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Conserved domains on  [gi|485653451|ref|WP_001298580|]
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MULTISPECIES: two-component system response regulator YpdB [Enterobacteriaceae]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-241 2.26e-86

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 256.28  E-value: 2.26e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQTSSTPATtvtrENDTINLVKDERIIVTPINDIYYAEA 160
Cdd:COG3279   82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE----EKDRIFVKSGGKLVKIPLDDILYIEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451 161 HEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTyiLRLKDlDFEVPVSRSKVKEFRQ 240
Cdd:COG3279  158 EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGE--VVLKN-GEEIPVSRRYKKEFKE 234


                 .
gi 485653451 241 L 241
Cdd:COG3279  235 W 235
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-241 2.26e-86

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 256.28  E-value: 2.26e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQTSSTPATtvtrENDTINLVKDERIIVTPINDIYYAEA 160
Cdd:COG3279   82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE----EKDRIFVKSGGKLVKIPLDDILYIEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451 161 HEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTyiLRLKDlDFEVPVSRSKVKEFRQ 240
Cdd:COG3279  158 EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGE--VVLKN-GEEIPVSRRYKKEFKE 234


                 .
gi 485653451 241 L 241
Cdd:COG3279  235 W 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-120 1.47e-58

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 181.20  E-value: 1.47e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 485653451  83 WKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQ 120
Cdd:cd17532   81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
PRK14084 PRK14084
DNA-binding response regulator;
1-244 3.86e-47

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 156.45  E-value: 3.86e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQ-QQTSSTPATTVT-RENDTINLVKDERIIVTPINDIYYA 158
Cdd:PRK14084  81 TAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKdDNNASAIANDMSaNFDQSLPIEIDDKIHMLNQQDIIAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451 159 EAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDlDFEVPVSRSKVKEF 238
Cdd:PRK14084 161 GVHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINKKHIKEVEQWFNYTYQVILTN-GVKMQVSRSFMKDF 239


                 ....*.
gi 485653451 239 RQLMHL 244
Cdd:PRK14084 240 KASIGL 245
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-242 1.94e-39

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 131.94  E-value: 1.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  145 ERIIVTPINDIYYAEAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDl 224
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKN- 79

                          90
                  ....*....|....*...
gi 485653451  225 DFEVPVSRSKVKEFRQLM 242
Cdd:pfam04397  80 GEKIPVSRRYLKELKELL 97
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-241 2.09e-35

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 121.53  E-value: 2.09e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   145 ERIIVTPINDIYYAEAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDL 224
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKNG 80

                           90
                   ....*....|....*..
gi 485653451   225 DfEVPVSRSKVKEFRQL 241
Cdd:smart00850  81 E-EVPVSRRYLKELKER 96
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 1-137 9.14e-12

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 63.27  E-value: 9.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451    1 MKVIIVED---------EFLAQQElswlikehsQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQF 71
Cdd:TIGR02875   3 IRIVIADDnkefcnllkEYLAAQP---------DMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEI 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485653451   72 A--HKPFIVFITAWKEHAV--EAFELEAFDYILKPYQ----ESRITGMLQKLEAAWQQQQTSSTPATTVTREND 137
Cdd:TIGR02875  74 ElsARPRVIMLSAFGQEKItqRAVALGADYYVLKPFDleilAARIRQLAWGTNADILADSPTVPPASHAAKTKD 147
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-241 2.26e-86

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 256.28  E-value: 2.26e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQTSSTPATtvtrENDTINLVKDERIIVTPINDIYYAEA 160
Cdd:COG3279   82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE----EKDRIFVKSGGKLVKIPLDDILYIEA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451 161 HEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTyiLRLKDlDFEVPVSRSKVKEFRQ 240
Cdd:COG3279  158 EGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGE--VVLKN-GEEIPVSRRYKKEFKE 234


                 .
gi 485653451 241 L 241
Cdd:COG3279  235 W 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-120 1.47e-58

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 181.20  E-value: 1.47e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 485653451  83 WKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQ 120
Cdd:cd17532   81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
PRK14084 PRK14084
DNA-binding response regulator;
1-244 3.86e-47

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 156.45  E-value: 3.86e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQ-QQTSSTPATTVT-RENDTINLVKDERIIVTPINDIYYA 158
Cdd:PRK14084  81 TAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKdDNNASAIANDMSaNFDQSLPIEIDDKIHMLNQQDIIAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451 159 EAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDlDFEVPVSRSKVKEF 238
Cdd:PRK14084 161 GVHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINKKHIKEVEQWFNYTYQVILTN-GVKMQVSRSFMKDF 239


                 ....*.
gi 485653451 239 RQLMHL 244
Cdd:PRK14084 240 KASIGL 245
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-242 1.94e-39

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 131.94  E-value: 1.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  145 ERIIVTPINDIYYAEAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDl 224
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKN- 79

                          90
                  ....*....|....*...
gi 485653451  225 DFEVPVSRSKVKEFRQLM 242
Cdd:pfam04397  80 GEKIPVSRRYLKELKELL 97
PRK11697 PRK11697
two-component system response regulator BtsR;
1-241 9.39e-36

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 126.88  E-value: 9.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQfAHKPFIVFI 80
Cdd:PRK11697   2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDP-EHMPYIVFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQTSSTPATTVTREndtINLVKDERIIVTPINDIYYAEA 160
Cdd:PRK11697  81 TAFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQPPLKH---IPCTGHNRIKLLPLEEVEFVSS 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451 161 HEKMTFVYTRRESYVMPMNITEFCSKLPpshFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDlDFEVPVSRSKVKEFRQ 240
Cdd:PRK11697 158 RLSGVHVVSAEGKGFTELTLKTLEEKTP---LLRCHRQYLVNPAAIQEIRLLDNGQAEIITRS-GHTVPVSRRYLKSLKE 233


                 .
gi 485653451 241 L 241
Cdd:PRK11697 234 A 234
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 145-241 2.09e-35

