|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
22-424 |
1.25e-143 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 415.04 E-value: 1.25e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG 101
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 102 RLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI--------EGWRWMLGLAVVPSVI 173
Cdd:cd17359 96 RIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAggadwlgaEGWRWMLGLEAIPAIL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 174 LLVGIYFMPESPRWLLENRNeeaarqvmkityddseidkelkemkeinaisestwtvikspwlgRILIVGCIFAIFQQFI 253
Cdd:cd17359 176 FLLGMLFIPESPRWLVSKGK--------------------------------------------PILIIGIGLAIFQQFV 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 254 GINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTI-GIAS 332
Cdd:cd17359 212 GINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFApGSQA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 333 SAWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGV 412
Cdd:cd17359 292 SGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICV 371
|
410
....*....|..
gi 487748494 413 LAMIFVIKFLPE 424
Cdd:cd17359 372 LAFLFVWKFVPE 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
22-437 |
2.07e-106 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 322.68 E-value: 2.07e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFI-----------HKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILA 90
Cdd:pfam00083 15 DTGVIGAFLTLIdffknfglsksVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 91 AST---NLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI---EGWRWML 164
Cdd:pfam00083 95 AAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTsnsDGWRIPL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 165 GLAVVPSVILLVGIYFMPESPRWLLENRNEEAARQVMKITYDDSEIDKELKEMK-EINAISESTWTVIKSPWLG----RI 239
Cdd:pfam00083 175 GLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKdSLEAGQEAEKASWKELFSTktrrQR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 240 LIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEaaSILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLL 319
Cdd:pfam00083 255 LLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 320 IMAI--LIWTIGIASSAWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDA 397
Cdd:pfam00083 333 ILGIvaLLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDA 412
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 487748494 398 LSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEEIEYEL 437
Cdd:pfam00083 413 IGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
22-424 |
3.12e-103 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 311.43 E-value: 3.12e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKD--IPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLI 99
Cdd:cd17315 12 DLGVINGALLYIAKDlgFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 100 IGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI--EGWRWMLGLAVVPSVILLVG 177
Cdd:cd17315 92 VGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFALAAVPALLQLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 178 IYFMPESprwllenrneeaarqvmkityddseidkelkemkeinaisestwtvikspwlgRILIVGCIFAIFQQFIGINA 257
Cdd:cd17315 172 MFFLPES-----------------------------------------------------RALLVGVGLQLLQQLTGINA 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 258 VIFYSSSIFAKAGlGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILI-WTIGIASSAWI 336
Cdd:cd17315 199 VMYYAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFlLPALAKAAGWL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 337 IIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMI 416
Cdd:cd17315 278 ALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALV 357
|
....*...
gi 487748494 417 FVIKFLPE 424
Cdd:cd17315 358 FVFFFVPE 365
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
36-432 |
7.30e-99 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 302.96 E-value: 7.30e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 36 DIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMST 115
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 116 VPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFAdiegWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRNEE 195
Cdd:cd17358 115 VPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 196 AARQVMK----ITYDDSEIDKELKEMKE--INAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKA 269
Cdd:cd17358 191 EAEKSLQflrgKDADISKEAAEIQEELAelEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 270 GLGEAASIlGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIW----TIGIASSAWIIIVCLSLFI 345
Cdd:cd17358 271 GSGLDPNT-ATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYlqehGALLSSVSWLPLVGLVIYI 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 346 VFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPET 425
Cdd:cd17358 350 ISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPET 429
|
....*..
gi 487748494 426 RGRSLEE 432
Cdd:cd17358 430 KGKSLEE 436
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
22-433 |
2.34e-95 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 295.40 E-value: 2.34e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFI--HKDIPLN------STTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAAS- 92
Cdd:TIGR00879 43 DTGVIGGALALPafEFKFTSAnsdsysSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAa 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 93 --TNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYA--FADIE-GWRWMLGLA 167
Cdd:TIGR00879 123 faLSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGkvSLNNTlGWRIPLGLQ 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 168 VVPSVILLVGIYFMPESPRWLLENRNEEAARQVMKITYDDSEIDKELKEMKEINAISESTWTVIKSPWLGRI-------- 239
Cdd:TIGR00879 203 LIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELIDIKRSIEKRSVQPSWGSLfsstrrir 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 240 --LIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIAS 317
Cdd:TIGR00879 283 rrLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAIC 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 318 LLIMAILIWTIGIASS---AWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPIL 394
Cdd:TIGR00879 363 LFVLGILGASFVTGSSkssGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTM 442
|
410 420 430
....*....|....*....|....*....|....*....
gi 487748494 395 SDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEEI 433
Cdd:TIGR00879 443 LESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
22-433 |
2.63e-95 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 291.95 E-value: 2.63e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIP-------LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTN 94
Cdd:cd17362 12 DIGATSGALLSITSPALsgtdwynLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 95 LALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFAD-IEGWRWMLGLAVVPSVI 173
Cdd:cd17362 92 YPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADvVGGWRYMYGLAAPPALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 174 LLVGIYFMPESPRWLLENRneeaarqvmkityddseidkelkemkeinaisestwtvikspwlgRILIVGCIFAIFQQFI 253
Cdd:cd17362 172 LGIGMWFLPPSPRWQGNYR---------------------------------------------KPLIIGLGLVLFQQIT 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 254 GINAVIFYSSSIFAKAGL-GEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTI--GI 330
Cdd:cd17362 207 GQPSVLYYAATIFKSAGFsAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVqmGP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 331 ASSAWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFI 410
Cdd:cd17362 287 AGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVI 366
|
410 420
....*....|....*....|...
gi 487748494 411 GVLAMIFVIKFLPETRGRSLEEI 433
Cdd:cd17362 367 GVLALLFIYFTVPETKGLSLEEI 389
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
22-424 |
4.50e-91 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 280.31 E-value: 4.50e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEG---IVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALL 98
Cdd:cd17360 12 DTGVISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 99 IIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIE-GWRWMLGLAVVPSVILLVG 177
Cdd:cd17360 92 IVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPgGWRWMLGLAAVPAVLQFIG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 178 IYFMPESPRWllenrneeaarqvmkityddseidkelkemkeinaisestwtviksPWLGRILIVGCIFAIFQQFIGINA 257
Cdd:cd17360 172 LLFLPESPRW----------------------------------------------PSTRRALIVGCGLQAFQQFSGINT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 258 VIFYSSSIFAKAGLGEAA-SILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigiassaWI 336
Cdd:cd17360 206 VMYYSATILQMAGFKDNQnAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLAV-----------WL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 337 IIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMI 416
Cdd:cd17360 275 ALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLI 354
|
....*...
gi 487748494 417 FVIKFLPE 424
Cdd:cd17360 355 FIYFCVPE 362
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
22-433 |
7.19e-82 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 257.33 E-value: 7.19e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG 101
Cdd:cd17437 12 DIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 102 RLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIE---GWRWMLGLAVVPSVILLVGI 178
Cdd:cd17437 92 RFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPlhvGWRLMLGVGAVPSLFLAIGV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 179 YFMPESPRWllenrneeaarqvmkityddseidkelkemkeinaisestwtvikSPWLGRILIVGCIFAIFQQFIGINAV 258
Cdd:cd17437 172 LAMPESPRW---------------------------------------------TPAVRRMLIAALGIHFFQQASGIDAV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 259 IFYSSSIFAKAGLGEAASILG-SVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGIA--SSAW 335
Cdd:cd17437 207 VLYSPRIFKKAGIKSKDKLLLaTVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSLTFIDRNggGLTW 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 336 ---IIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGV 412
Cdd:cd17437 287 alvLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAA 366
|
410 420
....*....|....*....|.
gi 487748494 413 LAMIFVIKFLPETRGRSLEEI 433
Cdd:cd17437 367 AAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
45-428 |
3.86e-81 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 257.58 E-value: 3.86e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAAS---TNLALLIIGRLIIGLAVGGSMSTVPVYLS 121
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 122 EMAPTEYRGSLGSLNQLMITIGILAAYLVN--YAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRN--EEAA 197
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGdeEEAE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 198 RQVMKITYDDSEIDKELKEMK-----EINAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLG 272
Cdd:cd17357 212 KSLKFLRGIEDDVDQELEEIKkeseqMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFS 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 273 EAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGIASS-AWIIIVCLSLFIVFFGIS 351
Cdd:cd17357 292 PQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWmSYGCIVAIFLFIFFFAIG 371
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 352 WGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTeWVFLIFAFIGVLAMIFVIKFLPETRGR 428
Cdd:cd17357 372 LGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGG-FVFIIFAIPCALFLLYLYRYLPETKGR 447
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
22-443 |
9.03e-80 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 255.00 E-value: 9.03e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGAL-----LFI---HKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAA-- 91
Cdd:PRK10077 27 DTAVISGTVeslntVFVapqNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWpe 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 92 -------STNLALLI---IGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFAD----- 156
Cdd:PRK10077 107 fgftsigPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARsgdas 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 157 ---IEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRNEEAARQVMKITYDDSEIDKELKEMKEINAISESTWTVIKS 233
Cdd:PRK10077 187 wlnTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTGGKLLM 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 234 PWLGrILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIG 313
Cdd:PRK10077 267 FGVG-VIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALG 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 314 MIASLLIMAILIWTigiASSAWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPI 393
Cdd:PRK10077 346 MAIGMFSLGTAFYT---QAPGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPM 422
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 487748494 394 ------LSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEEIEYELRERTGA 443
Cdd:PRK10077 423 mdknswLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEALWEPETKK 478
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
39-434 |
4.08e-76 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 242.93 E-value: 4.08e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTN-LALLIIGRLIIGLAVGGSMSTVP 117
Cdd:cd17356 42 PSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGkWYQLIVGRIIAGLGVGFASVLVP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 118 VYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEG---WRWMLGLAVVPSVILLVGIYFMPESPRWLlenrne 194
Cdd:cd17356 122 VYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGsaqWRIPLGLQIVWGLLLLIGMFFLPESPRWL------ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 195 eaarqvmkityddseidkelkemkeinaisestwtvikspwlgRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEA 274
Cdd:cd17356 196 -------------------------------------------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 275 ASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGIA---------SSAWIIIVCLSLFI 345
Cdd:cd17356 233 SPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLFIYAAVGVRYLIPnpqsgtsnkSAGNGMIVFICLFI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 346 VFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTeWVFLIFAFIGVLAMIFVIKFLPET 425
Cdd:cd17356 313 FSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGF-KYYYIFAGCNLLAFIVVFFFVPET 391
|
....*....
gi 487748494 426 RGRSLEEIE 434
Cdd:cd17356 392 KGLTLEEID 400
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
48-428 |
1.36e-74 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 240.32 E-value: 1.36e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 48 VSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAAS---TNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:cd17431 56 VAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSklaKSYEMLILGRFIIGLYCGLTTGLVPMYIGEIS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYL--VNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRNEEA-ARQVM 201
Cdd:cd17431 136 PTALRGALGTLHQLGIVVGILISQIfgLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEeAKSVL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 202 KITYDDSEIDKELKEMKE--INAISESTWTV---IKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAas 276
Cdd:cd17431 216 KKLRGTTDVSEDIQEMKEesRQMMREKKVTIlelFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQP-- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 277 ILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAI-LIWTIGIASSAWIIIVCLSLFIVFFGISWGPV 355
Cdd:cd17431 294 VYATIGAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAICAILMTIaLLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPI 373
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487748494 356 LWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALStEWVFLIFAFIGVLAMIFVIKFLPETRGR 428
Cdd:cd17431 374 PWFIVAELFSQGPRPAAMAVAGFSNWTSNFIVGMCFQYIANLCG-PYVFIIFTVFLLTFFIFTYFKVPETKGK 445
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
47-424 |
1.34e-73 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 235.99 E-value: 1.34e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 47 VVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPT 126
Cdd:cd17361 56 FTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 127 EYRGSLGSLNQLMITIGILAAYLVNYAFADIE--GWRWMLGLAVVPSVILLVGIYFMPESPrwllenrneeaarqvmkit 204
Cdd:cd17361 136 KLRGALNIGFQLAITIGILIANLINYGTSKIKpnGWRLSLGLAAVPALILLLGSLFLPETP------------------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidkelkemkeinaisestwtviKSPwlgrILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIG 284
Cdd:cd17361 197 ---------------------------NSP----QLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 285 TINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILI------WTIGIASSAWIIIVCLSLFIVFFGISWGPVLWV 358
Cdd:cd17361 246 AVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGILLavkfgdGGELPKAYAIAVVVLICLYVAAFAWSWGPLGWL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487748494 359 MLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTeWVFLIFAFIGVLAMIFVIKFLPE 424
Cdd:cd17361 326 VPSEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLCAMKF-GIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
46-433 |
6.53e-67 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 220.57 E-value: 6.53e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 46 IVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAAS---TNLALLIIGRLIIGLAVGGSMSTVPVYLSE 122
Cdd:cd17432 54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSkiaKSFEMIIVGRFLVGINAGISLNVVPMYLGE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 123 MAPTEYRGSLGSLNQLMITIGILAAYLVN--YAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLL-ENRNEEAARQ 199
Cdd:cd17432 134 SAPKNLRGAVGLVPAIFITLGILLGQVLGlrELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLiEKGDEEAARK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 200 VMKITYDDSEIDKELKEM-KEINAISE----STWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEA 274
Cdd:cd17432 214 ALQRLRGKEDVDDEMEEMlEEQRAEKGvgtvSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPED 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 275 ASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGM-IASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWG 353
Cdd:cd17432 294 KIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMaVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPA 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 354 PVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTeWVFLIFAFIGVLAMIFVIKFLPETRGRSLEEI 433
Cdd:cd17432 374 GVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVGLLFPFIQEGLGA-YCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-433 |
1.04e-66 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 217.74 E-value: 1.04e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 24 GVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRL 103
Cdd:cd17435 18 GIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 104 IIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI-EGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17435 98 AIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVsNGWKYMFGLVIPLAALQAIAMYFLP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 183 ESPRWLLENRNEEAarqvmkityddseidkelkemkeinaisestwtvikspwlgRILIvGCIFAIFQQFIGINAVIFYS 262
Cdd:cd17435 178 PSPRFLVMKDNMRA-----------------------------------------RLLI-GLTLVFFVQITGQPNILFYA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 263 SSIFAKAGL-GEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigiassaWIIIVCL 341
Cdd:cd17435 216 STVLKSVGFqSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMGL-----------WLSLASL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 342 SLFIVFFGISWGPVLWVMLPELFPMRARGAATGIsALVLNIGT-LIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIK 420
Cdd:cd17435 285 LVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMAL-TSSMNWGInLLISLTFLTVTELIGLPWVCFIYTAMSLASLVFVIM 363
|
410
....*....|...
