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGT-EHGIGLSLVRQSL 510
Cdd:cd16915    1 LITIVGNLIDNALDALAATGApnKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 491327000 511 ESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 42-177 3.54e-22

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 92.47  E-value: 3.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   42 QLSQMAQDSLQNKAVAVARALSFSPTIINGLSDPAAGQQIQAYVSEVQKANGLLFIVVTDIKGIRYSHPNPEMIGQHFIG 121
Cdd:pfam17203   1 QLRADLTRQLERRALALARSVAASPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491327000  122 NDLLPAL-AGKENIAINRGVLERALRIFIPVYEPHGKQIGVVAIGISLTSIDSVVSE 177
Cdd:pfam17203  81 PATAPALtAGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQDSITAALRE 137
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 434-535 1.41e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 86.93  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   434 LITVLGNLIENAMDAIGnlSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGTE-----HGIGLSLVRQ 508
Cdd:smart00387   6 LRQVLSNLLDNAIKYTP--EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiggTGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*..
gi 491327000   509 SLESIGGNIEFDSEAGVFTQFFINLPY 535
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLPL 110
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 221-333 3.41e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 46.52  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  221 EQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSGpmENLLLSNASKYWP------VRLYLQQVLETGIARRDEEIN 294
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSA--EELIGRNVLELIPeedreeVRERIERRLEGEPEPVSEERR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 491327000  295 F---NGSI--LLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRL 333
Cdd:TIGR00229  81 VrrkDGSEiwVEVSVSPIRTNGGELGVVGIVRDITERKEAEEAL 124
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-535 0e+00

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 934.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   1 MNNATTAAKQKVPLRLSTTITLMVSGVIVSVLLVVHTLFFIQLSQMAQDSLQNKAVAVARALSFSPTIINGLSDPAAGQQ 80
Cdd:PRK11086   1 RHSLPYMKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  81 IQAYVSEVQKANGLLFIVVTDIKGIRYSHPNPEMIGQHFIGNDLLPALAGKENIAINRGVLERALRIFIPVYEPHGKQIG 160
Cdd:PRK11086  81 IQTYAEAVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 161 VVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDTN 240
Cdd:PRK11086 161 VVAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 241 SRITVVNHEARRLFKQSGPMENLLLSNASKYWPVRLYLQQVLETGIARRDEEINFNGSILLTNTVPVIVKGDIIGAIATF 320
Cdd:PRK11086 241 GEVTLINDEAKRLFNYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATF 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 321 RDKTEVSQLMQRLTGMVHYADALRAQSHEFMNKLHVILGLLHMKYYQQLEDYIVKTSNNYQAEIGSLLRKVKSPVIAGFL 400
Cdd:PRK11086 321 RDKTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 401 LGKINRARDLGITLSISDDSLLPDTDNEQVTTTLITVLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIA 480
Cdd:PRK11086 401 LGKISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIA 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491327000 481 SELQSRIFDNGFSTKGTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPY 535
Cdd:PRK11086 481 PDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPW 535
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 159-536 7.06e-113

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 340.67  E-value: 7.06e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 159 IGVVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEP-YEISNLFEQRNAMLQSIKEGVIAV 237
Cdd:COG3290   21 LLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLlEEIARLVEEREAVLESIREGVIAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 238 DTNSRITVVNHEARRLFKQSGPMEnlllsnaskywPVRLYLQQVLETGiaRRDEEINFNGSILLTNTVPVIVKGDIIGAI 317
Cdd:COG3290  101 DRDGRITLINDAARRLLGLDAIGR-----------PIDEVLAEVLETG--ERDEEILLNGRVLVVNRVPIRDDGRVVGAV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 318 ATFRDKTEVSQLMQRLTGMVHYADALRAQSHEFMNKLHVILGLLHMKYYQQLEDYIVKTSNNYQAEIGSLLRKVKSPVIA 397
Cdd:COG3290  168 ATFRDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 398 GFLLGKINRARDLGITLSISDDSLLPDTdnEQVTTTLITVLGNLIENAMDAIGNL--SQREINVSFHYQNGRVHCVVSDD 475
Cdd:COG3290  248 ALLLGKAARARERGIDLTIDIDSDLPDL--PLSDTDLVTILGNLLDNAIEAVEKLpeEERRVELSIRDDGDELVIEVEDS 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491327000 476 GPGIASELQSRIFDNGFSTK-GTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPYN 536
Cdd:COG3290  326 GPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 13-534 1.36e-65

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 222.40  E-value: 1.36e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  13 PLRLSTTItLMVSGVIVSVLLVVHTLFFIQ-LSQMAQDSLQNKAVAVARALSfsptIINGLSDPAAgQQIQAYVSEVQKA 91
Cdd:PRK15053  19 PLRIFLLI-LVFSIFVIAALAQYFSASFEDyLTLHVRDMAMNQAKIIASNDS----VISAVKTRDY-KRLATIANKLQRD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  92 NGLLFIVVTDIKGIRYSHPNPEMIGQHFIGNDLLPALAGKENIAINRGVLERALRIFIPVYEPHGKQIGVVAIGISLTSI 171
Cdd:PRK15053  93 TDFDYVVIGDRHSIRLYHPNPEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 172 DSVVSEtrWTIPWTILFGALIGSLG--TWFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDTNSRITVVNHE 249
Cdd:PRK15053 173 DSWRLE--FLLPMAGVFVVLLGILMllSWFFAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRN 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 250 ARRLFKQSGPMENLLLSNASKYW-PVRLYLQQVLETgiaRRDEEINFNGSILLTNTVPVIVKGDIIGAIATFRDKTEVSQ 328
Cdd:PRK15053 251 ARKMLGLSSPGRQWLGKPIAEVVrPADFFTEQIDEK---RQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEIST 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 329 LMQRLTGMVHYADALRAQSHEFMNKLHVILGLLHMKYYQQLEDYIVKTSNNYQAEIGSLLRKVKSPVIAGFLLGKINRAR 408
Cdd:PRK15053 328 LNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRAR 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 409 DLGITLSISDDSLLPDTDNEQVTTTLITVLGNLIENAMDAigNLSQRE----INVSFHYQNGRVHCVVSDDGPGIASELQ 484
Cdd:PRK15053 408 ELGLKMVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEA--SLRSDEgnkiVELFLSDEGDDVVIEVADQGCGVPESLR 485

