|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
1-269 |
6.78e-116 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 333.23 E-value: 6.78e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 1 MKKILTLVAVFVLTIALAACGKGD-----SEDKTIKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKG 75
Cdd:COG1464 1 MKKLLALLLALALALALAACGSSSaaaaaADKKTIKVGATPGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEALADG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 76 ELDANYFQHTPYLKTESKEKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKK 155
Cdd:COG1464 81 EIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 156 GVKIeDAKFSDIVENKKNIKFNNKQsAEFLPKIYqnQDVDAAIINSNYAIDQKLSPKKDSIVLEKAtNNPYANLIAVRKG 235
Cdd:COG1464 161 GVGL-LATVKDITENPKNLKFVELD-AAQLPRSL--DDVDAAVINGNYALEAGLDPTKDALFLEDK-DSPYANIIVVRED 235
|
250 260 270
....*....|....*....|....*....|....
gi 488390266 236 HKDDKKIKALIEVLQSKEIKDFINKKYDGAVVPA 269
Cdd:COG1464 236 DKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPA 269
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
29-268 |
2.54e-100 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 292.64 E-value: 2.54e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLE 108
Cdd:cd13597 1 TLKVGATPVPHAEILEFIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 109 PMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIeDAKFSDIVENKKNIKFNNKQSAEfLPKI 188
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGL-TATVKDIVKNPKNLKFKELEAAQ-LPRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 189 YqnQDVDAAIINSNYAIDQKLSPKKDSIVLEKATNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINKKYDGAVVP 268
Cdd:cd13597 159 L--DDVDAAVINGNYALEAGLNPKKDALALEDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
30-269 |
2.88e-92 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 272.22 E-value: 2.88e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 30 IKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLEP 109
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 110 MAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGvKIEDAKFSDIVEnKKNIKFNNKQSAEFLPKIY 189
Cdd:pfam03180 81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDG-KGLLATVKDITE-NPKNLKIKELEAAQLPRAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 190 qnQDVDAAIINSNYAIDQKLSPKKDSIVLEkATNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINKKYDGAVVPA 269
Cdd:pfam03180 159 --DDVDAAVINTNYALEAGLNPKKDALFEE-DKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
3-267 |
2.57e-53 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 174.18 E-value: 2.57e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 3 KILTLVAVFVLTIALAACGKGDSEDKTIKVGASPAPHAEILEKAKPLL-EKKGYDLKIQSINDYTTPNKLLDKGELDANY 81
Cdd:PRK11063 6 KTFAAVGALIGTLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAkEKYGLDVELVTFNDYVLPNEALSKGDIDANA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 82 FQHTPYLKTESKEKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEd 161
Cdd:PRK11063 86 FQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVGLL- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 162 AKFSDIVENKKNIKFNNKQSAEfLPKIYQNQDVDAAIINSNYAIDQKLSPKKDSIVLEKaTNNPYANLIAVRKGHKDDKK 241
Cdd:PRK11063 165 PTVLDIVENPKNLKIVELEAPQ-LPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVED-KDSPYVNLIVAREDNKDAEN 242
|
250 260
....*....|....*....|....*.