gi 487748494 421 FLPETRGRSLEEI 433
Cdd:cd17435 364 FVPETKGCSLEQI 376
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
49-432 |
3.95e-63 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 209.73 E-value: 3.95e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 49 SSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEY 128
Cdd:cd17433 48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 129 RGSLGSLNQLMITIGILAAYLVNYAFAdiegWRWMLGLAVVPSVILLVGIYFMPESPRWLL-ENRNEEAARQVMKITYDD 207
Cdd:cd17433 128 RGTLGSCVQLMVVIGIMGAYLAGLVLD----WRWLAVLGSIPPTLMLLLMCFMPETPRFLLtQHRRQEAMAALRFLRGPD 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 208 SEIDKELKEMKEINAISESTWTV--IKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEaaSILGSVGIGT 285
Cdd:cd17433 204 QGWEWECIGIEQSFHLEEQSFSLalLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKD--SSVASVIVAA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 286 INVLVTIVAIFVVDKIDRKKLLVGGNIGMIASllimailiwtigIASSAWIIIVCLSLFIVFFGISWGPVLWVMLPELFP 365
Cdd:cd17433 282 IQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS------------TAAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFP 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 366 MRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEE 432
Cdd:cd17433 350 LHVRGVASGICVLTNWLMAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-433 |
3.77e-58 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 195.41 E-value: 3.77e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 24 GVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRL 103
Cdd:cd17436 18 GIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 104 IIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI-EGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17436 98 VVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVlTGWRYMFGLAIIPAAIQFASILLLP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 183 ESPRWLlenrneeaarqvmkityddseidkelkemkeinaisestwtVIKSPWLGRILiVGCIFAIFQQFIGINAVIFYS 262
Cdd:cd17436 178 KKPEVL-----------------------------------------NIKDNMRRRTL-VGLGLVLFQQFTGQPNVLCYA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 263 SSIFAKAGL-GEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIgmiasllIMAILIWTIGIassaWIIIVCL 341
Cdd:cd17436 216 STIFRSVGFqSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCS-------VMAVSVSGIGL----WITLLCL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 342 SLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKF 421
Cdd:cd17436 285 MAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFLLYGVVGVAGVVFIYLF 364
|
410
....*....|..
gi 487748494 422 LPETRGRSLEEI 433
Cdd:cd17436 365 VPETKGQSLEEI 376
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
49-432 |
3.53e-49 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 173.10 E-value: 3.53e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 49 SSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEY 128
Cdd:cd17434 48 SVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 129 RGSLGSLNQLMITIGILAAYlvnyAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLL-ENRNEEAARQVMKITYDD 207
Cdd:cd17434 128 RGALGACPQIMAVFGSLALY----ALGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLIsKGKDEKALKALAWLRGPN 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 208 SEIDKELKEMKE--INAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGL----GEAASILGSV 281
Cdd:cd17434 204 TDYMTEFEQIKDniRKQSSRLSWAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVilepKYDAALVGAV 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 282 gigtiNVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigiassawIIIVCLSLFIVFFGISWGPVLWVMLP 361
Cdd:cd17434 284 -----RLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMGL------------IPLIAAMLFIMGYAMGWGPITWLLMS 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 362 ELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEE 432
Cdd:cd17434 347 EILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-383 |
7.78e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 129.71 E-value: 7.78e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 2 KANKYLIFILGALGGLLYGYDNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIV 81
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 82 FIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWR 161
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 162 WMLGLAVVPSVILLVGIYF-MPESPRwllenrneeaarqvmkityddseidkelkemkeinAISESTWTVIKSPWLGRIL 240
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRlLPESRP-----------------------------------AARARLRGSLRELLRRPRL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 241 IVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLI 320
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487748494 321 MAiliwtigIASSAWIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIG 383
Cdd:COG2814 290 LA-------LAGSLWLLLLALFLLGFGFGLLF-PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-426 |
2.43e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 123.06 E-value: 2.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 2 KANKYLIFILGALGGLLYGYDNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIV 81
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 82 FIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWR 161
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 162 WMLGLAVVPSVILLVgiyfmpesprwllenrneeaarqvmkityddseidkelkemkeinaisestwtvikspwlgrILI 241
Cdd:COG2271 165 AAFLILGLPGLLLAL--------------------------------------------------------------LRF 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 242 VGCIFAIFQQFIGINAVIFYSSSIFAKA-GLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVggnigMIASLLI 320
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV-----LAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 321 MAILIWTIGIASSAWIIIVCLSLFiVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALST 400
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
410 420
....*....|....*....|....*.
gi 487748494 401 EWVFLIFAFIGVLAMIFVIKFLPETR 426
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-417 |
2.86e-31 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 122.71 E-value: 2.86e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTE--GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLI 99
Cdd:cd17316 14 DFFLIGFVAPVLAAEFSLGLSLLqtGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 100 IGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAA----YLVNYAFADIEGWRWMLGLAVVPSVILL 175
Cdd:cd17316 94 VLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAalvaSLLIPLLSGDWGWRILFLIGALPALLAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 176 vgiyfmpesprwllenrneeaarqvmkityddseidkelkemkeinaisestwtvikspWLGRILIVGCIFAIFQQFIGI 255
Cdd:cd17316 174 -----------------------------------------------------------LLRRRTLLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 256 NAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILiwtigIASSAW 335
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYL-----LSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 336 IIIVCLSLFIVFFGISWGpVLWVMLPELFPMRARGAATGISAlvlNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAM 415
Cdd:cd17316 270 LLLLLLFILSFFVGGVWG-ALYAYLAELFPTEVRATGVGLSY---NLGRLGGGGAPPLIALLLASTGGTGVPALILALLA 345
|
..
gi 487748494 416 IF 417
Cdd:cd17316 346 IV 347
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
45-432 |
7.79e-31 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 124.36 E-value: 7.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVNYAfadIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRNEEAARQVMK-- 202
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLVAYF---IPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQri 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 203 ---------ITYDDSEIDKELKEMKEINAISEstwtVIKSPWLGRILIVgCIFAIFqqfigINAVIFYSSSIFAkAGLGE 273
Cdd:TIGR00898 287 akingkklpAEVLSLSLEKDLSSSKKQYSFLD----LFRTPNLRKTTLC-LMMLWF-----TTAFSYYGLVLDL-GNLGG 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 274 AAsILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigIASSAWIIIVCLSLFIVFFGISWG 353
Cdd:TIGR00898 356 NI-YLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLF------VPVDLYFLRTALAVLGKFGITSAF 428
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 354 PVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFpiLSDALSTEWVFLIFAFIGVLAMIFVIkFLPETRGRSLEE 432
Cdd:TIGR00898 429 QMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV--YLGEKWLFLPLVLFGGLALLAGILTL-FLPETKGVPLPE 504
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-189 |
1.31e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.97 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 2 KANKYLIFILGALGGLLYGYDNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIV 81
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 82 FIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWR 161
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180
....*....|....*....|....*...
gi 487748494 162 WMLGLAVVPSVILLVGIYFMPESPRWLL 189
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLL 196
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-429 |
2.98e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.81 E-value: 2.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFM--- 181
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFlrd 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 182 PESPRWLLENRNEEAARQVMKityddseidkelkemkeinaisestwtvIKSPWLGRILIVGCIFAifqqFIGINAVIFY 261
Cdd:COG2223 183 PPAGAAAAAKASLRDQLEALR----------------------------DPRFWLLSLLYFGTFGS----FIGFSSWLPP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 262 SSSIFAKAGLGEAASILGSVGIgtINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIwtigiaSSAWIIIVCL 341
Cdd:COG2223 231 YLVDQFGLSAATAGLLAALFAL--LGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL------GSLWLFLVLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 342 SLFIVFFGISWGPVlWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDAL-STEWVFLIFAFIGVLAMIFVIK 420
Cdd:COG2223 303 LLLGLALGGGNGAV-FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLL 381
|
....*....
gi 487748494 421 FLPETRGRS 429
Cdd:COG2223 382 LYRRPRRAA 390
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
45-425 |
4.08e-23 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 100.45 E-value: 4.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVNYA----FADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWllenrneEAARQv 200
Cdd:cd17371 117 PARHRGKALGYVQSGWAVGWLLATLLAALlfplLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQW-------QAARA- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 201 mkityddseidkELKEMKEINAISEstwtvIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGS 280
Cdd:cd17371 189 ------------ARRHFADRPSLRE-----LFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 281 VGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGIAssAWIIIVCLSLFIVFFGiSWGPvlwvML 360
Cdd:cd17371 252 VVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLI--LILGFPLGFFASGPFS-GMGA----YL 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 361 PELFPMRARGAATGisalVLNIGTLIVSLFFPILSDALSTEW----VFLIFAFIGVLAMIFVIKFLPET 425
Cdd:cd17371 325 TELFPTAVRATAQG----FCYNVGRIIGALFPFLVGFLATSGslgtAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
45-422 |
8.21e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.19 E-value: 8.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPEsprwllenrneeaarqvmkit 204
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP--------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidkELKEMKEINAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGInAVIFYSSSIFAKAGLGEAASILGSV--G 282
Cdd:cd17325 173 --------EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF-GALEPFLPLYAAELGGLSPAQIGLLfgA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 283 IGTINVLVTIVAIFVVDKIDRKKLlvggnigMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWGPVLwVMLPE 362
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPL-------ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL-ALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 363 LFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFL 422
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-419 |
2.25e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.27 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG 101
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 102 RLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIE--GWRWMLGLAVVPSVILLVGIY 179
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 180 FMPESPRWLLENRNEEAArqvmkityddseidkelkemkeinaiSESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVI 259
Cdd:cd06174 171 LVVPDPPESARAKNEEAS--------------------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 260 FYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLvggnigMIASLLIMAILIWTIGIASSAWIIIV 339
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL------LLIGLLLMALGLALLLLAPSLLLLLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 340 CLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDA-LSTEWVFLIFAFIGVLAMIFV 418
Cdd:cd06174 299 LLLLLGFGLGGLL-PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 487748494 419 I 419
Cdd:cd06174 378 L 378
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
31-425 |
4.79e-22 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 97.35 E-value: 4.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTN------LALLIIGRLI 104
Cdd:cd17364 28 LYYGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI--------------EGWRWMLGLAVVP 170
Cdd:cd17364 108 LGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIfehplpagtyhhadLVWRIVLGLGAIP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 171 SVILLVgiyfmpesPRWLLenrneeaarqvmkityddseidkelkemkeinAISESTWtvikspwlgrilivgCIFAIFQ 250
Cdd:cd17364 188 ALSVLY--------FRKHL--------------------------------LGTAGTW---------------FLLDIAF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 251 QFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTI----VAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIW 326
Cdd:cd17364 213 YGQNLFQSTIISAIGFSKTMNAYQELFNIAVGQLIIALAGTVpgywFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYD 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 327 TIGIASSAWIIIVCLSLFIVFFGIswGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLI 406
Cdd:cd17364 293 HWKISTIGFFVLYGLTFFFSNFGP--NTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLII 370
|
410
....*....|....*....
gi 487748494 407 FAFIGVLAMIFVIKFLPET 425
Cdd:cd17364 371 LAGVALLGIILTLLFPEEK 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-394 |
1.59e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 95.89 E-value: 1.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG 101
Cdd:TIGR00895 32 DLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 102 RLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLA-VVPSVILLVGIYF 180
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGgIAPLLLLLLLMRF 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 181 MPESPRWLLENRNEEAARQVMKITYD-DSEIDKELKEMKEINAISESTWTVIKSPWLGRI---LIVGCIFAIFQQFIGIN 256
Cdd:TIGR00895 192 LPESIDFLVSKRPETVRRIVNAIAPQmQAEAQSALPEQKSTQGTKRSVFKALFQGKTARItvlLWLLYFMLLVGVYFLTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 257 AVIFYSSSIFAKAGLGEAASILGSVGigtiNVLVTIVAIFVVDKIDRKKLLVGgnigmiasLLIMAILIWTIGIASSAWI 336
Cdd:TIGR00895 272 WLPKLMVELGFSLSLAATGGALFNFG----GVIGSIIFGWLADRLGPRVTALL--------LLLGAVFAVLVGSTLFSPT 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 337 IIVCLSLFIVFFGISWGPVLWVMLPELFPMRARgaATGISALvLNIGTLiVSLFFPIL 394
Cdd:TIGR00895 340 LLLLLGAIAGFFVNGGQSGLYALMALFYPTAIR--ATGVGWA-IGIGRL-GAIIGPIL 393
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-421 |
1.79e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 95.33 E-value: 1.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 23 NGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGR 102
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 103 LIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIeGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 183 ESPRWLLENRNEEAARQVMKItyddseidkelkemkeinaisestwtvIKSPWLGRILIVGCIFaifqqFIGINAVIFYs 262
Cdd:cd17474 174 PEPKEKAKSSSATKLRDLKKA---------------------------LRGRGLLTFLVSAFLY-----FFLYFAFLTY- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 263 SSIFAKAGLGEAASILGSVgIGTINVLVTIVAIFVVDKIDRKkllVGGNIGMIASLLIMAILIWTIGIASSAWIIIVCLS 342
Cdd:cd17474 221 LPFLLELLYGISPIIIGLL-FAGWSVLLALGSLFVGRLLKKR---FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIV 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 343 LFIVFFGISwGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKF 421
Cdd:cd17474 297 LFGLGLGLN-LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
31-436 |
2.66e-21 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 96.34 E-value: 2.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAAS------TNLALLIIGRLI 104
Cdd:TIGR00887 45 VYYHGKGPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSpgsspkSVMATLCFWRFW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLV------------NYA--FADIEG---------WR 161
Cdd:TIGR00887 125 LGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIValivlagfkhslEAAadEASCTGscvpavdymWR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 162 WMLGLAVVPSVILLvgiYF---MPESPRW-LLENRNEEAARQVMKITY---DDSEIDKELKEMKEINAISESTWTVIK-- 232
Cdd:TIGR00887 205 ILIGFGAVPALLAL---YFrltIPETPRYtADVAKDVEQAASDMSAVLqvkIEAEPDEVEKASTAVEVPKASWSDFFThf 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 233 SPWLGRILIVG---CIFAIFQQFIGINaviFYSSSIFAKAGLGEAAS------ILGSVGIGtiNVLVTI--------VAI 295
Cdd:TIGR00887 282 FKWRHGKHLLGtagSWFLLDIAFYGVN---LNQKVILSAIGYSPPAAtnnayeELYKTAVG--NLIIALagtvpgywVTV 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 296 FVVDKIDRKKLLVGGNIgmiasllIMAILIWTIGIASSAWIIIVCLSLF-IVFFGISWGP--VLWVMLPELFPMRARGAA 372
Cdd:TIGR00887 357 FLVDIIGRKPIQLMGFF-------ILTVLFFVLGFAYNHLSTHGFLAIYvLAQFFANFGPnaTTFIVPGEVFPTRYRSTA 429
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 373 TGISALVLNIGTLIVSLFFPILSDALSTE-------------WVFLIFAFIGVLAMIFVikflPETRGRSLEEIEYE 436
Cdd:TIGR00887 430 HGISAASGKAGAIIGQFGFLYLAQHGDPTkgyptgiwmghvlEIFALFMFLGILFTLLI----PETKGKSLEELSGE 502
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-386 |
2.92e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 2.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVG 110
Cdd:pfam07690 21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 111 GSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRwlle 190
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 191 nrneeaarqvmkityddseiDKELKEMKEINAISESTWTVIKSPWLGRILIVGCIFaifqqFIGINAVIFYSSSIFAKAG 270
Cdd:pfam07690 177 --------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-----GFAFFGLLTYLPLYQEVLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 271 LGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVggnIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGI 350
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
330 340 350
....*....|....*....|....*....|....*.