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491327000 485 SRIFDNGFSTKGT---EHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:PRK15053 486 DKIFEQGVSTRADepgEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 225-540 2.52e-34

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 134.32  E-value: 2.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 225 AMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSG-PMENLLLSNASKYWPVRLYLQQVLETGIARRDEEINFNGSILLTN 303
Cdd:COG5000   94 TILENLPAGVIVLDADGRITLANPAAERLLGIPLeELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRRTLLVR 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 304 TVPVIVKGDIIgaiaTFRDKTEVSQlMQRLTGMvhyADALRAQSHEFMNKLHVI---LGLLHMKYYQQLEDY-------- 372
Cdd:COG5000  174 ASPLRDDGYVI----VFDDITELLR-AERLAAW---GELARRIAHEIKNPLTPIqlsAERLRRKLADKLEEDredleral 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 373 --IVKTS-------NNY------------QAEIGSLLRKVKspviagFLLGKINRARDLGITLSISDDSLLPDTDNEQvt 431
Cdd:COG5000  246 dtIIRQVdrlkrivDEFldfarlpepqlePVDLNELLREVL------ALYEPALKEKDIRLELDLDPDLPEVLADRDQ-- 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 432 ttLITVLGNLIENAMDAIGNlsQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTK--GTehGIGLSLVRQS 509
Cdd:COG5000  318 --LEQVLINLLKNAIEAIEE--GGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKpkGT--GLGLAIVKKI 391

                        330       340       350
                 ....*....|....*....|....*....|.
gi 491327000 510 LESIGGNIEFDSEAGVFTQFFINLPYNISAV 540
Cdd:COG5000  392 VEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
145-540 1.34e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 125.85  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 145 LRIFIPVYEpHGKQIGVVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIM---------------- 208
Cdd:PRK11360 156 LNSMIPIER-NGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANVdiikdglstlendlst 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 209 ----LGFEPYEISN--------LFEQRN---AMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSG------PMENLLLSN 267
Cdd:PRK11360 235 rlppLPGELGEISQainnlaqaLRETRSlneLILESIADGVIAIDRQGKITTMNPAAEVITGLQRhelvgkPYSELFPPN 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 268 AskywPVRLYLQQVLETGIARRDEEINFNGS----ILLTNTVPVI-VKGDIIGAIATFRDKTEVSQLMQRltgmVHYADA 342
Cdd:PRK11360 315 T----PFASPLLDTLEHGTEHVDLEISFPGRdrtiELSVSTSLLHnTHGEMIGALVIFSDLTERKRLQRR----VARQER 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 343 LRAQ-------SHEFMNKLHVILGllhmkYYQQLEDYIVKTSnnYQAEIGSLLRKVKS--PVIAGFL-LGKINRAR---- 408
Cdd:PRK11360 387 LAALgelvagvAHEIRNPLTAIRG-----YVQIWRQQTSDPP--SQEYLSVVLREVDRlnKVIDQLLeFSRPRESQwqpv 459

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 409 ------------------DLGITLSISDDSLLPD--TDNEQVTTtlitVLGNLIENAMDAIGNLSQREINVSfHYQNGRV 468
Cdd:PRK11360 460 slnalveevlqlfqtagvQARVDFETELDNELPPiwADPELLKQ----VLLNILINAVQAISARGKIRIRTW-QYSDGQV 534

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491327000 469 HCVVSDDGPGIASELQSRIFDNGFSTKGTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPYNISAV 540
Cdd:PRK11360 535 AVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 3.66e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 113.54  E-value: 3.66e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQ--REINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGT-EHGIGLSLVRQSL 510
Cdd:cd16915    1 LITIVGNLIDNALDALAATGApnKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 491327000 511 ESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
215-534 6.13e-28

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 114.94  E-value: 6.13e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 215 EISNLFEQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSG------PMENLLLSNAskywPVRLYLQQVLETGIAR 288
Cdd:COG3852    1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAeellgrPLAELFPEDS----PLRELLERALAEGQPV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 289 RDEEINF---NGS--ILLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRLtgmvHYADALRAQS-------HEFMNKLHV 356
Cdd:COG3852   77 TEREVTLrrkDGEerPVDVSVSPLRDAEGEGGVLLVLRDITERKRLEREL----RRAEKLAAVGelaaglaHEIRNPLTG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 357 ILG---LLHMK--------YYQ--------------QLEDYIVKTSNNYQA-EIGSLLRKVKSPVIAGFllgkinrARDL 410
Cdd:COG3852  153 IRGaaqLLERElpddelreYTQliieeadrlnnlvdRLLSFSRPRPPEREPvNLHEVLERVLELLRAEA-------PKNI 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 411 GITLSISDDslLPDT--DNEQvtttLITVLGNLIENAMDAIGN-----LS---QREINVSFHYQNGRVHCVVSDDGPGIA 480
Cdd:COG3852  226 RIVRDYDPS--LPEVlgDPDQ----LIQVLLNLVRNAAEAMPEggtitIRtrvERQVTLGGLRPRLYVRIEVIDNGPGIP 299

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 491327000 481 SELQSRIFDNGFSTKGTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG3852  300 EEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 437-534 1.13e-22

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 99.49  E-value: 1.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTK----GTehGIGLSLVRQSLES 512
Cdd:COG4191  260 VLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKpvgkGT--GLGLSISYGIVEK 337

                         90       100
                 ....*....|....*....|..
gi 491327000 513 IGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG4191  338 HGGRIEVESEPGGGTTFTITLP 359
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 42-177 3.54e-22

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 92.47  E-value: 3.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   42 QLSQMAQDSLQNKAVAVARALSFSPTIINGLSDPAAGQQIQAYVSEVQKANGLLFIVVTDIKGIRYSHPNPEMIGQHFIG 121
Cdd:pfam17203   1 QLRADLTRQLERRALALARSVAASPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491327000  122 NDLLPAL-AGKENIAINRGVLERALRIFIPVYEPHGKQIGVVAIGISLTSIDSVVSE 177
Cdd:pfam17203  81 PATAPALtAGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQDSITAALRE 137
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
406-534 1.30e-20

