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Conserved domains on  [gi|446393663|ref|WP_000471518|]
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MULTISPECIES: iron ABC transporter permease [Streptococcus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-339 1.00e-81

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.37  E-value: 1.00e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  35 SLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLAL 114
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 115 VVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN--RTVIGWQ 192
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEqlRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 193 AGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGL 272
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446393663 273 IIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRKGK 339
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-339 1.00e-81

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.37  E-value: 1.00e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  35 SLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLAL 114
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 115 VVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN--RTVIGWQ 192
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEqlRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 193 AGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGL 272
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446393663 273 IIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRKGK 339
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 27-337 4.91e-72

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 225.87  E-value: 4.91e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663   27 LFLIGCYASLRFGAINFKTSDLITVLKNPLkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGI 106
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGD-DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  107 NAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYF--KL 184
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLS-RGRGGASPLRLILAGIAVSALLSALTSLLLLLLnpEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  185 NRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALI 264
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446393663  265 GTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
58-337 2.16e-50

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 170.65  E-value: 2.16e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  58 NSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSM--HYSTILIVCLl 135
Cdd:PRK11228  40 PTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPfaGYSLAFIAAC- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 136 GSVISCLLVFTLSYTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILG 214
Cdd:PRK11228 119 GGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHaYGIFYWLAGGVSHARWQEVWQLLPFVVTA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 215 LLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIG 294
Cdd:PRK11228 199 VPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSM 278

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446393663 295 FSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK11228 279 LLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 73-335 4.98e-39

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 4.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  73 IIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYTKQ 152
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 153 KGYHqlRLILAGAMISTLFTSVGQVVTLYF-KLNRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLN 231
Cdd:cd06550   81 LSPS--KLILIGIVLSAFFSAGVILISLLSdDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 232 ESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRII 311
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 446393663 312 NpPSETPISSIISIVGLPCFLWLI 335
Cdd:cd06550  239 L-PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-339 1.00e-81

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.37  E-value: 1.00e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  35 SLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLAL 114
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 115 VVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN--RTVIGWQ 192
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEqlRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 193 AGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGL 272
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446393663 273 IIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRKGK 339
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 27-337 4.91e-72

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 225.87  E-value: 4.91e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663   27 LFLIGCYASLRFGAINFKTSDLITVLKNPLkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGI 106
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGD-DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  107 NAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYF--KL 184
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLS-RGRGGASPLRLILAGIAVSALLSALTSLLLLLLnpEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  185 NRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALI 264
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446393663  265 GTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
58-337 2.16e-50

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 170.65  E-value: 2.16e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  58 NSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSM--HYSTILIVCLl 135
Cdd:PRK11228  40 PTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPfaGYSLAFIAAC- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 136 GSVISCLLVFTLSYTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILG 214
Cdd:PRK11228 119 GGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHaYGIFYWLAGGVSHARWQEVWQLLPFVVTA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 215 LLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIG 294
Cdd:PRK11228 199 VPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSM 278

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446393663 295 FSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK11228 279 LLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
19-340 6.68e-47

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 168.09  E-value: 6.68e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  19 LVFFITLILFLIGCYASLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAI 98
Cdd:PRK10577  12 LPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  99 ADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYtkQKGYHQLRLILAGAMISTLFTSVGQVV 178
Cdd:PRK10577  92 ASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAG--GKRLSPLRLVLAGMVVSLYLGALTTLL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 179 TLYF--KLNRTVIgWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFL 256
Cdd:PRK10577 170 LLFNeqYLQGLFL-WGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 257 SASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISS--IISIVGLPCFLWL 334
Cdd:PRK10577 249 SAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGELLPTgaVTALIGAPLLLWL 328


                 ....*.
gi 446393663 335 IRKGKN 340
Cdd:PRK10577 329 LPRLRS 334
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
16-338 8.59e-45

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 162.32  E-value: 8.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  16 HFWLVFFITLILFLIGCYASLRFGainfKTSDLITVLknplkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTR 95
Cdd:PRK10577 353 RVLAWLLALGLLLLLALVVALSFG----RDAHGWNWL-----SGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTR 423

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  96 NAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSytKQKGYHQLRLILAGAMISTLFTSVG 175
Cdd:PRK10577 424 NPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLA--RRGGFAPERLLLTGIALSALFTALI 501

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 176 QVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVL 254
Cdd:PRK10577 502 QLLLASGDPRaAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAA 581

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 255 FLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWL 334
Cdd:PRK10577 582 LLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWL 661


                 ....
gi 446393663 335 IRKG 338
Cdd:PRK10577 662 LRRS 665
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 9-341 6.66e-40

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 143.07  E-value: 6.66e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663   9 VQKNKSNHFWLVFFITLILFLIGCYASLRFGAINFKTSDLITvlknplknSNAQDVIFDIRLPRIIAAILVGAAMSQAGA 88
Cdd:COG4139    3 LPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLS--------EAWQLFVWQLRLPRTLAAVLVGASLAVSGA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  89 IMQGVTRNAIADPGLLGINAGAGLALVVA-YAFLGSMHYSTILIVCLLGSVISCLLVFTLSytkQKGYHQLRLILAGAMI 167
Cdd:COG4139   75 VMQALFENPLAEPGLLGISNGAGVGLVLVvLLGGGLLPPWLLSLAAIAGALLVTLLLLAFA---RRRLSNARLLLIGVAL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 168 STLFTSVgQVVTLYFKLN---RTVIGWQAGGLSQINWKmLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQL 244
Cdd:COG4139  152 GIICSAI-MTWAVYFSSSldlRQLMYWMMGSFGGVDWR-QLWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 245 MTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIIS 324
Cdd:COG4139  230 WRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTA 309

