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Conserved domains on  [gi|446420416|ref|WP_000498271|]
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MULTISPECIES: alpha/beta fold hydrolase [Bacillus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-268 1.29e-51

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 167.87  E-value: 1.29e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   1 MFVTVEkDVHIFVQDVnpGPGSKTVFFVHGWPLNHQMYQYQLNFLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIA 80
Cdd:COG0596    5 RFVTVD-GVRLHYREA--GPDGPPVVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  81 IVLEALQVENATLVGFSVGGALSIRYMSRYnGRRISKLALIDAVSPSFVKNQESPYGVPKeqadalinqmyanlpkflnd 160
Cdd:COG0596   81 ALLDALGLERVVLVGHSMGGMVALELAARH-PERVAGLVLVDEVLAALAEPLRRPGLAPE-------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 161 vslsffnrnlgaatlewfsylgmqsasyALIKILQAAANEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIKNSQ 240
Cdd:COG0596  140 ----------------------------ALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191

                        250       260
                 ....*....|....*....|....*...
gi 446420416 241 LHALTNSGHGSPIDQADELNKELIKFLQ 268
Cdd:COG0596  192 LVVLPGAGHFPPLEQPEAFAAALRDFLA 219
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-268 1.29e-51

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 167.87  E-value: 1.29e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   1 MFVTVEkDVHIFVQDVnpGPGSKTVFFVHGWPLNHQMYQYQLNFLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIA 80
Cdd:COG0596    5 RFVTVD-GVRLHYREA--GPDGPPVVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  81 IVLEALQVENATLVGFSVGGALSIRYMSRYnGRRISKLALIDAVSPSFVKNQESPYGVPKeqadalinqmyanlpkflnd 160
Cdd:COG0596   81 ALLDALGLERVVLVGHSMGGMVALELAARH-PERVAGLVLVDEVLAALAEPLRRPGLAPE-------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 161 vslsffnrnlgaatlewfsylgmqsasyALIKILQAAANEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIKNSQ 240
Cdd:COG0596  140 ----------------------------ALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191

                        250       260
                 ....*....|....*....|....*...
gi 446420416 241 LHALTNSGHGSPIDQADELNKELIKFLQ 268
Cdd:COG0596  192 LVVLPGAGHFPPLEQPEAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-254 8.89e-32

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 117.61  E-value: 8.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   23 KTVFFVHGWPLNHQMYQYQLNFLPEHGFRCIAMDIRGNGQSDKP--WTGYTYDRLADDIAIVLEALQVENATLVGFSVGG 100
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  101 ALSIRYMSRYNgRRISKLALIDAVSPSFVKNQESPYGVPK------EQADALINQMYANLPKFLndVSLSFFNRNLGAAT 174
Cdd:pfam00561  81 LIALAYAAKYP-DRVKALVLLGALDPPHELDEADRFILALfpgffdGFVADFAPNPLGRLVAKL--LALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  175 LEWFSYLGMQSASYA------LIKILQAAANEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIKNSQLHALTNSG 248
Cdd:pfam00561 158 PLLNKRFPSGDYALAkslvtgALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*.
gi 446420416  249 HGSPID 254
Cdd:pfam00561 238 HFAFLE 243
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 19-268 2.64e-13

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 68.82  E-value: 2.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  19 GPGSKT-VFFVHG-------WPLNHQMyqyqlnfLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVEN 90
Cdd:PRK14875 127 GEGDGTpVVLIHGfggdlnnWLFNHAA-------LAAG-RPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIER 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  91 ATLVGFSVGGALSIRYMSRYNGrRISKLALIdavspsfvknqeSPYGVPKEQADALI---------NQMYANLPKFLNDV 161
Cdd:PRK14875 199 AHLVGHSMGGAVALRLAARAPQ-RVASLTLI------------APAGLGPEINGDYIdgfvaaesrRELKPVLELLFADP 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 162 SLsfFNRNLGAATLEwfsYLGMQSASYALIKILQAAA-----NEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRI 236
Cdd:PRK14875 266 AL--VTRQMVEDLLK---YKRLDGVDDALRALADALFaggrqRVDLRDRLASLAIPVLVIWGEQDRIIPAAHAQGLPDGV 340