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 93.05  E-value: 1.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 406 RARDLGITLSISDDSLLPDTDNEQvtttLITVLGNLIENAMDAIGnlSQREINVSFHYQNGRVHCVVSDDGPGIASELQS 485
Cdd:COG0642  200 EEKGIELELDLPDDLPTVRGDPDR----LRQVLLNLLSNAIKYTP--EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLE 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491327000 486 RIFDNGFSTKGTE----HGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG0642  274 RIFEPFFRTDPSRrgggTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 434-535 1.41e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 86.93  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   434 LITVLGNLIENAMDAIGnlSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGTE-----HGIGLSLVRQ 508
Cdd:smart00387   6 LRQVLSNLLDNAIKYTP--EGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiggTGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*..
gi 491327000   509 SLESIGGNIEFDSEAGVFTQFFINLPY 535
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLPL 110
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
340-534 9.96e-19

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 85.34  E-value: 9.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 340 ADALRAQ-----SHEFMNKLHVILGLLHM-------------KYYQQLE---DYIVKTSNN----YQAEIGSL-LRKVK- 392
Cdd:COG2205   12 LERLKSEflanvSHELRTPLTSILGAAELlldeedlspeerrELLEIIResaERLLRLIEDlldlSRLESGKLsLELEPv 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 393 --SPVIAGFL--LGKINRARDLGITLSISDDSLLPDTDNEQvtttLITVLGNLIENAMDAigNLSQREINVSFHYQNGRV 468
Cdd:COG2205   92 dlAELLEEAVeeLRPLAEEKGIRLELDLPPELPLVYADPEL----LEQVLANLLDNAIKY--SPPGGTITISARREGDGV 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491327000 469 HCVVSDDGPGIASELQSRIFD------NGFSTKGTehGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG2205  166 RISVSDNGPGIPEEELERIFErfyrgdNSRGEGGT--GLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 434-534 4.79e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 79.72  E-value: 4.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  434 LITVLGNLIENAMDAIGNLSQREINVSfhyQNGRVHCVVSDDGPGIASELQSRIFDNGFS---TKGTEHGIGLSLVRQSL 510
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 491327000  511 ESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
175-534 4.25e-17

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 83.45  E-value: 4.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 175 VSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLF 254
Cdd:COG5002    7 LLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 255 KQSGPMENLLLSNASKYWPVRLYLQQVLETGIARRDEEINFNGSILLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRLT 334
Cdd:COG5002   87 ALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRR 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 335 GMVhyADAlraqSHEFMNKLHVILGLLHMkyyqqLEDYIVKTSNNYQAEIGSLLRKV----------------------- 391
Cdd:COG5002  167 EFV--ANV----SHELRTPLTSIRGYLEL-----LLDGAADDPEERREYLEIILEEAerlsrlvndlldlsrlesgelkl 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 392 -KSPV-IAGFLLGKINRARDLG------ITLSISDDSLLPDTDNEQvtttLITVLGNLIENAMDAIGnlSQREINVSFHY 463
Cdd:COG5002  236 eKEPVdLAELLEEVVEELRPLAeekgieLELDLPEDPLLVLGDPDR----LEQVLTNLLDNAIKYTP--EGGTITVSLRE 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491327000 464 QNGRVHCVVSDDGPGIASELQSRIFD--------NGFSTKGTehGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG5002  310 EDDQVRISVRDTGIGIPEEDLPRIFErfyrvdksRSRETGGT--GLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 214-333 1.36e-16

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 82.13  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 214 YEISNLFEQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQsgPMENLLLSNASKYWPvRLYLQQVLETGIARRDEEI 293
Cdd:COG3829    4 LELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGL--PREEVIGKNVTELIP-NSPLLEVLKTGKPVTGVIQ 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491327000 294 NFNGSI--LLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRL 333
Cdd:COG3829   81 KTGGKGktVIVTAIPIFEDGEVIGAVETFRDITELKRLERKL 122
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 401-524 2.49e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 75.75  E-value: 2.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 401 LGKINRARDLGITLSISDDSLLPDTDNEqvtttLITVLGNLIENAmdaiGNLSQREINVSFHYQNGRVHCVVSDDGPGIA 480
Cdd:cd16954   10 LNKVYQRKGVSISLDISPELRFPGERND-----LMELLGNLLDNA----CKWCLEFVEVTARQTDGGLHLIVDDDGPGVP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 491327000 481 SELQSRIFDNGfsTKGTE----HGIGLSLVRQSLESIGGNIEF-DSEAG 524
Cdd:cd16954   81 ESQRSKIFQRG--QRLDEqrpgQGLGLAIAKEIVEQYGGELSLsDSPLG 127
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-533 4.78e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 73.65  E-value: 4.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTK--GTEHGIGLSLVRQSLE 511
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVE 80

                         90       100
                 ....*....|....*....|..
gi 491327000 512 SIGGNIEFDSEAGVFTQFFINL 533
Cdd:cd16976   81 EHGGRLSVANEEGAGARFTFDL 102
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 232-539 2.34e-14

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 75.40  E-value: 2.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 232 EGVIAVDTNSRITVVNHEARRLF--KQSGPMENLLLSNASKYWP--VRLYLQQVLETGIARrDEEINF---NGS--ILLT 302
Cdd:COG5809  152 DGIIVTDLDGRIIYANPAACKLLgiSIEELIGKSILELIHSDDQenVAAFISQLLKDGGIA-QGEVRFwtkDGRwrLLEA 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 303 NTVPVIVKGDIIGAIATFRDKTEVSQLMQRLTgmvhYADALRAQ-------SHEFMNKLHVILGLLHMKYYQQLEDY--- 372
Cdd:COG5809  231 SGAPIKKNGEVDGIVIIFRDITERKKLEELLR----KSEKLSVVgelaagiAHEIRNPLTSLKGFIQLLKDTIDEEQkty 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 373 --------------------IVKTSNnYQAEIGSLLRKVKSpVIAgFLLGKINRaRDLGITLSISDDslLPDT--DNEQV 430
Cdd:COG5809  307 ldimlseldriesiiseflvLAKPQA-IKYEPKDLNTLIEE-VIP-LLQPQALL-KNVQIELELEDD--IPDIlgDENQL 380