                        330
                 ....*....|....*..
gi 446393663 325 IVGLPCFLWLIRKGKNL 341
Cdd:COG4139  310 TLGAPVFIWLLLRRRKI 326
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 73-335 4.98e-39

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 4.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  73 IIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYTKQ 152
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 153 KGYHqlRLILAGAMISTLFTSVGQVVTLYF-KLNRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLN 231
Cdd:cd06550   81 LSPS--KLILIGIVLSAFFSAGVILISLLSdDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 232 ESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRII 311
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 446393663 312 NpPSETPISSIISIVGLPCFLWLI 335
Cdd:cd06550  239 L-PSELPVGPVTALLGAPYFLYLL 261
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
19-335 7.73e-39

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 140.18  E-value: 7.73e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  19 LVFFITLILFLIGCY-ASLRFGAINFKTSDLITVLKNPLKNsnaQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNA 97
Cdd:PRK09777   3 IALVIFITLALAGCAlLSLRMGVIPLPWRALLTDWQAGDEH---YYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  98 IADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSytkqkGYHQ-LRLILAGAMISTLFTSVgq 176
Cdd:PRK09777  80 LASPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLA-----GTHQpMKLALTGVALSALWASL-- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 177 vvTLYFKLNR-----TVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLL 251
Cdd:PRK09777 153 --TDYLMLSRpqdinNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 252 IVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCF 331
Cdd:PRK09777 231 LAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWF 310


                 ....
gi 446393663 332 LWLI 335
Cdd:PRK09777 311 FWLL 314
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 61-337 4.38e-38

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 138.55  E-value: 4.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  61 AQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVC-LLGSVI 139
Cdd:PRK03784  50 GELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCaIAGALL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 140 SCLLVFTLSYTKQKGyhQLRLILAGAMISTLFtsvGQVVT--LYFKLN---RTVIGWQAGGLSQINWKmLIIIAPIIILG 214
Cdd:PRK03784 130 ITLILLRFARRHRLS--TSRLLLAGVALGIIC---SALMTwaVYFSTSldlRQLMYWMMGGFGGVDWR-QSWLMLALLPV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 215 LLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIG 294
Cdd:PRK03784 204 LIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCA 283

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446393663 295 FSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK03784 284 LAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLR 326
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
25-337 1.41e-36

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 134.45  E-value: 1.41e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  25 LILFLIGCYASLRFGAINFKTSDLITVLKNPLKNSNAQdVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLL 104
Cdd:PRK10441  17 LLLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCT-IVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 105 GINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYTKQKGYHQLRLILAGAMISTLFTSVGQVVTLyfkL 184
Cdd:PRK10441  96 GVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIAL---L 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 185 NRTVIG----WQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASS 260
Cdd:PRK10441 173 NPDVYDqlrfWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSA 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446393663 261 VALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINpPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK10441 253 TAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRR 328
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 18-335 3.91e-35

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 130.63  E-value: 3.91e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  18 WLVFFITLILFLIGCYASLRFGAINFKTSDLITVLKNPLkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNA 97
Cdd:COG4779   23 LLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEG-DPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  98 IADPGLLGINAGAGLALVVAYAFLGSmHYSTILIVCLLGSVISCLLVFTLSYTkqKGYHQLRLILAGAMISTLFTSVGQV 177
Cdd:COG4779  102 LASPDIIGITAGASAGAVAAIVVLGG-SGLAVALGALAGGLATALLVYLLAWR--GGVSGYRLILVGIGVSAMLTAVNSY 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 178 VTLYFKLNR--TVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLF 255
Cdd:COG4779  179 LLTRADLEDaqSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 256 LSASSVALIGTVSFIGLIIPHfIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLI 335
Cdd:COG4779  259 LAAVATAAAGPIAFVALAAPQ-IARRLTRSPGPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLL 337
btuC PRK09535
cobalamin ABC transporter permease BtuC;
58-337 1.82e-33

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 126.79  E-value: 1.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  58 NSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYStILIVCLLGS 137
Cdd:PRK09535  84 PETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFG-LQAAAFAGA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 138 VISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILGLL 216
Cdd:PRK09535 163 LVAAFGVYAIA-TENGRTPVATLLLAGVAVQTFLGAVISYLLLHSGESlRRAVYWLMGHLHGSTWSDVEVALPVVVVGFV 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 217 ISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFS 296
Cdd:PRK09535 242 VLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALA 321

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446393663 297 GATFMIWVDLSSRiiNPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK09535 322 GASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRT 360
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
23-336 3.43e-23

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 98.24  E-value: 3.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  23 ITLILFLIGCYA----SLRFGAINFKTSDLITVLKNPlKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAI 98
Cdd:PRK10440  10 ITCLLLLAACVAaglwGLRSGAVTLETSQVFAALMGD-APRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663  99 ADPGLLGINAGAGLALVVAYAFLGSmHYSTILIVCLLGSVISCLLVFTLSYtkQKGYHQLRLILAGAMISTLFTSVGQVV 178
Cdd:PRK10440  89 GSPDVMGFNTGAWSGVLVAMVLFGQ-DLTAIALAAMAGGIVTSLLVWLLAW--RNGIDTFRLIIIGIGVRAMLVAFNTWL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 179 TLYFKLNRTVIG--WQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALG---QKTQLMtafLLLIV 253
Cdd:PRK10440 166 LLKASLETALTAglWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGvsvERSRLL---LMLVA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446393663 254 LFLSASSVALIGTVSFIGLIIPHfIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSI-ISIVGLPCFL 332
Cdd:PRK10440 243 VVLTAAATALAGPISFIALVAPH-IARRLSGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVtVSLGGIYLIV 321


                 ....
gi 446393663 333 WLIR 336
Cdd:PRK10440 322 LLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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