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 121.53  E-value: 2.09e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   145 ERIIVTPINDIYYAEAHEKMTFVYTRRESYVMPMNITEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDL 224
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKNG 80

                           90
                   ....*....|....*..
gi 485653451   225 DfEVPVSRSKVKEFRQL 241
Cdd:smart00850  81 E-EVPVSRRYLKELKER 96
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 3-120 3.63e-29

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 106.27  E-value: 3.63e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHS-QMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEElGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 485653451  82 AWKEH--AVEAFELEAFDYILKPYQESRITGMLQKLEAAWQ 120
Cdd:cd17536   81 GYDDFeyAQKAIRLGVVDYLLKPVDEEELEEALEKAKEELD 121
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-113 5.79e-27

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 100.30  E-value: 5.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451    3 VIIVEDEFLAQQELSWLIkEHSQMeIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGY-VVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 485653451   83 W--KEHAVEAFELEAFDYILKPYQESRITGMLQ 113
Cdd:pfam00072  79 HgdEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-102 1.38e-25

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 96.38  E-value: 1.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 485653451  82 AW--KEHAVEAFELEAFDYILKP 102
Cdd:COG4753   81 GYsdFEYAQEAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-125 1.03e-23

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 92.73  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 485653451  81 TAWKEHAV--EAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQTS 125
Cdd:COG4565   84 TAARDPETvrEALRAGVVDYLIKPFTFERLREALERYLEYRRLLRED 130
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-102 3.33e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 82.28  E-value: 3.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   5 IVEDEFLAQQELSWLIKEHSqmEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAW- 83
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKa 79

                         90       100
                 ....*....|....*....|
gi 485653451  84 -KEHAVEAFELEAFDYILKP 102
Cdd:cd00156   80 dEEDAVRALELGADDYLVKP 99
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-105 2.23e-18

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 77.83  E-value: 2.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIkEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIP-SLDGVLLAQNISQFAHKPFIvF 79
Cdd:cd17534    1 KKILIVEDEAIIALDLKEIL-ESLGYEVVGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFDIPVI-F 78

                         90       100
                 ....*....|....*....|....*...
gi 485653451  80 ITAWKEHAV--EAFELEAFDYILKPYQE 105
Cdd:cd17534   79 LTAYSDEETleRAKETNPYGYLVKPFNE 106
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-115 6.49e-17

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 74.50  E-value: 6.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHsQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI---SQFAHKPfI 77
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERL-GYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIralPRLPDIP-I 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 485653451  78 VFITA--WKEHAVEAFELEAFDYILKPYQESRITGMLQKL 115
Cdd:COG0784   83 IALTAyaDEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-105 2.04e-16

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 74.56  E-value: 2.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHsQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI---SQFAHKPfI 77
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEAA-GYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLradPRTADIP-I 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 485653451  78 VFITAW--KEHAVEAFELEAFDYILKPYQE 105
Cdd:COG3706   79 IFLTALddEEDRARALEAGADDYLTKPFDP 108
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-123 2.21e-16

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 77.31  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHsQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERA-GYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 485653451  81 TAW--KEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQ 123
Cdd:COG2204   81 TGYgdVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRR 125
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-117 2.55e-15

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 69.97  E-value: 2.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 485653451  82 AWKEHAV--EAFELEAFDYILKPYQESRitgMLQKLEA 117
Cdd:cd19925   82 AANDVETvrEALRLGVVDYLIKPFTFER---LRQRLER 116
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-148 2.56e-15

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 71.91  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSqMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREG-YEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIML 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485653451  81 TAW--KEHAVEAFELEAFDYILKPYQES----RITGMLQKLEAAWQQQQTSSTPAT-TVTRENDTINLVKDERII 148
Cdd:COG0745   80 TARddEEDRVRGLEAGADDYLTKPFDPEellaRIRALLRRRAAEVLRVGDLLDLAArEVTRDGEPVELTPKEFRL 154
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-137 2.65e-13

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 67.52  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVED--EFLaqQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDG--VLLAQNISQFAHKPF 76
Cdd:COG5801    5 IKVLIADDnrEFC--ELLEEYLSSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGlgVLEKLREMNLEKRPK 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485653451  77 IVFITAWKEHAV--EAFELEAFDYILKPYQE----SRITGMLQKLEAAWQQQQTSSTPATTVTREND 137
Cdd:COG5801   83 VIMLTAFGQEDItqRAVELGADYYILKPFDLdvlaERIRQLAGGKAESETSKKKSSPETASVDKARD 149
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-101 2.69e-13

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 64.46  E-value: 2.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100
                 ....*....|....*....|.
gi 485653451  83 WKEHAV--EAFELEAFDYILK 101
Cdd:cd17535   81 HDDPEYvlRALKAGAAGYLLK 101
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 3-108 6.75e-13

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 63.37  E-value: 6.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEF-LAQQELSWLIKEHSQMEIVGTfddGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:cd17572    1 VLLVEDSPsLAALYQEYLSDEGYKVTHVET---GKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77

                         90       100
                 ....*....|....*....|....*....
gi 485653451  82 AW--KEHAVEAFELEAFDYILKPYQESRI 108
Cdd:cd17572   78 AHgsVDIAVEAMRLGAYDFLEKPFDADRL 106
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-123 8.00e-13

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 65.57  E-value: 8.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHsQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFI--V 78
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTL-GYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRDIpvI 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 485653451  79 FITAW--KEHAVEAFELEAFDYILKPYQESRItgmLQKLEAAWQQQQ 123
Cdd:COG3437   85 FLTALadPEDRERALEAGADDYLTKPFDPEEL---LARVRNALELRR 128
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-103 8.88e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 62.84  E-value: 8.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGV-LLAQ--NISQFAHKPfI 77
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSAGYLEVV-SFTDPREALAWCRENPPDLILLDYMMPGMDGLeFIRRlrALPGLEDVP-I 78