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 431 TTTLITVLGNLIEnAMDAIGNLSqreINVSFHYQNGrVHCVVSDDGPGIASELQSRIFDNGFSTK--GTehGIGLSLVRQ 508
Cdd:COG5809  381 KQVFINLLKNAIE-AMPEGGNIT---IETKAEDDDK-VVISVTDEGCGIPEERLKKLGEPFYTTKekGT--GLGLMVSYK 453

                        330       340       350
                 ....*....|....*....|....*....|.
gi 491327000 509 SLESIGGNIEFDSEAGVFTQFFINLPYNISA 539
Cdd:COG5809  454 IIEEHGGKITVESEVGKGTTFSITLPIKLSE 484
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
434-537 4.61e-14

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 74.44  E-value: 4.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGnlSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGTEHGIGLSLVRQSLESI 513
Cdd:PRK10364 349 LTQVLLNLYLNAIQAIG--QHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQH 426

                         90       100
                 ....*....|....*....|....
gi 491327000 514 GGNIEFDSEAGVFTQFFINLPYNI 537
Cdd:PRK10364 427 GGTIQVASQEGKGATFTLWLPVNI 450
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 1.15e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 67.06  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQREINVSFHYQngRVHCVVSDDGPGIASELQSRIFDNGFSTK--GTEHGIGLSLVRQSLE 511
Cdd:cd16943    4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVD--QVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRIIQ 81

                         90       100
                 ....*....|....*....|...
gi 491327000 512 SIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16943   82 KHGGTIRVASVPGGGTRFTIILP 104
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 395-528 1.47e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 67.60  E-value: 1.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 395 VIAGFLLGKINRARDLGI--TLSISDDSLLPDTDNEqvtttLITVLGNLIENAMDAIGNLS--QREINVSFHYQNGRV-- 468
Cdd:cd16935    1 ALDSLLSEKLELAREKGIefTIEIDIPILLPISPLD-----LCIIFGNLLDNAIEACAKIDkeNRFIHLKIRQKKGFLii 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491327000 469 HCVVSDDGPgiaselQSRIFDNGFSTKG-TEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQ 528
Cdd:cd16935   76 SIENSYEGE------LKKKNGLFLSTKKdKNHGIGLKSIREIVKKYNGNLSIEYENGIFTL 130
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 4.51e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 65.50  E-value: 4.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNlSQREINVSFHYQNG--------RVHCVVS--DDGPGIASELQSRIFDNGFSTKGTEHGIGL 503
Cdd:cd16918    1 LIQVFLNLVRNAAQALAG-SGGEIILRTRTQRQvtlghprhRLALRVSviDNGPGIPPDLQDTIFYPMVSGRENGTGLGL 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491327000 504 SLVRQSLESIGGNIEFDSEAGvFTQFFINLP 534
Cdd:cd16918   80 AIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-534 9.07e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 64.34  E-value: 9.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMDAI--GNLSQREINVSFHYQNGR-VHCVVSDDGPGIASELQSRIFDNGFSTKGTEHGIGLSLVRQSLESI 513
Cdd:cd16920    4 VLINLVRNGIEAMseGGCERRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAH 83

                         90       100
                 ....*....|....*....|.
gi 491327000 514 GGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16920   84 GGRLSVESPAGGGATFQFTLP 104
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 221-534 1.05e-12

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 70.15  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 221 EQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFkqSGPMENLLLSNASKYWP------VRLYLQQVLETGIAR--RDEE 292
Cdd:COG5805  157 ERLQTLIENSPDLICVIDTDGRILFINESIERLF--GAPREELIGKNLLELLHpcdkeeFKERIESITEVWQEFiiEREI 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 293 INFNGSILLTNT--VPVI-VKGDIIGAIATFRD---KTEVSQLMQRLTgMVHYADALRAQ-SHEFMNKLHVILGLLHM-- 363
Cdd:COG5805  235 ITKDGRIRYFEAviVPLIdTDGSVKGILVILRDiteKKEAEELMARSE-KLSIAGQLAAGiAHEIRNPLTSIKGFLQLlq 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 364 -------KYYQQLEDYIVK--------------TSNNYQAE-IGSLLRKVKSpviagfLLGKINRARDLGITLSISDDSL 421
Cdd:COG5805  314 pgiedkeEYFDIMLSELDRiesiiseflalakpQAVNKEKEnINELIQDVVT------LLETEAILHNIQIRLELLDEDP 387

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 422 LPDTDNEQVTTTLItvlgNLIENAMDAIGNlsQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTK--GTeh 499
Cdd:COG5805  388 FIYCDENQIKQVFI----NLIKNAIEAMPN--GGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKekGT-- 459

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 491327000 500 GIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG5805  460 GLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 134-534 1.72e-12

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 69.81  E-value: 1.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 134 IAINRGVLERALRIFIPVYEPHGKQIGVVAIGISLTSIDSVVSETRWTIPWTILFGALIGSLGTWFLVKALKRIMLGFEP 213
Cdd:COG4251   69 LLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALA 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 214 YEISNLFEQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSGPMENLLLSNASKYWPVRLYLQQVLETGIARRDEEI 293
Cdd:COG4251  149 LLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLL 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 294 NFNGSILLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRLTgmvHYADALRAQ-----------SHEFMNKLHVILG--- 359
Cdd:COG4251  229 LLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELE---ERTAELERSneeleqfayvaSHDLREPLRKISGfsq 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 360 LLHMKYYQQLED-------YIVKTSNNYQAEIGSLLR--------KVKSPVIAGFLLGKI-----NRARDLGITLSISDd 419
Cdd:COG4251  306 LLEEDYGDKLDEegreyleRIRDAAERMQALIDDLLAysrvgrqeLEFEPVDLNELLEEVledlePRIEERGAEIEVGP- 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 420 slLP--DTDNEQvtttLITVLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFD------NG 491
Cdd:COG4251  385 --LPtvRGDPTL----LRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEifqrlhSR 458

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 491327000 492 FSTKGTehGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG4251  459 DEYEGT--GIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 434-528 9.90e-12

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 61.46  E-value: 9.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  434 LITVLGNLIENAMDAIGNL-SQREINVSFHYQNGRV--HCVVSDDGpgiaselQSRIFDNGFSTK--GTEHGIGLSLVRQ 508
Cdd:pfam14501   6 LCVIFGNLLDNAIEACSKIdDNRFIRLKIREKQNFLiiRIENTYEG-------ELKFEGKLPSTKtkGDGHGIGLKSIRR 78