gi 487748494 351 SwgPVLWVMLPELFPMRARGAATGISALVLNIGTLI 386
Cdd:pfam07690 309 F--PALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-419 |
9.19e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.52 E-value: 9.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFmpes 184
Cdd:cd17324 97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 185 prwLLENRNEEAARQVMKITyddseidkelkemkeinaiseSTWTVIKSPWLGRILIVGCIFaIFQQFIGINAVIFYsss 264
Cdd:cd17324 173 ---LLPSLPPKKPGSLGLLS---------------------SLLLLLRNPRLRLAYLITFLL-FGGFFALYTYLAPF--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 265 IFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLlvggnigMIASLLIMAILIWTIGIASSAWIIIVCLSLF 344
Cdd:cd17324 225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL-------LIALLLLAAALLLLTLLGPSPLLLLVGLVLW 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 345 IVFFGISwGPVLWVMLPELFPmRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17324 298 GLGFFAA-HSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
25-426 |
1.89e-17 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 84.46 E-value: 1.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:cd17363 17 VVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLA-------------VVPS 171
Cdd:cd17363 97 SGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGWGFSMGTAyqfhswrvfvivcALPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 172 VILLVGIYFMPESPRWLLENRNEEAARQVMKITYDDSEIDK-------ELKEMKEINAI--------------SESTW-- 228
Cdd:cd17363 177 VASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAKghpervfTVSHIKRMNTLflaivwftmsfsyyGLTVWfp 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 229 TVIKSPWLGRILIVGCIF-------AIFQQFIGINAVI--------------FYSSSIFAKAGLG-------EAASILGS 280
Cdd:cd17363 257 DMIKYLQFEDSLFEECYFedvtstnTFFENCTFINTVFyntdlfeykfidsrFLNSTFFLKEKCGchlnddeENAYLIYL 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 281 VG-IGTINVLV-TIVAIFVVDKIDRKKLLVGgnigmiaSLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWGpVLWV 358
Cdd:cd17363 337 VSfLGSLSVLPgNIVSALLMDKIGRLKMIGG-------SMLLSAVCCFFLFFGNSESAMIGLQCLFCGVSIAAWN-ALDV 408
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487748494 359 MLPELFPMRARGAATGI----SALVLNIGTLIVSLFFPIlsdalsTEWVFLIFAFIGVLAMIFVIKFLPETR 426
Cdd:cd17363 409 VTVELYPTDKRATAFGFlnglCKLAAILGNSIFGSFVGI------TKVIPILLASAALVCGGLLALKLPETR 474
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
35-206 |
4.15e-17 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 83.87 E-value: 4.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 35 KDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMS 114
Cdd:TIGR01299 195 KDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIP 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 115 TVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLA-------------VVPSVILLVGIYFM 181
Cdd:TIGR01299 275 IVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQMGSAyqfhswrvfvivcAFPCVFAIGALTFM 354
|
170 180
....*....|....*....|....*
gi 487748494 182 PESPRWLLENRNEEAARQVMKITYD 206
Cdd:TIGR01299 355 PESPRFFLENGKHDEAWMILKLIHD 379
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
53-417 |
5.17e-17 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 82.57 E-value: 5.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 53 IGAIVGagssGPLADKLGRRRlVMLIAIV------FIIGAL-------ILAAstnlALLIIGRLIIGLAVGGSMSTVPVY 119
Cdd:cd17369 59 LGGVVF----GHFGDRIGRKK-TLVLTLLlmgiatFLIGLLptyaqigILAP----ILLVLLRLLQGLALGGEWGGAVLM 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 120 LSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAF------ADIEGWRWMLGLaVVPSVILLVGIYF---MPESPrwllE 190
Cdd:cd17369 130 AVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLsallsdEAFLSWGWRIPF-LLSAVLVAVGLYIrlrLEETP----V 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 191 NRNEEAARQVMKItyddseidkelkemkeinaiseSTWTVIKSPWLGRILIVGCIFAIFqqfiginaVIFYSSSIFAkag 270
Cdd:cd17369 205 FRRAKEAGQVVRA----------------------PLVEVLRRHWRALLLAIGLRLAEN--------VLFYLFTTFA--- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 271 LGEAASILG-----SVGIGTINVLVTIVAIFVV----DKIDRKKLLVGgniGMIASLLIMAILIWTIGIASSAWIIIVCL 341
Cdd:cd17369 252 LSYATQTLGvdrstVLLAVLIASVVAAITIPLFgwlsDRVGRRPVYLA---GALLAALFAFPFFWLLDTGSTWLIVLAAV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 342 SLFIVFFGISWGPvLWVMLPELFPMRARgaATGISaLVLNIGTLIVSLFFPILSDALSTE--------WVFLIFAFIGVL 413
Cdd:cd17369 329 VVLGVLHGMMYGP-QAAFLAELFPTRVR--YTGAS-LGYQLGAILGGGFAPLIATALVAAtgswwpvaLYLAALAVISLV 404
|
....
gi 487748494 414 AMIF 417
Cdd:cd17369 405 AALF 408
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-419 |
1.08e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 81.08 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG 101
Cdd:cd17319 18 DRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 102 RLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIG-ILAAYLVNYAfADIEGWRWMLGLAVVPSVILLVGIYF 180
Cdd:cd17319 98 RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGaAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 181 MpesprwllenrneeaARQVMKITYddseidkelkemkeINAISESTWTVIkSPWLGRILIVGCIFAIFQqfiginaVIF 260
Cdd:cd17319 177 Y---------------LRQVWGLAL--------------GYFGINYALYGL-LTWLPTYLKQARGFSLKQ-------VGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 261 YSSSIFakaglgeAASILGSVGIGTINVLVTIVAifvvdkidRKKLLvggnigmIASLLIMAILIWTIGIASSAWIIIVC 340
Cdd:cd17319 220 LAAIPF-------LAGAIGMILGGRLSDRLLRGA--------RRLVI-------IIGLLLAAVGLLLAYLTTSPVVAVIL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 341 LSLFIVFFGIsWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDAL-STEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17319 278 LSLAGFGIGA-ASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVALLAALLVL 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-421 |
5.52e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.13 E-value: 5.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 23 NGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGR 102
Cdd:COG0738 24 TALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 103 LIIGLAVGGSMSTVPVYLSEMAPtEYRGSLGSLNQLMITIG-ILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFM 181
Cdd:COG0738 104 FLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGaLLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 182 PesprwllenrneeaarqvmkityddseidKELKEMKEINAISESTWTVIKSPWLGRILIVGCIFAIFqqFIGINAVIFY 261
Cdd:COG0738 183 R-----------------------------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFL--YVGAEGAIGD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 262 SSSIFAKAGLGEAASIlGSVGIGTINVLVTI---VAIFVVDKIDRKKLLVGGNIGMIASLLIMAiliwtigIASSAWIII 338
Cdd:COG0738 232 WLPLYLKDVLGLSEAT-AALGLSLFWGGMTIgrfLGGFLLKRFGPVRLLRLSALLAAVGLLLAL-------LAPGPWLAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 339 VCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLnIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFV 418
Cdd:COG0738 304 IGLALVGLGLSLMF-PTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLA 381
|
...
gi 487748494 419 IKF 421
Cdd:COG0738 382 LAL 384
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
25-206 |
1.24e-15 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 78.81 E-value: 1.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:cd17438 17 VVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLG-------------LAVVPS 171
Cdd:cd17438 97 SGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGFSMGtnyhfhswrvfviICALPC 176
|
170 180 190
....*....|....*....|....*....|....*
gi 487748494 172 VILLVGIYFMPESPRWLLENRNEEAARQVMKITYD 206
Cdd:cd17438 177 IASIIALKFMPESPRFLLEMGKHDEAWMILKNIHD 211
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
45-419 |
1.71e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.63 E-value: 1.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRwllenrneeaarqvmkit 204
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidkelkEMKEINAISESTWTVIKSPwlgRILIVGciFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILgsvgig 284
Cdd:cd17489 176 -----------VAAEEAEAGTRAFRRLVEK---KVLPPA--LILFLASIAYGAISTFLPLYAAERGISNAGLFF------ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 285 TINVLVTIVAIFVVDKI-DRKkllvGGNIGMIASLLIMAILIWTIGIASSAWIIIvclsLFIVFFGISWG---PVLWVML 360
Cdd:cd17489 234 TVYAIALLLSRPFSGKLsDRK----GPKTVIIPGLLLLALGLLLLSFAGSPWMLL----LAAVLYGLGFGllfPALQALA 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 361 PELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
24-176 |
2.03e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.24 E-value: 2.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 24 GVISGALLfihKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRL 103
Cdd:cd17365 19 GFVAPALA---QDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487748494 104 IIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLV 176
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
35-426 |
3.80e-15 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 77.38 E-value: 3.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 35 KDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMS 114
Cdd:cd17439 27 KDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 115 TVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLA-------------VVPSVILLVGIYFM 181
Cdd:cd17439 107 IVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQMGSAyqfhswrvfvlvcAFPSVFAIGALTTM 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 182 PESPRWLLENRNEEAARQVMKITYDDSEIDKELKE--------MKEINAISESTWTVIKSPWLGRI-------------- 239
Cdd:cd17439 187 PESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPErvfsvthiKRRITLMMMAVWFTMSFSYYGLTvwfpdmikhlqksv 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 240 -----LIVGCIF-------AIFQQFIGINAViFYSSSIFA----------------------KAGLGEAASILGSVG-IG 284
Cdd:cd17439 267 vfedsLFEECYFeditssnTFFKNCTFISTL-FYNTDLFEykfinsklinstflhnkegcllDFSDENNAYMIYFVSfLG 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 285 TINVLV-TIVAIFVVDKIDRKKLLVGGNIGMIASLLIMailiwTIGIASSAWIIIVCLslfivFFGI---SWGpVLWVML 360
Cdd:cd17439 346 TLAVLPgNIVSALLMDKIGRLRMLAGSSVMSCVSCFFL-----SFGNSESAMIALLCL-----FGGVsiaSWN-ALDVLT 414
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 361 PELFPMRARGAATG-ISALVLNIGTLIVSLFFPILSdalSTEWVFLIFAFIGVLAMIFVIKFLPETR 426
Cdd:cd17439 415 VELYPSDKRTTAFGfLNALCKLAAVLGISIFTSFVG---ITKAVPILLASAALAAGSSLALKLPETR 478
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
53-418 |
4.45e-15 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 76.64 E-value: 4.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 53 IGAIVgagsSGPLADKLGRRRLVMLIAIVFIIGALILA-----ASTNLA---LLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:cd17368 55 IGAIV----LGAYADRIGRKPAMTLTLAIMALGTLLIAlaptyATIGIAaplLVLLARLLQGFAAGGEVGGVTAYLVEAA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLN----QLMITIGILAAYLVNYAF--ADIEGWRW----MLGLAVVPsVILlvgiyfmpesprWLLENRNE 194
Cdd:cd17368 131 PPGRRGFYTSWQsasqQVAIVAGALVGYLLSLTLtaEALAEWGWripfFIGLLIIP-LGL------------WLRRSLEE 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 195 EAARQVMKITYDDSEIDKELKEMKEINAisestwtvikspwLGRILIVGCIFAIFqqfiginaVIFYSSSIFAKAGLGEA 274
Cdd:cd17368 198 TEAFLERKARPTRRELFALLANNRRIIL-------------LGMLLVAGSTVTFY--------FTTVYTPTYAKTVLGLS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 275 A--SILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVggnIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISW 352
Cdd:cd17368 257 ArdSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLL---VITLAALVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYG 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487748494 353 GPVLwVMLPELFPMRARGAATgisALVLNIGTLIVSLFFPILS--------DALSTEWVFLIFAFIGVLAMIFV 418
Cdd:cd17368 334 GAMV-VALVELFPVRVRSTGF---SLVYALAVAIFGGFAQFIVtwlieltgSPLAPAWYLMGAALLGLLATLML 403
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
63-426 |
1.41e-14 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 75.02 E-value: 1.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 63 GPLADKLGRRRLVMLIAIVFIIGALILAASTNLA--------LLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGS 134
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 135 LNQLMITIGILAAYLVNYAFADI--------EGWRWMLGLAVVPSVILLvgiyfmpesprWLlenrneeaaRQVMKITYD 206
Cdd:cd17367 141 FQYVTLIGGQLLALGVLLVLQHTlgedqmaaWGWRIPFLLGGVLAVVVL-----------WL---------RRGLEETES 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 207 DSEIDKELKEmkeinaiSESTWTVIKSPWLGRILIVGcifaifqqFIGINAVIFYSSSIFAK------AGLGEAASILGS 280
Cdd:cd17367 201 FEAIAESNEA-------SAGTLRELRRHPRELLLVVG--------LTAGGTLAFYTWTTYLQkflvntAGFSKGDATWIT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 281 VGIGTINVLVTIVAIFVVDKIDRKKLLVG-GNIGMIASLLIMAiliwTIGIASSAW--IIIVCLSLFIVFFGISWGPVLW 357
Cdd:cd17367 266 TAALLVFMLLQPLGGRLSDRIGRRPLLLFfGIGGTLATVPLLS----ALDHTDSPYtaFALVLVGLVFLSGYTSINAVVK 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 358 VmlpELFPMRARGAATGISAlvlnigTLIVSLF---FPILSDALST---EWVFLIFAFIGVLAMIFVIKFLPETR 426
Cdd:cd17367 342 A---ELFPTHVRALGVGLPY------ALAVAIFggtAPYVALWLKSighEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
28-421 |
1.47e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.91 E-value: 1.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 28 GALL-FIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIG 106
Cdd:COG2807 38 GPLLpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 107 LAVGGSMSTVPVYLSEMAPTEyRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGiyfmpespr 186
Cdd:COG2807 118 AGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLL--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 187 WLLENRNEEAARQVmkityddseidkelkemkeiNAISESTWTVIKSPwlgRILIVGCIFaifqqfiGINAVIFYSS--- 263
Cdd:COG2807 188 WLPLLRRRPAAAAA--------------------APAAASLRSLWRSP---LAWLLTLFF-------GLQSLLYYAVvaw 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 264 --SIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVggnigmIASLLIMAILIWTIGIASSAWIIivcl 341
Cdd:COG2807 238 lpPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL------LLLGLLGLAGLLGLLLAPGSLPW---- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 342 sLFIVFFGISWGpVLWVMLPELFPMRARGA--ATGISALVLNIGTLIvSLFFPILSDAL-----STEWVFLIFAFIGVLA 414
Cdd:COG2807 308 -LWAVLLGLGQG-GLFPLALTLIGLRARTPaeAAALSGMAQSVGYLL-AALGPLLVGALhdatgSWTAALLLLAALAVLM 384
|
....*..
