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Conserved domains on  [gi|446971421|ref|WP_001048677|]
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MULTISPECIES: GNAT family N-acetyltransferase [Bacillus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11447364)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-152 4.93e-17

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 73.49  E-value: 4.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   1 MNLHICEVTAKNWRSVVALDVAKDQQQFIESNAFSLAESL----------YEGNGTSVGLYDGET--LVGYAMYGWYSVK 68
Cdd:COG1670    6 ERLRLRPLRPEDAEALAELLNDPEVARYLPGPPYSLEEARawlerlladwADGGALPFAIEDKEDgeLIGVVGLYDIDRA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  69 HKSVWLdRFMIDQQYQGKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYESFGFRLNGDIDDEGPVVG----- 143
Cdd:COG1670   86 NRSAEI-GYWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLRDALVIDGryrdh 164


                 ....*....
gi 446971421 144 VVMELLIDE 152
Cdd:COG1670  165 VLYSLLREE 173
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-152 4.93e-17

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 73.49  E-value: 4.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   1 MNLHICEVTAKNWRSVVALDVAKDQQQFIESNAFSLAESL----------YEGNGTSVGLYDGET--LVGYAMYGWYSVK 68
Cdd:COG1670    6 ERLRLRPLRPEDAEALAELLNDPEVARYLPGPPYSLEEARawlerlladwADGGALPFAIEDKEDgeLIGVVGLYDIDRA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  69 HKSVWLdRFMIDQQYQGKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYESFGFRLNGDIDDEGPVVG----- 143
Cdd:COG1670   86 NRSAEI-GYWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLRDALVIDGryrdh 164


                 ....*....
gi 446971421 144 VVMELLIDE 152
Cdd:COG1670  165 VLYSLLREE 173
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-129 4.30e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.16  E-value: 4.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   13 WRSVVALDVAKDQQQFIESNAFSLAESLYEGNGTSVGLYDGETLVGYAMYGWYSVKHKSVWLDRFMIDQQYQGKGYAKRF 92
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 446971421   93 LRLLIQFLQEKfECKIIYLSLHPDNKLAMGLYESFGF 129
Cdd:pfam00583  81 LQALLEWARER-GCERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 35-130 9.74e-10

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 53.49  E-value: 9.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   35 SLAESLYEGNGTSVGLYDGETLVGYAMygwysvkhksVWLDRF-------MIDQQYQGKGYAKRFLRLLIQFLQEKfECK 107
Cdd:TIGR01575  21 QFAEELANYHLCYLLARIGGKVVGYAG----------VQIVLDeahilniAVKPEYQGQGIGRALLRELIDEAKGR-GVN 89

                          90       100
                  ....*....|....*....|...
gi 446971421  108 IIYLSLHPDNKLAMGLYESFGFR 130
Cdd:TIGR01575  90 EIFLEVRVSNIAAQALYKKLGFN 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-112 1.22e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 51.51  E-value: 1.22e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446971421  47 SVGLYDGETLVGYAMYGWYSVKHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLS 112
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 79-129 3.13e-05

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 41.45  E-value: 3.13e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446971421  79 IDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDNKLAMGLYESFGF 129
Cdd:PRK09491  71 VDPDYQRQGLGRALLEHLIDELEKR-GVATLWLEVRASNAAAIALYESLGF 120
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-152 4.93e-17

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 73.49  E-value: 4.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   1 MNLHICEVTAKNWRSVVALDVAKDQQQFIESNAFSLAESL----------YEGNGTSVGLYDGET--LVGYAMYGWYSVK 68
Cdd:COG1670    6 ERLRLRPLRPEDAEALAELLNDPEVARYLPGPPYSLEEARawlerlladwADGGALPFAIEDKEDgeLIGVVGLYDIDRA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  69 HKSVWLdRFMIDQQYQGKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYESFGFRLNGDIDDEGPVVG----- 143
Cdd:COG1670   86 NRSAEI-GYWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLRDALVIDGryrdh 164


                 ....*....
gi 446971421 144 VVMELLIDE 152
Cdd:COG1670  165 VLYSLLREE 173
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-129 4.30e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.16  E-value: 4.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   13 WRSVVALDVAKDQQQFIESNAFSLAESLYEGNGTSVGLYDGETLVGYAMYGWYSVKHKSVWLDRFMIDQQYQGKGYAKRF 92
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 446971421   93 LRLLIQFLQEKfECKIIYLSLHPDNKLAMGLYESFGF 129
Cdd:pfam00583  81 LQALLEWARER-GCERIFLEVAADNLAAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-147 1.28e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 65.06  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  58 GYAMYgWYSVKHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDNKLAMGLYESFGFRLNGDIDD 137
Cdd:COG0456    1 GFALL-GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYEKLGFEEVGERPN 78

                         90
                 ....*....|
gi 446971421 138 EGPVVGVVME 147
Cdd:COG0456   79 YYGDDALVME 88
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
48-150 8.52e-14

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 64.63  E-value: 8.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  48 VGLYDGEtLVGYAMYGWYSVK--HKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDNKLAMGLYE 125
Cdd:COG1247   56 VAEEDGE-VVGFASLGPFRPRpaYRGTAEESIYVDPDARGRGIGRALLEALIERARAR-GYRRLVAVVLADNEASIALYE 133

                         90       100       110
                 ....*....|....*....|....*....|
gi 446971421 126 SFGFRLNGDIDDEGPVVG-----VVMELLI 150
Cdd:COG1247  134 KLGFEEVGTLPEVGFKFGrwldlVLMQKRL 163
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 42-148 1.07e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 58.53  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  42 EGNGTSVGLYDGETLVGYAMYGWYSVKHksVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDNKLAM 121
Cdd:COG0454   31 LAGAEFIAVDDKGEPIGFAGLRRLDDKV--LELKRLYVLPEYRGKGIGKALLEALLEWARER-GCTALELDTLDGNPAAI 107

                         90       100
                 ....*....|....*....|....*..
gi 446971421 122 GLYESFGFRlngDIDDEGPVVGVVMEL 148
Cdd:COG0454  108 RFYERLGFK---EIERYVAYVGGEFEK 131
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-148 9.06e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 56.25  E-value: 9.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   5 ICEVTAKNWRSVVALDvakdQQQFIESNAFSLAESLYEG--NGTSVGLYDGETLVGYAMYGWYSV--KHKSVWLDRFMID 80
Cdd:COG3153    1 IRPATPEDAEAIAALL----RAAFGPGREAELVDRLREDpaAGLSLVAEDDGEIVGHVALSPVDIdgEGPALLLGPLAVD 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446971421  81 QQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDNklaMGLYESFGFRLNGDIDDEGPVVGVVMEL 148
Cdd:COG3153   77 PEYRGQGIGRALMRAALEAARER-GARAVVLLGDPSL---LPFYERFGFRPAGELGLTLGPDEVFLAK 140
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
48-148 3.26e-10

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 54.81  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  48 VGLYDGETLVGYAMygWYSVKHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLS--LHpdnklAMGLYE 125
Cdd:COG2153   37 LLAYDDGELVATAR--LLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARER-GARRIVLSaqAH-----AVGFYE 108

                         90       100
                 ....*....|....*....|...
gi 446971421 126 SFGFRLNGDIDDEGPVVGVVMEL 148
Cdd:COG2153  109 KLGFVPVGEEFLEAGIPHIDMRK 131
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 35-130 9.74e-10

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 53.49  E-value: 9.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   35 SLAESLYEGNGTSVGLYDGETLVGYAMygwysvkhksVWLDRF-------MIDQQYQGKGYAKRFLRLLIQFLQEKfECK 107
Cdd:TIGR01575  21 QFAEELANYHLCYLLARIGGKVVGYAG----------VQIVLDeahilniAVKPEYQGQGIGRALLRELIDEAKGR-GVN 89

                          90       100
                  ....*....|....*....|...
gi 446971421  108 IIYLSLHPDNKLAMGLYESFGFR 130
Cdd:TIGR01575  90 EIFLEVRVSNIAAQALYKKLGFN 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-112 1.22e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 51.51  E-value: 1.22e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446971421  47 SVGLYDGETLVGYAMYGWYSVKHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLS 112
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 50-130 9.46e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.76  E-value: 9.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   50 LYDGETLVGYAMYGWYSVKHKSVWLdRFMIDQQYQGKGYAKRflrlLIQFLQEKFECKIIYLSLHPDNKLAMGLYESFGF 129
Cdd:pfam13508   8 AEDDGKIVGFAALLPLDDEGALAEL-RLAVHPEYRGQGIGRA----LLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGF 82