                          90       100
                  ....*....|....*....|
gi 491327000  509 SLESIGGNIEFDSEAGVFTQ 528
Cdd:pfam14501  79 IVKKYGGNLSTEIENGIFTL 98
PRK09303 PRK09303
histidine kinase;
401-534 1.86e-11

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 65.74  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 401 LGKINRARDLGITLSISDDslLPDT--DNEQVTTtlitVLGNLIENAMDAIGNlsQREINVS-FHYQNGRVHCVVSDDGP 477
Cdd:PRK09303 244 LEKRWLAKSLEIQTDIPSD--LPSVyaDQERIRQ----VLLNLLDNAIKYTPE--GGTITLSmLHRTTQKVQVSICDTGP 315

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491327000 478 GIASELQSRIFDNGFSTK---GTE-HGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:PRK09303 316 GIPEEEQERIFEDRVRLPrdeGTEgYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 441-534 5.99e-10

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 58.36  E-value: 5.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 441 LIENAMD----------AIGNLSQREINVSFHYQNGRVHCVVSDDGPGIA------------------------SELQSR 486
Cdd:cd16916   46 LLRNAVDhgieapeerlAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDrekirekaierglitadeaatlsdDEVLNL 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491327000 487 IFDNGFSTKG--TE---HGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16916  126 IFAPGFSTAEqvTDvsgRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 436-534 2.04e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 55.46  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 436 TVLGNLIENAMDAIGNLSQREINVS---------FHYQN---GRVHCV-VSDDGPGIASELQSRIFDNGFSTK--GTEHG 500
Cdd:cd16919    3 LAILNLAVNARDAMPEGGRLTIETSnqrvdadyaLNYRDlipGNYVCLeVSDTGSGMPAEVLRRAFEPFFTTKevGKGTG 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491327000 501 IGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16919   83 LGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
PRK13557 PRK13557
histidine kinase; Provisional
 408-527 4.89e-09

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 58.91  E-value: 4.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 408 RDLGITLSISDDsLLPDTDNEQVTTTLITV-LGNLIENAMDAI---GNLSQREINVSFHYQN---------GRVHCV-VS 473
Cdd:PRK13557 252 RTLGDAVTIETD-LAPDLWNCRIDPTQAEVaLLNVLINARDAMpegGRVTIRTRNVEIEDEDlamyhglppGRYVSIaVT 330

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491327000 474 DDGPGIASELQSRIFDNGFSTK----GTehGIGLSLV----RQSlesiGGNIEFDSEAGVFT 527
Cdd:PRK13557 331 DTGSGMPPEILARVMDPFFTTKeegkGT--GLGLSMVygfaKQS----GGAVRIYSEVGEGT 386
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 437-534 6.28e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 53.65  E-value: 6.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMD--AIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIF------DNGFSTK--GTehGIGLSLV 506
Cdd:cd16922    4 ILLNLLGNAIKftEEGEVTLRVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFepfsqaDSSTTRKygGT--GLGLAIS 81

                         90       100
                 ....*....|....*....|....*...
gi 491327000 507 RQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16922   82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 438-525 8.47e-09

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 57.93  E-value: 8.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 438 LGNLIENAMDaignLSQR--EINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFST-------KGTehGIGLSLVRQ 508
Cdd:PRK11100 373 LGNLLDNAID----FSPEggTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLprpangrKST--GLGLAFVRE 446

                         90
                 ....*....|....*....
gi 491327000 509 SLESIGGNIEFDS--EAGV 525
Cdd:PRK11100 447 VARLHGGEVTLRNrpEGGV 465
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 341-534 9.08e-09

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 57.99  E-value: 9.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 341 DALRAQSHEFMNKLHVIlGLLHMKYYQqledyivkTSNNYQAEIGSLLRKVKSPVIAGFLLGKINrardlgITLSISDDS 420
Cdd:COG3920  327 PEAREALEESQNRIQAL-ALVHELLYQ--------SEDWEGVDLRDYLRELLEPLRDSYGGRGIR------IELDGPDVE 391

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 421 LLPDTdneqvTTTLITVLGNLIENAMD-AIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELqsrifdngfsTKGTEH 499
Cdd:COG3920  392 LPADA-----AVPLGLILNELVTNALKhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDV----------DPPARK 456

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 491327000 500 GIGLSLVRQSLESIGGNIEFDSEAGvfTQFFINLP 534
Cdd:COG3920  457 GLGLRLIRALVRQLGGTLELDRPEG--TRVRITFP 489
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-524 1.46e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 52.43  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMdaigNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIF------DNGFSTKGTEHGIGLSLVRQSL 510
Cdd:cd16939    4 ALDNLLRNAL----RYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFepfvrlDPSRDRATGGFGLGLAIVHRVA 79

                         90
                 ....*....|....*
gi 491327000 511 ESIGGNIEF-DSEAG 524
Cdd:cd16939   80 LWHGGHVECdDSELG 94
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 1.49e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 52.67  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQREINvSFHyQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGTEH-----GIGLSLVRQ 508
Cdd:cd16948    6 LSFIIGQIVSNALKYSKQGGKIEIY-SET-NEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfqestGMGLYLVKK 83

                         90       100
                 ....*....|....*....|....*.
gi 491327000 509 SLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16948   84 LCDKLGHKIDVESEVGEGTTFTITFP 109
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
457-534 1.65e-08

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 57.11  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 457 INVSFHYQNGRVHCVVSDDGPGI------------------------ASELQSRIFDNGFSTKG--TEH---GIGLSLVR 507
Cdd:COG0643  311 ITLSAYHEGGRVVIEVSDDGRGLdlekirakaiekglitaeeaaalsDEELLELIFAPGFSTAEevTDLsgrGVGMDVVK 390

                         90       100
                 ....*....|....*....|....*..
gi 491327000 508 QSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG0643  391 TNIEALGGTIEIESEPGKGTTFTLRLP 417
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
437-536 2.36e-08

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 56.56  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMD-AIGNL-SQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFdNGFSTKGTEHGIGLSLVRQSLESIG 514
Cdd:COG2972  340 ILQPLVENAIEhGIEPKeGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLL-EELSSKGEGRGIGLRNVRERLKLYY 418