gi 488390266 242 IKALIEVLQSKEIKDFINKKYDGAVV 267
Cdd:PRK11063 243 VKKFVQAYQSDEVYEAANKVFNGGAV 268
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
15-268 |
1.41e-49 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 163.92 E-value: 1.41e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 15 IALAACGKGDSEDKTIKVGASPAPHAEILEKAKPLL-EKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESK 93
Cdd:TIGR00363 5 LVLTGCKQDKKDPLHIKVGVISGAEQQVAEVAAKVAkEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 94 EKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEDAKFsDIVENKKN 173
Cdd:TIGR00363 85 AKGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLPTVL-DIVENPKK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 174 IKFNNKQSAEfLPKIYQNQDVDAAIINSNYAIDQKLSPKKDSIVLEKaTNNPYANLIAVRKGHKDDKKIKALIEVLQSKE 253
Cdd:TIGR00363 164 LNITELETSQ-LPRALDDPKVDLAVINTTYAGQVGLNPQDDGVFVED-KDSPYVNIIVSREDNKDAENVKDFIQSYQSEE 241
|
250
....*....|....*
gi 488390266 254 IKDFINKKYDGAVVP 268
Cdd:TIGR00363 242 VYQAAQKHFNGGAVK 256
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
1-269 |
6.78e-116 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 333.23 E-value: 6.78e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 1 MKKILTLVAVFVLTIALAACGKGD-----SEDKTIKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKG 75
Cdd:COG1464 1 MKKLLALLLALALALALAACGSSSaaaaaADKKTIKVGATPGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEALADG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 76 ELDANYFQHTPYLKTESKEKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKK 155
Cdd:COG1464 81 EIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 156 GVKIeDAKFSDIVENKKNIKFNNKQsAEFLPKIYqnQDVDAAIINSNYAIDQKLSPKKDSIVLEKAtNNPYANLIAVRKG 235
Cdd:COG1464 161 GVGL-LATVKDITENPKNLKFVELD-AAQLPRSL--DDVDAAVINGNYALEAGLDPTKDALFLEDK-DSPYANIIVVRED 235
|
250 260 270
....*....|....*....|....*....|....
gi 488390266 236 HKDDKKIKALIEVLQSKEIKDFINKKYDGAVVPA 269
Cdd:COG1464 236 DKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPA 269
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
29-268 |
2.54e-100 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 292.64 E-value: 2.54e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLE 108
Cdd:cd13597 1 TLKVGATPVPHAEILEFIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 109 PMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIeDAKFSDIVENKKNIKFNNKQSAEfLPKI 188
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGL-TATVKDIVKNPKNLKFKELEAAQ-LPRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 189 YqnQDVDAAIINSNYAIDQKLSPKKDSIVLEKATNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINKKYDGAVVP 268
Cdd:cd13597 159 L--DDVDAAVINGNYALEAGLNPKKDALALEDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
30-269 |
2.88e-92 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 272.22 E-value: 2.88e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 30 IKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLEP 109
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 110 MAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGvKIEDAKFSDIVEnKKNIKFNNKQSAEFLPKIY 189
Cdd:pfam03180 81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDG-KGLLATVKDITE-NPKNLKIKELEAAQLPRAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 190 qnQDVDAAIINSNYAIDQKLSPKKDSIVLEkATNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINKKYDGAVVPA 269
Cdd:pfam03180 159 --DDVDAAVINTNYALEAGLNPKKDALFEE-DKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235
|
|
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
29-260 |
4.02e-70 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 215.64 E-value: 4.02e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLE 108
Cdd:cd13526 1 KLKIGVTAGPSADVVEAAKKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 109 PMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEDAKFsDIVENKKNIKFNNKQSAEfLPKI 188
Cdd:cd13526 81 PIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLFATVL-DITENPKNLEIVEVDAAQ-LPRS 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488390266 189 YqnQDVDAAIINSNYAIDQKLSPKKDSIVLEKATNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINK 260
Cdd:cd13526 159 L--DDVDAAVINGNYAISAGLDPRKDAIFLEDSDASPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
30-260 |
1.25e-68 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 211.82 E-value: 1.25e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 30 IKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLEP 109
Cdd:cd13598 2 IKVGVIRGPDAQIWEVVQKVAKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVYP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 110 MAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIeDAKFSDIVENKKNIKFNNKQSAEfLPKIY 189
Cdd:cd13598 82 IGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGVGL-LATVRDIAENPKKLKIVELDAGQ-LPRAL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488390266 190 qnQDVDAAIINSNYAIDQKLSPKKDSIVLEKAtNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINK 260
Cdd:cd13598 160 --DDVDLAAINTDYASKAGLTPARDAIAQEDK-RSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
3-267 |
2.57e-53 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 174.18 E-value: 2.57e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 3 KILTLVAVFVLTIALAACGKGDSEDKTIKVGASPAPHAEILEKAKPLL-EKKGYDLKIQSINDYTTPNKLLDKGELDANY 81
Cdd:PRK11063 6 KTFAAVGALIGTLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAkEKYGLDVELVTFNDYVLPNEALSKGDIDANA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 82 FQHTPYLKTESKEKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEd 161
Cdd:PRK11063 86 FQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVGLL- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 162 AKFSDIVENKKNIKFNNKQSAEfLPKIYQNQDVDAAIINSNYAIDQKLSPKKDSIVLEKaTNNPYANLIAVRKGHKDDKK 241
Cdd:PRK11063 165 PTVLDIVENPKNLKIVELEAPQ-LPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVED-KDSPYVNLIVAREDNKDAEN 242
|
250 260
....*....|....*....|....*.