gi 487748494 415 MIFVIKF 421
Cdd:COG2807 385 LVAGLLA 391
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
30-383 |
5.14e-13 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 70.34 E-value: 5.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 30 LLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAV 109
Cdd:PRK12307 41 MYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 110 GGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIG-ILAAYLVNyAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWl 188
Cdd:PRK12307 121 AGEYACASTYAVESWPKHLKSKASAFLVSGFGIGnIIAAYFMP-SFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEW- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 189 lenrnEEAarqvmkityddseidkelkEMKEINAISESTWTVIKSPWLG-----RILIVGCIFAIFQQFIGINAVIF-YS 262
Cdd:PRK12307 199 -----EEA-------------------KLSGKGKHSQSAWSVFSLSMKGlfnraQFPLTLCVFIVLFSIFGANWPIFgLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 263 SSIFAKAGL--GEAASILGSVGIGTinVLVTIVAIFVVDKIDRKKLLVggnIGMIASLLIMAILIWtIGIASSAWIIIVC 340
Cdd:PRK12307 255 PTYLAGEGFdtGVVSNLMTAAAFGT--VLGNIVWGLCADRIGLKKTFS---IGLLMSFLFIFPLFR-IPQDNYLLLGACL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 487748494 341 LSLFIVFFGIswGPVLWVMLPELFPMRARGAATGisaLVLNIG 383
Cdd:PRK12307 329 FGLMATNVGV--GGLVPKFLYDYFPLEVRGLGTG---LIYNLA 366
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
46-423 |
5.65e-13 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 69.53 E-value: 5.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 46 IVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAP 125
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 126 TEYRGSLGSLNQLMITIGILAAYLVNYAFADiegWRWMLGLAVVPSVILLVGIYFMPesprwllenrneeaarqvmkity 205
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLWWLP----------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 206 ddseidkelkemkeinaisestwtvikspwlGRILIVGCIFAifqqfigINAVIFYSSSIFAKAGLGEAasILGSVGIGT 285
Cdd:cd17317 163 -------------------------------RRTIIVGLIWF-------VTSLVYYGLSLNSSNLGGNL--YLNFFLSGL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 286 INVLVTIVAIFVVDKIDRKKLLVGG-NIGMIASLLIMailiWTIGIASSAWIIIVCLSLFIVffGISWGpVLWVMLPELF 364
Cdd:cd17317 203 VEIPAYFLALLLLDRLGRRWTLSGSlLLAGLACLVTA----LLPDDENTLALTLALVGKFAI--SAAFS-VIYLYTAELY 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 365 PMRARGAATGISALVLNIGTLIVSLFFPilsdaLSTEWVFLIFAFIGVLAMI--FVIKFLP 423
Cdd:cd17317 276 PTVVRNTGVGLCSTVARVGAILAPFIVL-----LGKIGPLLPLIIFGVLALLggLLTLLLP 331
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-419 |
1.10e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 53 IGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSL 132
Cdd:cd17473 46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 133 GSLNQLMITIGILAAYLVNYAFADIeGWRWMLGLAVVPSVILLVGIYFMPESPRwllenrneeaarqvmkityddseidk 212
Cdd:cd17473 126 LGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPAR-------------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 213 elkEMKEINAISESTWTVIKSPwlgriLIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASIlgSVGIGTINVLVTI 292
Cdd:cd17473 179 ---KSKSAASPGAATAAALPWK-----RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI--GLALAIASLAGAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 293 VAIF---VVDKIDRKKLLVGGNIGMIASLLIMAiliwtigIASSAWIIIVCLSLFIVFFGISwGPVLWVMLPELFPMRAR 369
Cdd:cd17473 249 GALLfgrLKRRLGKRRLLAIGFALMALGFLLLA-------LASGLWVVLLGAILAGLGFGLL-LPTLNSWAMSLVPPELR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 487748494 370 GAATGISALVLNIGTLIVSLFF-PILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17473 321 GRAMGIVTSAFFLGQFLSPLVLgPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
36-206 |
1.83e-12 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 68.79 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 36 DIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMST 115
Cdd:cd17440 28 DMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 116 VPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLA-------------VVPSVILLVGIYFMP 182
Cdd:cd17440 108 VFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAyqfhswrvfvivcALPCVSSVVALTFMP 187
|
170 180
....*....|....*....|....
gi 487748494 183 ESPRWLLENRNEEAARQVMKITYD 206
Cdd:cd17440 188 ESPRFLLEVGKHDEAWMILKQIHD 211
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
51-443 |
9.06e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.46 E-value: 9.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 51 MLIGAIVGAGSS---GPLAD----KLGRRRLVMLIAIVFIIGALILAAST-------NLALLIIGRLIIGLAVggSMSTV 116
Cdd:COG2211 52 LLVARLWDAITDpliGALSDrtrtRWGRRRPWILIGAIPLALSFVLLFTApdlsptgKLIYALVTYLLLGLAY--TLVNI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 117 PVY--LSEMAPT-EYRGSLGSLNQLMITIGILAAYLVNYAFADI------EGWRWMLGLAVVPSVILLVGIYF-MPESPR 186
Cdd:COG2211 130 PYSalGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFgTKERPV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 187 wllenrneeaarqvmkityddseidkelkEMKEINAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIF 266
Cdd:COG2211 210 -----------------------------PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 267 AKAGLgeaASILGSVGIGTiNVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTigiasSAWIIIVCLSLFIV 346
Cdd:COG2211 261 LSAAL---VGLLLALYFLA-ALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG-----NLWLLLVLAALAGI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 347 FFGISWgPVLWVMLPELFP-------MRARGAATGISALVLNIGTLIVSLFFPILSDA--------------LSTEWVFL 405
Cdd:COG2211 332 GLGAIL-VLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALfgyvagaaqspsalTGIRLLFF 410
|
410 420 430
....*....|....*....|....*....|....*...
gi 487748494 406 IFAFIGVLAMIFVIKFLPETRGRsLEEIEYELRERTGA 443
Cdd:COG2211 411 LLPAVLLLLAALLLLFYPLTRER-HAEIRAELAARRAA 447
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
232-439 |
2.25e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.00 E-value: 2.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 232 KSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGN 311
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 312 IGMIASLLIMAIliwtigiASSAWIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFF 391
Cdd:COG2814 83 LLFALGSLLCAL-------APSLWLLLAARFLQGLGAGALF-PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 487748494 392 PILSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRSLEEIEYELRE 439
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE 202
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-418 |
2.33e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.90 E-value: 2.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 46 IVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAP 125
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 126 TEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWM-LGLAVVPSVILLVGIYFMPESPrwllenrneeaarqvmkit 204
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIfVFLALLGLLLLLLVLLFLPETL------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidKELKEMKEINAISESTWTVIKSP-WLGRILIVGCIFAIFQQFIGINAVIFYSssifakaGLGEAASILGSVGI 283
Cdd:cd17320 179 -------PEEKRKPLLSSLLRAYKRVLKNRrFLGYALALGLSFAGLFAYLAAAPFIYIE-------QLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 284 GTI--NVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLimAILIWTIGIASSAWIIIvcLSLFIVFFGISW-GPVLWVML 360
Cdd:cd17320 245 LNAiaLILGSLLNGRLVRRFGPRRLLRLGLLLLLAAAL--VLLLAALLGGLSLWPLV--APLFLIFFGFGLiFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 361 PELFPMRARGAATGISALVLNIGTLIVSLFFPILSD-ALSTEWVFLIFAFIGVLAMIFV 418
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGtALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
33-182 |
2.67e-11 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 64.86 E-value: 2.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 33 IHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGS 112
Cdd:cd17372 25 VQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGG 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 113 MSTVPVYLsEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17372 105 PQLASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTP 173
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-421 |
3.33e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.56 E-value: 3.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVML-----IAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVY 119
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 120 LSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENRNEEAARq 199
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 200 vmkityddseidkelkemkeinAISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSIfaKAGLGEAASILG 279
Cdd:cd06173 196 ----------------------DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL--GGGAAGYGLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 280 SVGIGTInvLVTIVAIFVVDKIDRKKLlvggnigMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGIsWGPVLWVM 359
Cdd:cd06173 252 AFGVGAL--LGALLLGRLSKRRRRGRL-------LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGL-FNVPLNTL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487748494 360 LPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKF 421
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-418 |
3.84e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.18 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 32 FIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRlVMLIAIVFIIGALILAA-STNLALLIIGRLIIGLAVG 110
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERR-VLAVGLLLMGAAALLMAlVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 111 GSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWmlGLAVVPSVILLVGIYFMpespRWLle 190
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRA--AFVVAGLVSILAAVLFW----LFY-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 191 nRNEEAARQVMKITyddSEIDKELKEMkeinaisestwtvIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSS----SIF 266
Cdd:cd17475 172 -REPPAASAATESA---STLLRSLKEV-------------LRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhlglSVV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 267 AKAGLGEAASILGSVGigtinvlvTIVAIFVVDKID---RKKLLVGGNIGMIASLLIMAILIWTIGIAssawiIIVCLSL 343
Cdd:cd17475 235 AAGALLAVAQLGGALG--------RIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLW-----LLVLLLI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487748494 344 FIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDAL-STEWVFLIFAFIGVLAMIFV 418
Cdd:cd17475 302 LLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
29-421 |
1.41e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 62.63 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLA 108
Cdd:cd17329 22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 109 VGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIG-----ILAAYLVNYAFadiegwRWMLGLAVVPSVILLVGIYFmpe 183
Cdd:cd17329 102 GGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGvaigpLLGGLLLLYSF------RLLFLAAAVLFLLAALVLLF--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 184 sprWLLENRNEEAARQVMkityddseidkelkemkeinAISESTWTVIKS-PWLGRILIVGCIFAIFQQFIGINAVIFYS 262
Cdd:cd17329 173 ---LLPETRPKRRAAEKT--------------------EILRGYKIVLRDrAFLLFLLASFLISLIYFQLESTLPVYVVE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 263 SSIFAKAGLGEAASILgsvgiGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLImailiwtIGIASSAWIIIVCLS 342
Cdd:cd17329 230 ILGLGESLLGLLLALN-----ALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAV-------LAFANTLAVLILAMI 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 343 LFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKF 421
Cdd:cd17329 298 VLTLGEMLVF-PAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-147 |
2.02e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.91 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 24 GVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRL 103
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 487748494 104 IIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAA 147
Cdd:COG2814 305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-419 |
4.27e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.05 E-value: 4.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPes 184
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 185 prwllenrneeaarqvmkityddseidkelkemKEINAISestwtvikspwlgriLIVGCIFAIFQQFIGINAVIFYSSS 264
Cdd:cd17323 175 ---------------------------------PIVLLLG---------------LYVGLVYAILYLFLTAFPYVFGEVY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 265 IFAKAGLGeaasiLGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIG---------MIASLLIMAILIWtIGIASSAW 335
Cdd:cd17323 207 GFSPGEVG-----LMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPepearlppaFIGAFLFPIGLFI-FGWTIYPH 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 336 IIIVCLSLFIVFFGISWGPVLWVM---LPELFPMRArGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIgV 412
Cdd:cd17323 281 IHWIVPIIGSAFFGFGLMLIFQSSltyLVDSYPKYA-ASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFI-S 358
|
....*..
gi 487748494 413 LAMIFVI 419
Cdd:cd17323 359 LAMIPIP 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-418 |
5.43e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 60.65 E-value: 5.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVnYAFADIEGWRWMLGLAVVPSVILLVgIYFMPESPrwllenrneeaarqvmkit 204
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVLLLLALVP-LLLTRRAA------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidKELKEMKEINAisestWTVIKSPWLGrilIVGCIFAIFQQFIGINAVIFYSSSIfakaGLGE--AASILGSVG 282
Cdd:cd17477 173 -------PEIEEAESISL-----RRLLRIAPLA---LLGAFVAGFLEGAFYSLLPLYGLRL----GLSVaqAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 283 IGTInvLVTIVAIFVVDKIDRKKLLVGgnigmIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISwgPVLWVMLPE 362
Cdd:cd17477 234 LGGL--LLQWPLGWLADRFDRRRVLLG-----CALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLY--TLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 487748494 363 LFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFV 418
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
22-178 |
8.79e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 8.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG 101
Cdd:cd17321 11 DVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAA 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 102 RLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGI 178
Cdd:cd17321 91 RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
45-200 |
9.92e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 59.98 E-value: 9.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAV 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWR---WMLGlaVVPSVILLVGIYFMPESPRWLLENRNEEAARQV 200
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRhifYVGG--VGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPV 209
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-419 |
1.88e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.13 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAvggsMSTVPVYLS---EMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLglaVVPSVILLVGIYFM 181
Cdd:cd17504 94 QGIG----GAVFPLAFAlvrEEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIF---WTAAPVAVLLAALV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 182 PESPRWLLENRNeeaarqvmkityddseidkelkemkeinaisestwtviksPWLGRILIVGCIFAIFQQFIGINAVIFY 261
Cdd:cd17504 167 PLIDLRLLRRRN----------------------------------------VLLANITALLAGFGMFMVFQLLPQLLQL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 262 SSSIFAKAGLGEAASILGSVGIGTInvLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIgiassaWIIIVCL 341
Cdd:cd17504 207 PTPTGFGLGITEAGLLLLPGALVML--IAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSL------WALVVAL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 342 SLFIVFFGISWGPVLWVMLpELFPMRARGAATGISALVLNIGTLI-------------VSLFFPILSDALSTEWVFLIFA 408
Cdd:cd17504 279 LLIGIGLGLAFASLPNIVV-ESVPPDRTGIATGMNTVLRTIGSAIgpaiagailttytVSITSGGVPTEGAYVLAFLIGA 357
|
410
....*....|.
gi 487748494 409 FIGVLAMIFVI 419
Cdd:cd17504 358 ALALAALLLSL 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-181 |
2.70e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 2.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVG 110
Cdd:cd17325 224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 111 GSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFM 181
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
47-418 |
3.41e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.96 E-value: 3.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 47 VVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPT 126
Cdd:cd17502 35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 127 EYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIyfmpesprwllenrneeaarqvmkityd 206
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL---------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 207 dseidkelkemkeinaisestwtvikspwlgRILIVGCIFAIFQQFIGInaVIFYSSSIFAKAGLGEAASILGSVGIGTI 286
Cdd:cd17502 167 -------------------------------RTILLSSIFGFLFGGALF--GLIYYLPLYFQLVLGDSATKSGVRLLPLI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 287 --NVLVTIVAIFVVDKIDR-KKLLVGGNIGMIASLLIMAILIWTigiaSSAWIIIVCLSLFIVFFGISWgPVLWVMLPEL 363
Cdd:cd17502 214 igLVIGSIISGALISKTGRyKPLIVIGTILMSVGAGLLTTLTLD----TSKWLLIGYLILLGLGLGIGF-QQPLVAVQNA 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 364 FPMRARGAATGISALVLNIGTLIvslffpilsdALSTEWVF---LIFAFIGVLAMIFV 418
Cdd:cd17502 289 VPPADVGVATATNTFFRSLGGTL----------GVAITDVFlvaLALAALAFLLSLFL 336
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-181 |
4.58e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.01 E-value: 4.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 24 GVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRL 103
Cdd:cd06173 226 ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALF 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 104 IIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFM 181
Cdd:cd06173 306 LLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
25-186 |
5.51e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 58.02 E-value: 5.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 25 VISGALLFIHKDIPlNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLI 104
Cdd:cd06179 16 LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVyLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAF--ADIEGWRW---MLGLAVVPSVILLVGIY 179
Cdd:cd06179 95 IGIGAGTQGLGAAV-ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWifyINAIFNALALILLFFFY 173
|
....*..