                        250       260       270
                 ....*....|....*....|....*....|..
gi 446420416 237 knsQLHALTNSGHGSPIDQADELNKELIKFLQ 268
Cdd:PRK14875 341 ---AVHVLPGAGHMPQMEAAADVNRLLAEFLG 369
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-268 1.29e-51

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 167.87  E-value: 1.29e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   1 MFVTVEkDVHIFVQDVnpGPGSKTVFFVHGWPLNHQMYQYQLNFLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIA 80
Cdd:COG0596    5 RFVTVD-GVRLHYREA--GPDGPPVVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  81 IVLEALQVENATLVGFSVGGALSIRYMSRYnGRRISKLALIDAVSPSFVKNQESPYGVPKeqadalinqmyanlpkflnd 160
Cdd:COG0596   81 ALLDALGLERVVLVGHSMGGMVALELAARH-PERVAGLVLVDEVLAALAEPLRRPGLAPE-------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 161 vslsffnrnlgaatlewfsylgmqsasyALIKILQAAANEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIKNSQ 240
Cdd:COG0596  140 ----------------------------ALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191

                        250       260
                 ....*....|....*....|....*...
gi 446420416 241 LHALTNSGHGSPIDQADELNKELIKFLQ 268
Cdd:COG0596  192 LVVLPGAGHFPPLEQPEAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-254 8.89e-32

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 117.61  E-value: 8.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   23 KTVFFVHGWPLNHQMYQYQLNFLPEHGFRCIAMDIRGNGQSDKP--WTGYTYDRLADDIAIVLEALQVENATLVGFSVGG 100
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  101 ALSIRYMSRYNgRRISKLALIDAVSPSFVKNQESPYGVPK------EQADALINQMYANLPKFLndVSLSFFNRNLGAAT 174
Cdd:pfam00561  81 LIALAYAAKYP-DRVKALVLLGALDPPHELDEADRFILALfpgffdGFVADFAPNPLGRLVAKL--LALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  175 LEWFSYLGMQSASYA------LIKILQAAANEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIKNSQLHALTNSG 248
Cdd:pfam00561 158 PLLNKRFPSGDYALAkslvtgALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*.
gi 446420416  249 HGSPID 254
Cdd:pfam00561 238 HFAFLE 243
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
2-268 9.83e-22

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 90.06  E-value: 9.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   2 FVTVEKDVHIFVQDVNPGPGSK-TVFFVHGWPLNHQMYQYQLNFLPEHGFRCIAMDIRGNGQSDKPwTGY--TYDRLADD 78
Cdd:COG2267    7 TLPTRDGLRLRGRRWRPAGSPRgTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGP-RGHvdSFDDYVDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  79 IAIVLEALQVENAT---LVGFSVGGALSIRYMSRYnGRRISKLALIDavspsfvknqespygvPKEQADALInqmyanlp 155
Cdd:COG2267   86 LRAALDALRARPGLpvvLLGHSMGGLIALLYAARY-PDRVAGLVLLA----------------PAYRADPLL-------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 156 kflndvslsffnrnlgAATLEWFSYLgmqsasyalikilqaaaneDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQR 235
Cdd:COG2267  141 ----------------GPSARWLRAL-------------------RLAEALARIDVPVLVLHGGADRVVPPEAARRLAAR 185

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446420416 236 I-KNSQLHALTNSGHGSPIDQA-DELNKELIKFLQ 268
Cdd:COG2267  186 LsPDVELVLLPGARHELLNEPArEEVLAAILAWLE 220
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
21-269 3.41e-21

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 89.23  E-value: 3.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  21 GSKTVFFVHG--------WPLNHqmyqyqlnFLPEHGFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQ--VEN 90
Cdd:COG1647   14 GRKGVLLLHGftgspaemRPLAE--------ALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKagYDK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  91 ATLVGFSVGGALSIRYMSRYNgrRISKLALIdavSPSFVKNQESPYGVPkeqadaLINQMYANLPKFLNDVslsffnrNL 170
Cdd:COG1647   86 VIVIGLSMGGLLALLLAARYP--DVAGLVLL---SPALKIDDPSAPLLP------LLKYLARSLRGIGSDI-------ED 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 171 GAATLEWFSYLGMQSAsYALIKILqaaanEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRI--KNSQLHALTNSG 248
Cdd:COG1647  148 PEVAEYAYDRTPLRAL-AELQRLI-----REVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLgsPDKELVWLEDSG 221

                        250       260
                 ....*....|....*....|..
gi 446420416 249 HGSPID-QADELNKELIKFLQT 269
Cdd:COG1647  222 HVITLDkDREEVAEEILDFLER 243
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 25-262 3.17e-15

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 72.51  E-value: 3.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   25 VFFVHGWPLNHQmyqyQLNFLPEHGFRCIAMDIRGNGQSDKPWtgYTYDRLADDIAIVLEALQVENATLVGFSVGGALSI 104
Cdd:pfam12697   1 VVLVHGAGLSAA----PLAALLAAGVAVLAPDLPGHGSSSPPP--LDLADLADLAALLDELGAARPVVLVGHSLGGAVAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  105 RYMSRYNGRRIsklaLIDavspsfvknqesPYGVPKEQADALINQMYANLPkflNDVSLSFFNRNLGAATL-EWFSYLGM 183
Cdd:pfam12697  75 AAAAAALVVGV----LVA------------PLAAPPGLLAALLALLARLGA---ALAAPAWLAAESLARGFlDDLPADAE 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446420416  184 QSASYALIKILQAAANEDVTKDLNKINVPTKIFHGvHDQLIPYKSAELTQQRIKnSQLHALTNSGHgSPIDQADELNKE 262
Cdd:pfam12697 136 WAAALARLAALLAALALLPLAAWRDLPVPVLVLAE-EDRLVPELAQRLLAALAG-ARLVVLPGAGH-LPLDDPEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-237 3.59e-14

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 69.94  E-value: 3.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   23 KTVFFVHGwpLN-H-QMYQYQLNFLPEHGFRCIAMDIRGNGQSDkPWTGY--TYDRLADDIAIVLEALQVENAT----LV 94
Cdd:pfam12146   5 AVVVLVHG--LGeHsGRYAHLADALAAQGFAVYAYDHRGHGRSD-GKRGHvpSFDDYVDDLDTFVDKIREEHPGlplfLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   95 GFSVGGALSIRYMSRYnGRRISKLALidaVSPSFvknQESPYGVPKEQadALINQMYANL-PKFL--NDVSLSFFNRNlg 171
Cdd:pfam12146  82 GHSMGGLIAALYALRY-PDKVDGLIL---SAPAL---KIKPYLAPPIL--KLLAKLLGKLfPRLRvpNNLLPDSLSRD-- 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  172 AATLEWFS----YLGMQSASYALiKILQAAanEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIK 237
Cdd:pfam12146 151 PEVVAAYAadplVHGGISARTLY-ELLDAG--ERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAG 217
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 19-268 2.64e-13

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 68.82  E-value: 2.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  19 GPGSKT-VFFVHG-------WPLNHQMyqyqlnfLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVEN 90
Cdd:PRK14875 127 GEGDGTpVVLIHGfggdlnnWLFNHAA-------LAAG-RPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIER 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  91 ATLVGFSVGGALSIRYMSRYNGrRISKLALIdavspsfvknqeSPYGVPKEQADALI---------NQMYANLPKFLNDV 161
Cdd:PRK14875 199 AHLVGHSMGGAVALRLAARAPQ-RVASLTLI------------APAGLGPEINGDYIdgfvaaesrRELKPVLELLFADP 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 162 SLsfFNRNLGAATLEwfsYLGMQSASYALIKILQAAA-----NEDVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRI 236
Cdd:PRK14875 266 AL--VTRQMVEDLLK---YKRLDGVDDALRALADALFaggrqRVDLRDRLASLAIPVLVIWGEQDRIIPAAHAQGLPDGV 340

                        250       260       270
                 ....*....|....*....|....*....|..
gi 446420416 237 knsQLHALTNSGHGSPIDQADELNKELIKFLQ 268
Cdd:PRK14875 341 ---AVHVLPGAGHMPQMEAAADVNRLLAEFLG 369
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
24-267 6.23e-13