                         90       100
                 ....*....|....*....|....*
gi 491327000 515 GN---IEFDSEAGVFTQFFINLPYN 536
Cdd:COG2972  419 GEeygLEIESEPGEGTTVTIRIPLE 443
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 4.73e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 51.42  E-value: 4.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQReINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTK------GTEHGIGLSLVR 507
Cdd:cd16953    1 LGQVLRNLIGNAISFSPPDTGR-ITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneafGQHSGLGLSISR 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491327000 508 QSLESIGGNI--EFDSEAGVFT--QFFINLP 534
Cdd:cd16953   80 QIIEAHGGISvaENHNQPGQVIgaRFTVQLP 110
PRK10490 PRK10490
sensor protein KdpD; Provisional
 412-534 5.40e-08

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 55.81  E-value: 5.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 412 ITLSISDDSLLPDTDNeqvttTLIT-VLGNLIENAMDAIGnlSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDN 490
Cdd:PRK10490 761 INLSLPEPLTLIHVDG-----PLFErVLINLLENAVKYAG--AQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK 833

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 491327000 491 gFSTKGTEH-----GIGLSLVRQSLESIGGNI--EFDSEAGVftQFFINLP 534
Cdd:PRK10490 834 -FARGNKESaipgvGLGLAICRAIVEVHGGTIwaENRPEGGA--CFRVTLP 881
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-524 5.40e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 50.91  E-value: 5.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMDaIGNLsqrEINVSFHYQNGRVHCVVSDDGPGIASELQSRIF------DNGFSTKGTehGIGLSLVRQSL 510
Cdd:cd16950    4 VLSNLVDNALR-YGGG---WVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFqpfyrgDNARGTSGT--GLGLAIVQRIS 77

                         90
                 ....*....|....
gi 491327000 511 ESIGGNIEFDSEAG 524
Cdd:cd16950   78 DAHGGSLTLANRAG 91
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
437-534 6.19e-08

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 55.45  E-value: 6.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMDAIGNLSQREINVSFHY---QNGRVHCV----------VSDDGPGIASELQSRIFDNGFSTKGTEHGIGL 503
Cdd:PRK13837 564 VLMNLCSNAAQAMDGAGRVDISLSRAKlraPKVLSHGVlppgryvllrVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGL 643

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491327000 504 SLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:PRK13837 644 ATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 407-543 7.70e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 55.33  E-value: 7.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 407 ARDLGITLSISDDSLLPD---TDNeqvtTTLITVLGNLIENAMdaigNLSQR-EINVSFHYQNG-RVHCVVSDDGPGIAS 481
Cdd:PRK11091 373 AEQKGLRFDLEPLLPLPHkviTDG----TRLRQILWNLISNAV----KFTQQgGVTVRVRYEEGdMLTFEVEDSGIGIPE 444

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491327000 482 ELQSRIFDNGF---STKGTEH----GIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLPYNISAVNHD 543
Cdd:PRK11091 445 DELDKIFAMYYqvkDSHGGKPatgtGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVE 513
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
329-534 1.07e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 53.08  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 329 LMQRLTGMVHYADALRAQSHEFMNKLHVILgllhmkyyqqleDYIVKTSNNYQAEIGSLLRKVKSPVIAGF--------L 400
Cdd:COG4585   65 VGQSLSAIKLQLEAARRLLDADPEAAREEL------------EEIRELAREALAELRRLVRGLRPPALDDLglaaaleeL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 401 LGKINRARDLGITLSISDDsllPDTDNEQVTTTLITVLGNLIENAM---DAignlsqREINVSFHYQNGRVHCVVSDDGP 477
Cdd:COG4585  133 AERLLRAAGIRVELDVDGD---PDRLPPEVELALYRIVQEALTNALkhaGA------TRVTVTLEVDDGELTLTVRDDGV 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491327000 478 GIASElqsrifdngfstKGTEHGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:COG4585  204 GFDPE------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-517 4.74e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 48.09  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 440 NLIENAMdaigNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIF------DNGFSTKGTEHGIGLSLVRQSLESI 513
Cdd:cd16949    7 NVLRNAL----RYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFlpfyrvDSARDRESGGTGLGLAIAERAIEQH 82


                 ....
gi 491327000 514 GGNI 517
Cdd:cd16949   83 GGKI 86
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 221-322 6.85e-07

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 48.18  E-value: 6.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  221 EQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQS-----GPMENLLLSNASKYWPVRLyLQQVLETGIARRDEEINF 295
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSreeviGKSLLDLIPEEDDAEVAEL-LRQALLQGEESRGFEVSF 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 491327000  296 ---NGSI--LLTNTVPVI-VKGDIIGAIATFRD 322
Cdd:pfam00989  80 rvpDGRPrhVEVRASPVRdAGGEILGFLGVLRD 112
SPOB_a pfam14689
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ...
 341-373 8.02e-07

Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.


Pssm-ID: 434130 [Multi-domain]  Cd Length: 62  Bit Score: 46.47  E-value: 8.02e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 491327000  341 DALRAQSHEFMNKLHVILGLLHMKYYQQLEDYI 373
Cdd:pfam14689  14 KALRHQRHDFLNHLQVISGYLQLGRYDRAEEYI 46
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 437-534 9.41e-07

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 47.49  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMDAIGNLSQREINVSFhYQNGRVHCVVSDDGPGIASELQSRIF--------DNGFSTKGTehGIGLSLVRQ 508
Cdd:cd16925    8 VVLNLLSNAFKFTPDGGRIRCILEK-FRLNRFLLTVSDSGPGIPPNLREEIFerfrqgdgSSTRAHGGT--GLGLSIVKE 84

                         90       100
                 ....*....|....*....|....*.
gi 491327000 509 SLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16925   85 FVELHGGTVTVSDAPGGGALFQVELP 110
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 438-519 1.74e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 47.02  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 438 LGNLIENAMDAIGNLSQREINVSfhyqnGRVHCV--VSDDGPGIASELQSRIFD-----NGFSTKGTehGIGLSLVRQSL 510
Cdd:cd16940   18 LRNLVDNAVRYSPQGSRVEIKLS-----ADDGAVirVEDNGPGIDEEELEALFErfyrsDGQNYGGS--GLGLSIVKRIV 90