gi 487748494 180 FMPESPR 186
Cdd:cd06179 174 HPPPRPQ 180
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-396 |
5.88e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 57.77 E-value: 5.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLA 108
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 109 VGGSMSTVPVYLSEMAPTEYRGSLGS-LNQLMITIGILAAYLVNYAFADIEGWRWML----GLAVVPSVILLVGIYFMPE 183
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSfWNCSHNVGGGLLPPLVLFGIAELYSWHWVFivpgIIAIIVSLICFLLLRDSPQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 184 SP--RWLLENRNEEAArqvmkityDDSEIDKELKEMKEINAisestWTVIKSPWLgrILIVGCIFAIFQQFIGIN--AVI 259
Cdd:TIGR00881 177 SCglPPAEEMPNEEPD--------GDAEKKEEELTKKQIFL-----QYVLLNKVL--WYISLGYVFVYVVRTGILdwSPL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 260 FYSSSIFAKAGLGEAASILGSVGigtiNVLVTIVAIFVVDKIDRKKllvGGNIGMIASLLIM--AILIWTIGIASSAWII 337
Cdd:TIGR00881 242 YLTQEKGFSKEKASWAFTLYELG----GLVGTLLAGWLSDKLFNGR---RGPLAVFFMALIIvsLLVYWLNPAANPLMDL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 338 IvclSLFIVFFgISWGPVL--WVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSD 396
Cdd:TIGR00881 315 I---CLFALGF-LVYGPQMliGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
49-182 |
1.63e-08 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 56.21 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 49 SSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEY 128
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 487748494 129 RGSLGSLNQLMITIGILAAYLVNYAfadIEGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLILPGIAYF---IPHWRWLQLAVTLPNFLFLLYYWFIP 170
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-419 |
2.06e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 2.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 48 VSSMLIGAIVGAG---------SSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGrLIIGLAVGGSMSTVP- 117
Cdd:cd17370 31 ASAAAVGLIEGLAealgsllrlFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVLL-LRILERLGKGIRTPPr 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 118 -VYLSEMAPTEYRGSLGSLNQLMITIG----ILAAYLVNYAFAdiEGWRWMLGLAVVPSVILLVGIYFMPESPRWLLENR 192
Cdd:cd17370 110 dALLADATPPSGRGKAFGLHRALDTLGavlgPLLAALLLYLLG--GNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 193 NEEAARQVMKItyddseiDKELKemkeinaisestwtvikspwlgRILIVGCIFAIFQQFigiNAVIFYSssiFAKAGLG 272
Cdd:cd17370 188 KKSKKTSLKKL-------PKAFW----------------------LYLLAVALFALGNFS---FAFLILR---AQELGLS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 273 EAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigiASSAWIIIVCLSLFIVFFGIsW 352
Cdd:cd17370 233 AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL-------GSSLWLLLLGFILWGLYMGA-Q 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 353 GPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17370 305 ESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
244-445 |
8.55e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 8.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 244 CIFAIFQQFIGINAVIFYSSSIFAKAGLGEAAS--ILGSVGIGtiNVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIM 321
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIglIVAAYALA--QLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 322 AIliwtigiASSAWIIIVcLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTE 401
Cdd:cd17325 79 AF-------ATSYWQLLL-ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYR 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 487748494 402 WVFLIFAFIGVLAMIFVIKFLPETRGRSLEEIEYELRERTGART 445
Cdd:cd17325 151 APFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL 194
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
39-188 |
9.38e-08 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 53.66 E-value: 9.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPV 118
Cdd:cd17441 31 LPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTL 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 119 YlSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRWL 188
Cdd:cd17441 111 Y-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYW 179
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-193 |
9.92e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.73 E-value: 9.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLA 108
Cdd:cd17503 18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 109 VGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIG-----ILAAYLVNYAfadieGWRWMLGLAVVPSVILLVGIYFMpe 183
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLApaigpTLGGWLTDNL-----SWRWIFYINLPIGILALLLAPLL-- 170
|
170
....*....|
gi 487748494 184 sPRWLLENRN 193
Cdd:cd17503 171 -DLRLFKDRN 179
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
53-182 |
2.40e-07 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 52.43 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 53 IGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSL 132
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 487748494 133 GSLNQLMITIGILAAYLVNYAFADiegWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17447 126 GVLISLFWTVGNMLLALVAYLIRD---WRWLILAVTLPCAPGIITWWWVP 172
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
46-184 |
2.88e-07 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 52.50 E-value: 2.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 46 IVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSmSTVPVYLSEMAP 125
Cdd:cd17442 40 LVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGH-SQGLIIKTEFLP 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 126 TEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPES 184
Cdd:cd17442 119 TKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIPRT 177
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
45-182 |
2.93e-07 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 51.98 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLAD-KLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEM 123
Cdd:cd17378 36 GLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEP 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 124 APTEYRGSLGSLNQLMITIGILAayLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17378 116 VGPKWRGQVGMSTFFFFVLGFMS--LPGIAYLNGSSWRVLYFWTSIPALIYCILVYLFA 172
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
41-181 |
3.44e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 52.27 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 41 STTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYL 120
Cdd:cd17391 239 AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLL 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 121 SEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLglaVVPSVILLVGIYFM 181
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF---VVTALLVLLNAIWS 376
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-398 |
3.73e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 52.24 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 22 DNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGrRRLVMLIAIVFIIGALIL-AASTNLALLII 100
Cdd:cd17328 14 DRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILIWSAATLLsSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 101 GRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFAD-IEGWRWMLGLAVVPSVILLVGIY 179
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 180 FMPESPRWLLEnrnEEAARQVMKITyddseidKELKEMKEInaISESTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVI 259
Cdd:cd17328 173 LFVREPPRGAA---EGGVMAKSTAT-------SFLADLKAL--AKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 260 FYSSSIFAKAGLGEAASILGSVGIgtinVLVTIVAIFVVDKIDRKKLLVGGnIGMIASLLIMAILIwtIGIASSAWIIIV 339
Cdd:cd17328 241 GDLSSADVGLIFGAITCIAGVLGV----LLGGILADRLRRKTPRADPLVCA-VGLLAAAPFLFLAL--VLALSNLLLAWV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 340 CLSLFIVFFGISWGPVLWVMLPELFPmRARGAATGISALVLN-IGTLIVSLFFPILSDAL 398
Cdd:cd17328 314 LLFLGEFLLSLNWAPVFAILLYVVIP-TRRSTASAIQILLSHlLGDAGSPYLIGLISDLL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
280-428 |
3.81e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.78 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 280 SVGIGTINVLVTIVAIFVV----------DKIDRKKLlvggnigMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFG 349
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYAlgalllgplsDRIERRRL-------LLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 350 ISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGR 428
Cdd:cd17324 103 GFW-AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
26-205 |
4.05e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 52.01 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 26 ISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRrLVMLIAIV-FIIGALILAASTNLALLIIGRLI 104
Cdd:PRK03893 39 ITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRR-LAMVISIVlFSVGTLACGFAPGYWTLFIARLV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 105 IGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPES 184
Cdd:PRK03893 118 IGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEA 197
|
170 180
....*....|....*....|.
gi 487748494 185 PRWLLENRNEEAARQVMKITY 205
Cdd:PRK03893 198 EDWKEKHAGKAPVRTMVDILY 218
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
244-434 |
4.84e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 244 CIFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLlvggnigMIASLLIMAI 323
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-------LLIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 324 LIWTIGIASSAWIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWV 403
Cdd:pfam07690 75 GLLLLLFASSLWLLLVLRVLQGLGAGALF-PAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
170 180 190
....*....|....*....|....*....|.
gi 487748494 404 FLIFAFIGVLAMIFVIKFLPETRGRSLEEIE 434
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
48-419 |
5.43e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 5.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 48 VSSMLIGAIVGA-GSS--------GPLADKLGRRRLVMLIAIVF-IIGALILAASTNLALLIIGRLIIGLAvGGSMSTVP 117
Cdd:cd17490 28 ASLSMIGIILGAyGISqmllriplGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSGIA-AATWVSFT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 118 VYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRwllenrneeaa 197
Cdd:cd17490 107 VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 198 rqvmkityDDSEIDKELKEMKEinaisestwtVIKSPwlgRILIVGcIFAIFQQFIGInAVIFYSSSIFAKaGLGEAASI 277
Cdd:cd17490 176 --------EKKPVLTELKELLS----------VLKDK---KLLFFS-LLAILQQMITF-STTFGFTPLIAK-QLGASSFQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 278 LGSvgIGTINVLVTIVAIFVVDKIDRKKLlvGGNIGMIASLLIMAILiwTIGIASSAWIIIVCLSLFIVFFGISWG-PVL 356
Cdd:cd17490 232 LGL--LSIIYLLPNALASLLSGTLFYKKL--GERNTIIIGFLLLGAY--CFLIPFAPNLTLLYLLQALNGFGTGILfPLL 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487748494 357 WVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17490 306 MSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
35-351 |
7.84e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.10 E-value: 7.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 35 KDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRlvMLIAIVFIIGALIL--AASTNLALLIIGRLIIGLAVGGS 112
Cdd:cd17327 34 EDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSK--WLSVFIVLWGLLTLltAAVKNFGGLIALRFFLGLFESGV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 113 MSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADI------EGWRWM-LGLAVVPSVILLVGIYFMPESP 185
Cdd:cd17327 112 FPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLfIIEGLITIIIGLVIFFWLPDNP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 186 --RWLLENRNEEaarqVMKITYDDSEIDKELKEMKeinaisestWTVIKSPWLGRILIVGCIFAIFQQfiGINAVIFYSS 263
Cdd:cd17327 192 skAWFLTEEEKE----LAVERLRANQTGKGDQKFK---------WKQIKEAFKDPRTWLLFLFFFCSQ--ITNNGISNFL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 264 SIFAKAGLGEAASI-LGSVGIGTINVLVTIVAIFVVDKIDRKKLlvggnIGMIASLLIMAILIWTIGIASSAWIIIVCLS 342
Cdd:cd17327 257 PLILKSLGFYSLQTnLLSVPIGALGAVSLLIAALLSDRFKKRGL-----FAIFACVLALVGSIILLAAPNPPGAYFAAYI 331
|
....*....
gi 487748494 343 LFIVFFGIS 351
Cdd:cd17327 332 LGGGSYAGF 340
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
29-381 |
9.17e-07 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 50.96 E-value: 9.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPL-NSTTE-----GIVVSSMLIGAIvGAGSSGPLADKLGRRRLVMLIAIVFIIGALILA--------ASTN 94
Cdd:PRK10406 45 SLYFAHIFFPSgNTTTQllqtaGVFAAGFLMRPI-GGWLFGRIADKHGRKKSMLISVCMMCFGSLVIAclpgyetiGTWA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 95 LALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLV----NYAFADIE----GWRWMLGL 166
Cdd:PRK10406 124 PALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVvvvlQQTLEDAElrewGWRIPFAL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 167 AVVPSVILLvgiyfmpesprWLLENRNEEAarqvmkityddseiDKELKEMKEINAisestwtvIKSPWLGR---ILIVG 243
Cdd:PRK10406 204 GAVLAVVAL-----------WLRRQLDETS--------------QQETRALKEAGS--------LKGLWRNRrafIMVLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 244 cifaifqqFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIF------VVDKIDRKKLLVggNIGMIAS 317
Cdd:PRK10406 251 --------FTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIqpligaLSDKIGRRTSML--CFGSLAA 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 318 LLIMAILIWTIGIASS-AWIIIVCLSLFIVFFGISWGPVLWVmlpELFPMRARGAATGISALVLN 381
Cdd:PRK10406 321 LFTVPILSALQNVSSPyAAFGLVMCALLIVSFYTSISGILKA---EMFPAQVRALGVGLSYAVAN 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
39-183 |
1.39e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.38 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIV-FIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVP 117
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGsAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMG 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487748494 118 VYLSEMAPTEYRGS-LGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPE 183
Cdd:cd17371 322 AYLTELFPTAVRATaQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-150 |
1.76e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 40 NSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVY 119
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
90 100 110
....*....|....*....|....*....|.
gi 487748494 120 LSEMAPTEYRGSLGSLNQLMITIGILAAYLV 150
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
27-188 |
2.47e-06 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 49.67 E-value: 2.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 27 SGALLFIHKDIPlNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIG 106
Cdd:pfam06609 64 ASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 107 LAVGGSMSTvPVYLSEMAPTEYRgslgSLNQLMITIGILAAYLVNYAFAD---IEG-WRWMLGLAVVPSVI--LLVGIYF 180
Cdd:pfam06609 143 VAAGPAGAS-PLFIGELMSNKTK----FLGLLIVSAPTIAMNGAGPYFGQrlaIQGnWRWIFYIYIIMSAIavLLIIIWY 217
|
....*...
gi 487748494 181 MPESPRWL 188
Cdd:pfam06609 218 HPPSFAQL 225
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
281-425 |
3.70e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.49 E-value: 3.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 281 VGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigiASSAWIIIVCLSLFIVFFGISWGPVLwVML 360
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFAL-------SSNITVLIIARFLQGFGAAFALVAGA-ALI 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 361 PELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPET 425
Cdd:TIGR00880 77 ADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
38-182 |
5.29e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 48.06 E-value: 5.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 38 PLNSTTEGIVVSSMLIGAIVGagssGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVP 117
Cdd:cd17374 35 SLKSVAQSIFMAGLLVGALIF----GHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTL 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 118 VYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADiegWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17374 111 ILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRD---WRLLQLVVSVPFFLFFLYSWWLP 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-198 |
6.43e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 6.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 23 NGVISGALLFIHKD-IPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIG--ALILAASTNLALLI 99
Cdd:COG2211 244 LALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGllLLFFLGPGNLWLLL 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 100 IGRLIIGLAVGGSMSTVPVYLSEMAP-------TEYRGSLGSLNQLMITIGILAAYLVNYAFADIEG------------W 160
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsalT 403
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 487748494 161 RWMLGLAVVPSVILLVGI---YFMPESPRWLLENRNEEAAR 198
Cdd:COG2211 404 GIRLLFFLLPAVLLLLAAlllLFYPLTRERHAEIRAELAAR 444
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
246-432 |
6.87e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.19 E-value: 6.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 246 FAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIli 325
Cdd:cd06174 3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 326 wtigiASSAWIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEW--V 403
Cdd:cd06174 81 -----APSFWLLLLGRFLLGLGSGLID-PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWraV 154
|
170 180
....*....|....*....|....*....