                         90       100
                 ....*....|....*....|....*...
gi 485653451  78 VFITAWKEHAV--EAFELEAFDYILKPY 103
Cdd:cd17551   79 VMITADTDREVrlRALEAGATDFLTKPF 106
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-102 1.97e-12

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 61.65  E-value: 1.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   5 IVEDEflaqQELSWLIKEHSQME--IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd17574    2 VVEDD----EEIAELLSDYLEKEgyEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTA 77

                         90       100
                 ....*....|....*....|...
gi 485653451  83 wK---EHAVEAFELEAFDYILKP 102
Cdd:cd17574   78 -KdeeEDKVLGLELGADDYITKP 99
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 1-102 4.49e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 61.25  E-value: 4.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMVS 80

                         90       100
                 ....*....|....*....|....*
gi 485653451  81 TAWKEHA---VEAFELEAFDYILKP 102
Cdd:cd17541   81 SLTEEGAeitLEALELGAVDFIAKP 105
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-123 4.55e-12

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 63.05  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSqMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLREAG-YEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 485653451  81 -TAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQQQQ 123
Cdd:COG3707   83 aYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELR 126
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 1-137 9.14e-12

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 63.27  E-value: 9.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451    1 MKVIIVED---------EFLAQQElswlikehsQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQF 71
Cdd:TIGR02875   3 IRIVIADDnkefcnllkEYLAAQP---------DMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEI 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 485653451   72 A--HKPFIVFITAWKEHAV--EAFELEAFDYILKPYQ----ESRITGMLQKLEAAWQQQQTSSTPATTVTREND 137
Cdd:TIGR02875  74 ElsARPRVIMLSAFGQEKItqRAVALGADYYVLKPFDleilAARIRQLAWGTNADILADSPTVPPASHAAKTKD 147
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 1-115 9.34e-12

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 60.37  E-value: 9.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSqMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAG-YEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 485653451  81 TAWKEHA--VEAFELEAFDYILKPYQESRITGMLQKL 115
Cdd:cd17542   80 SAMGQEEmvKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 2-103 1.07e-11

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 59.93  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVED--EFLaqQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDG--VLLAQNISQFAHKPFI 77
Cdd:cd17561    3 KVLIADDnrEFV--QLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGigVLEKLRRMRLEKRPKI 80

                         90       100
                 ....*....|....*....|....*...
gi 485653451  78 VFITAWKEHAV--EAFELEAFDYILKPY 103
Cdd:cd17561   81 IMLTAFGQEDItqRAVELGASYYILKPF 108
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 1-106 1.31e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 59.73  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQmEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFI 80
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGY-EVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAP-IVLL 78

                         90       100
                 ....*....|....*....|....*...
gi 485653451  81 TAW--KEHAVEAFELEAFDYILKPYQES 106
Cdd:cd19932   79 TAYsqQDLVERAKEAGAMAYLVKPFSES 106
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 3-114 5.31e-11

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 57.99  E-value: 5.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQMeiVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLA--VKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 485653451  83 wkeH-----AVEAFELEAFDYILKPYQESRITGMLQK 114
Cdd:cd17537   81 ---HgdvpmAVEAMKAGAVDFLEKPFRDQVLLDAIEQ 114
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-68 5.43e-11

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 58.36  E-value: 5.43e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI 68
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 31-103 6.55e-11

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 58.05  E-value: 6.55e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485653451  31 TFDDGLDVLKFLQHNRVDAIFLDINIPSLDG-VLLAQNISQFAHKPFIVfITAWK--EHAVEAFELEAFDYILKPY 103
Cdd:cd19919   29 SFENAQEALAALASSQPDVLISDIRMPGMDGlALLAQIKQRHPDLPVII-MTAHSdlDSAVSAYQGGAFEYLPKPF 103
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 2-114 3.95e-10

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 55.84  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEF-LAQQELSWLIKEHSQmeiVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFI 80
Cdd:cd19939    1 RILIVEDELeLARLTRDYLIKAGLE---VSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVP-ILML 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 485653451  81 TAWKEHA--VEAFELEAFDYILKPYQE----SRITGMLQK 114
Cdd:cd19939   77 TARTEEMdrVLGLEMGADDYLCKPFSPrellARVRALLRR 116
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 1-103 9.30e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 54.65  E-value: 9.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSqMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI---SQFAHKPFI 77
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKELG-FNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIradGALSHLPVL 79

                         90       100
                 ....*....|....*....|....*..
gi 485653451  78 VFIT-AWKEHAVEAFELEAFDYILKPY 103
Cdd:cd19923   80 MVTAeAKKENVIAAAQAGVNNYIVKPF 106
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-108 9.89e-10

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 54.94  E-value: 9.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKE-------HSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAH 73
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENilkieniEYVIELTGKTEELLEKIKERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDP 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 485653451  74 KPFIVFITAWKEHAVEAFE--LEAFDYILKPYQESRI 108
Cdd:cd17533   81 YAIIIFVTTHSEFAPLTFEykVAALDFILKPLKLEEF 117
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-103 1.17e-09

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 54.32  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQEL-SWLIKEHSQMEIVGtfdDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFIT 81
Cdd:cd17619    3 ILIVEDEPVTRATLkSYFEQEGYDVSEAG---DGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVG-IILVT 78

                         90       100
                 ....*....|....*....|....*
gi 485653451  82 AwKEHAVE---AFELEAFDYILKPY 103
Cdd:cd17619   79 G-RDDEVDrivGLEIGADDYVTKPF 102
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 3-123 1.41e-09

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 55.88  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLikehsqMEIVG----TFDDGLDVLKFLQHNRVDAIFLDINIPSLDGV-LLAQNISQFAHKPfI 77
Cdd:COG4566    2 VYIVDDDEAVRDSLAFL------LESAGlrveTFASAEAFLAALDPDRPGCLLLDVRMPGMSGLeLQEELAARGSPLP-V 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 485653451  78 VFITAW--KEHAVEAFELEAFDYILKPYQESRitgMLQKLEAAWQQQQ 123
Cdd:COG4566   75 IFLTGHgdVPMAVRAMKAGAVDFLEKPFDDQA---LLDAVRRALARDR 119
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 3-90 1.48e-09