gi 488390266 242 IKALIEVLQSKEIKDFINKKYDGAVV 267
Cdd:PRK11063 243 VKKFVQAYQSDEVYEAANKVFNGGAV 268
|
|
| PBP2_lipoprotein_like_1 |
cd13600 |
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ... |
29-260 |
3.01e-50 |
|
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270318 Cd Length: 228 Bit Score: 164.82 E-value: 3.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGASPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLE 108
Cdd:cd13600 1 TLKVATNSGPMTEILEYIAAELAPDGITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPIYHW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 109 PMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEDAKFSDIVENKKNIKFNNKQSAEfLPKI 188
Cdd:cd13600 81 AFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTEVDLLA-LPRA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488390266 189 YqnQDVDAAIINSNYAIDQKLsPKKDSIVLEKATNNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINK 260
Cdd:cd13600 160 L--DDVDLAFGYPSYFDAAGL-TPKDGILLEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
9-268 |
6.58e-50 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 165.58 E-value: 6.58e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 9 AVFVLTIALAACGKGDSEDKTIKVGASPAPHAEILEKAKPLL-EKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPY 87
Cdd:PRK09861 13 ALLLAGILLAGCDQSSSDAKHIKVGVINGAEQDVAEVAKKVAkEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 88 LKTESKEKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEDAKFsDI 167
Cdd:PRK09861 93 LEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTAL-DI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 168 VENKKNIKFNNKQSAEfLPKIYQNQDVDAAIINSNYAIDQKLSPKKDSIVLEKaTNNPYANLIAVRKGHKDDKKIKALIE 247
Cdd:PRK09861 172 TDNPRHLQIMELEGAQ-LPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIED-KNSPYVNILVAREDNKNAENVKEFLQ 249
|
250 260
....*....|....*....|.