gi 487748494 404 FLIFAFIGVLAMIFVIKFLPETRGRSLEE 432
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESARAK 183
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-419 |
7.27e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 7.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 23 NGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGR 102
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 103 LIIGLAVGGSMSTVPVYLSeMAPTEYRGSLGSLNQLMITIG-----ILAAYLVNYafadiegwRWMLGLAVVPSVILLVG 177
Cdd:cd17478 92 ALAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGfalgpLIAAALVAL--------FGGLGLLILLIIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 178 IYFMPESPRWLLENRNEEAARQVMKITYddseidkelkemkeinaisestwtviKSPWLGRILIVGCIF--AIFQQFIGI 255
Cdd:cd17478 163 ALLLLRLRPLKKPEAKKAAAKSSARSTL--------------------------KGVWRALLLLLIIVFlrSWVLSSLTT 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 256 NAVIFYSSSIFAKAGLGEAASI-LGSVGIGtinvlvTIVAIFVVDKIDRKKLLVggnIGMIASLLIMAILIWTIGIASSA 334
Cdd:cd17478 217 FLPFYLVQRGYSLVFAGLLLSLfLFAGAIG------TLIGGPLSDRFGRRRVII---ASLLLAAPFLLLFLLTPGIWSYI 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 335 WIIIVCLSLFivffgiSWGPVLWVMLPELFPmRARGAATGIS-ALVLNIGTLIVSLfFPILSDALSTEWVFLIFAFIGVL 413
Cdd:cd17478 288 LLVLAGFLLF------ASFPVTVVLAQELLP-GNVGLASGLMmGLSFGLGGIGAPV-LGALADAFGLESVLLILALLPLL 359
|
....*.
gi 487748494 414 AMIFVI 419
Cdd:cd17478 360 GALLAF 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
39-182 |
7.34e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.96 E-value: 7.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAA-STNLALLIIGRLIIGLAVGGSMSTVP 117
Cdd:cd17504 214 LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLP 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 118 VYLSEMAPTEYRGSLGSLNQLMITIG------ILAAYLVNYA-------FADIEGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17504 294 NIVVESVPPDRTGIATGMNTVLRTIGsaigpaIAGAILTTYTvsitsggVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
46-180 |
1.04e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.52 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 46 IVVSSMLIGAIVGAGS---SGPLADKLGRRRLVM---LIAIVFIIGALILAASTNLALLIIGRLII-GLAVGGSMSTVPV 118
Cdd:cd17369 265 TVLLAVLIASVVAAITiplFGWLSDRVGRRPVYLagaLLAALFAFPFFWLLDTGSTWLIVLAAVVVlGVLHGMMYGPQAA 344
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487748494 119 YLSEMAPTEYRGSLGSLNQLMITI--GILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYF 180
Cdd:cd17369 345 FLAELFPTRVRYTGASLGYQLGAIlgGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
246-424 |
1.50e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 246 FAIFQQFIGINAVIFYSSSIFAKAGLgeaasilgsvgIGTINVLVTIVAIFV-------VDKID-----RKKLLVGGNIG 313
Cdd:COG2211 22 LNLAFGLLSAYLLYFYTDVLGLSAAL-----------VGLILLVARLWDAITdpligalSDRTRtrwgrRRPWILIGAIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 314 MIASLLIMAILIwTIGIASSAWIIIVCLSLFIVFFGISWGPvLWVMLPELFP-MRARGAATGISALVLNIGTLIVSLFFP 392
Cdd:COG2211 91 LALSFVLLFTAP-DLSPTGKLIYALVTYLLLGLAYTLVNIP-YSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPP 168
|
170 180 190
....*....|....*....|....*....|....*...
gi 487748494 393 ILSDALSTE------WVFLIFAFIGVLAMIFVIKFLPE 424
Cdd:COG2211 169 PLVAAFGGDaalgyrLTALIFAVLGLLAFLLTFFGTKE 206
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
53-398 |
1.55e-05 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 46.86 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 53 IGAIVgagsSGPLADKLGRRRLVMLIAIVFIIGALILA-----ASTNLA---LLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:PRK15075 71 LGAIV----LGAYIDRVGRRKGLIVTLSIMASGTLLIAfvpgyATIGLAaplLVLLGRLLQGFSAGVELGGVSVYLAEIA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSL----NQLMITIGILAAYLVNYAFADIE----GWR--WMLGLAVVPSVILLvgiyfmpespRWLLENRNE 194
Cdd:PRK15075 147 TPGRKGFYTSWqsasQQVAVVFAALLGYLLNQWLSPAQmaewGWRipFLIGCLIVPFIFLI----------RRSLEETEE 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 195 EAARqvmkityddseidKELKEMKEINAISESTWtvikspwlgRILIVGCIFAIfqqfigINAVIFYSSSI----FAKA- 269
Cdd:PRK15075 217 FLAR-------------KHRPSMREIFRSLAANW---------RIVLAGMLMVA------MTTVSFYLITVytptFGKTv 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 270 -GLGEAASILGSVGIGTINVLVTIVAIFVVDKIDRKKLLVGgnIGMIASLLIMAILIWTIGIASSAWIIIVclSLFIVFF 348
Cdd:PRK15075 269 lHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIA--FTVLAILTAYPALSWLVAAPSFARMLAV--ELWLSFL 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 487748494 349 GISWGPVLWVMLPELFPMRARgaATGISaLVLNIGTLIVSLFFPILSDAL 398
Cdd:PRK15075 345 YGSYNGAMVVALTEVMPAEVR--TAGFS-LAYSLATAIFGGFTPAISTWL 391
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
238-436 |
1.92e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 238 RILIVGCIFAIFQQFIGINAVIFYsssIFAKAGLGEAASILGSVGIGTInVLVTIVAIFVVDKIDRKKLLVGGNIGMIAS 317
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWL---VLQLTGSALLVGLVLAAFFLPF-LLFSPFAGVLADRFDRRRLLILADLLRALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 318 LLIMAILIWTIGIAssaWIIIVCLSLFIVFFGISWGPVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDA 397
Cdd:cd06173 78 AAVLALLALLGSLS---LWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 487748494 398 LSTEWVFLI--FAFIGVLAMIFVIKFLPETRGRSLEEIEYE 436
Cdd:cd06173 155 LGPGGAFAInaLSFLLSALLLLFIRRPPPAAPGESSSLLLR 195
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
47-185 |
2.17e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 46.60 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 47 VVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGlaVGGSMSTVPVY--LSEMA 124
Cdd:TIGR00711 42 VITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQG--FGGGPLIPLSFstLLNIY 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 125 PTEYRGSLGSLNQLMITIG-----ILAAYLVnyafaDIEGWRWMLGLAVVP--SVILLVGIYFMPESP 185
Cdd:TIGR00711 120 PPEKRGRAMAIWGLTVLVApalgpTLGGWII-----ENYHWRWIFLINVPIgiIVVVVAFFILPRDKP 182
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
299-430 |
2.42e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.96 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 299 DKIDRKKLLVGGNIGMIASLLImailiwtIGIASSAWIIIVclslFIVFFGISWG---PVLWVMLPELFPMRARGAATGI 375
Cdd:COG0477 74 DRYGRKRVLLIGLLLFGLASLL-------CGLAPSPELLIA----ARALQGIGAGglmPGALALIAELFPARERGRALGL 142
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 376 SALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIkFLPETRGRSL 430
Cdd:COG0477 143 WGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRL-RLPESRGLLL 196
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
63-184 |
2.47e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 46.44 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 63 GPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGL--AVGGSMS-TVPVYLSEMAPTEYRGSLgsLNQLM 139
Cdd:PRK11652 64 GPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLgtGVGGVMArTLPRDLYEGTQLRHANSL--LNMGI 141
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 487748494 140 ITIGILAAYLVNYAfADIEGWR-WMLGLAVVPSVILLVGIYFMPES 184
Cdd:PRK11652 142 LVSPLLAPLIGGLL-TTLFGWRaCYLFLLLLGAGVTFSMARWMPET 186
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-173 |
2.63e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.11 E-value: 2.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 36 DIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIG-RLIIGLAVGGSMS 114
Cdd:cd17355 239 DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVP 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 115 TVPVYLSEMAPTEYRGSLGSLNQLMITIGI-LAAYLVNYAFADIEGWRWMLGLAVVPSVI 173
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSaLGPWLGGLLYDRTGSYTAAWALAVALGLI 378
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
49-108 |
3.16e-05 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 46.06 E-value: 3.16e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 49 SSMLIGAIVGagssgPLADKLGRRRLVMLIAIVFIIGALiLAASTNLALLIIGRLIIGLA 108
Cdd:cd17487 50 SSVVFGTFVG-----SLADKFGRKRACLLFCVLYSLSCL-TKHSPNFGVLLLGRVLGGIS 103
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
54-182 |
3.27e-05 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 45.92 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 54 GAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGsMSTVP-VYLSEMAPTEYRGSL 132
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGG-MSLVAfVLLNECVGKSYWALA 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 487748494 133 GSLNQLMITIGILAAYLVNYAfadIEGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17377 130 GSLGGLFFAVGIAQYALLGYF---IRSWRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
26-422 |
5.34e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.34 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 26 ISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLII 105
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 106 GLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWmlGLAVVPSVILLVGIYFMpesp 185
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRA--AFLVPGIVGLVVAIILF---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 186 rwllenrneeaarqvmkityddseidkelkemkeinaisestWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFYSSSI 265
Cdd:cd17312 176 ------------------------------------------FFLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 266 FAKAgLGEAASILGSVGIGTInvLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGiasSAWIIIVCLSLFI 345
Cdd:cd17312 214 KGYS-LIDAGWFSSLYEVGGI--AGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPH---NKLLSIVLLFLIG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 346 VFFGiswGP--VLWVMLPELFPMR-ARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFL 422
Cdd:cd17312 288 FFVG---GPinLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
62-395 |
5.78e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 45.38 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 62 SGPLADKL----GRRRLVMLIAIVFIIGALILAAST----NLALLI-IGRLIIGLAVGGSMSTVP--VYLSEMAPT-EYR 129
Cdd:pfam13347 53 VGHIIDRTrtrwGRRRPWLLLSAIILAVSFILLFTPpelgRAPLFIwLLATYILLRIAYTFFEIPywSLGPELTRDyDER 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 130 GSLGSLNQLMITIGILAAYLVNYAFADIE--------GWRWMlglAVVPSVILLVGIYFMPESPRWLLENRNEEAARQVM 201
Cdd:pfam13347 133 TSLTSYRSFFSVGGGLLAAALAFPLVLILggtglerkGYRIF---ALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 202 KITYDDseidkELKEMKEINAIsestwtvikspwlgRILIVGCIFAIFQQFIGINAVIFYSSSIfakagLGEAASILGSV 281
Cdd:pfam13347 210 AGSLLD-----MLKEVFRNRAF--------------LILLASFLLAALAMGVLNGLLLYYFRYV-----LGNGFAASAFP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 282 GIGTI-NVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILiwtigIASSAWIIIVCLSLFIVFFGISWgPVLWVML 360
Cdd:pfam13347 266 LVFTIgALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLL-----GPNNTLLFLVLYIIIGFGYGSSF-FLPWSML 339
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 487748494 361 PELF-------PMRARGAATGISALVLNIGTLI-VSLFFPILS 395
Cdd:pfam13347 340 ADVVdygelrtGKRREGTFFAMWSFISKLATGVgLGVSGLLLS 382
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
63-418 |
6.98e-05 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 44.66 E-value: 6.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 63 GPLADKLGRRR-----LVMLIAIVFIIGALILAASTNL---ALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGS 134
Cdd:cd17366 61 GPLGDKYGRQKvlaitIILMAASTFCIGLLPTYATIGVwapILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 135 LnqlmITIGILAAYLVNYAF----------ADIEGWRWMLGLaVVPSVILLVGIYFMPEsprwllenrneeaarqvmkit 204
Cdd:cd17366 141 W----LEFGTLAGFILGAGLvtlltlllteAQMLDWGWRIPF-LIAAPLGLVGLYLRRP--------------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidkelkemkeinaisestwtvikspwlgrILIVGCIFAIFQqfIGINAVIFYSSSIFAKA-GLGEAASILGSVGI 283
Cdd:cd17366 195 ----------------------------------LLICIGLVLVFN--VTNYMLLSYMPSYLEETlGYSETHGLLVIIII 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 284 GTINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWGpvlwvMLPEL 363
Cdd:cd17366 239 MVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMAS-----TLPAL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 364 FPMRARGAATGIS-----ALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFV 418
Cdd:cd17366 314 FPTHVRYSALAIAfnisvSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGLVAVLFL 373
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
46-425 |
1.06e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.91 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 46 IVVSSMLIGAIVGAGSSGPLADKLGRRRlVMLIAIVFIIGALILAASTNLALLIIGRLIIgLAVGGSMSTV--PV---YL 120
Cdd:PRK08633 51 IVNALFLLPFLLLSSPAGFLADKFSKNR-VIRIVKLFEVGLTLLIVLAYYLGWFWLAFAV-TFLLGAQSAIysPAkygII 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 121 SEMAPTEYRGSLGSLNQLMITIGILAA---------YLVNYAFADIEGWRWMLGLAVVPsvILLVGIYFMpesprWLLEN 191
Cdd:PRK08633 129 PELVGKENLSRANGLLEAFTIVAILAGtalfsflfeSVNGNTPSEILGRIAPAGLVLLA--VAVLGLIFA-----YRLPK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 192 RNEEAARQVMKITYDD-SEIDKELKEMKEINAIsestwtvikspWLGrilIVGCIFaifqqFIGINAVIFYSSSIFAKAG 270
Cdd:PRK08633 202 VPAAAPEVFDKKKYLFpKLLWRNLKLLRSDRVL-----------WLA---IIGLSY-----FWFISQLAQANFPAYAKEV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 271 LGE----------AASILGsVGIGTInvlvtivaifVVDKIDRKKLLVG----GNIGMIASLLIMAIliwtigiASSAWI 336
Cdd:PRK08633 263 LGLdntfqvqyllAASAIG-IGIGSL----------LAGRLSGRHIELGlvplGALGLALSLFLLPT-------APSLAS 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 337 IIVCLslfiVFFGISWGpVLWVMLPELFPMRARGAATG----ISALVLNIGTLIVSLFFPILSDA-LSTEWVFLIFAFIG 411
Cdd:PRK08633 325 VLVLF----FLFGFSAG-LFIVPLNALIQFRAPEKELGkvlaANNFLQNVGMLLFLALTTLFSGLgLSPAGLFYLIALVT 399
|
410
....*....|....