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 54.20  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90
                 ....*....|...
gi 485653451  83 WK-----EHAVEA 90
Cdd:cd19930   81 FGrpgyfRRALAA 93
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 2-103 1.76e-09

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 53.92  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDE-FLAQQELSWLIKEHSQMEIVgtfDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFI 80
Cdd:cd19938    1 RILIVEDEpKLAQLLIDYLRAAGYAPTLL---AHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVP-IIMV 76

                         90       100
                 ....*....|....*....|....*
gi 485653451  81 TAWKEHA--VEAFELEAFDYILKPY 103
Cdd:cd19938   77 TARVEEIdrLLGLELGADDYICKPY 101
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-103 2.15e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 53.82  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   5 IVEDEflaqQELSWLIKEHSQME--IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI-SQFAHKPF-IVFI 80
Cdd:cd19937    2 VVDDE----EDIVELLKYNLEKEgyEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILrSDPKTSSIpIIML 77

                         90       100
                 ....*....|....*....|....*
gi 485653451  81 TAWKEHA--VEAFELEAFDYILKPY 103
Cdd:cd19937   78 TAKGEEFdkVLGLELGADDYITKPF 102
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 29-114 2.65e-09

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 53.27  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  29 VGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT--AWKEHAVEAFELEAFDYILKPYQES 106
Cdd:cd17550   25 VDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISghGTIETAVKATKLGAYDFIEKPLSLD 104


                 ....*...
gi 485653451 107 RITGMLQK 114
Cdd:cd17550  105 RLLLTIER 112
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 34-103 2.78e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 52.90  E-value: 2.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485653451  34 DGLDVLKFLQHNRVDAIFLDINIPSLDGV----LLAQNiSQFAHKPfIVFITAW--KEHAVEAFELEAFDYILKPY 103
Cdd:cd19920   30 DGQQALQRAQAEPPDLILLDVMMPGMDGFevcrRLKAD-PATRHIP-VIFLTALtdTEDKVKGFELGAVDYITKPF 103
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 2-102 2.93e-09

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 53.54  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEflaqQELSWLIK---EHSQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIV 78
Cdd:cd17622    2 RILLVEDD----PKLARLIAdflESHGFNVV-VEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGP-IL 75

                         90       100
                 ....*....|....*....|....*.
gi 485653451  79 FITAW--KEHAVEAFELEAFDYILKP 102
Cdd:cd17622   76 LLTALdsDIDHILGLELGADDYVVKP 101
orf27 CHL00148
Ycf27; Reviewed
 1-152 3.59e-09

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 55.49  E-value: 3.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSwlikehSQMEIVG----TFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPf 76
Cdd:CHL00148   7 EKILVVDDEAYIRKILE------TRLSIIGyeviTASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVP- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  77 IVFITAWKEHA--VEAFELEAFDYILKPYQ----ESRITGMLQKLEAAwqQQQTSSTPATTVTRENDTINLVK------D 144
Cdd:CHL00148  80 IIMLTALGDVSdrITGLELGADDYVVKPFSpkelEARIRSVLRRTNKK--SFSSKIPNSSIIRIGFLKIDLNKkqvyknN 157


                 ....*...
gi 485653451 145 ERIIVTPI 152
Cdd:CHL00148 158 ERIRLTGM 165
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 31-128 1.46e-08

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 54.49  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  31 TFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAWK--EHAVEAFELEAFDYILKPYQESRI 108
Cdd:PRK10923  32 TFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSdlDAAVSAYQQGAFDYLPKPFDIDEA 111

                         90       100
                 ....*....|....*....|
gi 485653451 109 TGMLQKLEAAWQQQQTSSTP 128
Cdd:PRK10923 112 VALVERAISHYQEQQQPRNI 131
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-113 2.11e-08

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 53.62  E-value: 2.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNIsqFAHKPFIV-- 78
Cdd:PRK00742   4 IRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKI--MRLRPTPVvm 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 485653451  79 FITAWKEHA---VEAFELEAFDYILKPyQESRITGMLQ 113
Cdd:PRK00742  82 VSSLTERGAeitLRALELGAVDFVTKP-FLGISLGMDE 118
fixJ PRK09390
response regulator FixJ; Provisional
 3-134 2.66e-08

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 52.31  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIkEHSQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:PRK09390   6 VHVVDDDEAMRDSLAFLL-DSAGFEVR-LFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 485653451  83 wkeH-----AVEAFELEAFDYILKPYQESRITGMLQK-LEAAWQQQQTSSTPATTVTR 134
Cdd:PRK09390  84 ---HgdvplAVEAMKLGAVDFIEKPFEDERLIGAIERaLAQAPEAAKSEAVAADIRAR 138
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 3-102 2.73e-08

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 50.53  E-value: 2.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQmeIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFA--HKPFIVFI 80
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGA--EVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPwlANTPAIAL 78

                         90       100
                 ....*....|....*....|....*.
gi 485653451  81 TAW--KEHAVEAfeLEA-FD-YILKP 102
Cdd:cd17580   79 TGYgqPEDRERA--LEAgFDaHLVKP 102
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 3-112 2.97e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 50.55  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIkEHSQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQF---AHKPFIVF 79
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLL-EKLGYEVD-VAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELeggGRRTPIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 485653451  80 ITA--WKEHAVEAFELEAFDYILKPYQESRITGML 112
Cdd:cd17546   79 LTAnaLEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 3-102 3.80e-08

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 49.75  E-value: 3.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDE-----FLAQQelswLIKEHSQMEIVgtfDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFI 77
Cdd:cd19935    1 ILVVEDEkklaeYLKKG----LTEEGYAVDVA---YDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPV 73

                         90       100
                 ....*....|....*....|....*...
gi 485653451  78 VFITAwK---EHAVEAFELEAFDYILKP 102
Cdd:cd19935   74 LMLTA-RdsvEDRVKGLDLGADDYLVKP 100
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 3-103 5.53e-08