gi 488390266 248 VLQSKEIKDFINKKYDGAVVP 268
Cdd:PRK09861 250 SYQSPEVAKAAETIFNGGAVP 270
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
15-268 |
1.41e-49 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 163.92 E-value: 1.41e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 15 IALAACGKGDSEDKTIKVGASPAPHAEILEKAKPLL-EKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESK 93
Cdd:TIGR00363 5 LVLTGCKQDKKDPLHIKVGVISGAEQQVAEVAAKVAkEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 94 EKGYKIESAGNVHLEPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEDAKFsDIVENKKN 173
Cdd:TIGR00363 85 AKGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLPTVL-DIVENPKK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 174 IKFNNKQSAEfLPKIYQNQDVDAAIINSNYAIDQKLSPKKDSIVLEKaTNNPYANLIAVRKGHKDDKKIKALIEVLQSKE 253
Cdd:TIGR00363 164 LNITELETSQ-LPRALDDPKVDLAVINTTYAGQVGLNPQDDGVFVED-KDSPYVNIIVSREDNKDAENVKDFIQSYQSEE 241
|
250
....*....|....*
gi 488390266 254 IKDFINKKYDGAVVP 268
Cdd:TIGR00363 242 VYQAAQKHFNGGAVK 256
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
29-260 |
3.48e-46 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 154.48 E-value: 3.48e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGASPAPHAEILEKA-KPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHL 107
Cdd:cd13599 1 TIVIGFTPGPYGDMVKNGvAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 108 EPMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKGVKIEDAKFSDIVENKKNIKFNNKQSAEfLPK 187
Cdd:cd13599 81 PPMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNIDPLKASVNDIAENPKNIKIVELEAAQ-LPR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488390266 188 IYqnQDVDAAIINSNYAIDQKLSPkKDSIVLEKATnNPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINK 260
Cdd:cd13599 160 SL--DDVDFAAIQGNFAISSGIKL-TSALALEEMT-DPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIHA 228
|
|
| PBP2_lipoprotein_GmpC |
cd13596 |
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ... |
29-260 |
6.57e-43 |
|
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270314 Cd Length: 230 Bit Score: 145.97 E-value: 6.57e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGaSPAPHAEILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTPYLKTESKEKGYKIESAGNVHLE 108
Cdd:cd13596 1 TVKIG-VTGEDTDIWDKIVEEAEEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 109 PMAVYSKKYKSLKDLPNGATVYVSNNPAEQGRFLKFFVDADLIKIKKgvkiEDAKF---SDIVENKKNIKFNNKQSAEfl 185
Cdd:cd13596 80 PMGIYSKKITSVDELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKK----DAGDFptvNDITENPKNLEIVPVDADQ-- 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488390266 186 pkIYQN-QDVDAAIINSNYAIDQKLSPKKDSIVLEKATN---NPYANLIAVRKGHKDDKKIKALIEVLQSKEIKDFINK 260
Cdd:cd13596 154 --VYRAlNDVDAAVINNTFALDAGLDPKKDAIFLEDPSSygsKPYINLIAVREEDKDNPLYKKLVETYHDERVQKAVEE 230
|
|
| TauA |
COG0715 |
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ... |
9-266 |
5.82e-07 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];
Pssm-ID: 440479 [Multi-domain] Cd Length: 297 Bit Score: 49.62 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 9 AVFVLTIALAACGK--GDSEDKTIKVGASPAPHAE--ILEKAKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQH 84
Cdd:COG0715 1 LAALAALALAACSAaaAAAEKVTLRLGWLPNTDHAplYVAKEKGYFKKEGLDVELVEFAGGAAALEALAAGQADFGVAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 85 TPYLKteSKEKGYKIESAGNVHL-EPMAVYSKK---YKSLKDLpNGATVYVSNNPAEQgRFLKFFVDADLIKIKKgVKIE 160
Cdd:COG0715 81 PPALA--ARAKGAPVKAVAALSQsGGNALVVRKdsgIKSLADL-KGKKVAVPGGSTSH-YLLRALLAKAGLDPKD-VEIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 161 DAKFSDIVENkknikfnnkqsaeflpkiYQNQDVDAAIINSNYAIDQKLSPKKDSIV-LEKATNNPYANLIAVRKGHKDD 239
Cdd:COG0715 156 NLPPPDAVAA------------------LLAGQVDAAVVWEPFESQAEKKGGGRVLAdSADLVPGYPGDVLVASEDFLEE 217
|
250 260
....*....|....*....|....*....