                 ....*....
gi 491327000 511 ESIGGNIEF 519
Cdd:cd16940   91 ELHGGQIFL 99
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 221-333 3.41e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 46.52  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  221 EQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSGpmENLLLSNASKYWP------VRLYLQQVLETGIARRDEEIN 294
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSA--EELIGRNVLELIPeedreeVRERIERRLEGEPEPVSEERR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 491327000  295 F---NGSI--LLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRL 333
Cdd:TIGR00229  81 VrrkDGSEiwVEVSVSPIRTNGGELGVVGIVRDITERKEAEEAL 124
glnL PRK11073
nitrogen regulation protein NR(II);
226-534 3.41e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 49.31  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 226 MLQSIKEGVIAVDTNSRITVVNHEARRLFKQSG------PMENLLlsnasKYWPVRL-YLQQVLETGIARRDEEINF--- 295
Cdd:PRK11073  12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSrklfgtPLPELL-----SYFSLNIeLMRESLQAGQGFTDNEVTLvid 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 296 NGSILLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRLTGMVHYADALRAQSHEFMNKLHVILG----LLHMKYYQQLED 371
Cdd:PRK11073  87 GRSHILSLTAQRLPEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGaaqlLSKALPDPALTE 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 372 Y---IVKTSNNYQAEIGSLL------RKVKSPVIAgfLLGKINRARDL----GITLSISDDSLLPD--TDNEQVTTTLIt 436
Cdd:PRK11073 167 YtkvIIEQADRLRNLVDRLLgpqrpgTHVTESIHK--VAERVVQLVSLelpdNVRLIRDYDPSLPElaHDPDQIEQVLL- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 vlgNLIENAMDAI----GNLSQR---EINVSFHYQNGRV--HCVVSDDGPGIASELQSRIFDNGFSTKGTEHGIGLSLVR 507
Cdd:PRK11073 244 ---NIVRNALQALgpegGTITLRtrtAFQLTLHGERYRLaaRIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIAR 320

                        330       340
                 ....*....|....*....|....*..
gi 491327000 508 QSLESIGGNIEFDSEAGvFTQFFINLP 534
Cdd:PRK11073 321 NLIDQHSGKIEFTSWPG-HTEFSVYLP 346
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-524 3.60e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 45.99  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 431 TTTLITVLGNLIENAMDAIGNLSQREINVSFHY---QNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGTEHGIGLSLVR 507
Cdd:cd16944    2 TTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVeadQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVK 81

                         90
                 ....*....|....*...
gi 491327000 508 QSLESIGGNIEF-DSEAG 524
Cdd:cd16944   82 KIMEEHGGRISLsNREAG 99
PRK15347 PRK15347
two component system sensor kinase;
405-536 1.24e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 48.10  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 405 NRARDLGITLS--ISDD-SLLPDTDNEQVTTTLITVLGNlienamdAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIAS 481
Cdd:PRK15347 486 GPAQSKSLTLRtfVGAHvPLYLHLDSLRLRQILVNLLGN-------AVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDI 558

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491327000 482 ELQSRIFDNGFSTKGTEHGIGLSL-VRQSLES-IGGNIEFDSEAGVFTQFFINLPYN 536
Cdd:PRK15347 559 QQQQQIFTPFYQADTHSQGTGLGLtIASSLAKmMGGELTLFSTPGVGSCFSLVLPLN 615
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 227-328 1.38e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 44.33  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  227 LQSIKEGVIAVDTNSRITVVNHEARRLFKQSGpmENLLLSNASKYWP------VRLYLQQVLETG-IARRDEEINFNGS- 298
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPP--EELLGKTLAELLPpedaarLERALRRALEGEePIDFLEELLLNGEe 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 491327000  299 -ILLTNTVPVI-VKGDIIGAIATFRDKTEVSQ 328
Cdd:pfam08448  79 rHYELRLTPLRdPDGEVIGVLVISRDITERRR 110
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-534 1.55e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 43.85  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 434 LITVLGNLIENAMDAIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIF------DNGFSTKGTehGIGLSLVR 507
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFgifqrlHSREEYEGT--GVGLAIVR 78

                         90       100
                 ....*....|....*....|....*..
gi 491327000 508 QSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16921   79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
PRK10604 PRK10604
sensor protein RstB; Provisional
 437-521 2.35e-05

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 46.91  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMdaigNLSQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFD--------NGFSTKGteHGIGLSLVRQ 508
Cdd:PRK10604 323 VLDNLLNNAL----RYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEpfvrldpsRDRATGG--CGLGLAIVHS 396

                         90
                 ....*....|...
gi 491327000 509 SLESIGGNIEFDS 521
Cdd:PRK10604 397 IALAMGGSVNCDE 409
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
367-524 2.52e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 46.93  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 367 QQLEDYIVKTSnnYQAEIGSLLRKVKSpvIAGFL------LGKINRARDLGITLSISDDSLLPDTDNEqvtttLITVLGN 440
Cdd:PRK10815 315 QQIGYYLHRAS--MRSEHNLLSRELHS--VAPLLdnltsaLNKVYQRKGVNITLDISPEITFVGEKND-----FMEVMGN 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 441 LIENAMDAIgnLSQREINVsfHYQNGRVHCVVSDDGPGIASELQSRIFDNG--FSTKGTEHGIGLSLVRQSLESIGGNIE 518
Cdd:PRK10815 386 VLDNACKYC--LEFVEISA--RQTDEHLHIVVEDDGPGIPESKRELIFDRGqrADTLRPGQGLGLSVAREITEQYEGKIS 461


                 ....*..
gi 491327000 519 F-DSEAG 524
Cdd:PRK10815 462 AgDSPLG 468
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 361-517 3.25e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 46.60  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 361 LHMKYYQQLEDYIVKTSNnyQAE-----IGSL---LRKVKSPVIAGFLLGKIN--------RARDLGITLSISDDSLLP- 423
Cdd:COG4192  462 LEQENYAQLPTSLDKIEG--LIErmdkiIKSLrqfSRKSDTPLQPVDLRQVIEqawelvesRAKPQQITLHIPDDLMVQg 539

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 424 -DTDNEQVtttlitvLGNLIENAMDAIGnlSQREINVSFHYQNGRVHCVVSDDGPGIAseLQSRIFDNGFSTKGTEHGIG 502
Cdd:COG4192  540 dQVLLEQV-------LVNLLVNALDAVA--TQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLG 608