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 49.59  E-value: 5.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELS-WLIKEHSQMEIVGTFDDGLDVlkFLQHNrVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFIT 81
Cdd:cd18159    1 ILIVEDDETIASLLKkHLEKWGYEVVLIEDFEDVLEE--FLQFK-PDLVLLDINLPYFDGFYWCREIRQISNVP-IIFIS 76

                         90       100
                 ....*....|....*....|....
gi 485653451  82 AWKEHA--VEAFELEAFDYILKPY 103
Cdd:cd18159   77 SRDDNMdqVMAINMGGDDYITKPF 100
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 29-124 8.44e-08

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 49.80  E-value: 8.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  29 VGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHK-PFIVfITAwkeH-----AVEAFELEAFDYILKP 102
Cdd:cd17549   25 VRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDlPVIL-ITG---HgdvpmAVEAMRAGAYDFLEKP 100

                         90       100
                 ....*....|....*....|..
gi 485653451 103 YQESRitgMLQKLEAAWQQQQT 124
Cdd:cd17549  101 FDPER---LLDVVRRALEKRRL 119
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-103 1.10e-07

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 51.22  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDE-FLAQQELSWLIKEHSQMEIVgtfDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFIT 81
Cdd:PRK10710  13 ILIVEDEpKLGQLLIDYLQAASYATTLL---SHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIP-IVMVT 88

                         90       100
                 ....*....|....*....|....
gi 485653451  82 AWKEHAVEAFELE--AFDYILKPY 103
Cdd:PRK10710  89 AKIEEIDRLLGLEigADDYICKPY 112
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
2-130 1.33e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 50.96  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEflaqQELSWLIKEHSQME--IVGTFDDGLDVLKFLQhNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVF 79
Cdd:PRK10955   3 KILLVDDD----RELTSLLKELLEMEgfNVIVAHDGEQALDLLD-DSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIML 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 485653451  80 ITAWKE-HAVEAFELEAFDYILKPYQE----SRITGMLQKLEAAWQQQQTSSTPAT 130
Cdd:PRK10955  78 TARGSElDRVLGLELGADDYLPKPFNDrelvARIRAILRRSHWSEQQQNNDNGSPT 133
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-114 1.90e-07

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.00  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSWLIKEhsQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFAL--QGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMT 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 485653451  82 AWKE--HAVEAFELEAFDYILKPYQESRITGMLQK 114
Cdd:PRK11361  84 AYAEveTAVEALRCGAFDYVIKPFDLDELNLIVQR 118
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 28-114 3.32e-07

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 47.76  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  28 IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAWKEHA--VEAFELEAFDYILKPY-- 103
Cdd:cd17627   24 EVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARDSVSdrVAGLDAGADDYLVKPFal 103

                         90
                 ....*....|...
gi 485653451 104 QE--SRITGMLQK 114
Cdd:cd17627  104 EEllARVRALLRR 116
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 1-115 3.53e-07

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 47.53  E-value: 3.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIvgTF-DDGLDVLKFLQHNRVDAIFLDINIPSLDG--VLlaQNISQFAHKPFI 77
Cdd:cd17593    1 MKVLICDDSSMARKQLARALPADWDVEI--TFaENGEEALEILREGRIDVLFLDLTMPVMDGyeVL--EALPVEQLETKV 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 485653451  78 VFITA-WKEHAVE-AFELEAFDYILKPYQESRITGMLQKL 115
Cdd:cd17593   77 IVVSGdVQPEAKErVLELGALAFLKKPFDPEKLAQLLEEL 116
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-102 7.04e-07

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 49.11  E-value: 7.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNIsqFAHKPF-IVF 79
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRI--MAERPCpILI 78

                         90       100
                 ....*....|....*....|....*..
gi 485653451  80 ITAWKEHAV----EAFELEAFDYILKP 102
Cdd:PRK12555  79 VTSLTERNAsrvfEAMGAGALDAVDTP 105
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-57 9.63e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 44.87  E-value: 9.63e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 485653451     1 MKVIIVEDEFLAQQELSWLIKEHSqmEIVGTFDDGLDVLKFLQHNRVDAIFLDINIP 57
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEG--YEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 3-102 1.71e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 45.27  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLI-KEHSQMEIVgtfDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFIT 81
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLrKEGFEVTVA---TDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVP-VIMVT 76

                         90       100
                 ....*....|....*....|...
gi 485653451  82 AWKEH--AVEAFELEAFDYILKP 102
Cdd:cd17621   77 AKDSEidKVVGLELGADDYVTKP 99
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-145 1.95e-06

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 47.20  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEflaQQELSWLIKEHSQME-IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNIsQFAHKPFIVF 79
Cdd:PRK11517   1 MKILLIEDN---QRTQEWVTQGLSEAGyVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTL-RTAKQTPVIC 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485653451  80 ITAWK--EHAVEAFELEAFDYILKPYQES----RITGMLQKLEAAWQQQQTS----STPATTVTRENDTINLVKDE 145
Cdd:PRK11517  77 LTARDsvDDRVRGLDSGANDYLVKPFSFSellaRVRAQLRQHHALNSTLEISglrmDSVSQSVSRDNISITLTRKE 152
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 5-102 2.14e-06

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 44.96  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   5 IVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT--A 82
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISqvS 82

                         90       100
                 ....*....|....*....|
gi 485653451  83 WKEHAVEAFELEAFDYILKP 102
Cdd:cd17565   83 DKEMIGKAYQAGIEFFINKP 102
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
34-134 2.46e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 47.72  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  34 DGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAWK--EHAVEAFELEAFDYILKPYQESRITGM 111
Cdd:PRK10365  37 SGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSsvETAVEALKTGALDYLIKPLDFDNLQAT 116

                         90       100
                 ....*....|....*....|...
gi 485653451 112 LQKlEAAWQQQQTSSTPATTVTR 134
Cdd:PRK10365 117 LEK-ALAHTHSIDAETPAVTASQ 138
PRK15369 PRK15369
two component system response regulator;
2-101 2.52e-06