gi 488390266 240 KK--IKALIEVLQskEIKDFINKKYDGAV 266
Cdd:COG0715 218 NPeaVKAFLRALL--KAWAWAAANPDEAA 244
|
|
| ProX |
COG2113 |
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
1-124 |
1.07e-04 |
|
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 42.91 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 1 MKKILTLVAVFVLTIALAACGKGDSE---DKTIKVG----ASPAPHAEILEKakpLLEKKGYDLKIQSInDYTTPNKLLD 73
Cdd:COG2113 1 MKKLLLLLLAAALALALAGCAAAAAApgsCKTVTIAdvgwTSATATTAVAKQ---ILEELGYEVELVEL-DVPVTYQGLA 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488390266 74 KGELDA---NYF--QHTPYLKTESKEkgyKIESAGnVHLE--------PMAVYSKKYKSLKDLP 124
Cdd:COG2113 77 NGDIDVfleAWLptTHADYDEAYGDG---KVEDLG-TNYEgakqglavPKYVAEPGIKSIADLK 136
|
|
| OsmF |
COG1732 |
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system ... |
1-56 |
5.71e-04 |
|
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441338 [Multi-domain] Cd Length: 294 Bit Score: 40.51 E-value: 5.71e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 488390266 1 MKKILTLVAVFVLTIALAACGKGDS--EDKTIKVGASPAPHAEIL-EKAKPLLEKKGYD 56
Cdd:COG1732 1 MKRLLLLALALAAALALAGCGLASAaaAGDTIVVGSKNFTEQEILaEIYAQALEAAGLK 59
|
|
| Periplasmic_Binding_Protein_Type_2 |
cd00648 |
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent ... |
29-234 |
1.01e-03 |
|
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent the ligand-binding domains found in solute binding proteins that serve as initial receptors in the transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1 (PBP1), but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The origin of PBP module can be traced across the distant phyla, including eukaryotes, archebacteria, and prokaryotes. The majority of PBP2 proteins are involved in the uptake of a variety of soluble substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction. The substrate binding domain of the LysR transcriptional regulators and the oligopeptide-like transport systems also contain the type 2 periplasmic binding fold and thus they are significantly homologous to that of the PBP2; however, these two families are grouped into a separate hierarchy of the PBP2 superfamily due to the large number of protein sequences.
Pssm-ID: 270214 [Multi-domain] Cd Length: 196 Bit Score: 39.09 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 29 TIKVGASPAPHAEILEK--AKPLLEKKGYDLKIQSINDYTTPNKLLDKGELDANYFQHTP-YLKTESKEKGYKIESAGNV 105
Cdd:cd00648 1 TLTVASIGPPPYAGFAEdaAKQLAKETGIKVELVPGSSIGTLIEALAAGDADVAVGPIAPaLEAAADKLAPGGLYIVPEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488390266 106 HLEPMAVYSKKYKSLK-----DLPNGATVYVSNNPAEQGRFLKFFVDADLIKiKKGVKIEDAKFSDivenkknikfnnkQ 180
Cdd:cd00648 81 YVGGYVLVVRKGSSIKgllavADLDGKRVGVGDPGSTAVRQARLALGAYGLK-KKDPEVVPVPGTS-------------G 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 488390266 181 SAEFLpkiyQNQDVDAAIINSNYAIDQKLSPKKDSIVLEKATNNPYANLIAVRK 234
Cdd:cd00648 147 ALAAV----ANGAVDAAIVWVPAAERAQLGNVQLEVLPDDLGPLVTTFGVAVRK 196
|
|
| UgpB |
COG1653 |
ABC-type glycerol-3-phosphate transport system, periplasmic component [Carbohydrate transport ... |
1-67 |
1.37e-03 |
|
ABC-type glycerol-3-phosphate transport system, periplasmic component [Carbohydrate transport and metabolism];
Pssm-ID: 441259 [Multi-domain] Cd Length: 363 Bit Score: 39.64 E-value: 1.37e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488390266 1 MKKILTLVAVfVLTIALAACGKG------DSEDKTIKVGASPAPHAEILEKAKPLLEKK--GYDLKIQSI--NDYTT 67
Cdd:COG1653 1 MRRLALALAA-ALALALAACGGGgsgaaaAAGKVTLTVWHTGGGEAAALEALIKEFEAEhpGIKVEVESVpyDDYRT 76
|
|
| |