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 66.58  E-value: 6.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  24 TVFFVHGWPLN-HQMYQYQLNFLPEHGFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQV--ENATLVGFSVGG 100
Cdd:COG1506   25 VVVYVHGGPGSrDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARPYVdpDRIGIYGHSYGG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 101 ALSIRYMSRYNgRRISKLALIDAVSpsfvkNQESPYGVPKEQADALINQmYANLPKFLNDVSLSFFnrnlgaatlewfsy 180
Cdd:COG1506  105 YMALLAAARHP-DRFKAAVALAGVS-----DLRSYYGTTREYTERLMGG-PWEDPEAYAARSPLAY-------------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 181 lgmqsasyalikilqaaanedvtkdLNKINVPTKIFHGVHDQLIPYKSAELTQQRI----KNSQLHALTNSGHGSPIDQA 256
Cdd:COG1506  164 -------------------------ADKLKTPLLLIHGEADDRVPPEQAERLYEALkkagKPVELLVYPGEGHGFSGAGA 218

                        250
                 ....*....|.
gi 446420416 257 DELNKELIKFL 267
Cdd:COG1506  219 PDYLERILDFL 229
PRK05855 PRK05855
SDR family oxidoreductase;
1-87 6.78e-13

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 68.08  E-value: 6.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416   1 MFVTVEKDVHIFVQDVNPgPGSKTVFFVHGWPLNHQMYQYQLNFLPEHgFRCIAMDIRGNGQSDKP-WT-GYTYDRLADD 78
Cdd:PRK05855   5 RTVVSSDGVRLAVYEWGD-PDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPkRTaAYTLARLADD 82


                 ....*....
gi 446420416  79 IAIVLEALQ 87
Cdd:PRK05855  83 FAAVIDAVS 91
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 25-124 2.23e-11

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 62.70  E-value: 2.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  25 VFFVHGWPLNHQMYQYQLNFLPEHGfRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVENATLVGFSVGGALSI 104
Cdd:PRK03592  30 IVFLHGNPTSSYLWRNIIPHLAGLG-RCLAPDLIGMGASDKPDIDYTFADHARYLDAWFDALGLDDVVLVGHDWGSALGF 108

                         90       100
                 ....*....|....*....|
gi 446420416 105 RYMSRYNGrRISKLALIDAV 124
Cdd:PRK03592 109 DWAARHPD-RVRGIAFMEAI 127
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 17-269 2.19e-10

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 59.54  E-value: 2.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  17 NPGPGSKTVFFVHGWPLNHQMYQYQLNFLPEHGFRCIAMDIRGNGQSDKPWTGY-TYDRLadDI--AI--VLEALQVENA 91
Cdd:COG1073   32 GASKKYPAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEgSPERR--DAraAVdyLRTLPGVDPE 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  92 TLV--GFSVGGALSIRYMSRYngRRISKLALidavspsfvknqESPYGVPKEQADALINQMYAnlpkflndvslsffnrn 169
Cdd:COG1073  110 RIGllGISLGGGYALNAAATD--PRVKAVIL------------DSPFTSLEDLAAQRAKEARG----------------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 170 lgaATLEWFSYLgmqsasyALIKILQAAANE-DVTKDLNKINVPTKIFHGVHDQLIPYKSAELTQQRIK-NSQLHALTNS 247
Cdd:COG1073  159 ---AYLPGVPYL-------PNVRLASLLNDEfDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAePKELLIVPGA 228

                        250       260
                 ....*....|....*....|...
gi 446420416 248 GHGSPIDQADELNKE-LIKFLQT 269
Cdd:COG1073  229 GHVDLYDRPEEEYFDkLAEFFKK 251
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 15-105 2.56e-07

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 50.74  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  15 DVNPGPGsKTVFFVHGWPLNHQMYQYQLNFLPEHGFRCIAMDIRGNGQSDKPW--TGYTYDRLADDIAIVLEALQVENAT 92
Cdd:PRK00870  40 DEGPADG-PPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGRSDKPTrrEDYTYARHVEWMRSWFEQLDLTDVT 118

                         90
                 ....*....|...
gi 446420416  93 LVGFSVGGALSIR 105
Cdd:PRK00870 119 LVCQDWGGLIGLR 131
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 20-261 1.63e-05