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 47.00  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:PRK15369   5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLT 84

                         90       100
                 ....*....|....*....|..
gi 485653451  82 AWKE--HAVEAFELEAFDYILK 101
Cdd:PRK15369  85 ARQEehMASRTLAAGALGYVLK 106
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
29-82 2.57e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 48.05  E-value: 2.57e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 485653451  29 VGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:PRK10841 828 CKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGVTA 881
PRK13435 PRK13435
response regulator; Provisional
 1-117 2.66e-06

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 45.81  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKE--HSQMEIVGTFDDGLDVLKFLQHnrvDAIFLDINIP-SLDGVLLAQNISQFAHKPFI 77
Cdd:PRK13435   6 LKVLIVEDEALIALELEKLVEEagHEVVGIAMSSEQAIALGRRRQP---DVALVDVHLAdGPTGVEVARRLSADGGVEVV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 485653451  78 vFITAWKEHAVEAFElEAFDYILKPYQESRITGMLQKLEA 117
Cdd:PRK13435  83 -FMTGNPERVPHDFA-GALGVIAKPYSPRGVARALSYLSA 120
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 3-104 2.81e-06

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 44.97  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELS-WLIKEHSQMEIVgtfDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFIT 81
Cdd:cd19934    1 LLLVEDDALLAAQLKeQLSDAGYVVDVA---EDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77

                         90       100
                 ....*....|....*....|....*.
gi 485653451  82 A---WKEHaVEAFELEAFDYILKPYQ 104
Cdd:cd19934   78 ArdsWQDK-VEGLDAGADDYLTKPFH 102
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 29-102 6.25e-06

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 43.59  E-value: 6.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 485653451  29 VGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFITAWKEHAVEAFELE--AFDYILKP 102
Cdd:cd19936   25 VETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLP-VIFLTSKDDEIDEVFGLRmgADDYITKP 99
PRK15479 PRK15479
transcriptional regulator TctD;
1-124 8.84e-06

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 45.48  E-value: 8.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDeflaQQELS-WLIKEHSQ----MEIVGtfdDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKP 75
Cdd:PRK15479   1 MRLLLAED----NRELAhWLEKALVQngfaVDCVF---DGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTL 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 485653451  76 FIVFITAWKEHA--VEAFELEAFDYILKPYQ----ESRITGMLQKLEAAWQQQQT 124
Cdd:PRK15479  74 PVLLLTARSAVAdrVKGLNVGADDYLPKPFEleelDARLRALLRRSAGQVQEVQQ 128
PRK10610 PRK10610
chemotaxis protein CheY;
1-115 1.13e-05

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 43.81  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSqMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI---SQFAHKP-F 76
Cdd:PRK10610   6 LKFLVVDDFSTMRRIVRNLLKELG-FNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIradGAMSALPvL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 485653451  77 IVFITAWKEHAVEAFELEAFDYILKPYQ----ESRITGMLQKL 115
Cdd:PRK10610  85 MVTAEAKKENIIAAAQAGASGYVVKPFTaatlEEKLNKIFEKL 127
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 3-108 1.16e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 43.47  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHS-QMEIVGtfdDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNIS---QFAHKPFIV 78
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGyKVQVAR---NGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKsdpDLKDIPVIL 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 485653451  79 FIT-AWKEHAVEAFELEAFDYILKPYQE----SRI 108
Cdd:cd17598   78 LTTlSDPRDVIRGLECGADNFITKPYDEkyllSRI 112
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 2-103 1.39e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 43.20  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSWLIKEHSQMEIVGTfdDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVfIT 81
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFDVTAAA--DGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIII-IS 77

                         90       100
                 ....*....|....*....|....*
gi 485653451  82 AWK---EHAVEAFELEAFDYILKPY 103
Cdd:cd17594   78 GDRrdeIDRVVGLELGADDYLAKPF 102
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 3-103 1.45e-05

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 43.18  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSW-LIKEhsQMEIVGTFDdGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFIT 81
Cdd:cd17614    1 ILVVDDEKPISDILKFnLTKE--GYEVVTAYD-GREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVP-IIMLT 76

                         90       100
                 ....*....|....*....|....
gi 485653451  82 AWKEH--AVEAFELEAFDYILKPY 103
Cdd:cd17614   77 AKDSEvdKVLGLELGADDYVTKPF 100
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 2-105 1.54e-05

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 42.96  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELS-WLikEHSQMEIVGTfDDGLDVLKFLQHNRVDAIFLDINIPSLDGV-LLAQNISQFAHKPFIVF 79
Cdd:cd17555    2 TILVIDDDEVVRESIAaYL--EDSGFQVLQA-ADGRQGLELFRSEQPDLVLCDLRMPEMDGLeVLKQITKESPDTPVIVV 78

                         90       100
                 ....*....|....*....|....*..
gi 485653451  80 ITAWK-EHAVEAFELEAFDYILKPYQE 105
Cdd:cd17555   79 SGAGVmSDAVEALRLGAWDYLTKPIED 105
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 48-152 1.82e-05

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 44.41  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  48 DAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAWKEH-AVEAFELEAFDYILKPYQesrITGMLQKLEAAWQQQQTSS 126
Cdd:PRK10529  47 DLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSARSEESdKIAALDAGADDYLSKPFG---IGELQARLRVALRRHSATP 123

                         90       100       110
                 ....*....|....*....|....*....|..
gi 485653451 127 TPATTVTRENDTINLVK------DERIIVTPI 152
Cdd:PRK10529 124 APDPLVKFSDVTVDLAArvihrgEEEVHLTPI 155
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 2-103 2.32e-05

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 42.54  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFlaqqELSWLIKEHSQMEIVGTFD--DGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVF 79
Cdd:cd17553    2 KILIVDDQY----GIRILLNEVFNKEGYQTFQaaNGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVII 77