                  .
gi 446971421  130 R 130
Cdd:pfam13508  83 E 83
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
56-135 1.57e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 46.44  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  56 LVGYAMYGWYSvkHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKFeCKIIYLSLHPDNKLAMGLYESFGFRLNGDI 135
Cdd:COG3393    2 LVAMAGVRAES--PGVAEISGVYTHPEYRGRGLASALVAALAREALARG-ARTPFLYVDADNPAARRLYERLGFRPVGEY 78
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 48-151 1.43e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 44.98  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421  48 VGLYDGEtLVGYAmyGWYSVKHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDnklAMGLYESF 127
Cdd:COG1246   32 VAEEDGE-IVGCA--ALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEAREL-GLKRLFLLTTSA---AIHFYEKL 104

                         90       100
                 ....*....|....*....|....*...
gi 446971421 128 GFRLNGDIDDEGPVVG----VVMELLID 151
Cdd:COG1246  105 GFEEIDKEDLPYAKVWqrdsVVMEKDLE 132
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 35-130 5.97e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.03  E-value: 5.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   35 SLAESLYEGNGTSVGLYDGETLVGYAmygwySVKHKSVwLDRFMIDQQYQGKGYAKRFLRLLIQFLqEKFECKIIYLSLH 114
Cdd:pfam13673  21 ALRERIDQGEYFFFVAFEGGQIVGVI-----ALRDRGH-ISLLFVDPDYQGQGIGKALLEAVEDYA-EKDGIKLSELTVN 93

                          90
                  ....*....|....*.
gi 446971421  115 PDNKlAMGLYESFGFR 130
Cdd:pfam13673  94 ASPY-AVPFYEKLGFR 108
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 79-129 3.13e-05

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 41.45  E-value: 3.13e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446971421  79 IDQQYQGKGYAKRFLRLLIQFLQEKfECKIIYLSLHPDNKLAMGLYESFGF 129
Cdd:PRK09491  71 VDPDYQRQGLGRALLEHLIDELEKR-GVATLWLEVRASNAAAIALYESLGF 120
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 47-130 4.43e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 40.79  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   47 SVGLYDGETLVGYAMYGWysvkhksvwldrfMIDQQYQGKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYES 126
Cdd:pfam13302  69 SIGLYDIDGEPERAELGY-------------WLGPDYWGKGYATEAVRALLEYAFEELGLPRLVARIDPENTASRRVLEK 135


                  ....
gi 446971421  127 FGFR 130
Cdd:pfam13302 136 LGFK 139
PRK15130 PRK15130
spermidine N1-acetyltransferase; Provisional
 78-138 3.67e-03

spermidine N1-acetyltransferase; Provisional


Pssm-ID: 237916  Cd Length: 186  Bit Score: 35.93  E-value: 3.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446971421  78 MIDQQYQGKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYESFGFRLNGDIDDE 138
Cdd:PRK15130  89 IISPEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFEVEGELIHE 149
Acetyltransf_4 pfam13420
Acetyltransferase (GNAT) domain;
49-134 3.99e-03

Acetyltransferase (GNAT) domain;


Pssm-ID: 433192 [Multi-domain]  Cd Length: 153  Bit Score: 35.81  E-value: 3.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   49 GLYDGETLVGYAMYGW--YSVKHKSVWLDRFMIDQQyqgKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYES 126
Cdd:pfam13420  53 GVAESDRLIGYATLRQfdYVKTHKAELSFYVVKNND---EGINRELINAIIQYARKNQNIENLEACIASNNINAIVFLKA 129


                  ....*...
gi 446971421  127 FGFRLNGD 134
Cdd:pfam13420 130 IGFEWLGI 137
PRK10140 PRK10140
N-acetyltransferase;
79-133 8.47e-03

N-acetyltransferase;


Pssm-ID: 182263 [Multi-domain]  Cd Length: 162  Bit Score: 34.96  E-value: 8.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446971421  79 IDQQYQGKGYAKRFLRLLIQFLQEKFECKIIYLSLHPDNKLAMGLYESFGFRLNG 133
Cdd:PRK10140  86 VDSRWKNRGVASALMREMIEMCDNWLRVDRIELTVFVDNAPAIKVYKKYGFEIEG 140
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 47-131 9.48e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 33.46  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446971421   47 SVGLYDGETLvgyAMYGWySVKHKSVWLDRFMIDQQYQGKGYAKRFLRLLIQFLQEKfeCKIIYLSLHPDNKLAMGLYES 126
Cdd:pfam08445   1 VLGIYRGDTG---ELAAW-CLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAER--GITPFAVVVAGNTPSRRLYEK 74


                  ....*
gi 446971421  127 FGFRL 131
Cdd:pfam08445  75 LGFRK 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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