gi 487748494 412 VLAMIFVIKFLPET 425
Cdd:PRK08633 400 LIGTLYTLLLLPDS 413
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
63-419 |
1.34e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 43.74 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 63 GPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLavGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITI 142
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 143 GILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMpesprwllenrneeaarqvmkityddseidkeLKEMKEINA 222
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFF--------------------------------VPDPPKIVQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 223 ISESTWTVIKSPWLGRILIVGCiFAIFQQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIGTINVLVTIVAIFVVDKID 302
Cdd:cd17472 179 ISEKEKKKLKKLLKNKRLLRLD-FSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 303 RKKLLVGGNIGMIAslliMAILIWTIGIASSAWIIIVCLSLFIVFFGISwgPVLWVMLPELFPMRARGAATGISALVLNI 382
Cdd:cd17472 258 KMKQVFVSSILLIA----VGFLLLLFAATSLWLLIIGLIIFFIGFNLLE--ALLPSLVSKIAPKEYRGTAMGIYNTSQFL 331
|
330 340 350
....*....|....*....|....*....|....*..
gi 487748494 383 GTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17472 332 GSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
40-176 |
1.53e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 43.76 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 40 NSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVML-IAIVFIIGALI-LAASTNLALLIIGRLIIGLAVGGSMSTVP 117
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYsILITALLTLLTpLAARGGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487748494 118 VYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWM------LGLAVVPSVILLV 176
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIfyifggLGLLWCLLWFFLV 198
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-147 |
1.59e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRR---LVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMST 115
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
90 100 110
....*....|....*....|....*....|..
gi 487748494 116 VPVYLSEMAPTEYRGSLGSLNQLMITIGILAA 147
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
283-429 |
2.32e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.32 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 283 IGTINVLVTIVAIFVVDKIDRKkllVGGNIGMIASLLIMAILIWTIGIASSAWIIIvcLSLFIVFFGISWGPVLW-VMLP 361
Cdd:COG2807 58 LTTLPLLAFGLFAPLAPRLARR---FGLERTLLLALLLLAAGLLLRSLAPSVALLL--AGTALIGAGIAVGNVLLpGLIK 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 362 ELFPMRaRGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLPETRGRS 429
Cdd:COG2807 133 RWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
45-417 |
2.44e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLaVGGSMSTVPVYLSEMA 124
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 125 PTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWRWMLGLAVVPSVILLVGIYFMPesprwllenrneeaarqvmkit 204
Cdd:cd17330 116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL---------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 yddseidkelkemkeinaisestwtviksPWLGRILIVGCIFAIfqQFIGINAVIFYSSSIFAKAGLGEAASILGSVGIG 284
Cdd:cd17330 174 -----------------------------PPLRRLLLVYFLIAL--AFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 285 TINVLVTIVAIFvVDKIDRKKLLVGGnigmiasLLIMAILIWTIGIASSawIIIVCLSLFIVFFGISW-GPVLWVMLPEL 363
Cdd:cd17330 223 GILAQLLLIPRL-AKRLGERKLLRLG-------LLLAIIGLLLLPFASS--VPLLVLAAAILAFGTGIvFPALSALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 487748494 364 FPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIF 417
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
68-419 |
2.46e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.38 E-value: 2.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 68 KLGRRRLVMLIAIVFIIGALIL--------------AASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLG 133
Cdd:cd17313 64 RIGRRRPFILVGAPLAALGLILipnaadiglalgdgPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKAN 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 134 SLNQLMITIGILAAYLVNYAFADIEGWRWMLG---------LAVVPSVILLVGIYFMPEsprwllenrneeaarqvmkit 204
Cdd:cd17313 144 GIINFMGGLGGVLGYLLGAILWDHNWFGFALGgnlkvpfyiGAIILLVCVLVTLFFVKE--------------------- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 205 YDDSEIDKELKEMKEINAISESTWTVIKS--PWLGRILIVgcifaIFQQFIGINAVIFYSSSIFAKA---GLGEAASILG 279
Cdd:cd17313 203 PPLSPEAGEHSENPSLGEVLKSLLKLLKImpRSLLRLLLV-----IFFWWIAFFPFELFFTDYMGEEvyhGTSAASSHYG 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 280 -SVGIGTIN--------VLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigIASSAWIIIVCLSLFIVFFGI 350
Cdd:cd17313 278 aGVRMGAWGllifslafLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMAL------VHNVTVALVLFALGGIGWATI 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 351 SWGPVLWV--MLPELfpMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17313 352 NINPYPLVsdYHSES--GRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGAL 420
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
308-423 |
2.84e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 308 VGGNIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLNIGTLIV 387
Cdd:cd17319 65 FGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFF-PGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
90 100 110
....*....|....*....|....*....|....*.
gi 487748494 388 SLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLP 423
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
45-419 |
3.36e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGR-LIIGLAVGGSMSTVPVYLSEM 123
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 124 APTEYRGslgslnqLMITIGILAAYLVNYAFA-------DIEGWRW-MLGLAVVPSVILLVGIYFMPESPrwllenrnee 195
Cdd:cd17355 121 WFERRRG-------LALGILTAGGGLGSLVFLplgaaliEAFGWRTaLLVLALLALLVLVPVLLLLRRRP---------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 196 aARQVMKITYDDSEIDkelkemkeinaiSESTWTVIKSPWLGRILIVGCIFAIFQQfigiNAVIFYSSSIFAKAGLG--E 273
Cdd:cd17355 184 -ADLALRAYDDASPAS------------PGSTLKEALRSASFWLLALAFFLCGFAV----VGLIVHLVPYLADRGISpaA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 274 AASILGSVGIGtiNVLVTIVAIFVVDKIDRKKLLVggnIGMIASLLIMAILIWTIGIASSAWiiivclsLFIVFFGISWG 353
Cdd:cd17355 247 AAVALALIGLF--NIVGRLLSGWLGDRYSPRRLLA---ASYALRALGLALLLLLPFPPLALL-------LFAALFGLGWG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 354 ---PVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDAL-STEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17355 315 atvPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
30-418 |
3.48e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.62 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 30 LLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILA-ASTNLALLIIGRLIIGLA 108
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALAlAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 109 vGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIE-------GWRWMLGLAVVPSVILLVGIYFM 181
Cdd:cd17341 102 -GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWRNAFFVPGILLAIAAVLVLLF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 182 PESPrwllenrneeaarqvmkitydDSEIDKELKEMKEINAISEStwtviKSPWLGRILIVGCifaiFQQFIGINAVIfy 261
Cdd:cd17341 181 GDDL---------------------PTGKASALEFLKVQLAVLKN-----YRTWILSLLYGVT----FGSFVGFSNVL-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 262 SSSIFAKAGLG-EAASILGSVGIGtINVLVTIVAIFVVDKIDRKKLLVGGNIGMIASlliMAILIWTIGIAS-SAWIIIV 339
Cdd:cd17341 229 PTYFKTRFGLPlVTAGILAALFPL-AGALARPAGGWLSDRFGGRRRLWWLFIVMTIG---AALLSLSLPTSGtNLVLFLA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 340 CLSLFIVFFGISWGpvlwvMLPELFPMRAR---GAATGISALVLNIGT-LIVSLFFPILSDALSTEWVFLIFAFIGVLAM 415
Cdd:cd17341 305 LFVALGLGAGAGNG-----SVFRMVPFIFRrelGAVTGLVGAIGGLGGfFLPLLFGSSALMTGSGVGAFSLFGVLAVACT 379
|
...
gi 487748494 416 IFV 418
Cdd:cd17341 380 LLV 382
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
31-108 |
3.71e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 42.74 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRR--LVMLIAIVFIIGALILAAST------NLALLIIGR 102
Cdd:PRK12382 40 LFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRsaLQGMLACGLAGLAYLLAAILpvsapfKFALLVVGR 119
|
....*.
gi 487748494 103 LIIGLA 108
Cdd:PRK12382 120 LILGFG 125
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
257-439 |
4.31e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 257 AVIFYSSSIFAKAGLGEAASILGSV--GIGTINVLVTIVAIFVVDKIDRKKLlvggnigMIASLLIMAILIWTIGIASSA 334
Cdd:cd17329 16 FMVWPFMAIYLHQQLGLSASIVGLVlaLSAVAGIVASLIGGRLADRFGRKPV-------MLAGLLLRALGFALLGFAHSP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 335 WIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISALVLN----IGTLIVSLFFpilsdALSTEWVFLIFAFI 410
Cdd:cd17329 89 WLFAIALVLTGFGGGLFE-PASEAMIADVTTPENRTRAFSLLYWAINlgvaIGPLLGGLLL-----LYSFRLLFLAAAVL 162
|
170 180
....*....|....*....|....*....
gi 487748494 411 GVLAMIFVIKFLPETRGRSLEEIEYELRE 439
Cdd:cd17329 163 FLLAALVLLFLLPETRPKRRAAEKTEILR 191
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
29-109 |
4.33e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 42.37 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLA 108
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
.
gi 487748494 109 V 109
Cdd:TIGR00710 107 A 107
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
271-431 |
5.21e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 271 LGEAASILGSVGIGTInvLVTIVAIFVVDKIDRKKLLVGGNIGMIASLLIMAIliwtigiASSAWIIIVCLslfiVFFGI 350
Cdd:cd17475 30 LAQVGLLLSALNLGVA--VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL-------VGSYPVLLVLL----FLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 351 SWGPVL---------WvmlpelFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKF 421
Cdd:cd17475 97 GYGSVQpgggraimrW------FPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
170
....*....|
gi 487748494 422 LPETRGRSLE 431
Cdd:cd17475 171 YREPPAASAA 180
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
49-182 |
6.33e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 41.63 E-value: 6.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 49 SSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEY 128
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 487748494 129 RGSLGSLNQLMITIGILAAYLVNYAfadIEGWRWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYA---IRDWRWLQLAVSLPFFIFFLYSWWFP 170
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
63-422 |
6.69e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.85 E-value: 6.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 63 GPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLaVGGSMSTVPVYLSEMAPTEYR----GSLGSLNQL 138
Cdd:cd17388 59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRarnfGLLGAAFGL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 139 MITI-----GILAAYLVNYAFadiegwrwmLGLAVVPSVILLVGIYFMPESprwllenRNEEAARqvmkityddseidke 213
Cdd:cd17388 138 GFIAgpalgGLLGEISPRAPF---------LVAAGLNGLNFLLGLFVLPES-------LPPERRR--------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 214 LKEMKEINAISeSTWTVIKSPWLGRILIVGCIFAIFQQFIGINAVIFysssIFAKAGLGEAASILGSVGIGTINVLV-TI 292
Cdd:cd17388 187 AFRWRRANPFG-SLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLF----TEDRFDWSPTMVGLSLAVFGLLHALFqAF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 293 VAIFVVDKIDRKKLLVggnIGMIASLLIMAILiwtiGIASSAWIIIVCLSLFiVFFGISwGPVLWVMLPELFPMRARGAA 372
Cdd:cd17388 262 VTGPIAKRLGEKRAIL---LGLAADALGFLLL----AFATQGWMVFPILILL-ALGGIA-GPALQGLLSRQVPENEQGEL 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 487748494 373 TGISALVLNIGTLIVSLFFPILSDALSTEW---VFLIFAFIGVLAMIFVIKFL 422
Cdd:cd17388 333 QGVLTSLTSLTSIIGPLLFTGIFAASPATWpglAWIIGAALYLICLVLAYRFF 385
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
53-131 |
6.95e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 6.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 53 IGAIVGAGSSGPLADKLGRRRLVML-IAIVFIIGALILAASTNLALLIIGrLIIGLAVGGSMSTVPVYLSEMAPTEYRGS 131
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVILVsLVIWIVVCLAAYFLTTALAFWILG-LLIGLVMGGIQALSRSLLARLIPPGREAE 363
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
39-155 |
8.48e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLI-AIVFIIGALILA---ASTNLALLIIGRLIIGLAVGGSMS 114
Cdd:cd17502 200 DSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIgTILMSVGAGLLTtltLDTSKWLLIGYLILLGLGLGIGFQ 279
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 487748494 115 TVPVYLSEMAPTEYRGSLGSLNQLMITIG------ILAAYLVNYAFA 155
Cdd:cd17502 280 QPLVAVQNAVPPADVGVATATNTFFRSLGgtlgvaITDVFLVALALA 326
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
35-129 |
9.25e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 41.19 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 35 KDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIA---IVFIIGALILAASTNLALLIIGRLIIGLAVGG 111
Cdd:cd17366 222 ETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLaglLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSC 301
|
90
....*....|....*...
gi 487748494 112 SMSTVPVYLSEMAPTEYR 129
Cdd:cd17366 302 YTATMASTLPALFPTHVR 319
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-184 |
9.81e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.05 E-value: 9.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLA 108
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 109 VGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYAFADIEGWR---WMLGLAVVPSVILLVgiYFMPES 184
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHaifWVLALAAILAAALVF--FFIPET 169
|
|
| MFS_5 |
pfam05631 |
Sugar-tranasporters, 12 TM; MFS_5 is a family of sugar-transporters from both prokaryotes and ... |
49-108 |
1.08e-03 |
|
Sugar-tranasporters, 12 TM; MFS_5 is a family of sugar-transporters from both prokaryotes and eukaryotes.
Pssm-ID: 283321 Cd Length: 356 Bit Score: 41.10 E-value: 1.08e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 49 SSMLIGAIVGAgssgpLADKLGRRRLVMLIAIVFiIGALILAASTNLALLIIGRLIIGLA 108
Cdd:pfam05631 81 SSLLFGTFIGS-----IADKFGRKNACIMYAILY-GGACITKHFGEMKILMIGRFLGGIA 134
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
297-419 |
1.17e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.07 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 297 VVDKIDRKKLLVggnIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWGP-----VLWvmlpelFPMRARGA 371
Cdd:cd17345 61 LSDRSNPKRFLA---IGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPsgrtmVHW------FSKKERGT 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 487748494 372 ATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17345 132 WTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAV 179
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
70-394 |
1.19e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.05 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 70 GRRRLVMLIAIVFIIGALIL----AASTNLALLIIGRLIIGLAVGGSMSTVPV--YLSEMAPT-EYRGSLGSLNQLMITI 142
Cdd:cd17332 68 RFRPWLLWGAIPLALLFVLLfttpDGSGTGKLIYALITYILLDLLYTLVNIPYtaLIPELTDDpEERTSLTSWRMFFATI 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 143 GILAAY-----LVNYaFADIEGWRWMLGLAVVPSVILLVGIYFmpesprwllenrneeaarqVMKITYddsEIDKELKEM 217
Cdd:cd17332 148 GGLLVTvlpppLVAY-FGGGNASRGYFLTALIIGIIGIILLLI-------------------CFFGTR---ERVVPPEEE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 218 KEINAISESTWTVIKSPWLgrILIVGCIFAIFQQFIGINAVIFYsssIFAKAGLGEAASILGSVGIGTINVLVTIVAIFV 297
Cdd:cd17332 205 KSKLPLLKSLKALLKNRPF--LILLLAYLLYFLAFNIVNTVLVY---YFKYVLGGRAELVLLLLLILSGALLALLPWPPL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 298 VDKIDRKKLLVGGNIGMIASLLIMAILiwtigIASSAWIIIVCLSLFIVFFGISWgPVLWVMLPEL-------FPMRARG 370
Cdd:cd17332 280 KKRFGKKKAFFIGLLLAILGLLLLFFL-----PPGNLVLILVLAVLAGIGYGGAN-LLPWAMLADVidygelkTGKRREG 353
|
330 340
....*....|....*....|....