                         90       100
                 ....*....|....*....|....*.
gi 485653451  80 ITAWKEHAV--EAFELEAFDYILKPY 103
Cdd:cd17553   78 MTAYGELDMiqESKELGALTHFAKPF 103
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-103 2.59e-05

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 42.24  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEfLAQQELSWLIKEHSQMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI---SQFAHKPfIV 78
Cdd:cd17618    2 TILIVEDE-PAIREMIAFNLERAGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLkrdEMTRDIP-II 78

                         90       100
                 ....*....|....*....|....*..
gi 485653451  79 FITAW--KEHAVEAFELEAFDYILKPY 103
Cdd:cd17618   79 MLTARgeEEDKVRGLEAGADDYITKPF 105
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 3-103 3.09e-05

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 42.09  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQmeIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI-SQFAHKPfIVFIT 81
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGY--AVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWrRQGQSLP-VLILT 77

                         90       100
                 ....*....|....*....|....
gi 485653451  82 AWK--EHAVEAFELEAFDYILKPY 103
Cdd:cd17624   78 ARDgvDDRVAGLDAGADDYLVKPF 101
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 1-103 3.60e-05

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 43.76  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQmeIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:PRK09836   1 MKLLIVEDEKKTGEYLTKGLTEAGF--VVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLL 78

                         90       100
                 ....*....|....*....|....*
gi 485653451  81 TAWK--EHAVEAFELEAFDYILKPY 103
Cdd:PRK09836  79 TALGtiEHRVKGLELGADDYLVKPF 103
PRK11173 PRK11173
two-component response regulator; Provisional
 2-206 4.89e-05

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 43.08  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSwlikehSQMEIVG--TFD--DGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFI 77
Cdd:PRK11173   5 HILIVEDELVTRNTLK------SIFEAEGydVFEatDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVALM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  78 vFITAwKEHAVE---AFELEAFDYILKPYQESRIT----GMLQKleaawqQQQTSSTPATTVTRENDTIN---LVKDERI 147
Cdd:PRK11173  79 -FLTG-RDNEVDkilGLEIGADDYITKPFNPRELTirarNLLSR------TMNLGTVSEERRSVESYKFNgweLDINSRS 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 485653451 148 IVTPINDIYyaeahekmtfvytrresyvmpmnitefcsKLPPSHfFRCHRSFCVNLNKI 206
Cdd:PRK11173 151 LISPDGEQY-----------------------------KLPRSE-FRAMLHFCENPGKI 179
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 1-101 6.36e-05

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 41.05  E-value: 6.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEflaqQELSWLIKEHSQME--IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI-SQFAHKPfI 77
Cdd:cd17554    1 KKILVVDDE----ENIRELYKEELEDEgyEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIrEKKPDLP-V 75

                         90       100
                 ....*....|....*....|....
gi 485653451  78 VFITAWKEHAVEAFELEAFDYILK 101
Cdd:cd17554   76 IICTAYSEYKSDFSSWAADAYVVK 99
PRK10766 PRK10766
two-component system response regulator TorR;
2-104 6.94e-05

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 42.72  E-value: 6.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQEL-SWLIKEHSQmeiVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFI 80
Cdd:PRK10766   4 HILVVEDEPVTRARLqGYFEQEGYT---VSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVG-IILV 79

                         90       100
                 ....*....|....*....|....*.
gi 485653451  81 TAWKEH--AVEAFELEAFDYILKPYQ 104
Cdd:PRK10766  80 TGRTDSidRIVGLEMGADDYVTKPLE 105
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 34-115 7.55e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 41.13  E-value: 7.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  34 DGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNI---SQFAHKPFIVFIT----AWKEHAVEAfelEAFDYILKPYQES 106
Cdd:cd17562   32 DGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELrklPAYKFTPILMLTTessdEKKQEGKAA---GATGWLVKPFDPE 108


                 ....*....
gi 485653451 107 RITGMLQKL 115
Cdd:cd17562  109 QLLEVVKKV 117
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-103 7.87e-05

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 41.05  E-value: 7.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   5 IVEDEflaqQELSWLIKEHSQME--IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:cd17625    2 VVEDE----KDLSEAITKHLKKEgyTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTA 77

                         90       100
                 ....*....|....*....|...
gi 485653451  83 WKEHA--VEAFELEAFDYILKPY 103
Cdd:cd17625   78 LDAVEdrVKGLDLGADDYLPKPF 100
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 2-103 1.44e-04

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 39.79  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDEFLAQQELSWLIKEHSqMEIVgTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFI--VF 79
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEG-YEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIpvIM 78

                         90       100
                 ....*....|....*....|....*.
gi 485653451  80 ITAWKEHA--VEAFELEAFDYILKPY 103
Cdd:cd17538   79 ITALDDREdrIRGLEAGADDFLSKPI 104
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
3-85 2.71e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 41.01  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITA 82
Cdd:PRK09935   6 VIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSS 85


                 ...
gi 485653451  83 WKE 85
Cdd:PRK09935  86 KSE 88
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 2-119 3.94e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 39.32  E-value: 3.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   2 KVIIVEDE----FLAQQELSwliKEHSQMEIVgTFDDGLDVLKFLQHN-------RVDAIFLDINIPSLDG--VL--LAQ 66
Cdd:cd17557    1 TILLVEDNpgdaELIQEAFK---EAGVPNELH-VVRDGEEALDFLRGEgeyadapRPDLILLDLNMPRMDGfeVLreIKA 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 485653451  67 NiSQFAHKPFIVFIT-AWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAW 119
Cdd:cd17557   77 D-PDLRRIPVVVLTTsDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGEYW 129
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-86 5.68e-04

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 39.88  E-value: 5.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIkEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:PRK09958   1 MNAIIIDDHPLAIAAIRNLL-IKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIV 79


                 ....*.
gi 485653451  81 TAWKEH 86
Cdd:PRK09958  80 SAKNDH 85
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-122 5.72e-04