                        170
                 ....*....|....*
gi 491327000 503 LSLVRQSLESIGGNI 517
Cdd:COG4192  609 LSICRSIMQQFGGDL 623
envZ PRK09467
osmolarity sensor protein; Provisional
 437-507 8.01e-05

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 45.29  E-value: 8.01e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491327000 437 VLGNLIENAMdAIGNlsqREINVSFHYQNGRVHCVVSDDGPGIASELQSRIF------DNGFSTKGTehGIGLSLVR 507
Cdd:PRK09467 335 ALANLVVNAA-RYGN---GWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFqpftrgDSARGSSGT--GLGLAIVK 405
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-533 1.38e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 41.73  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 437 VLGNLIENAMDAIGNlsQREINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFSTKGTEH------GIGLSLVRQSL 510
Cdd:cd16947   24 ILKNLISNAIKYGSD--GKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqgnGLGLTITKRLA 101

                         90       100
                 ....*....|....*....|...
gi 491327000 511 ESIGGNIEFDSEAGVFTQFFINL 533
Cdd:cd16947  102 ESMGGSIYVNSKPYEKTVFTVTL 124
PAS COG2202
PAS domain [Signal transduction mechanisms];
215-333 2.37e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 43.09  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 215 EISNLFEQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSgpMENLLLSNASKYWP------VRLYLQQVLETGIAR 288
Cdd:COG2202    5 ALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYS--AEELLGKTLRDLLPpedddeFLELLRAALAGGGVW 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491327000 289 RDEEINF--NGSI--LLTNTVPVI-VKGDIIGAIATFRDKTEVSQLMQRL 333
Cdd:COG2202   83 RGELRNRrkDGSLfwVELSISPVRdEDGEITGFVGIARDITERKRAEEAL 132
PAS COG2202
PAS domain [Signal transduction mechanisms];
221-333 4.37e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 42.32  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 221 EQR-NAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSgPMENLLLSNASKYWP-----VRLYLQQVLETGIARRDEEI- 293
Cdd:COG2202  136 EERlRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYS-PEELLGKSLLDLLHPedrerLLELLRRLLEGGRESYELELr 214

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491327000 294 ----NFNGSILLTNTVPVIVKGDIIGAIATFRDKTEVSQLMQRL 333
Cdd:COG2202  215 lkdgDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
428-508 8.41e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.51  E-value: 8.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 428 EQVTTTLITVLGNLIENAMD-AIGNLSQREINVSFHYQNGRVHCVVSDDGPGIASELqsriFDNGFSTKGtEHGIGLSLV 506
Cdd:COG2172   29 EDDADDLVLAVSEAVTNAVRhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPED----LPDPYSTLA-EGGRGLFLI 103


                 ..
gi 491327000 507 RQ 508
Cdd:COG2172  104 RR 105
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 455-534 1.55e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.92  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 455 REINVSFHYQNGRVHCVVSDDGPGIASELQSRIFdngfstkgtehGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:cd16917   19 SRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGG-----------GFGLLGMRERAELLGGTLTIGSRPGGGTRVTARLP 87
PRK10547 PRK10547
chemotaxis protein CheA; Provisional
 442-534 1.57e-03

chemotaxis protein CheA; Provisional


Pssm-ID: 236712 [Multi-domain]  Cd Length: 670  Bit Score: 41.25  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 442 IENAMDAIGNLSqreinVSFHYQNGRVHCVVSDDGPG-----IASELQSR----------------IFDNGFST--KGTE 498
Cdd:PRK10547 409 LAAGKNSVGNLI-----LSAEHQGGNICIEVTDDGAGlnrerILAKAASQglavsenmsdeevgmlIFAPGFSTaeQVTD 483

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491327000 499 ---HGIGLSLVRQSLESIGGNIEFDSEAGVFTQFFINLP 534
Cdd:PRK10547 484 vsgRGVGMDVVKRNIQEMGGHVEIQSKQGKGTTIRILLP 522
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 42-179 1.73e-03

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 40.40  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000   42 QLSQMAQ--DSLQNKAVAVARALSFSPTIINGLSDPAAGQQIQAYvSEVQKANGLLFIVVTDIKG--IRYSHPNPEMIGQ 117
Cdd:pfam02743  14 LAKQLAEniESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLE-SLLRSNPGISSIYLVDADGrvLASSDESPSYPGL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  118 HFIGNDLLPAL--AGKENIAINRGVL------ERALRIFIPVYEPHGKQIGVVAIGISLTSIDSVVSETR 179
Cdd:pfam02743  93 DVSERPWYKEAlkGGGGIIWVFSSPYpssesgEPVLTIARPIYDDDGEVIGVLVADLDLDTLQELLSQIK 162
PAS_10 pfam13596
PAS domain; This is a sensor domain that recognizes O2, CO and NO (Matilla et. al., FEMS ...
 224-322 1.84e-03

PAS domain; This is a sensor domain that recognizes O2, CO and NO (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 404482 [Multi-domain]  Cd Length: 106  Bit Score: 37.94  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000  224 NAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQSG-----PMENllLSNASKYWPVRLYLQQVLETGIARRDEEINFNGS 298
Cdd:pfam13596   2 NNLLNSTPIETTFLDENLRIRRFTPAATRLFNLIPgdvgrPLAD--IHPPLIVPNVEEIIDALRTGETDEVEVVVPKDGR 79

                          90       100
                  ....*....|....*....|....*
gi 491327000  299 ILLTNTVPVI-VKGDIIGAIATFRD 322
Cdd:pfam13596  80 WYLVRYLPYRdEDGVIDGVVETFVD 104
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 438-518 1.86e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 38.21  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491327000 438 LGNLIENAMD---AIGnlsqrEINVSFHYQNGRVHCVVSDDGPGIASELQSRIFDNGFS-----TKGTEHGIGLSLVRQS 509
Cdd:cd16945    9 INNLLDNAIDfspEGG-----LIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEV 83


                 ....*....
gi 491327000 510 LESIGGNIE 518
Cdd:cd16945   84 AQLHGGRIT 92
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 221-257 3.01e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 36.22  E-value: 3.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 491327000   221 EQRNAMLQSIKEGVIAVDTNSRITVVNHEARRLFKQS 257
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYS 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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