gi 487748494 371 AATGISALVLNIGTLIVSLFFPIL 394
Cdd:cd17332 354 IFYSVMTFFRKLGLALAGALVGLI 377
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
31-108 |
1.38e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 40.64 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVML-IAIVFIIGALILAASTN-------LALLIIGR 102
Cdd:PRK05122 40 GYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFgLCGCALSGLLYLLAGLLaawpvlsLLLLLLGR 119
|
....*.
gi 487748494 103 LIIGLA 108
Cdd:PRK05122 120 LLLGIG 125
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
29-175 |
1.84e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 29 ALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKL--GRRRLVM----LIAIVFIIGALILAASTNLALLIIGR 102
Cdd:cd17475 221 LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLvitaAIAAAALLVLSLLSPGTPLWLLVLLL 300
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487748494 103 LIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGILAA-----YLVNYAFADIEGWRWMLGLAVVPSVILL 175
Cdd:cd17475 301 ILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGpplfgLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
299-422 |
1.91e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.28 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 299 DKIDRKKLLvggnigmIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWgPVLWVMLPELFPMRARGAATGISAL 378
Cdd:cd17316 61 DRIGRKKAL-------ILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEY-PGASTYVAEFAPSKRRGFALGLLQS 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 487748494 379 VLNIGTLIVSLFFPILSDALSTEW----VFLIFAFIGVLAMIFVIKFL 422
Cdd:cd17316 133 GWALGALLAALVASLLIPLLSGDWgwriLFLIGALPALLALLLRRRTL 180
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-143 |
2.13e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILA---ASTNLALLIIGRLIIGLAVGGSMSTVPVYLS 121
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllgADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
90 100
....*....|....*....|..
gi 487748494 122 EMAPTEYRGSLGSLNQLMITIG 143
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLG 308
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
45-182 |
2.36e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMa 124
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGAL- 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487748494 125 pteYRGSLGSLNQLM---ITIGILAAYLVNYAFADIEGWrWMLGLAVVPSVILLVGIYFMP 182
Cdd:cd17333 113 ---FEESSATRLNVLhgfFGLGALIGPLIATSLLTSELS-WSWAYLIIGLIYLLLAILILL 169
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
41-131 |
2.68e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.88 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 41 STTEGIVVSSML-IGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTN-LALLIIGRLIIGLAVGGSMSTVPV 118
Cdd:cd17365 204 SLSQALTITLLLnIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAsLVLLYVLVFLAGACVNGAQVGLYA 283
|
90
....*....|...
gi 487748494 119 YLSEMAPTEYRGS 131
Cdd:cd17365 284 LAARFYPTEVRAT 296
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
283-418 |
2.79e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 2.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 283 IGTINVLVTIVAI----FVVDKIDRKKLlvggnigMIASLLIMAILIWTIGIASSAWIIIvclsLFIVFFGISWG---PV 355
Cdd:cd17503 36 VITSYLLALAIMIplsgWLADRFGTRRL-------FLTALALFTLGSLLCGLAPNLASLI----IFRILQGFGGGvliPL 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487748494 356 LWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFV 418
Cdd:cd17503 105 AQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA 167
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
45-419 |
2.83e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.84 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVF-IIGALILAASTN-LALLIIGRLIIGLAvGGSMSTVPVYLSE 122
Cdd:cd17471 35 GIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAgALGYLLFAFLRNyWVLLLVGVVLLSLG-AAAFPQLFALARE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 123 MAPTEYRGSLGSLNQLMIT-------IGILAAYLVNYAFadieGWRWMLGLAVVPSVILLVGIYFMPESPRwllenrnee 195
Cdd:cd17471 114 YADRSSGRDATLFNSVLRAafslawvIGPPLAFLLLDVL----GFTGLFLLAALLYLVVALLVLFLLPSVK--------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 196 aarqvmkityddseidkeLKEMKEINAISESTWTVIKSPWLgriLIVGCIFAIFQQFIGINAVifyssSIFAKAGLGEAA 275
Cdd:cd17471 181 ------------------PPAQKATPASSLVKAPVNRRLLL---LFAAFTLLFAANSMYIIAM-----PLYVTNELGGSE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 276 SILGS-VGIGT-INVLVTIVAIFVVDKIDRKKLlvggnigMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWG 353
Cdd:cd17471 235 SWVGLlFGLAAaLEIPIMLLAGLLAKRFGKRRL-------LLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAG 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487748494 354 pVLWVMLPELFPMRArGAATGISALVLNIGTLIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17471 308 -LGISYFQDLMPGQP-GLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
31-169 |
3.06e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIH-KDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAV 109
Cdd:cd17335 221 LFWHlQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487748494 110 GGSMSTVPVYLSEMAPTEYRGSLGSLNQ------LMITIGILAAYLVNYaFADIEGWRWMLGLAVV 169
Cdd:cd17335 301 ALVWAAAVSYASAAAPPGLRATAQGLLQglyfglGGGLGSLIGGYLYEA-FGARTTFRFFAIAALA 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-187 |
3.27e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 39 LNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPV 118
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFS 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 119 YLSEMAPTEYRGSLGSLNQLMITIGILAAYLVNYaFADIEGWRWMLGLAVVPSVILLVGIYFMPESPRW 187
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGF-LADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
307-419 |
3.50e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.54 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 307 LVGGNIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFFGISWGPVLwVMLPELFPMRARGAATGISALVLNIGTLI 386
Cdd:cd17341 60 RFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAV 138
|
90 100 110
....*....|....*....|....*....|...
gi 487748494 387 VSLFFPILSDALSTEWVFLIFAFIGVLAMIFVI 419
Cdd:cd17341 139 SQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLA 171
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
7-176 |
3.92e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 3.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 7 LIFILGA------------------LGGLLYGYDNGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADK 68
Cdd:cd17316 160 ILFLIGAlpallalllrrrtlllilLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 69 LGRRRLVMLIAIVFIIGALIL--AASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGS-LGSLNQLMITIGIL 145
Cdd:cd17316 240 IGRKKTLVIGLILSGILALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATgVGLSYNLGRLGGGG 319
|
170 180 190
....*....|....*....|....*....|....
gi 487748494 146 AAYLVNYAFADIEG---WRWMLGLAVVPSVILLV 176
Cdd:cd17316 320 APPLIALLLASTGGtgvPALILALLAIVALIVAL 353
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
31-340 |
4.64e-03 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 4.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 31 LFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRR--------LVMLIAIVFIIGALILAASTNLALLIIGR 102
Cdd:cd06172 24 IWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKhllwfisgLLVLFGPFFIFVYGPLLQSNILLGAIVGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 103 LIIGLAVGGSMSTVPVYLSEMAPT---EYR-----GSLGslnqlmitiGILAAYLVNYAFA---DIEGWrwmlgLAVVPS 171
Cdd:cd06172 104 IYLGFAFLAGCGAIESYIERVSRRfnfEYGrarmwGSLG---------WALAAFFAGILFNinpNINFW-----LGSGFA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 172 VILLVGIYFmpesprWLLENRNEEAARQVMKITYDDSEIDKELKemkeinaisestwtvIKSPWLGRILIVG--CIFAIF 249
Cdd:cd06172 170 LILLLLLLF------AKPEDSDTAAAAGANASSVSLKDVLELFR---------------MPKFWFFILFVIGvsCFYDVF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 250 -QQFIginaviFYSSSIFAKAGLGEAA-SILGSVGIGtINVLVTIVAIFVVDKIDRKKllvggniGMIASLLIMAILIWT 327
Cdd:cd06172 229 dQQFP------PYFTSLFATPEQGNRVfGYLNSAQVF-LEAGMMFLAPLIVNRIGAKN-------GLLLAGTIMAVRIIG 294
|
330
....*....|...
gi 487748494 328 IGIASSAWIIIVC 340
Cdd:cd06172 295 SGLATSPLEISIL 307
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
41-419 |
4.92e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.15 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 41 STTE-GIVVSSMLIGAIVGAGSSGPLADKLGRRRLV----MLIAIVFIIGALILAASTNLALLIIGRLIIGL----AVGG 111
Cdd:cd17345 36 SKTEiGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLaiglILSAIINILIGFVPSATSSVGLMFILLFLNGWfqgmGWPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 112 SMSTVPVYLSEMApteyRGSLGSL-----NQLMITIGILAAYLVNYAFADieGWRWMLGLAVVPSVILLVGIYFM----P 182
Cdd:cd17345 116 SGRTMVHWFSKKE----RGTWTSIwnishNVGGGLVGPLAGLGLAIFGDG--WWRGAFIFPAIIAIIVAVIVLFLgkdtP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 183 ESPRW--LLENRNEEaarqvmkitYDDSEIDKELKEMkeinaiseSTWT-----VIKSPWLGRILIVGcIFAIFQQFIGI 255
Cdd:cd17345 190 ESEGLppIEEYKGDY---------PEEADGEEEEQEL--------SAWEifvkyVLKNKLLWYIAIAN-VFVYLVRYGIL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 256 NAVIFYSSSI--FAKAGLGEAASILGSVGIgtinvLVTIVAIFVVDKIDRKKLlvgGNIGMIASLLIMAILI--WTigiA 331
Cdd:cd17345 252 DWAPTYLSEVkgFSKAQAMWAFSLFEWAAI-----PGTLLAGWLSDKLFKGRR---APTGIIFMILVIVALIvyWL---A 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 332 SSAWIIIVclSLFIVFFGIsWGPVLW--VMLPELFPMRARGAATGISALVLNI-GTLIVSLFFPILSDALSTEWVFLIFA 408
Cdd:cd17345 321 PNVLVDLI--ALIALGFLI-YGPVMLigLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLL 397
|
410
....*....|.
gi 487748494 409 FIGVLAMIFVI 419
Cdd:cd17345 398 ASCILAIIFLA 408
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
319-425 |
5.58e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 319 LIMAILIW---TIGIASSAWIIIVCLSLFIVFFGISWG---PVLWVMLPELFPMRARGAATGISALVLNIGTLIVSLFFP 392
Cdd:cd17380 67 LLLAVALWslaTLLTPLLAYSSLPLLILSRILLGLGEGvhfPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGP 146
|
90 100 110
....*....|....*....|....*....|...
gi 487748494 393 ILSDALSTEWVFLIFAFIGVLAMIFVIKFLPET 425
Cdd:cd17380 147 LLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPV 179
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
45-146 |
6.20e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 38.96 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:pfam05977 257 GILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSV 336
|
90 100
....*....|....*....|..
gi 487748494 125 PTEYRGSLGSLNQLMITIGILA 146
Cdd:pfam05977 337 PRWVRGRALAVYQTVFFGGMAA 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
65-180 |
6.72e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 6.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 65 LADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMAPTEYRGSLGSLNQLMITIGI 144
Cdd:cd17329 259 LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGR 338
|
90 100 110
....*....|....*....|....*....|....*...
gi 487748494 145 LAAYLVNYAFAD--IEGWRWMLGLAVVPSVILLVGIYF 180
Cdd:cd17329 339 AIGPLVGGLLLDllGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
34-422 |
7.03e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.57 E-value: 7.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 34 HKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKL-GRRRLVMLIAIVFIIGALI-LAASTNLALLIIGRLIIGLAVGG 111
Cdd:TIGR00894 68 NPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYvFKWSIGIGMFLSSVISIVIpWAAGGGIALVVFCRVIQGLAQGS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 112 SMSTVPVYLSEMAPTEYRGSLGSlnqlMITIGILAAYLVNYAFADIEGWRWMlglaVVPSVILLVGIYFMPESPRWLLen 191
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISGWLCESWG----GWPMIFYVFGIVGCAWSLLWFV-- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 192 rneeaarqvmkITYDDSEI-DKELKEMKEinAISESTW-----TVIKSPWLGRIL---IVGCIFAIFQQFIGINAVIFYS 262
Cdd:TIGR00894 218 -----------FPADDPSIhPCISKFEKK--YINSSLQgqkgsTRQSLPIKAIPKslpVWAIWFAIFGHFWLYTILPTYL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 263 SSIFAK------------AGLGEAASILGSVGIGTINVLVTIVAIFVVDKIdrKKLLVGgnigmIASLLIMAILIWTIGI 330
Cdd:TIGR00894 285 PTFISWvlrvsgkengllSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTAA--RKIFNG-----IGGLGPGIFAYALPYL 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 331 ASSAWIIIVCLSLFIVFFGISWGPVLwVMLPELFPmRARGAATGISALVLNIGTLIVS-LFFPILSDALSTEW--VFLIF 407
Cdd:TIGR00894 358 SAAFYLTIIILTLANAVSSGPLAGVL-INSLDLAP-RFLGFIKGITGLPGFIGGLIAStLAGNILSQDSKNVWliVFLIM 435
|
410
....*....|....*
gi 487748494 408 AFIGVLAMIFVIKFL 422
Cdd:TIGR00894 436 AFVNILCVIFYLIFG 450
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
23-122 |
7.12e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 7.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 23 NGVISGALLFIHKDIPLNSTTEGIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALIL--AASTNLALLII 100
Cdd:cd17332 237 FNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLffLPPGNLVLILV 316
|
90 100
....*....|....*....|..
gi 487748494 101 GRLIIGLAVGGSMSTVPVYLSE 122
Cdd:cd17332 317 LAVLAGIGYGGANLLPWAMLAD 338
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
307-423 |
7.84e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.37 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 307 LVGGNIGMIASLLIMAILIWTIGIASSAWIIIVCLSLFIVFF--GISWgPVLWVMLPELFPMRARGAATGISALVLNIGT 384
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLaqGVTF-PAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
90 100 110
....*....|....*....|....*....|....*....
gi 487748494 385 LIVSLFFPILSDALSTEWVFLIFAFIGVLAMIFVIKFLP 423
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
47-183 |
8.52e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 38.38 E-value: 8.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 47 VVSSM---LIGAIVGAGSSGPLADKLGRRRlVMLIAIV-FIIGALILAASTNLALLIIGRLI--IGLAVGGSMS--TVPV 118
Cdd:PRK15402 50 VPTSMtayLAGGMFLQWLLGPLSDRIGRRP-VMLAGVAfFILTCLAILLAQSIEQFTLLRFLqgIGLCFIGAVGyaAIQE 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487748494 119 YLSEMAPTEyrgslgsLNQLMITIGILAAY---LVNYAFADIEGWRWMLGLAVVPSVILLVGIY-FMPE 183
Cdd:PRK15402 129 SFEEADAIK-------ITALMANVALLAPLlgpLVGAALIHVLPWRGMFVLFAALAALSFFGLWrAMPE 190
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
45-130 |
9.98e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.02 E-value: 9.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487748494 45 GIVVSSMLIGAIVGAGSSGPLADKLGRRRLVMLIAIVFIIGALILAASTNLALLIIGRLIIGLAVGGSMSTVPVYLSEMA 124
Cdd:PRK11551 258 GLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFY 337
|
....*.
gi 487748494 125 PTEYRG 130
Cdd:PRK11551 338 PTQVRG 343
|
|
| |