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 40.00  E-value: 5.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDE-FLAQQELSWL--IKEHSQMEIVGTFDDG-LDVLKFlqhnRVDAIFLDINIPSLDGVLLAQNISQFAHKPF 76
Cdd:PRK10046   5 LTLLIVEDEtPLAEMHAEYIrhIPGFSQILLAGNLAQArMMIERF----KPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451  77 IVFITAWK--EHAVEAFELEAFDYILKP------------YQESRitGMLQKLEAAWQQQ 122
Cdd:PRK10046  81 VVFTTAASdmETVSEAVRCGVFDYLIKPiayerlgqtltrFRQRK--HMLESIDSASQKQ 138
PRK10816 PRK10816
two-component system response regulator PhoP;
1-115 6.04e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 39.72  E-value: 6.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMeiVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:PRK10816   1 MRVLVVEDNALLRHHLKVQLQDAGHQ--VDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVL 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 485653451  81 TA---WKEHaVEAFELEAFDYILKPYQESRITGMLQKL 115
Cdd:PRK10816  79 TAresWQDK-VEVLSAGADDYVTKPFHIEEVMARMQAL 115
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 3-103 1.39e-03

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 37.28  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEflaqQELSWLIKEHSQME--IVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFI 80
Cdd:cd17623    1 ILLIDDD----RELTELLTEYLEMEgfNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVP-VLML 75

                         90       100
                 ....*....|....*....|....*
gi 485653451  81 TAWKEHA--VEAFELEAFDYILKPY 103
Cdd:cd17623   76 TARGDDIdrILGLELGADDYLPKPF 100
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 42-102 3.82e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 35.98  E-value: 3.82e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 485653451  42 LQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFITAW--KEHAVEAFELEAFDYILKP 102
Cdd:cd19926   38 LASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYgsLDTAIEALKAGAFDFLTKP 100
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-103 4.94e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 37.25  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDE--------FLAQQE---LSWlikehsqmeivgtFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNIS 69
Cdd:PRK11083   4 PTILLVEDEqaiadtlvYALQSEgftVEW-------------FERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLL 70

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 485653451  70 QFAHKPFIVFITAWKEHA--VEAFELEAFDYILKPY 103
Cdd:PRK11083  71 AFHPALPVIFLTARSDEVdrLVGLEIGADDYVAKPF 106
PRK09483 PRK09483
response regulator; Provisional
 1-85 5.11e-03

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 37.01  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVFI 80
Cdd:PRK09483   2 INVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIML 81


                 ....*
gi 485653451  81 TAWKE 85
Cdd:PRK09483  82 TVHTE 86
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 3-103 5.58e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 35.85  E-value: 5.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKehSQMEIVGTFD---DGLDVLKFLQHnrvDAIFLDINIPSLDG--VLLAQNISQFAHKPFI 77
Cdd:cd17616    1 VLLIEDDSATAQSIELMLK--SEGFNVYTTDlgeEGLDLGKLYDY---DIILLDLNLPDMSGyeVLRTLRLAKVKTPILI 75

                         90       100
                 ....*....|....*....|....*.
gi 485653451  78 VFITAWKEHAVEAFELEAFDYILKPY 103
Cdd:cd17616   76 LSGLADIEDKVKGLGFGADDYMTKPF 101
PRK10336 PRK10336
two-component system response regulator QseB;
1-115 5.65e-03

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 36.80  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSWLIkehSQMEI-VGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVF 79
Cdd:PRK10336   1 MRILLIEDDMLIGDGIKTGL---SKMGFsVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLI 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 485653451  80 ITAWK--EHAVEAFELEAFDYILKPYQESRITGMLQKL 115
Cdd:PRK10336  78 LTARDalAERVEGLRLGADDYLCKPFALIEVAARLEAL 115
PRK10643 PRK10643
two-component system response regulator PmrA;
1-103 7.44e-03

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 36.55  E-value: 7.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELSW-LIKEHSQMEIVGTFDDGldvLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIVF 79
Cdd:PRK10643   1 MKILIVEDDTLLLQGLILaLQTEGYACDCASTAREA---EALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLI 77

                         90       100
                 ....*....|....*....|....*.
gi 485653451  80 ITAWK--EHAVEAFELEAFDYILKPY 103
Cdd:PRK10643  78 LTARDtlEDRVAGLDVGADDYLVKPF 103
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 1-103 8.22e-03

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 36.72  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   1 MKVIIVEDEFLAQQELswlIKEHSQMEI--VGTFDDGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPFIV 78
Cdd:PRK13856   1 MKHVLVIDDDVAMRHL---IVEYLTIHAfkVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIII 77

                         90       100
                 ....*....|....*....|....*..
gi 485653451  79 FITAWKEHA--VEAFELEAFDYILKPY 103
Cdd:PRK13856  78 ISGDRLEEAdkVVALELGATDFIAKPF 104
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 3-103 8.53e-03

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 35.10  E-value: 8.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   3 VIIVEDEFLAQQELSWLIKEHS-QMEIVGTFDDG---LDVLKFlqhnrvDAIFLDINIPSLDGVLLAQNISQfAHKPFIV 78
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGyQADVAESLKDGeyyIDIRNY------DLVLVSDKLPDGNGLSIVSRIKE-KHPSIVV 73

                         90       100
                 ....*....|....*....|....*...
gi 485653451  79 FITAWK---EHAVEAFELEAFDYILKPY 103
Cdd:cd17573   74 IVLSDNpktEQEIEAFKEGADDYIAKPF 101
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 4-104 9.90e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 35.14  E-value: 9.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485653451   4 IIVEDEFLAQQELSWLIKEHSQMEIVGTFDdGLDVLKFLQHNRVDAIFLDINIPSLDGVLLAQNISQFAHKPfIVFITAW 83
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGD-GTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVP-IVMLTAK 80

                         90       100
                 ....*....|....*....|...
gi 485653451  84 KEHA--VEAFELEAFDYILKPYQ 104
Cdd:cd17626   81 SDTVdvVLGLESGADDYVAKPFK 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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