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 45.64  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  20 PGSKTVFFVHGWPlnHQMYQYQlNFLP--EHGFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVENAT-LVGF 96
Cdd:PLN03084 125 NNNPPVLLIHGFP--SQAYSYR-KVLPvlSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLIDELKSdKVSL 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  97 SVGGALS---IRYMSRyNGRRISKLALIDavsPSFVKNQESPYGVPKEQADALINQMYANLPKFLND---VSLSFFNRNL 170
Cdd:PLN03084 202 VVQGYFSppvVKYASA-HPDKIKKLILLN---PPLTKEHAKLPSTLSEFSNFLLGEIFSQDPLRASDkalTSCGPYAMKE 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416 171 GAATLEWFSYLGMQSASYALIKILQAAANE--DVTKDLNKI------NVPTKIFHGVHDQLIPYKSAELTQQRiKNSQLH 242
Cdd:PLN03084 278 DDAMVYRRPYLTSGSSGFALNAISRSMKKElkKYIEEMRSIltdknwKTPITVCWGLRDRWLNYDGVEDFCKS-SQHKLI 356

                        250
                 ....*....|....*....
gi 446420416 243 ALTNSGHGSPIDQADELNK 261
Cdd:PLN03084 357 ELPMAGHHVQEDCGEELGG 375
PRK10673 PRK10673
esterase;
53-122 9.71e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 42.79  E-value: 9.71e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446420416  53 IAMDIRGNGQSdkPWT-GYTYDRLADDIAIVLEALQVENATLVGFSVGGALSIRyMSRYNGRRISKLALID 122
Cdd:PRK10673  46 IQVDMRNHGLS--PRDpVMNYPAMAQDLLDTLDALQIEKATFIGHSMGGKAVMA-LTALAPDRIDKLVAID 113
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 15-104 1.02e-04

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 42.92  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  15 DVNPGPgskTVFFVHGWPLNHQMYQYQLNFLPEHgFRCIAMDIRGNGQSDKPWT-GYTYDRLADDIAIVLEALQVENATL 93
Cdd:PRK03204  30 DEGTGP---PILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPSGfGYQIDEHARVIGEFVDHLGLDRYLS 105

                         90
                 ....*....|.
gi 446420416  94 VGFSVGGALSI 104
Cdd:PRK03204 106 MGQDWGGPISM 116
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
18-110 3.70e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 40.72  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  18 PGPGsktVFFVHGWPLNHQMYQYQLNFLPEHGFRCIAMDIRGNG-------QSDKPWTGYTYDRLADDIAIVLEALQVEN 90
Cdd:COG0412   28 PRPG---VVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGgpgddpdEARALMGALDPELLAADLRAALDWLKAQP 104

                         90       100
                 ....*....|....*....|....*.
gi 446420416  91 AT------LVGFSVGGALSIRYMSRY 110
Cdd:COG0412  105 EVdagrvgVVGFCFGGGLALLAAARG 130
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 17-102 1.72e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 39.37  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  17 NPGPGSKTVFFVHGWPlNHQMYQYQLN--FLPEHGFRCIAMDIRGNGQSDKpWTGYT--YDRLADDIAIVLEALQVENAT 92
Cdd:PLN02298  54 SSSPPRALIFMVHGYG-NDISWTFQSTaiFLAQMGFACFALDLEGHGRSEG-LRAYVpnVDLVVEDCLSFFNSVKQREEF 131

                         90
                 ....*....|....*.
gi 446420416  93 ------LVGFSVGGAL 102
Cdd:PLN02298 132 qglprfLYGESMGGAI 147
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
44-100 4.63e-03

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 37.56  E-value: 4.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446420416  44 FLPEHGFRCIAMDIRGNGQSDKP---WTGYTYDRLAD-DIAIVLEALQ--VENA--TLVGFSVGG 100
Cdd:COG4757   54 YLAERGFAVLTYDYRGIGLSRPGslrGFDAGYRDWGElDLPAVLDALRarFPGLplLLVGHSLGG 118
YpfH COG0400
Predicted esterase [General function prediction only];
18-121 5.03e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 37.19  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420416  18 PGPGSKTVFFVHGW---PlnHQMYQYqLNFLPEHGFRCIA--------------MDIRG-NGQSDKPWTGYTYDRLADDI 79
Cdd:COG0400    1 GGPAAPLVVLLHGYggdE--EDLLPL-APELALPGAAVLAprapvpegpggrawFDLSFlEGREDEEGLAAAAEALAAFI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446420416  80 AIVLEALQV--ENATLVGFSVGGALSIRYMSRYnGRRISKLALI 121
Cdd:COG0400   78 DELEARYGIdpERIVLAGFSQGAAMALSLALRR-PELLAGVVAL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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